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The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing Rebecca A. Frum, Shilpa Singh, Catherine Vaughan, Nitai D. Mukhopadhyay, Steven R. Grossman, Brad Windle, Sumitra Deb and Swati Palit Deb Nucl. Acids Res. (2014) 42 (2): 926-940