no publications this week

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Genome-wide identification and characterisation of human DNA replication origins by initiation site sequencing (ini-seq) Alexander R. Langley, Stefan Gräf, James C. Smith, and Torsten Krude Nucl. Acids Res. 2016 44: 10230-10247

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Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM Yuli Xua, Tamzin Gristwood, Ben Hodgson, Jonathan C. Trinidad, Sonja-Verena Alberse, and Stephen D. Bell 13390–13395 | PNAS | November 22, 2016 | vol. 113 | no. 47

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R.I.P. to the PIP: PCNA-binding motif no longer considered specific Elizabeth M. Boehm,
 M. Todd Washington Bioesasys Volume 38, Issue 11 November 2016 Pages 1117–1122

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A SUMO and ubiquitin code coordinates protein traffic at replication factories Emilio Lecona,



Oscar Fernandez-Capetillo Bioessays Volume 38, Issue 12 December 2016 Pages 1209–1217

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Mcm10: The glue at replication forks Anja-Katrin Bielinsky Cell cycle 15 Pages 3024-3025

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An Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication Initiation Patricia Perez-Arnaiz, Daniel L. Kaplan J.Mol. Biol. 23 Pages 4608-4625

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no publications this week

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Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks Matthew R. Northam and Kelly M. Trujillo Nucl. Acids Res. 2016 44: 9245-9255

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TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin Xiaohua Xu, Jiin-Tarng Wang, Min Li, and Yilun Liu J. Biol. Chem. 2016; 291:22544-22558

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FANCD2 Facilitates Replication through Common Fragile Sites Advaitha Madireddy, Settapong T. Kosiyatrakul, Rebecca A. Boisvert, Emilia Herrera-Moyano, María L. García-Rubio, Jeannine Gerhardt, Elizabeth A. Vuono, Nichole Owen, Zi Yan, Susan Olson, Andrés Aguilera, Niall G. Howlett, Carl L. Schildkraut mol cell 64 388-404

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Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation Masahiro Aizawa, Nozomi Sugimoto, Shinya Watanabe, Kazumasa Yoshida, Masatoshi Fujita BBA Pages 2739-2748

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Cytology of DNA Replication Reveals Dynamic Plasticity of Large-Scale Chromatin Fibers Xiang Deng, Oxana A. Zhironkina, Varvara D. Cherepanynets, Olga S. Strelkova, Igor I. Kireev, Andrew S. Belmont Current biology Volume 26, Issue 18, p2527–2534, 26 September 2016

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New Insights into the Mechanism of DNA Duplication by the Eukaryotic Replisome Luca Pellegrini, Alessandro Costa tibs Pages 859-871

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G-Quadruplexes in DNA Replication: A Problem or a Necessity?Review Article Anne-Laure Valton, Marie-Noëlle Prioleau Tigs 32 697-706

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High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases Kelly M. Schermerhorn, Nathan Tanner, Zvi Kelman, and Andrew F. Gardner Nucl. Acids Res. 2016 44: 8764-8771

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Strand displacement synthesis by yeast DNA polymerase ε Rais A. Ganai, Xiao-Ping Zhang, Wolf-Dietrich Heyer, and Erik Johansson Nucl. Acids Res. 2016 44: 8229-8240

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Crystal Structure of the Apicoplast DNA Polymerase from Plasmodium falciparum: The First Look at a Plastidic A-Family DNA Polymerase Morgan E. Milton, Jun-Yong Choe, Richard B. Honzatko, Scott W. Nelson Journal of Molecular BiologyVolume 428, Issue 20, 9 October 2016, Pages 3920–3934

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Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells Alberto Moreno, Jamie T. Carrington, Luca Albergante, Mohammed Al Mamun, Emma J. Haagensen, Eirini-Stavroula Komseli, Vassilis G. Gorgoulis, Timothy J. Newman, and J. Julian Blow PNAS 2016 113 (39) E5757-E5764

