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MCM10, a novel YAP1/TEAD4 target, drives gastric cancer progression by bridging DNA replication to stemness acquisition Fuda Xie, Hoi Wing Leung, Yang Lyu, Peiyao Yu, Tiejun Feng, Bonan Chen, Jialin Wu, Jenson Tham, Canbin Fang, Alvin H.K. Cheung, Chit Chow, Jianhui Jiang, Jintao Hu, Fengbin Zhang, Chaowei Zhu, Keli Zhong, Meiheng Sun, Ge Zhang, Sifan Yu, Dazhi Xu, Shouyu Wang, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Aimin Li, Qing Guo, Chanchan Gao, Bin Zhang, Yuan Ma, William KK Wu, Liwei An, Chi Chun Wong, Jun Yu, Ka Fai To & Wei Kang Molecular cancer

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Molecular impacts of Meier–Gorlin syndrome mutations on human origin licensing Ran Yang ∙ Olivia Hunker ∙ Jenna Kim ∙ Franziska Bleicher Journal of Biological Chemistry, Volume 302, Issue 2, 111100

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Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells Elisa Balzano∙ Shyam Twayana ∙ Settapong T. Kosiyatrakul ∙ Glennis A. Logsdon ∙ Bhushan L. Thakur ∙ Evan E. Eichler ∙ Bettina Bohl ∙ Philipp Koch ∙ Simone Sidoli ∙ Anupama Kumari ∙ Katherine M. Munson ∙ Kendra Hoekzema ∙ Mirit I. Aladjem ∙ Carl L. Schildkraut iScience, Volume 29, Issue 2, 114707

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A Meier–Gorlin syndrome mutation impairs the loading of the MCM2–7 complex during DNA replication initiation Yusong Liu , Mengquan Yang , Ping Lu, +8 , and Hongtao Yu PNAS February 20, 2026 123 (8) e2526022123

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A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis Gabriella N.L. Chua ∙ Emily C. Beckwitt ∙ Victoria Miller-Browne ∙ Olga Yuriev ∙ Dan Zhang ∙ Bryce J. Katch ∙ Nina Y. Yao ∙ John W. Watters ∙ Kaitlin Abrantes ∙ Ryogo Funabiki ∙ Xiaolan ZhaoMichael E. O’Donnell ∙ Shixin Liu Cell volume 189, Issue 4P1124-1134.E14February 19, 2026

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Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability Carlos Origel Marmolejo ∙ Celina Sanchez ∙ Erin Helms ∙ Melissa J. McEvoy ∙ Juyoung Lee ∙ Marcel Werner ∙ Paige Robert’s ∙ Stephan Hamperl ∙ Joshua C. Saldivar Mol cell Volume 86, Issue 4P640-655.E6February 19, 2026

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ADAR1 is an editor of DNA replication forks. Petryk, N. Nat Struct Mol Biol 33, 198–199 (2026).

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Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity Bin Chen, Guangchao Sun, Jake A. Kloeber, Huaping Xiao, Yaobin Ouyang, Fei Zhao, Ya Li, Shilin Xu, Sonja Dragojevic, Zheming Wu, Shouhai Zhu, Yiqun Han, Ping Yin, Xinyi Tu, Hongran Qin, Xiang Zhou, Kuntian Luo, Kevin L. Peterson, Jinzhou Huang, Taro Hitosugi, Haiming Dai, Min Deng, Robert W. Mutter & Zhenkun Lou  Nature Structural & Molecular Biology volume 33, pages 293–303 (2026)

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FANCD2 restrains fork progression and prevents fragility at early origins upon re-replication Nibal Badra-Fajardo, Elena Karydi, Aleix Bayona-Feliu, Belén Gómez-González, Ourania Preza, Marina Arbi, Argyro Kalogeropoulou, Juha K. Rantala, Stavros Taraviras, Andrés Aguilera & Zoi Lygerou  Nature Communications ,

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DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains Yui Imaizumi, François Charon, Caroline Surcis, Christel Picard, Pol Arnau-Romero, Jean-Christophe Andrau, Daan Noordermeer, Benoit Moindrot, Jean-Charles Cadoret & Robert Feil  Nature Communications ,(2026)

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Automated mapping of DNA replication fork progression in human cells with ForkML Victoria Rojat, Diletta Ciardo, Alan Tourancheau, Florence Proux, Etienne Jean, Jean- Michel Arbona, Benjamin Audit, Gael A. Millot, Frédéric Bonhomme, Paola B. Arimondo, Olivier Hyrien & Benoît Le Talle Nat Commun (2026).

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PAF15–PCNA exhaustion governs the strand-specific control of DNA replication Gita Chhetri, Sugith Babu Badugu, Narcis-Adrian Petriman, Mikkel Bo Petersen, Aylin Seren Güller, Nora Fajri, Manon Coulée, Ganesha Pandian Pitchai, Jan Novotný, Frederik Tibert Larsen, Andreas Fønss Møller, Morten Frendø Ebbesen, Tina Ravnsborg, Anoop Kumar Yadav, Barath Balarasa, Anita Lunding, Hana Polasek-Sedlackova, Ole N. Jensen, Kim Ravnskjaer, Jonathan R. Brewer, Jesper Grud Skat Madsen, Nataliya Petryk, Jens S. Andersen & Kumar Somyajit Nature (2026).

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Evidence for a functional interaction between yeast Pol ε and PCNA in vivo Noopur Singh , Roni Odai , Ulf Persson , Göran O Bylund , Ikenna Obi , Nasim Sabouri , Gemma C Atkinson , Erik Johansson Nucleic Acids Research, Volume 53, Issue 22, 11 December 2025, gkaf1339,

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OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells Eddie Rodriguez-Carballo, Vasilis S. Dionellis, Sotirios G. Ntallis, Lilia Bernasconi, Ezgi G. Keskin & Thanos D. Halazonetis  Nature Communications ,

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AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms. Hunker, O., Bleichert, F. EMBO J 45, 310–333 (2026).