31 March 2020

publication alert

Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO–POL enzyme Shreya Ghosh, Yehuda Goldgur, Stewart Shuman Nucleic Acids Research, Volume 48, Issue 6, 06 April 2020, Pages 3165–3180,

16 March 2020

publication alert

Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles Anupam Singh, Manjula Pandey, Divya Nandakumar, Kevin D Raney, Y Whitney Yin, Smita S Patel EMBO J (2020)39:e103367

publication alert

Structure of the processive human Pol δ holoenzyme Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan & Alfredo De Biasio Nature Communications volume 11, Article number: 1109 (2020)

publication alert

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells Annabel Quinet, Stephanie Tirman, Jessica Jackson, Saša Šviković, Delphine Lemaçon, Denisse Carvajal-Maldonado, Daniel González-Acosta, Alexandre T. Vessoni, Emily Cybulla, Matthew Wood, Steven Tavis, Luis F.Z. Batista, Juan Méndez, Julian E. Sale, Alessandro Vindigni Mol Cell VOLUME 77, ISSUE 3, P461-474.E9,

publication alert

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer Hu Fang, Jayne A. Barbour, Rebecca C. Poulos, Riku Katainen, Lauri A. Aaltonen, Jason W. H. Wong PLoS Genet 16(2): e1008572

publication alert

Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis Jiaming Zhang, Deyin Hou, James Annis, Forough Sargolzaeiaval, Julia Appelbaum, Eishi Takahashi, George M. Martin, Alan Herr, and Junko Oshima DNA and Cell BiologyVol. 39, No. 1

publication alert

DNA unwinding mechanism of a eukaryotic replicative CMG helicase Zuanning Yuan, Roxana Georgescu, Lin Bai, Dan Zhang, Huilin Li & Michael E. O’Donnell Nature Communications volume 11, Article number: 688 (2020)

publication alert

HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells Andrew J. Kueh, Samantha Eccles, Leonie Tang, Alexandra L. Garnham, Rose E. May, Marco J. Herold, Gordon K. Smyth, Anne K. Voss, Tim Thomas Mol Cell Biol 40:e00506-19.

6 January 2020

publication alert

Mechanisms of replication origin licensing: a structural perspective Franziska Bleichert Current Opinion in Structural BiologyVolume 59, December 2019, Pages 195-204

publication alert

Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication Jacob S. Lewis, Lisanne M. Spenkelink, Grant D. Schauer, Callum Kay, Michael E. O’Donnell, Antoine M. van Oijen Mol Cell VOLUME 77, ISSUE 1, P17-25.E5, JANUARY 02, 2020

publication alert

Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks Ronald P. Wong, Néstor García-Rodríguez, Nicola Zilio, Mária Hanulová, Helle D. Ulrich Mol Cell VOLUME 77, ISSUE 1, P3-16.E4, JANUARY 02, 2020

publication alert

Fork pausing complex engages topoisomerases at the replisome Maksym Shyian, Benjamin Albert, Andreja Moset Zupan, Vitalii Ivanitsa, Gabriel Charbonnet, Daniel Dilg and David Shore Genes & Dev. 2020. 34: 87-98

publication alert

Top1 and Top2 promote replication fork arrest at a programmed pause site Mélanie V. Larcher and Philippe Pasero Genes & Dev. 2020. 34: 1-3

publication alert

A gatekeeping function of the replicative polymerase controls pathway choice in the resolution of lesion-stalled replisomes Seungwoo Chang, Karel Naiman, Elizabeth S. Thrall, James E. Kath, Slobodan Jergic, Nicholas E. Dixon, Robert P. Fuchs, and Joseph J. Loparo PNAS December 17, 2019 116 (51) 25591-25601

publication alert

Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism Malgorzata Jedrychowska, Milena Denkiewicz-Kruk, Malgorzata Alabrudzinska, Adrianna Skoneczna, Piotr Jonczyk, Michal Dmowski , Iwona J. Fijalkowska PLoS Genet 15(12): e1008494.