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Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase Mohammed Al Mamun, Luca Albergante, Alberto Moreno, James T. Carrington, J. Julian Blow, and Timothy J. Newman PNAS 2016 113 (39) E5765-E5774

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Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases Ashwani Kumar Vashishtha, Jimin Wang, and William H. Konigsberg J. Biol. Chem. 2016; 291:20869-20875

no publications this week

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USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication Veronique A.J. Smits, Bioessays Volume 38, Issue 9 Pages 863–868

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DNA Polymerases Divide the Labor of Genome ReplicationReview Article Scott A. Lujan, Jessica S. Williams, Thomas A. Kunkel Trends in cell biology Pages 640-654

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Xenopus Mcm10 is a CDK-substrate required for replication fork stability Gaganmeet Singh Chadha, Agnieszka Gambus, Peter J. Gillespie & J. Julian Blow Cell cycle 15 Page 2183-2195

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MCM2-7 conformational changes in the presence of DNA Christiane Schaffitzel Cell cycle 15 2391-2392

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Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA Jasminka Boskovic, Elisabeth Bragado-Nilsson, Bhargrav Saligram Prabhakar, Igor Yefimenko, Jaime Martínez-Gago, Sergio Muñoz, Juan Méndez & Guillermo Montoya Cell cycle 15 2431 – 2440

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Spatio-temporal re-organization of replication foci accompanies replication domain consolidation during human pluripotent stem cell lineage specification Korey A. Wilson, Andrew G. Elefanty, Edouard G. Stanley & David M. Gilbert Cell cycle 15 2464-2475

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A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M Sriram Vijayraghavan ,Feng-Ling Tsai , Anthony Schwacha PLoS Genet 12(8): e1006277.

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Establishment of a promoter-based chromatin architecture on recently replicated DNA can accommodate variable inter-nucleosome spacing Ross T. Fennessy and Tom Owen-Hughes Nucl. Acids Res. 2016 44: 7189-7203

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Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila Yulong Li, Robin L. Armstrong, Robert J. Duronio, and David M. MacAlpine Nucl. Acids Res. 2016 44: 7204-7218

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In vivo evidence for translesion synthesis by the replicative DNA polymerase δ Kouji Hirota, Masataka Tsuda, Mohiuddin, Toshiki Tsurimoto, Isadora S. Cohen, Zvi Livneh, Kaori Kobayashi, Takeo Narita, Kana Nishihara, Junko Murai, Shigenori Iwai, Guillaume Guilbaud, Julian E. Sale, and Shunichi Takeda Nucl. Acids Res. 2016 44: 7242-7250

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Role of the Polymerase ϵ sub-unit DPB2 in DNA replication, cell cycle regulation and DNA damage response in Arabidopsis José Antonio Pedroza-Garcia, Séverine Domenichini, Christelle Mazubert, Mickael Bourge, Charles White, Elodie Hudik, Rémi Bounon, Zakia Tariq, Etienne Delannoy, Ivan del Olmo, Manuel Piñeiro, Jose Antonio Jarillo, Catherine Bergounioux, Moussa Benhamed, and Cécile Raynaud Nucl. Acids Res. 2016 44: 7251-7266

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POLD3 Is Haploinsufficient for DNA Replication in Mice Matilde Murga, Emilio Lecona, Irene Kamileri, Marcos Díaz, Natalia Lugli, Sotirios K. Sotiriou, Marta E. Anton, Juan Méndez, Thanos D. Halazonetis, Oscar Fernandez-Capetillo Molecular cell Volume 63, Issue 5, p877–883, 1 September 2016

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Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain- terminating nucleosides Kaori Kobayashi, Thomas A. Guilliam, Masataka Tsuda, Junpei Yamamoto, Laura J. Bailey, Shigenori Iwai, Shunichi Takeda, Aidan J. Doherty & Kouji Hirota Cell Cycle 15 1997-2008

