2 April 2013

publication alert

Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains Niels Van der Aa, Jiqiu Cheng, Ligia Mateiu, Masoud Zamani Esteki, Parveen Kumar, Eftychia Dimitriadou, Evelyne Vanneste, Yves Moreau, Joris Robert Vermeesch, and Thierry Voet Nucl. Acids Res. 2013 41: e66

18 March 2013

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Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome Tom Stiff, Meryem Alagoz,Diana Alcantara, Emily Outwin, Han G. Brunner, Ernie M. H. F. Bongers, Mark O'Driscoll, Penny A. Jeggo PLoS Genet 9(3): e1003360

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Cdc45 Protein-Single-stranded DNA Interaction Is Important for Stalling the Helicase during Replication Stress Irina Bruck and Daniel L. Kaplan J. Biol. Chem. 2013 288: 7550-7563.

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In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization Cecile Evrin, Alejandra Fernández-Cid, Juergen Zech, M. Carmen Herrera, Alberto Riera, Pippa Clarke, Shlomo Brill, Rudi Lurz, and Christian Speck Nucl. Acids Res. 2013 41: 3162-3172

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Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology Ian M. Slaymaker, Yang Fu, Daniel B. Toso, Nimna Ranatunga, Aaron Brewster, Susan L. Forsburg, Z. Hong Zhou, and Xiaojiang S. Chen Nucl. Acids Res. 2013 41: 3446-3456

11 March 2013

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The Fission Yeast Minichromosome Maintenance (MCM)-binding Protein (MCM-BP), Mcb1, Regulates MCM Function during Prereplicative Complex Formation in DNA Replication Venny Santosa, Sabrina Martha, Noriaki Hirose, and Katsunori Tanaka J. Biol. Chem. 2013 288: 6864-6880.

4 March 2013

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SCFFbxw15 Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation Chunbin Zou, Yan Chen, Rebecca M. Smith, Courtney Snavely, Jin Li, Tiffany, A. Coon, Bill B. Chen, Yutong Zhao, and Rama K. Mallampalli J. Biol. Chem. 2013 288: 6306-6316.

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Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis Hui Hua, Mandana Namdar, Olivier Ganier, Juraj Gregan, Marcel Méchali, and Stephen E. Kearsey Mol. Biol. Cell 2013 24:5 578-587

25 February 2013

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A Substitution in the Fingers Domain of DNA Polymerase {delta} Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site Marc J. Prindle, Michael W. Schmitt, Fabio Parmeggiani, and Lawrence A. Loeb J. Biol. Chem. 2013 288: 5572-5580.

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Chromatin-dependent and -independent regulation of DNA replication origin activation in budding yeast Marko Lõoke, Kersti Kristjuhan, Signe Värv & Arnold Kristjuhan EMBO reports (2013), 14,191 – 198

18 February 2013

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Translocation and Stability of Replicative DNA Helicases upon Encountering DNA-Protein Cross-links Toshiaki Nakano, Mayumi Miyamoto-Matsubara, Mahmoud I. Shoulkamy, Amir M. H. Salem, Seung Pil Pack, Yukio Ishimi, and Hiroshi Ide J. Biol. Chem. 2013 288: 4649-4658.

13 February 2013

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Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases Won-Ho Cho, Young-Hoon Kang, Yun-Young An, Inger Tappin, Jerard Hurwitz, and Joon-Kyu Lee, PNAS February 12, 2013 vol. 110 no. 7 2523-2527

4 February 2013

publication aler

Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase {delta} for Degradation in Response to DNA Damage Sufang Zhang, Yajing Zhou, Ali Sarkeshik, John R. Yates III, Timothy M. Thomson, Zhongtao Zhang, Ernest Y. C. Lee and Marietta Y. W. T. Lee J. Biol. Chem. 2013 288: 2951.

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Identification of Early Replicating Fragile Sites that Contribute to Genome Instability Jacqueline H. Barlow, Robert B. Faryabi, Elsa Callén, Nancy Wong, Amy Malhowski, Hua Tang Chen, Gustavo Gutierrez-Cruz, Hong-Wei Sun, Peter McKinnon, George Wright, Rafael Casellas, Davide F. Robbiani, Louis Staudt, Oscar Fernandez-Capetillo, André Nussenzweig Cell, Volume 152, Issue 3, 620-632, 24 January 2013

28 January 2013

publication alert

Location, location, location: it's all in the timing for replication origins Oscar M. Aparicio Genes & Dev. 2013. 27: 117-128