31 March 2020
publication alert
Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO–POL enzyme
Shreya Ghosh, Yehuda Goldgur, Stewart Shuman
Nucleic Acids Research, Volume 48, Issue 6, 06 April 2020, Pages 3165–3180,
16 March 2020
publication alert
Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles
Anupam Singh, Manjula Pandey, Divya Nandakumar, Kevin D Raney, Y Whitney Yin, Smita S Patel
EMBO J (2020)39:e103367
publication alert
Structure of the processive human Pol δ holoenzyme
Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan & Alfredo De Biasio
Nature Communications volume 11, Article number: 1109 (2020)
publication alert
PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
Annabel Quinet, Stephanie Tirman, Jessica Jackson, Saša Šviković, Delphine Lemaçon, Denisse Carvajal-Maldonado, Daniel González-Acosta, Alexandre T. Vessoni, Emily Cybulla, Matthew Wood, Steven Tavis, Luis F.Z. Batista, Juan Méndez, Julian E. Sale, Alessandro Vindigni
Mol Cell VOLUME 77, ISSUE 3, P461-474.E9,
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Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer
Hu Fang, Jayne A. Barbour, Rebecca C. Poulos, Riku Katainen, Lauri A. Aaltonen, Jason W. H. Wong
PLoS Genet 16(2): e1008572
publication alert
Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis
Jiaming Zhang, Deyin Hou, James Annis, Forough Sargolzaeiaval, Julia Appelbaum, Eishi Takahashi, George M. Martin, Alan Herr, and Junko Oshima
DNA and Cell BiologyVol. 39, No. 1
publication alert
DNA unwinding mechanism of a eukaryotic replicative CMG helicase
Zuanning Yuan, Roxana Georgescu, Lin Bai, Dan Zhang, Huilin Li & Michael E. O’Donnell
Nature Communications volume 11, Article number: 688 (2020)
publication alert
HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells
Andrew J. Kueh, Samantha Eccles, Leonie Tang, Alexandra L. Garnham, Rose E. May, Marco J. Herold, Gordon K. Smyth, Anne K. Voss, Tim Thomas
Mol Cell Biol 40:e00506-19.
6 January 2020
publication alert
Mechanisms of replication origin licensing: a structural perspective
Franziska Bleichert
Current Opinion in Structural BiologyVolume 59, December 2019, Pages 195-204
publication alert
Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication
Jacob S. Lewis, Lisanne M. Spenkelink, Grant D. Schauer, Callum Kay, Michael E. O’Donnell, Antoine M. van Oijen
Mol Cell VOLUME 77, ISSUE 1, P17-25.E5, JANUARY 02, 2020
publication alert
Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks
Ronald P. Wong, Néstor García-Rodríguez, Nicola Zilio, Mária Hanulová, Helle D. Ulrich
Mol Cell VOLUME 77, ISSUE 1, P3-16.E4, JANUARY 02, 2020
publication alert
Fork pausing complex engages topoisomerases at the replisome
Maksym Shyian, Benjamin Albert, Andreja Moset Zupan, Vitalii Ivanitsa, Gabriel Charbonnet, Daniel Dilg and David Shore
Genes & Dev. 2020. 34: 87-98
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Top1 and Top2 promote replication fork arrest at a programmed pause site
Mélanie V. Larcher and Philippe Pasero
Genes & Dev. 2020. 34: 1-3
publication alert
A gatekeeping function of the replicative polymerase controls pathway choice in the resolution of lesion-stalled replisomes
Seungwoo Chang, Karel Naiman, Elizabeth S. Thrall, James E. Kath, Slobodan Jergic, Nicholas E. Dixon, Robert P. Fuchs, and Joseph J. Loparo
PNAS December 17, 2019 116 (51) 25591-25601
publication alert
Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism
Malgorzata Jedrychowska, Milena Denkiewicz-Kruk, Malgorzata Alabrudzinska, Adrianna Skoneczna, Piotr Jonczyk, Michal Dmowski , Iwona J. Fijalkowska
PLoS Genet 15(12): e1008494.
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