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DNA replication origins—where do we begin? Marie-Noëlle Prioleau1 and David M. MacAlpine Genes Dev. August 1, 2016 30: 1683-1697

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A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation SimonGemble,GéraldineBuhagiar-Labarched̀e,RosineOnclercq-Delic,DenisBiard, Sarah Lambert and Mounira Amor-Guéret J. Cell Science 129 3167

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ORChestrating the human DNA replication program David M. MacAlpine PNAS 113 9136 - 9138

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Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers Benoit Miottoa, Zhe Jia, and Kevin Struhl PNAS 113 e4819

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RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells Vaclav Urban, Jana Dobrovolna, Daniela Hühn, Jana Fryzelkova, Jiri Bartek and Pavel Janscak JCB vol. 214 no. 4 401-415

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Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome Catarina P. Samora, Julie Saksouk, Panchali Goswami, Ben O. Wade, Martin R. Singleton, Paul A. Bates, Armelle Lengronne, Alessandro Costa, Frank Uhlmann Mol cell Volume 63, Issue 3, p371–384, 4 August 2016

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Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase Fabrizio Villa, Aline C. Simon, Maria Angeles Ortiz Bazan, Mairi L. Kilkenny, David Wirthensohn, Mel Wightman, Dijana Matak-Vinkovíc, Luca Pellegrini, Karim Labib Volume 63, Issue 3, p385–396, 4 August 2016

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POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies Emmanuelle Nicolas, Erica A. Golemis, Sanjeevani Arora GeneVolume 590, Issue 1, 15 September 2016, Pages 128–141

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miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation Zhenyou Zou, Mengjie Ni, Jing Zhang, Yongfeng Chen, Hongyu Ma, Shihan Qian, Longhua Tang, Jiamei Tang, Hailun Yao, Chengbin Zhao, Xiongwen Lu, Hongyang Sun, Jue Qian, Xiaoting Mao, Xulin Lu, Qun Liu, Juping Zen, Hanbing Wu, Zhaosheng Bao, Shudan Lin, Hongyu Sheng, Yunlong Li, Yong Liang, Zhiqiang Chen, Dan Zong Biochemical Journal 473(14) 2131-2139;

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Exceeding the limits – Cdc45 overexpression turns bad Christian Speck Cell cycle 15 Page 1809-1810

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Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides Kaori Kobayashi, Thomas A. Guilliam, Masataka Tsuda, Junpei Yamamoto, Laura J. Bailey, Shigenori Iwai, Shunichi Takeda, Aidan J. Doherty & Kouji Hirota Cell Cycle 15 Page 1997-2008

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A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp Amanda S. Altieri, Jane E. Ladner, Zhuo Li, Howard Robinson, Zahur F.Sallman, John P. Marino, and Zvi Kelman Nucl. Acids Res. 2016 44: 6232-6241

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The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion Martina Stevanoni , Elisa Palumbo , Antonella Russo PLoS Genet 12(7): e1006201.

no publications this week

no publications this week

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Force regulated dynamics of RPA on a DNA fork Felix E. Kemmerich, Peter Daldrop, Cosimo Pinto, Maryna Levikova, Petr Cejka, and Ralf Seidel Nucl. Acids Res. 2016 44: 5837-5848

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Dynamic binding of replication protein a is required for DNA repair Ran Chen, Shyamal Subramanyam, Adrian H. Elcock, Maria Spies, and Marc S.Wold Nucl. Acids Res. 2016 44: 5758-5772

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Regulation of DNA replication proteins in parasitic protozoans: possible role of CDK-like kinases Abhijit S. Deshmukh , Meetu Agarwal , Suman Kumar Dhar Current Genetics August 2016, Volume 62, Issue 3, pp 481-486

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PCNA-binding proteins in the archaea: novel functionality beyond the conserved core Stuart A. MacNeill Current Genetics August 2016, Volume 62, Issue 3, pp 527–532

