Publication Alert

Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication

Yayoi Kinoshita, Edward M. Johnson, Ronald E. Gordon, Heather Negri-Bell, Mark T. Evans, Jennifer Coolbaugh, Yaseris Rosario-Peralta, Joseph Samet, Evelyn Slusser, Mark P. Birkenbach, Dianne C. Daniel

Microscopy Research and Technique DOI: 10.1002/jemt.20553

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Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stress

Xin Quan Ge, Dean A. Jackson, and J. Julian Blow

GENES & DEVELOPMENT 21:3331-3341, 2007

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The role of pre-replicative complex (pre-RC) components in oncogenesis

Eric Lau, Toshiya Tsuji, Liping Guo, Shih-Hsin Lu and Wei Jiang

The FASEB Journal. 2007;21:3786-3794

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The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

Katsuhiro Hanada, Magda Budzowska, Sally L Davies, Ellen van Drunen, Hideo Onizawa, H Berna Beverloo, Alex Maas, Jeroen Essers, Ian D Hickson & Roland Kanaar

Nature Structural & Molecular Biology 14, 1096 - 1104 (2007) 


Publication Alert

The Origin Recognition Complex Localizes to Telomere Repeats and Prevents Telomere-Circle Formation

Zhong Deng, Jayaraju Dheekollu, Dominique Broccoli, Anindya Dutta, and Paul M. Lieberman

Current Biology, Vol 17, 1989-1995, 20 November 2007

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Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2

S Bellanger, A de Gramont,and J Sobczak-Thépot

Oncogene (2007) 26, 7175–7184

Publication Alert

Knockdown of human MCM10 exhibits delayed and incomplete chromosome replication

Jong Hoon Park, Sung Woong Bang, Yesu Jeon, Sukhyun Kang and Deog Su Hwang

Biochemical and Biophysical Research Communications Volume 365, Issue 3, 18 January 2008, Pages 575-582

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Knockdown of human MCM10 activates G2 checkpoint pathway

Jong Hoon Parka, Sung Woong Bangb, Sung Ho Kima and Deog Su Hwang

Biochemical and Biophysical Research Communications Volume 365, Issue 3, 18 January 2008, Pages 490-495

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Functional differentiation and cooperative interaction between two eukaryote-like archaeal Orc1/Cdc6 proteins on the replication origin

Pei-Xia Jianga, Ying Fenga and Zheng-Guo He

Biochemical and Biophysical Research Communications Volume 364, Issue 4, 28 December 2007, Pages 945-951

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Interactions and subcellular distribution of DNA replication initiation proteins in eukaryotic cells

Normen Brand, Thomas Faul and Friedrich Grummt

Molecular Genetics and Genomics 1617-4615 Volume 278, Number 6 / December, 2007

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DNA Combing Reveals Intrinsic Temporal Disorder in the Replication of Yeast Chromosome VI

Daniel M. Czajkowsky, Jie Liu, Joyce L. Hamlin and Zhifeng Shao

Journal of Molecular Biology Volume 375, Issue 1, 4 January 2008, Pages 12-19

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Conservation of Epigenetic Regulation, ORC Binding and Developmental Timing of DNA Replication Origins in the Genus Drosophila

B. R. Calvi, B. A. Byrnes and A. J. Kolpakas

Genetics, Vol. 177, 1291-1301

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Sequential and Synergistic Modification of Human RPA Stimulates Chromosomal DNA Repair

Rachel W. Anantha, Vitaly M. Vassin, and James A. Borowiec

Vol. 282, Issue 49, 35910-35923, December 7, 2007

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Dynamics of human replication factors in the elongation phase of DNA replication

Yuji Masuda1 Miki Suzuki1, Jinlian Piao, Yongqing Gu, Toshiki Tsurimoto and Kenji Kamiya

Nucleic Acids Research 2007 35(20):6904-6916; doi:10.1093/nar/gkm822

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Site-specific interaction of the murine pre-replicative complex with origin DNA: assembly and disassembly during cell cycle transit and differentiation

