Publication alert

A TRIM28–MCM7 regulatory axis sustains DNA replication programs in glioblastoma Xiaosong Hu, Li Yang, Hongjuan Cui Biochemical and Biophysical Research Communications Volume 829, 3 September 2026, 154150

Publication alert

Structural and mechanistic insights into primer synthesis initiation by DNA primase Pengzhi Wu, Fred F. Damberger, Johannes Zehnder, Nina Wehr, Niklas Senning, Georg Lipps, Thomas Wiegand & Frédéric H.-T. Allain Nature Communications (2026)

Publication alert

CHD1L maintains genome integrity by facilitating okazaki fragment maturation Litong Nie , Jialing Fu , Min Huang , Huimin Zhang , Tiantian Ma , Chang Yang , Siting Li , Chao Wang , Junjie Chen Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag606,

Publication alert

DNA-damage dependent interaction of Orc6 to SMARCA1 in S-phase modulates chromatin remodeling Dazhen Liu , Mohit Mishra , Youyang Wang , Humayra Oishi , Aneek Mirza , Iman Fatimah Mohajir , Neha Chetlangia , Jay Sonalkar , Yo-Chuen Lin , Kannanganattu V Prasanth and Supriya G Prasanth Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag582,

Publication alert

RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks Ning Ma , Xiaohua Xu , Michael Espinoza , Chou-Wei Chang , Yukari Shiozaki , Zhigang Guo , Louis Izuagie , Binghui Shen , Yanzhong Yang , Yilun Liu Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag655,

Publication alert

Replication origin firing capacity indicates ATR inhibitor sensitivity A. Lumeau, P. L. Pfuderer, J. A. Scarth, E. Maniati, M. A. Guscott, N. Shaikh, F. B. Copley, H. Gerdes, S. De Angelis, E. L. Alard, J. Wang, P. R. Cutillas, F. K. Mardakheh, M. A. Boemo, J. V. Forment & S. E. McClelland Nature Communications (2026)

Publication alert

Spatial organization and dynamics of genome replication: from forks to foci Sunil K Pradhan , Maria Arroyo , Maruthi K Pabba , Heinrich Leonhardt , M Cristina Cardoso Nucleic Acids Research, Volume 54, Issue 11, 24 June 2026, gkag550,

Publication alert

Distinct repair outcomes from single and convergent replication fork collapse Sara C. Conwell, Khushi V. N. Patel, Savannah J. Weeks-Pollenz, Steven N. Dahmen, Matthew T. Cranford, William G. Dunphy, David T. Long, David Cortez & James M. Dewar Nature Structural & Molecular Biology volume 33, pages 939–952 (2026)

Publication alert

Structure of the pre-initiation complex explains CMGE biogenesis Thomas Pühringer, Berta Canal, Giacomo Palm, Agata Butryn, Emma C. Couves, Oliver Willhoft, Jacob S. Lewis, John F. X. Diffley & Alessandro Costa Nature (2026)

Publication alert

TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells Jordane Goulas, Basile Guignier, Barbara Ben Yamin, Caroline Pouvelle, Andrey Yurchenko, Emmanuelle Despras, Luciana de Oliveira, Pierre Laplante, Dorian Bochaton, Damien Plassard, Wei Yang, François-Xavier Theillet, Xavier Veaute, Richard D. Wood, Sergey Nikolaev, Agnès M. Cordonnier & Patricia L. Kannouche  Nature Communications (2026)

Publication alert

ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity Richard R. Spinks, Aleksa Lakic, Celine Kelso, Slobodan Jergic, Olga Yurieva, Zhi-Qiang Xu, Michael E. O’Donnell, Nicholas E. Dixon, Antoine M. van Oijen, Jacob S. Lewis & Lisanne M. Spenkelink  Nat Commun (2026).

