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Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε Vladislav O. Sviderskiy, Lili Blumenberg, Elizabeth Gorodetsky, Sylvia Adams, Kelly V. Ruggles, Richard Possemato Mol Cell VOLUME 80, ISSUE 4, P682-698.E7,

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Pif1, RPA, and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis Melanie A. Sparks, Peter M. Burgers* and Roberto Galletto The Journal of Biological Chemistry 295, 15883-15891.

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Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy Kouta Mayanagi, Keisuke Oki, Naoyuki Miyazaki, Sonoko Ishino, Takeshi Yamagami, Kosuke Morikawa, Kenji Iwasaki, Daisuke Kohda, Tsuyoshi Shirai & Yoshizumi Ishino BMC Biology volume 18, Article number: 152 (2020)

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Equilibrium between nascent and parental MCM proteins protects replicating genomes Hana Sedlackova, Maj-Britt Rask, Rajat Gupta, Chunaram Choudhary, Kumar Somyajit & Jiri Lukas Nature (2020).

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Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path Thomas Dodd, Margherita Botto, Fabian Paul, Rafael Fernandez-Leiro , Meindert H. Lamers and Ivaylo Ivanov NATURE COMMUNICATIONS (2020)11:5379

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The DNA replication fork suppresses CMG unloading from chromatin before termination Emily Low, Gheorghe Chistol, Manal S. Zaher, Olga V. Kochenova, and Johannes C. Walter GENES & DEVELOPMENT 34:1534–1545

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PRIM1 deficiency causes a distinctive primordial dwarfism syndrome David A. Parry,Lukas Tamayo-Orrego, Paula Carroll, Joseph A. Marsh, Philip Greene, Olga Murina, Carolina Uggenti,Andrea Leitch, The Scottish Genomes Partnership, Rita Káposzta, Gabriella Merő, Andrea Nagy, Brigitta Orlik, Balázs Kovács-Pászthy, Alan J. Quigley,Magdolna Riszter, Julia Rankin, Martin A.M. Reijns, Katalin Szakszon, and Andrew P. Jackson GENES & DEVELOPMENT 34:1520–1533

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Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication Ikenna Obi, Matilda Rentoft, Vandana Singh, Jan Jamroskovic, Karam Chand, Erik Chorell, Fredrik Westerlund, Nasim Sabouri Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10998–11015,

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CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication Haihua Feng, Jingchen Lu, Xiaotian Song, Angkana Thongkum, Fan Zhang, Lihong Lou, Ofer Reizes, Alexandru Almasan, Zihua Gong Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10940–10952,

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A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine Matthew T Cranford, Joseph D Kaszubowski, Michael A Trakselis Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10986–10997,

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Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA Naining Xu, Yingying You, Changdong Liu, Maxim Balasov, Lee Tung Lun, Yanyan Geng, Chun Po Fung, Haitao Miao, Honglei Tian, To To Choy Xiao Shi, Zhuming Fan, Bo Zhou, Katarina Akhmetova, Rahman Ud Din, Hongyu Yang, Quan Hao, Peiyuan Qian, Igor Chesnokov, Guang Zhu Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 11146–11161,

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Prevention of unwanted recombination at damaged replication forks Carl P. Lehmann, Alberto Jiménez-Martín, Dana Branzei & José Antonio Tercero Current Genetics volume 66, pages1045–1051(2020)

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Limiting homologous recombination at stalled replication forks is essential for cell viability: DNA2 to the rescue Rowin Appanah, David Jones, Benoît Falquet & Ulrich Rass Current Genetics volume 66, pages1085–1092(2020)

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How yeast cells deal with stalled replication forks Matan Arbel, Batia Liefshitz & Martin Kupiec Current Genetics volume 66, pages911–915(2020)

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Positive and Negative Regulation of DNA Replication Initiation Qiliang Din, Amnon Koren TIGS VOLUME 36, ISSUE 11, P868-879, NOVEMBER 01, 2020