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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction Sana I. Algasaier, Jack C. Exell, Ian A. Bennet, Mark J. Thompson, Victoria J. B. Gotham, Steven J. Shaw, Timothy D. Craggs, L. David Finger, and Jane A. Grasby J. Biol. Chem. 2016; 291:8258-826