Publication alert

Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart Peter L. Ducos, Alexander T. Duckworth, Kenneth A. Satyshur, James L. Keck & Timothy Grant Nature Communications (2026)

Publication alert

Distinct roles of MCM2-7 subunits in replication licensing in human cells Xinyu Fan, Wai Hei Lam, Daqi Yu, Huadong Jiang, Yan Chit Hui, Qiongdan Zhang, Weiran Li, Jian Li, Ziyang Lin, Zhan Yin, Wenxiong Wu, Yingyi Zhang, Nan Liu, Masato T. Kanemaki, Shangyu Dang & Yuanliang Zhai  Nature Communications

Publication alert

Topological stress regulates replication fork dynamics in unperturbed S phase Deepika Jayaprakash, Josie Gannon Patterson, Ruthie Mulvaney, Quinn Dickinson, Courtney Lovejoy, Mads Lerdrup, Juan Carlos Rivera-Mulia, David Cortez & Rahul Bhowmick  Nature Communications (2026)

Publication alert

ATM lifts the cGAS handbrake on DNA replication. Lin, YL., Pasero, P. Nat Cell Biol 28, 842–843 (2026).

Publication alert

ATM counteracts chromatin-bound cGAS during DNA replication Yunhao Song, Xiaojuan Ran, Yu Xu, Kartik Subramanian, Chao Dai, Mavrakis Konstantinos, Li Lan, Vipin Yadav & Lee Zou  Nature Cell Biology volume 28, pages 946–956 (2026)

Publication alert

Proximal proteomics analysis reveals DNA polymerase δ subunit 3 is a new MCM2 binding partner and promotes parental histones inheritance in mammalian cells Yaping Sun, Xiaoyan Liang, Fang Liu, Wenjuan Zhao, Jiaqi Zhou, Yue Li, Yuan Yao, Ziwei Zhang, Gang Li, Kuiming Chan, Daoqin Zhang, Zhiquan Wang, Yuan Gao, Chuanhe Yu, Yuchun Wu, Xing Kang, Lingyu Qiu, Nan Li & Haiyun Gan Cell Death & Differentiation volume  33, pages 1050–1064 (2026)

Publication alert

A thumb-domain insertion balances processivity and fidelity in DNA polymerase ε Noopur Singh , Göran O Bylund , Erik Johansson Nucleic Acids Research, Volume 54, Issue 6, 13 April 2026, gkag282,

Publication alert

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1–DNA crosslinks Mathilde Courtes , Thierry Boissière , Antoine Barthe , Philippe Pasero , Benjamin Pardo Nucleic Acids Research, Volume 54, Issue 7, 24 April 2026, gkag295,

Publication alert

ATR and TopBP1 oppose to control dormant origin activity and global replication dynamics, providing a first defense against replication stress Stéphane Koundrioukoff , Nathan Alary , Su-Jung Kim , Thibault Collin , Antoine Toffano , Rodrigo Melendez-Garcia , Xia Wu , Yaqun Liu , Stefano Gnan , Sami El-Hilali, Olivier Brison , Filippo Rosselli , Chun-Long Chen , Michelle Debatisse Nucleic Acids Research, Volume 54, Issue 7, 24 April 2026, gkag315,

Publication alert

Archaeal family B DNA polymerase facilitates lagging strand DNA replication in the Thermococcales Geraldy Lie Stefanus Liman , Marina D Black , Vladimir Potapov , Brett W Burkhart , Katherine Levine , Brenda Baker , Jaylin L Mandley , Sarah C Davidson , Andrew F Gardner , Thomas J Santangelo , Kelly M Zatopek Nucleic Acids Research, Volume 54, Issue 8, 8 May 2026, gkag395,

Publication alert

Transcription at an inducible common fragile site reveals replication origin strength hierarchy Juliette Mandelbrojt , Caroline Tonnerre-Doncarli , Théo Baret , Aurélie Masson , Michelle Debatisse , Marie-Noëlle Prioleau Nucleic Acids Research, Volume 54, Issue 6, 13 April 2026, gkag297,

Publication alert

Transcription elongation can be sufficient, but is not necessary, to advance replication timing. Athanasios E Vouzas, Takayo Sasaki, Juan Carlos Rivera-Mulia, Jesse L Turner, Amber N Brown, Karen E Alexander, Laura Brueckner, Bas van Steensel & David M Gilbert EMBO Rep 27, 1964–1999 (2026).

Publication alert

An updated view on lagging strand DNA replication: implications for the replication stress response Rodrigo Martín-Rufo and Emilio Lecona Cell Cycle, 25(1), 1–16.

Publication alert

BRCA2-dependent maturation of nascent strands during DNA replication Larissa Milano ∙ Sophie Wells ∙ Alina Vaitsiankova ∙ Lylah Drummond-Clarke ∙ Xiaoxuan Zhu ∙ Aura Carreira ∙ Masato T. Kanemaki ∙ Keith W. Caldecott Molecular Cell, 2026; 86, 1427-1440.e5

Publication alert

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication. Paula Armina V Buco, Wilson Castillo-Tandazo, Alistair M Chalk, Courtney Pilcher, Jessica K Holien, Jörg Heierhorst, Tiong Y Tan, Amnon Koren, Monique F Smeets & Carl R Walkley EMBO Rep 27, 1759–1788 (2026).