Elisabeth Zellner, Thomas Herrmann, Carsten Schulz and Friedrich Grummt

Nucleic Acids Research 2007 35(20):6701-6713;

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Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation

Xiaoyi Deng, Jeff E. Habel, Venkataramen Kabaleeswaran, Edward H. Snell, Marc S. Wold and Gloria E.O. Borgstahl

Journal of Molecular Biology Volume 374, Issue 4, 7 December 2007, Pages 865-876

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MCM Forked Substrate Specificity Involves Dynamic Interaction with the 5'-Tail

Eli Rothenberg, Michael A. Trakselis, Stephen D. Bell, and Taekjip Ha,

J. Biol. Chem., Vol. 282, Issue 47, 34229-34234, November 23, 2007

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Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

Priya Aggarwal, Matthew D. Lessie, Douglas I. Lin, Laura Pontano, Andrew B. Gladden, Beth Nuskey, Ami Goradia, Mariusz A. Wasik, Andres J.P. Klein-Szanto, Anil K. Rustgi, Craig H. Bassing, and J. Alan Diehl

GENES & DEVELOPMENT 21:2908-2922, 2007

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Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2–7 loading

Shuyan Chen, Milan A. de Vries, and Stephen P. Bell

GENES & DEVELOPMENT 21:2897-2907, 2007

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The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA

Olga Chilkova, Peter Stenlund, Isabelle Isoz, Carrie M. Stith, Pawel Grabowski, Else-Britt Lundström, Peter M. Burgers and Erik Johansson,

Nucleic Acids Research, 2007, Vol. 35, No. 19 6588-6597

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ELYS/MEL-28 Chromatin Association Coordinates Nuclear Pore Complex Assembly and Replication Licensing

Peter J. Gillespie, Guennadi A. Khoudoli, Graeme Stewart, Jason R. Swedlow, and J. Julian Blow

Current Biology, Vol 17, 1657-1662, 09 October 2007

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p53-Dependent change in replication timing of the human genome

Yoshihisa Watanabea, Kiyoshi Shibatab, Haruhiko Sugimurac and Masato Maekawaa

Biochemical and Biophysical Research Communications
Volume 364, Issue 2, 14 December 2007, Pages 289-293

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Characterization of proliferating cell nuclear antigen (PCNA) isoforms in normal and cancer cells: There is no cancer-associated form of PCNA

Stanislav N. Naryzhny, and Hoyun Leea

Febs leters Volume 581, Issue 25, 16 October 2007, Pages 4917-4920

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Drosophila follicle cell amplicons as models for metazoan DNA replication: A cyclinE mutant exhibits increased replication fork elongation

Eugenia A. Park, David M. MacAlpine,, and Terry L. Orr-Weaver

PNAS | October 23, 2007 | vol. 104 | no. 43 | 16739-16746

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ATP-dependent Assembly of the Human Origin Recognition Complex

Khalid Siddiqui1 and Bruce Stillman2

J. Biol. Chem., Vol. 282, Issue 44, 32370-32383, November 2, 2007

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The Mre11/Rad50/Nbs1 Complex Plays an Important Role in the Prevention of DNA Rereplication in Mammalian Cells

Alan Yueh-Luen Lee, Enbo Liu, and Xiaohua Wu

J. Biol. Chem., Vol. 282, Issue 44, 32243-32255, November 2, 2007

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Mutation at the Polymerase Active Site of Mouse DNA Polymerase Increases Genomic Instability and Accelerates Tumorigenesis

Ranga N. Venkatesan, Piper M. Treuting, Evan D. Fuller, Robert E. Goldsby, Thomas H. Norwood, Ted A. Gooley, Warren C. Ladiges, Bradley D. Preston, and Lawrence A. Loeb

Molecular and Cellular Biology, November 2007, p. 7669-7682, Vol. 27, No. 21

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Structural Changes in Mcm5 Protein Bypass Cdc7-Dbf4 Function and Reduce Replication Origin Efficiency in Saccharomyces cerevisiae