Publication alert

Replication origin flexibility: a tool to mitigate the hazards of excess replication Haiqing Fu ∙ Christophe E. Redon ∙ Hannah M. Brenner ∙ Michael R. Ack ∙ Mirit I. Aladjem Trends in Genetics, 2026; 42, 510-523

Publication alert

Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways Biochimica et Biophysica Acta (BBA) - General Subjects Volume 1870, Issue 7, July 2026, 130947

Publication alert

Regulation of DNA replication and 3D genome organization during early embryogenesis Ichiro Hiratani Current Opinion in Genetics & Development June 2026 Article: 102469 Volume: Volume 98

Publication alert

An updated view on lagging strand DNA replication: implications for the replication stress response Rodrigo Martín-Rufo & Emilio Lecona Cell cycle 25 Pages 1-16 22 Mar 2026

Publication alert

Deciphering the dual effects of transcription on DNA replication elongation by replication-associated Micro-C Zhengrong Zhangding ∙ Xuhao Liu ∙ Haoxin Liang ∙ Yaxu Fan ∙ Yu Peng ∙ Wanqin Rao ∙ Wanlin Chen ∙ Jiazhi Hu Molecular Cell, 2026; 86, 1870-1880.e5

Publication alert

Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR Jung-Hoon Yoon, Karthi Sellamuthu, Robert E. Johnson, Louise Prakash and Satya Prakash Genes & Dev. 2026.

Publication alert

Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Elizabeth M. Irvin, Shuo Zhou, Amyn A. Habib, David S. Libich, Robert Hromas, Alexander V. Mazin, Manjeet K. Rao, Shaun K. Olsen, Elizabeth V. Wasmuth, Ana Losada, Daohong Zhou, Hong Wang, Li Lan, Eric C. Greene, Weixing Zhao, Youngho Kwon, Sandeep Burma & Patrick Sung  Nature Communications (2026)

Publication alert

Dynamic regulation of origin firing factors links CDK activity to dormant origin activation Md Shahadat Hossain, Courtney G. Sansam, Kimberlie A. Wittig, Tyler D. Noble, Kevin A. Boyd & Christopher L. Sansam  Nature Communications (2026)

Publication alert

Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart Peter L. Ducos, Alexander T. Duckworth, Kenneth A. Satyshur, James L. Keck & Timothy Grant Nature Communications (2026)

Publication alert

Distinct roles of MCM2-7 subunits in replication licensing in human cells Xinyu Fan, Wai Hei Lam, Daqi Yu, Huadong Jiang, Yan Chit Hui, Qiongdan Zhang, Weiran Li, Jian Li, Ziyang Lin, Zhan Yin, Wenxiong Wu, Yingyi Zhang, Nan Liu, Masato T. Kanemaki, Shangyu Dang & Yuanliang Zhai  Nature Communications

Publication alert

Topological stress regulates replication fork dynamics in unperturbed S phase Deepika Jayaprakash, Josie Gannon Patterson, Ruthie Mulvaney, Quinn Dickinson, Courtney Lovejoy, Mads Lerdrup, Juan Carlos Rivera-Mulia, David Cortez & Rahul Bhowmick  Nature Communications (2026)

Publication alert

ATM lifts the cGAS handbrake on DNA replication. Lin, YL., Pasero, P. Nat Cell Biol 28, 842–843 (2026).

Publication alert

ATM counteracts chromatin-bound cGAS during DNA replication Yunhao Song, Xiaojuan Ran, Yu Xu, Kartik Subramanian, Chao Dai, Mavrakis Konstantinos, Li Lan, Vipin Yadav & Lee Zou  Nature Cell Biology volume 28, pages 946–956 (2026)

Publication alert

Proximal proteomics analysis reveals DNA polymerase δ subunit 3 is a new MCM2 binding partner and promotes parental histones inheritance in mammalian cells Yaping Sun, Xiaoyan Liang, Fang Liu, Wenjuan Zhao, Jiaqi Zhou, Yue Li, Yuan Yao, Ziwei Zhang, Gang Li, Kuiming Chan, Daoqin Zhang, Zhiquan Wang, Yuan Gao, Chuanhe Yu, Yuchun Wu, Xing Kang, Lingyu Qiu, Nan Li & Haiyun Gan Cell Death & Differentiation volume  33, pages 1050–1064 (2026)

Publication alert

A thumb-domain insertion balances processivity and fidelity in DNA polymerase ε Noopur Singh , Göran O Bylund , Erik Johansson Nucleic Acids Research, Volume 54, Issue 6, 13 April 2026, gkag282,

Publication alert

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1–DNA crosslinks Mathilde Courtes , Thierry Boissière , Antoine Barthe , Philippe Pasero , Benjamin Pardo Nucleic Acids Research, Volume 54, Issue 7, 24 April 2026, gkag295,

