publication alert

Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans Vincent Gaggioli , Manuela R. Kieninger , Anna Klucnika, Richard Butler, Philip Zegerman PLoS Genet 16(12): e1008948.

publication alert

The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization Yuanliang Yan, Zhijie Xu, Jinzhou Huang, Guijie Guo, Ming Gao, Wootae Kim, Xiangyu Zeng, Jake A Kloeber, Qian Zhu, Fei Zhao ... Show more Nucleic Acids Research, Volume 48, Issue 22, 16 December 2020, Pages 12711–12726,

publication alert

Developmental differences in genome replication program and origin activation Cathia Rausch, Patrick Weber, Paulina Prorok, David Hörl, Andreas Maiser, Anne Lehmkuhl, Vadim O Chagin, Corella S Casas-Delucchi, Heinrich Leonhardt, M Cristina Cardoso Author Notes Nucleic Acids Research, Volume 48, Issue 22, 16 December 2020, Pages 12751–12777,

publication alert

The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner Rosaline Y.C. Hsu , Sumanprava Giri , Yating Wang , Yo-Chuen Lin , Dazhen Liu , Susan Wopat , Arindam Chakraborty , Kannanganattu V. Prasanth & Supriya G. Prasanth Cell cycle Volume 19, 2020 - Issue 21 Pages 2927-2938 |

publication alert

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε Vladislav O. Sviderskiy, Lili Blumenberg, Elizabeth Gorodetsky, Sylvia Adams, Kelly V. Ruggles, Richard Possemato Mol Cell VOLUME 80, ISSUE 4, P682-698.E7,

publication alert

Pif1, RPA, and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis Melanie A. Sparks, Peter M. Burgers* and Roberto Galletto The Journal of Biological Chemistry 295, 15883-15891.

publication alert

Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy Kouta Mayanagi, Keisuke Oki, Naoyuki Miyazaki, Sonoko Ishino, Takeshi Yamagami, Kosuke Morikawa, Kenji Iwasaki, Daisuke Kohda, Tsuyoshi Shirai & Yoshizumi Ishino BMC Biology volume 18, Article number: 152 (2020)

publication alert

Equilibrium between nascent and parental MCM proteins protects replicating genomes Hana Sedlackova, Maj-Britt Rask, Rajat Gupta, Chunaram Choudhary, Kumar Somyajit & Jiri Lukas Nature (2020).

publication alert

Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path Thomas Dodd, Margherita Botto, Fabian Paul, Rafael Fernandez-Leiro , Meindert H. Lamers and Ivaylo Ivanov NATURE COMMUNICATIONS (2020)11:5379

publication alert

The DNA replication fork suppresses CMG unloading from chromatin before termination Emily Low, Gheorghe Chistol, Manal S. Zaher, Olga V. Kochenova, and Johannes C. Walter GENES & DEVELOPMENT 34:1534–1545

publication alert

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome David A. Parry,Lukas Tamayo-Orrego, Paula Carroll, Joseph A. Marsh, Philip Greene, Olga Murina, Carolina Uggenti,Andrea Leitch, The Scottish Genomes Partnership, Rita Káposzta, Gabriella Merő, Andrea Nagy, Brigitta Orlik, Balázs Kovács-Pászthy, Alan J. Quigley,Magdolna Riszter, Julia Rankin, Martin A.M. Reijns, Katalin Szakszon, and Andrew P. Jackson GENES & DEVELOPMENT 34:1520–1533

publication alert

Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication Ikenna Obi, Matilda Rentoft, Vandana Singh, Jan Jamroskovic, Karam Chand, Erik Chorell, Fredrik Westerlund, Nasim Sabouri Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10998–11015,

publication alert

CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication Haihua Feng, Jingchen Lu, Xiaotian Song, Angkana Thongkum, Fan Zhang, Lihong Lou, Ofer Reizes, Alexandru Almasan, Zihua Gong Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10940–10952,

publication alert

A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine Matthew T Cranford, Joseph D Kaszubowski, Michael A Trakselis Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10986–10997,

publication alert

Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA Naining Xu, Yingying You, Changdong Liu, Maxim Balasov, Lee Tung Lun, Yanyan Geng, Chun Po Fung, Haitao Miao, Honglei Tian, To To Choy Xiao Shi, Zhuming Fan, Bo Zhou, Katarina Akhmetova, Rahman Ud Din, Hongyu Yang, Quan Hao, Peiyuan Qian, Igor Chesnokov, Guang Zhu Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 11146–11161,