21 February 2022
publication alert
Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ
Joseph M Dahl, Natalie Thomas, Maxwell A Tracy, Brady L Hearn, Lalith Perera, Scott R Kennedy, Alan J Herr, Thomas A Kunkel
Nucleic Acids Research, Volume 50, Issue 2, 25 January 2022,
24 January 2022
publication alert
How asymmetric DNA replication achieves symmetrical fidelity
Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Jordan St. Charles, Joseph Dahl, Corinne E. Farrell, Jessica S. Williams & Thomas A. Kunkel
Nature Structural & Molecular Biology volume 28, pages 1020–1028 (2021)
publication alert
Blm helicase facilitates rapid replication of repetitive DNA sequences in early Drosophila development
Jolee M Ruchert, Morgan M Brady, Susan McMahan, Karly J Lacey, Leigh C Latta, Jeff Sekelsky, Eric P Stoffregen
Genetics, Volume 220, Issue 1, January 2022, iyab169
publication alert
Geminin is essential for DNA re-replication in the silk gland cells of silkworms
Tai-HangLiu, Xiao-Long Dong, Peng Chen, QianZhang, Xiao-LinZhou, ChengLu, Min-HuiPan
Experimental Cell Research Volume 410, Issue 1, 1 January 2022, 112951
publication alert
Water skating: How polymerase sliding clamps move on DNA
Huilin Li, Fengwei Zheng, Mike O’Donnell
Febs JournalVolume288, Issue24 December 2021 Pages 7256-7262
publication alert
CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism
Nina Y. Yao, Dan Zhang, Olga Yurieva, and Michael E. O’Donnell
PNAS January 25, 2022 119 (4) e2119580119
publication alert
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase
Julia F. Greiwe, Thomas C. R. Miller, Julia Locke, Fabrizio Martino, Steven Howell, Anne Schreiber, Andrea Nans, John F. X. Diffley & Alessandro Costa
Nature Structural & Molecular Biology volume 29, pages 10–20 (2022)
7 December 2021
publication alert
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites
Shyam Twayana, Albino Bacolla, Angelica Barreto-Galvez, Ruth B. De-Paula, William C. Drosopoulos, Settapong T. Kosiyatrakul, Eric E. Bouhassira, John A. Tainer, Advaitha Madireddy, and Carl L. Schildkraut
PNAS November 30, 2021 118 (48) e2106477118;
publication alert
The genetic architecture of DNA replication timing in human pluripotent stem cells
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark & Amnon Koren
Nature Communications volume 12, Article number: 6746 (2021)
publication alert
Molecular Mechanisms of the RECQ4 Pathogenic Mutations
Xiaohua Xu, Chou-Wei Chang, Min Li, Chao Liu and Yilun Liu
Front. Mol. Biosci., 18 November 2021
publication alert
Replication timing analysis in polyploid cells reveals Rif1 uses multiple mechanisms to promote underreplication in Drosophila
Souradip Das, Madison Caballero, Tatyana Kolesnikova, Igor Zhimulev, Amnon Koren, Jared Nordman
Genetics, Volume 219, Issue 3, November 2021, iyab147,
publication alert
Error-prone, stress-induced 3′ flap–based Okazaki fragment maturation supports cell survival
HAITAO SUN, ZHAONING LU, AMANPREET SINGH, YAJING ZHOU, ERIC ZHENG, MIAN ZHOU, JINHUI WANG, XIWEI WU, ZUNSONG HU, ZHAOHUI GU, JUDITH L. CAMPBELL, LI ZHENG, AND BINGHUI SHEN
SCIENCE 2 Dec 2021,Vol 374, Issue 6572 pp. 1252-1258
publication alert
Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry
Yoko Hayashi-Takanaka, Yuichiro Hayashi, Yasuhiro Hirano, Atsuko Miyawaki-Kuwakado, Yasuyuki Ohkawa, Chikashi Obuse, Hiroshi Kimura, Tokuko Haraguchi, Yasushi Hiraoka
Nucleic Acids Research, Volume 49, Issue 21, 2 December 2021, Pages 12152–12166
publication alert
The human telomeric proteome during telomere replication
Chih-Yi Gabriela Lin, Anna Christina Näger, Thomas Lunardi, Aleksandra Vančevska, Gérald Lossaint, Joachim Lingner
Nucleic Acids Research, Volume 49, Issue 21, 2 December 2021, Pages 12119–12135
publication alert
Structure of a human replisome shows the organisation and interactions of a DNA replication machine
Morgan L Jones, Yasemin Baris, Martin R G Taylor, Joseph T P Yeeles
EMBO J (2021)40:e108819
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