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How and why multiple MCMs are loaded at origins of DNA replication Shankar P. Das and Nicholas Rhind Bioessays 38 pages 613–617

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Replication origins: determinants or consequences of nuclear organization? Anna B Marks, Owen K Smith, Mirit I Aladjem Current Opinion in Genetics & Development Volume 37, April 2016, Pages 67–75

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EdU and BrdU incorporation resolve their differences Paul J. Smith Cell Cycle, 15:12, 1527-1528

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Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest Deepak Bastiaa, Pankaj Srivastavaa, Shamsu Zamana, Malay Choudhurya, Bidyut K. Mohantya, Julien Bacal, Lance D. Langstonc, Philippe Pasero, and Michael E. O’Donnell Pnas vol. 113 no. 26

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WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress Giuseppe Leuzzi, Veronica Marabitti, Pietro Pichierri, Annapaola Franchitto The EMBO Journal (2016) 35: 1437–1451

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Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 in Saccharomyces cerevisiae Keiko Kono, Amr Al-Zain, Lea Schroeder, Makoto Nakanishi, and Amy E. Ikui PNAS 113 no. 25, 6910–6915

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DNA Interactions Probed by Hydrogen-Deuterium Exchange (HDX) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Confirm External Binding Sites on the Minichromosomal Maintenance (MCM) Helicase Brian W. Graham, Yeqing Tao, Katie L. Dodge, Carly T. Thaxton, Danae Olaso, Nicolas L. Young, Alan G. Marshall and Michael A. Trakselis The Journal of Biological Chemistry 291, 12467-12480.

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HUWE1 comes to the rescue at stalled replication forks Kate E Coleman, Tony T Huang EMBO reports (2016) 17, 781-782

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HUWE1 interacts with PCNA to alleviate replication stress Katherine N Choe, Claudia M Nicolae, Daniel Constantin, Yuka Imamura Kawasawa, Maria Rocio Delgado‐Diaz, Subhajyoti De, Raimundo Freire, Veronique AJ Smits, EMBO reports (2016) 17, 874-886

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Replication timing and transcriptional control: beyond cause and effect — part III Juan Carlos Rivera-Mulia, David M Gilbert current opinion in cell biology Pages 168-178

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Replicating repetitive DNA Silvia Tognetti & Christian Speck NCB 18 pp593 - 594

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Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression Antoine Aze, Vincenzo Sannino, Paolo Soffientini, Angela Bachi & Vincenzo Costanzo NCB 18 pp684 - 691

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Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex Zhiying You, Koji L. Ode, Mayumi Shindo, Haruhiko Takisawa & Hisao Masai Cell cycle 15 pages 1213-1226

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ABCE1 is essential for S phase progression in human cells Marina Toompuua, Kairi Kärblanea, Pille Pataa, Erkki Truvea & Cecilia Sarmientoa* Cell cycle 15 pages 1234-1247

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Cdk1-mediated phosphorylation of Cdc7 suppresses DNA re-replication James Knockleby, Byung Ju Kim, Avani Mehta & Hoyun Lee Cell Cycle 15 pages 1494-1505

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New origin firing is inhibited by APC/C^Cdh1 activation in S-phase after severe replication stress Amaia Ercilla, Alba Llopis, Sonia Feu, Sergi Aranda, Patrik Ernfors, Raimundo Freire, and Neus Agell Nucl. Acids Res. 2016 44: 4745-4762

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Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation Catarina A. Marques, Calvin Tiengwe, Leandro Lemgruber, Jeziel D. Damasceno, Alan Scott, Daniel Paape, Lucio Marcello, and Richard McCulloch Nucl. Acids Res. 2016 44: 4763-4784

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Stability versus exchange: a paradox in DNA replication Christoffer Åberg, Karl E. Duderstadt, and Antoine M. van Oijen Nucl. Acids Res. 2016 44: 4846-4854