Publication alert

ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress Stéphane Koundrioukoff , Nathan Alary , Su-Jung Kim , Thibault Collin , Antoine Toffano , Rodrigo Melendez-Garcia , Xia Wu , Yaqun Liu , Stefano Gnan , Sami El-Hilali, Olivier Brison , Filippo Rosselli , Chun-Long Chen , Michelle Debatisse Nucleic Acids Research, Volume 54, Issue 7, 24 April 2026, gkag315,

Publication alert

Archaeal family B DNA polymerase facilitates lagging strand DNA replication in the Thermococcales Geraldy Lie Stefanus Liman , Marina D Black , Vladimir Potapov , Brett W Burkhart , Katherine Levine , Brenda Baker , Jaylin L Mandley , Sarah C Davidson , Andrew F Gardner , Thomas J Santangelo , Kelly M Zatopek Nucleic Acids Research, Volume 54, Issue 8, 8 May 2026, gkag395,

Publication alert

Transcription at an inducible common fragile site reveals replication origin strength hierarchy Juliette Mandelbrojt , Caroline Tonnerre-Doncarli , Théo Baret , Aurélie Masson , Michelle Debatisse , Marie-Noëlle Prioleau Nucleic Acids Research, Volume 54, Issue 6, 13 April 2026, gkag297,

Publication alert

Transcription elongation can be sufficient, but is not necessary, to advance replication timing. Athanasios E Vouzas, Takayo Sasaki, Juan Carlos Rivera-Mulia, Jesse L Turner, Amber N Brown, Karen E Alexander, Laura Brueckner, Bas van Steensel & David M Gilbert EMBO Rep 27, 1964–1999 (2026).

Publication alert

An updated view on lagging strand DNA replication: implications for the replication stress response Rodrigo Martín-Rufo and Emilio Lecona Cell Cycle, 25(1), 1–16.

Publication alert

BRCA2-dependent maturation of nascent strands during DNA replication Larissa Milano ∙ Sophie Wells ∙ Alina Vaitsiankova ∙ Lylah Drummond-Clarke ∙ Xiaoxuan Zhu ∙ Aura Carreira ∙ Masato T. Kanemaki ∙ Keith W. Caldecott Molecular Cell, 2026; 86, 1427-1440.e5

Publication alert

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication. Paula Armina V Buco, Wilson Castillo-Tandazo, Alistair M Chalk, Courtney Pilcher, Jessica K Holien, Jörg Heierhorst, Tiong Y Tan, Amnon Koren, Monique F Smeets & Carl R Walkley EMBO Rep 27, 1759–1788 (2026).

Publication alert

MCM10, a novel YAP1/TEAD4 target, drives gastric cancer progression by bridging DNA replication to stemness acquisition Fuda Xie, Hoi Wing Leung, Yang Lyu, Peiyao Yu, Tiejun Feng, Bonan Chen, Jialin Wu, Jenson Tham, Canbin Fang, Alvin H.K. Cheung, Chit Chow, Jianhui Jiang, Jintao Hu, Fengbin Zhang, Chaowei Zhu, Keli Zhong, Meiheng Sun, Ge Zhang, Sifan Yu, Dazhi Xu, Shouyu Wang, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Aimin Li, Qing Guo, Chanchan Gao, Bin Zhang, Yuan Ma, William KK Wu, Liwei An, Chi Chun Wong, Jun Yu, Ka Fai To & Wei Kang Molecular cancer

Publication alert

Molecular impacts of Meier–Gorlin syndrome mutations on human origin licensing Ran Yang ∙ Olivia Hunker ∙ Jenna Kim ∙ Franziska Bleicher Journal of Biological Chemistry, Volume 302, Issue 2, 111100

Publication alert

Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells Elisa Balzano∙ Shyam Twayana ∙ Settapong T. Kosiyatrakul ∙ Glennis A. Logsdon ∙ Bhushan L. Thakur ∙ Evan E. Eichler ∙ Bettina Bohl ∙ Philipp Koch ∙ Simone Sidoli ∙ Anupama Kumari ∙ Katherine M. Munson ∙ Kendra Hoekzema ∙ Mirit I. Aladjem ∙ Carl L. Schildkraut iScience, Volume 29, Issue 2, 114707

Publication alert

A Meier–Gorlin syndrome mutation impairs the loading of the MCM2–7 complex during DNA replication initiation Yusong Liu , Mengquan Yang , Ping Lu, +8 , and Hongtao Yu PNAS February 20, 2026 123 (8) e2526022123