Margaret L. Hoang, Ronald P. Leon, Luis Pessoa-Brandao, Sonia Hunt,, M. K. Raghuraman, Walton L. Fangman, Bonita J. Brewer, and Robert A. Sclafani

Molecular and Cellular Biology, November 2007, p. 7594-7602, Vol. 27, No. 21

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Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex

Soma Banerjeea, Nilabja Sikdara and Kyungjae Myung

Biochemical and Biophysical Research Communications 362, 546-549

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Cdc45 degradation during differentiation and apoptosis

S. Pollok and F. Grosse

Biochemical and Biophysical Research Communications 362 910-915

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Three eukaryote-like Orc1/Cdc6 proteins functionally interact and mutually regulate their activities of binding to the replication origin in the hyperthermophilic archaeon Sulfolobus solfataricus P2

Jun Wang, Pei-Xia Jiang, Hui Feng, Ying Feng and Zheng-Guo He

Bioc.biop.res.comm 363 (1) 63-70

Publication Alert

Hexameric ring structure of human MCM10 DNA replication factor

Andrei L Okorokov, Alastair Waugh, Julie Hodgkinson, Andal Murthy, Hye Kyung Hong, Elisabetta Leo, Michael B Sherman, Kai Stoeber, Elena V Orlova & Gareth H Williams

EMBO reports 8, 10, 925–930 (2007)

Publication Alert

Identification and Characterization of Human Cdc7 Nuclear Retention and Export Sequences in the Context of Chromatin Binding

Byung Ju Kim, So-Young Kim, and Hoyun Lee

J. Biol. Chem., Vol. 282, Issue 41, 30029-30038, October 12, 2007

Publication Alert

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

Valerie Notenboom, Richard G. Hibbert, Sarah E. van Rossum-Fikkert, Jesper V. Olsen, Matthias Mann and Titia K. Sixma*


Nucleic Acids Research, 2007, Vol. 35, No. 17 5819-5830

Publication Alert

Properties of an unusual DNA primase from an archaeal plasmid

Kirsten Beck and Georg Lipps*

Nucleic Acids Research, 2007, Vol. 35, No. 17 5635-5645

Publication Alert

Low rate of replication fork progression lengthens the replication timing of a locus containing an early firing origin

Marianne Bénard*, Chrystelle Maric and Gérard Pierron

Nucleic Acids Research, 2007, Vol. 35, No. 17 5763-5774

Publication Alert

Low rate of replication fork progression lengthens the replication timing of a locus containing an early firing origin

Marianne Bénard*, Chrystelle Maric and Gérard Pierron

Nucleic Acids Research, 2007, Vol. 35, No. 17 5763-5774

Publication Alert

Human Mcm10 Regulates the Catalytic Subunit of DNA Polymerase- and Prevents DNA Damage during Replication

Sharbani Chattopadhyay, and Anja-Katrin Bielinsky

Vol. 18, Issue 10, 4085-4095, October 2007

Publication Alert

Mrc1 and Tof1 Regulate DNA Replication Forks in Different Ways during Normal S Phase

Ben Hodgson*,, Arturo Calzada,, and Karim Labib

Vol. 18, Issue 10, 3894-3902, October 2007

Tipin is required for stalled replication forks to resume DNA replication after removal
of aphidicolin in Xenopus egg extracts

Alessia Errico, Vincenzo Costanzo, and Tim Hunt

PNAS September 18, 2007 vol. 104 no. 38 14929 –14934

Mcm10 and And-1/CTF4 recruit DNA polymerase to chromatin for initiation of DNA replication

Wenge Zhu, Chinweike Ukomadu, Sudhakar Jha, Takeshi Senga, Suman K. Dhar, James A. Wohlschlegel, Leta K. Nutt, Sally Kornbluth, and Anindya Dutta

GENES & DEVELOPMENT 21:2288-2299, 2007

Publication Alert

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells

Gilles Crevel, Reina Hashimoto, Sharron Vass, Jake Sherkow, Masamitsu Yamaguchi, Margarete M.S. Heck, and Sue Cotterill

PLoS ONE. 2007; 2(9): e833.

