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Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities Akshay Jayachandran, Martin Mütze, Kostiantyn Romaniuk, Jessica J.R. Hudson, Maria Rosaria Dello Stritto, Raphaël Guérois, Ananya Acharya, Stefan Braunshier, Giordano Reginato, Issam Senoussi, Ulrich Rass3 Ralf Seidel and Petr Cejka. Genes & Dev. 2026. 40: 1747-1764