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Recent advances on mammalian DNA replication initiation and timing: From chromatin features to nuclear organization Rocío Nunez-Vazquez, Geneviève Almouzni Current Opinion in Structural Biology Volume 98, June 2026, 103274

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Partitioning of parental histones between leading and lagging strands is modulated by DNA polymerase dosage Quinn Dickinson , Srinivasu Karri , Odile Djom Kenmogne , Shuang Zhu , Juan Carlos Rivera-Mulia , Zhenqing Ye , Zhiquan Wang , Haiyun Gan , Chuanhe Yu Nucleic Acids Research, Volume 54, Issue 15, 27 August 2026, gkag787

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FANCJ and RTEL1 facilitate pre-replication complex disassembly following replisome collision George Cameron ∙ Simran Negi ∙ Koichi Sato ∙ Sevim Yardimci ∙ Çağla Kaya ∙ Cameron McClymont ∙ Anoop Kumar Yadav ∙ Jana Krejci ∙ Puck Knipscheer ∙ Hana Polasek-Sedlackova∙ Hasan Yardimci Cell Reports, 2026; 45

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Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation Yasunori Noguchi, Almutasem Saleh, Sarah Schneider, Marina E. Ivanova, Zhuo Angel Chen, Lepakshi Ranjha, Ricardo Aramayo, Silvia Tognetti, Sarah V. Faull, Juri Rappsilber & Christian Speck Nat Commun (2026).

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Mechanistic diversity of clamp loading at small DNA gaps Fengwei Zheng ∙ Michael E. O’Donnell ∙ Huilin Li JBC REVIEWSArticles in Press113397August 2026

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Pol γ possesses separate metal binding sites for polymerase and strand displacement functions Noe Baruch-Torres , Joon Park , Josue Mora-Garduño , Arkanil Roy , Anupam Singh , G Andrés Cisneros , Luis G Brieba , Smita S Patel , Y Whitney Yin Nucleic Acids Research, Volume 54, Issue 14, 12 August 2026, gkag720,

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TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges RYO FUJISAWA AND KARIM P. M. LABIB SCIENCE 2 Jul 2026Vol 393, Issue 6812

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RTF2 and CLASPIN localize CHK1 to the replication fork to control S-phase progression CAYLA BROTON, CATHERINE L. W. MILLER, PENELOPE D. RUIZ, NICOLAS J. BLOBEL, YIBING YAO, BROOKE A. CONTI, ERNST W. SCHMID, JOHANNES C. WALTER , AND AGATA SMOGORZEWSKA SCIENCE ADVANCES 5 Aug 2026 Vol 12, Issue 32

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Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities Akshay Jayachandran, Martin Mütze, Kostiantyn Romaniuk, Jessica J. R. Hudson, Maria Rosaria Dello Stritto, Raphaël Guérois, Ananya Acharya, Stefan Braunshier, Giordano Reginato, Issam Senoussi, Ulrich Rass, Ralf Seidel and Petr Cejka Genes & Dev. 2026.

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A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis GEYLANI CAN , MAKSYM SHYIAN , ARCHANA KRISHNAMOORTHY , SAMREEN AHMED, YANG LIM , ALEX WU, RAPHAEL PAVANI, MANAL S. ZAHER, ANDRÉ NUSSENZWEIG MARKUS RÄSCHLE , THOMAS E. WILSON , THOMAS W. GLOVER , JOHANNES C. WALTER AND DAVID PELLMAN Science Vol 393, Issue 6812

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CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication Samsara W. Upadhya, Nalin Ratnayeke, Katherine R. Ferrick, David L. Rosenthal & Tobias Meyer Nature Communications (2026)

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Mechanisms of MCM2–7 helicase activation and initial DNA melting at near base-pair resolution Christopher Weekes, Lia Willerding, Sanjay P. Khadayate, Korbinian Liebl, Audrey Mossler, Alex Montoya, Vanessa Rauthe, Mohammad M. Karimi, Martin Zacharias, Helle D. Ulrich, Christian Speck& L. Maximilian Reuter  Nature Communications (2026)

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A TRIM28–MCM7 regulatory axis sustains DNA replication programs in glioblastoma Xiaosong Hu, Li Yang, Hongjuan Cui Biochemical and Biophysical Research Communications Volume 829, 3 September 2026, 154150

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Structural and mechanistic insights into primer synthesis initiation by DNA primase Pengzhi Wu, Fred F. Damberger, Johannes Zehnder, Nina Wehr, Niklas Senning, Georg Lipps, Thomas Wiegand & Frédéric H.-T. Allain Nature Communications (2026)

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CHD1L maintains genome integrity by facilitating okazaki fragment maturation Litong Nie , Jialing Fu , Min Huang , Huimin Zhang , Tiantian Ma , Chang Yang , Siting Li , Chao Wang , Junjie Chen Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag606,