Publication Alert

Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast

Naomi Fersht, Damien Hermand, Jacqueline Hayles, and Paul Nurse

Nucl. Acids Res. 2007 35: 5323-5337;

Publication Alert

Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication

Poonam Tanejaa, Irene Bochea, Hella Hartmannb, Heinz-Peter Nasheuer, Frank Grosse, Ellen Fanning and Klaus Weisshart,

Febs letters Volume 581, Issue 21, 21 August 2007, Pages 3973-3978

Publication Alert

Geminin is cleaved by caspase-3 during apoptosis in Xenopus egg extracts

Camille Auziol1, a, Marcel Méchalia and Domenico Maiorano

Biochemical and Biophysical Research Communications Volume 361, Issue 2, 21 September 2007, Pages 276-280

Publication Alert

Divergent functions of multiple eukaryote-like Orc1/Cdc6 proteins on modulating the loading of the MCM helicase onto the origins of the hyperthermophilic archaeon Sulfolobus solfataricus P2

Pei-Xia Jianga, Jun Wanga, Ying Fenga and Zheng-Guo He

Biochemical and Biophysical Research Communications Volume 361, Issue 3, 28 September 2007, Pages 651-658

Publication Alert

Replication in Hydroxyurea: It's a Matter of Time ,

Gina M. Alvino, David Collingwood, John M. Murphy, Jeffrey Delrow, Bonita J. Brewer, and M. K. Raghuraman

Molecular and Cellular Biology, September 2007, p. 6396-6406, Vol. 27, No. 18

Publication Alert

Pol is required for DNA replication during nucleotide deprivation by hydroxyurea

S de Feraudy, C L Limoli, E Giedzinski, D Karentz, T M Marti, L Feeney and J E Cleaver

Oncogene (2007) 26, 5713–5721.

Publication Alert

Schizosaccharomyces pombe Rad4/Cut5 Protein Modification and Chromatin Binding Changes in DNA Damage

Rania Siam, Eliana B. Gomez, Susan L. Forsburg.

DNA and Cell Biology. 2007, 26(8): 565-575.

Publication Alert

Human Cdc45 is a proliferation-associated antigen

S. Pollok, C. Bauerschmidt, J. Sanger, H.-P. Nasheuer and F. Grosse

FEBS Journal 274 (2007) 3669–3684

Publication Alert

Replication Licensing: Oops! I Did It Again

Jerome Korzelius and Sander van den Heuvel

Current Biology Vol 17 No 16 R630

Publication Alert

A Genetic Analysis of the Drosophila mcm5 Gene Defines a Domain Specifically Required for Meiotic Recombination

Cathleen M. Lake, Kathy Teeter, Scott L. Page, Rachel Nielsen and R. Scott Hawley

Genetics, Vol. 176, 2151-2163, August 2007

Publication Alert

Structural Basis of DNA Replication Origin Recognition by an ORC Protein

Martin Gaudier, Barbara S. Schuwirth, Sarah L. Westcott, and Dale B. Wigley

Science 31 August 2007: 1213-1216

Publication Alert

Replication Origin Recognition and Deformation by a Heterodimeric Archaeal Orc1 Complex

Erin L. Cunningham Dueber, Jacob E. Corn, Stephen D. Bell, and James M. Berger

Science 31 August 2007: 1210-1213

Publication Alert

Getting DNA to Unwind

Roxana E. Georgescu and Mike O’Donnell

SCIENCE VOL 317 31 AUGUST 2007 1181

Publication Alert

Cdc6 Stability Is Regulated by the Huwe1 Ubiquitin Ligase after DNA Damage

Jonathan R. Hall, Evelyn Kow, Kathleen R. Nevis, Chiajung Karen Lu, K. Scott Luce, Qing Zhong, and Jeanette Gowen Cook