Publication alert

A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis Gabriella N.L. Chua ∙ Emily C. Beckwitt ∙ Victoria Miller-Browne ∙ Olga Yuriev ∙ Dan Zhang ∙ Bryce J. Katch ∙ Nina Y. Yao ∙ John W. Watters ∙ Kaitlin Abrantes ∙ Ryogo Funabiki ∙ Xiaolan ZhaoMichael E. O’Donnell ∙ Shixin Liu Cell volume 189, Issue 4P1124-1134.E14February 19, 2026

Publication alert

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability Carlos Origel Marmolejo ∙ Celina Sanchez ∙ Erin Helms ∙ Melissa J. McEvoy ∙ Juyoung Lee ∙ Marcel Werner ∙ Paige Robert’s ∙ Stephan Hamperl ∙ Joshua C. Saldivar Mol cell Volume 86, Issue 4P640-655.E6February 19, 2026

Publication alert

ADAR1 is an editor of DNA replication forks. Petryk, N. Nat Struct Mol Biol 33, 198–199 (2026).

Publication alert

Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity Bin Chen, Guangchao Sun, Jake A. Kloeber, Huaping Xiao, Yaobin Ouyang, Fei Zhao, Ya Li, Shilin Xu, Sonja Dragojevic, Zheming Wu, Shouhai Zhu, Yiqun Han, Ping Yin, Xinyi Tu, Hongran Qin, Xiang Zhou, Kuntian Luo, Kevin L. Peterson, Jinzhou Huang, Taro Hitosugi, Haiming Dai, Min Deng, Robert W. Mutter & Zhenkun Lou  Nature Structural & Molecular Biology volume 33, pages 293–303 (2026)

Publication alert

FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication Nibal Badra-Fajardo, Elena Karydi, Aleix Bayona-Feliu, Belén Gómez-González, Ourania Preza, Marina Arbi, Argyro Kalogeropoulou, Juha K. Rantala, Stavros Taraviras, Andrés Aguilera & Zoi Lygerou  Nature Communications ,

Publication alert

DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains Yui Imaizumi, François Charon, Caroline Surcis, Christel Picard, Pol Arnau-Romero, Jean-Christophe Andrau, Daan Noordermeer, Benoit Moindrot, Jean-Charles Cadoret & Robert Feil  Nature Communications ,(2026)

Publication alert

Automated mapping of DNA replication fork progression in human cells with ForkML Victoria Rojat, Diletta Ciardo, Alan Tourancheau, Florence Proux, Etienne Jean, Jean- Michel Arbona, Benjamin Audit, Gael A. Millot, Frédéric Bonhomme, Paola B. Arimondo, Olivier Hyrien & Benoît Le Talle Nat Commun (2026).

Publication alert

PAF15–PCNA exhaustion governs the strand-specific control of DNA replication Gita Chhetri, Sugith Babu Badugu, Narcis-Adrian Petriman, Mikkel Bo Petersen, Aylin Seren Güller, Nora Fajri, Manon Coulée, Ganesha Pandian Pitchai, Jan Novotný, Frederik Tibert Larsen, Andreas Fønss Møller, Morten Frendø Ebbesen, Tina Ravnsborg, Anoop Kumar Yadav, Barath Balarasa, Anita Lunding, Hana Polasek-Sedlackova, Ole N. Jensen, Kim Ravnskjaer, Jonathan R. Brewer, Jesper Grud Skat Madsen, Nataliya Petryk, Jens S. Andersen & Kumar Somyajit Nature (2026).

Publication alert

Evidence for a functional interaction between yeast Pol ε and PCNA in vivo Noopur Singh , Roni Odai , Ulf Persson , Göran O Bylund , Ikenna Obi , Nasim Sabouri , Gemma C Atkinson , Erik Johansson Nucleic Acids Research, Volume 53, Issue 22, 11 December 2025, gkaf1339,

Publication alert

OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells Eddie Rodriguez-Carballo, Vasilis S. Dionellis, Sotirios G. Ntallis, Lilia Bernasconi, Ezgi G. Keskin & Thanos D. Halazonetis  Nature Communications ,

Publication alert

AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms. Hunker, O., Bleichert, F. EMBO J 45, 310–333 (2026).

Publication alert

Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes Dario D’Asaro, Jean-Michel Arbona, Vinciane Piveteau, Aurèle Piazza, Cédric Vaillant & Daniel Jost Genome Biology Volume 26, article number 431, (2025)