MBC Vol. 18, Issue 9, 3340-3350, September 2007

Publication Alert

The Mre11 Complex Mediates the S-Phase Checkpoint through an Interaction with Replication Protein A

Erin Olson, Christian J. Nievera, Enbo Liu,Alan Yueh-Luen Lee, Longchuan Chen and Xiaohua Wu

Molecular and Cellular Biology, September 2007, p. 6053-6067, Vol. 27, No. 17

Publication Alert

DNA Replication Stress Is a Determinant of Chronological Lifespan in Budding Yeast

Martin Weinberger, Li Feng, Anita Paul, Daniel L. Smith, Jr., Robert D. Hontz, Jeffrey S. Smith, Marija Vujcic, Keshav K. Singh, Joel A. Huberman, William C. Burhans

PLoS ONE 2(8): e748.

Publication Alert

Reducing DNA Polymerase in the Absence of Drosophila ATR Leads to P53-Dependent Apoptosis and Developmental Defects

Jeannine R. LaRocque, Diana L. Dougherty, Sumreen K. Hussain and Jeff Sekelsky

Genetics 176: 1441–1451 ( July 2007)

Publication Alert

Global Profiling of DNA Replication Timing and Efficiency Reveals that Efficient Replication/Firing Occurs Late during S-Phase in S. pombe

Majid Eshaghi, R. Krishna M. Karuturi, Juntao Li, Zhaoqing Chu, Edison T. Liu, Jianhua Liu

PLoS ONE 2(8): e722.

Publication Alert

Human INT6 interacts with MCM7 and regulates its stability during
S phase of the cell cycle

S Buchsbaum, C Morris, V Bochard and P Jalinot

Oncogene (2007) 26, 5132–5144

Publication Alert

Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation

Rodrigo Bermejo, Ylli Doksani, Thelma Capra, Yuki-Mori Katou, Hirokazu Tanaka, Katsuhiko Shirahige, and Marco Foiani

GENES & DEVELOPMENT 21:1921-1936, 2007

Publication Alert

The Intra-S-Phase Checkpoint Affects both DNA Replication Initiation and Elongation: Single-Cell and -DNA Fiber Analyses

Jennifer A. Seiler, Chiara Conti, Ali Syed, Mirit I. Aladjem, and Yves Pommier

Molecular and Cellular Biology, August 2007, p. 5806-5818, Vol. 27, No. 16

Publication Alert

High-throughput mapping of origins of replication in human cells

Isabelle Lucas, Aparna Palakodeti, Yanwen Jiang, David J Young, Nan Jiang, Anthony A Fernald & Michelle M Le Beau

EMBO reports 8, 8, 770–777 (2007)

Publication Alert

Crystal structure of the GINS complex and functional
insights into its role in DNA replication

Y. Paul Chang, Ganggang Wang, Vladimir Bermudez, Jerard Hurwitz, and Xiaojiang S. Chen


PNAS July 31, 2007 vol. 104 12685-12690

Publication Alert

Non-transcriptional control of DNA replication by c-Myc

David Dominguez-Sola, Carol Y. Ying, Carla Grandori, Luca Ruggiero, Brenden Chen, Muyang Li, Denise A. Galloway, Wei Gu, Jean Gautier & Riccardo Dalla-Favera

Nature 448, 445-451 (26 July 2007)

Publication Alert

Yeast DNA Polymerase Participates in Leading-Strand DNA Replication

Zachary F. Pursell, Isabelle Isoz, Else-Britt Lundström, Erik Johansson, Thomas A. Kunkel

Science 6 July 2007: Vol. 317. no. 5834, pp. 127 - 130

Publication Alert

Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases δ and during S phase

Christina Bauerschmidt, Sibyll Pollok, Elisabeth Kremmer, Heinz-Peter Nasheuer, Frank Grosse (2007)

Genes to Cells 12 (6), 745–758