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ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila Daria Kopytova, Varvara Popova, Maria Kurshakova, Yulii Shidlovskii, Elena Nabirochkina, Alexander Brechalov, Georgii Georgiev, and Sofia Georgieva Nucl. Acids Res. 2016 44: 4920-4933

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DNA Replication—A Matter of Fidelity Rais A. Ganai, Erik Johansson Mol cell Volume 62, Issue 5, p745–755, 2 June 2016

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Replicating Large Genomes: Divide and Conquer Juan Carlos Rivera-Mulia, David M. Gilbert Volume 62, Issue 5, p756–765, 2 June 2016

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Proficient Replication of the Yeast Genome by a Viral DNA Polymerase Joseph L. Stodola, Carrie M. Stith, and Peter M. Burgers J. Biol. Chem. 2016; 291:11698-11705

no publications this week

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Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome Andrey G. Baranovskiy, Nigar D. Babayeva, Yinbo Zhang, Jianyou Gu, Yoshiaki Suwa, Youri I. Pavlov and Tahir H. Tahirov The Journal of Biological Chemistry 291, 10006-10020.

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Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt Iglika G. Ivanova and Laura Maringele Nucl. Acids Res. 2016 44: 3728-3738

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Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ Katrina N. Koc, Saurabh P. Singh, Joseph L. Stodola, Peter M. Burgers, and Roberto Galletto Nucl. Acids Res. 2016 44: 3811-3819

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The MCM Helicase Motor of the Eukaryotic Replisome Ferdos Abid Ali, Alessandro Costa Journal of Molecular Biology Volume 428, Issue 9, Part B, 8 May 2016, Pages 1822–1832

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Elucidating the DDK‐dependent step in replication initiation Hiroyuki Araki The EMBO Journal (2016) 35, 907-908

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Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation Tom D Deegan, Joseph TP Yeeles, John FX Diffley The EMBO Journal (2016) 35, 961-973

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MCM: one ring to rule them all Tom D Deegan, Joseph TP Yeeles, John FX Diffley Current opinion in structural biology 37 Pages 145-151

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Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale Joseph L Stodola & Peter M Burgers Nature Structural and Molecular Biology 23 p p402 - 408

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DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis Petro Starokadomskyy, Terry Gemelli, Jonathan J Rios, Chao Xing, Richard C Wang, Haiying Li, Vladislav Pokatayev, Igor Dozmorov, Shaheen Khan, Naoteru Miyata, Guadalupe Fraile, Prithvi Raj, Zhe Xu, Zigang Xu, Lin Ma, Zhimiao Lin, Huijun Wang, Yong Yang, Dan Ben-Amitai, Naama Orenstein, Huda Mussaffi, Eulalia Baselga, Gianluca Tadini, Eyal Grunebaum, Adrijan Sarajlija, Konrad Krzewski, Edward K Wakeland, Nan Yan, Maria Teresa de la Morena, Andrew R Zinn & Ezra Burstein Nature Immunology 17, 495–504 (2016)

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Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae Hiroko Okimoto, Seiji Tanaka, Hiroyuki Araki, Eiji Ohashi and Toshiki Tsurimoto Genes to Cells Volume 21, Issue 5, pages 482–491, May 2016

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PrimPol-deficient cells exhibit a pronounced G2 checkpoint response following UV damage Laura J. Bailey, Julie Bianchi, Nadia Hégarat, Helfrid Hochegger & Aidan J. Doherty Cell cycle 15 pages 908-918

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Cdc45 is limiting for replication initiation in humans Carsten Köhler, Dennis Koalick, Anja Fabricius, Ann Christin Parplys, Kerstin Borgmann, Helmut Pospiech & Frank Grosse Cell cycle 15 pages 974-985

no postings this week

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PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities Thomas A. Guilliam, Laura J. Bailey, Nigel C. Brissett and Aidan J. Doherty Nucl. Acids Res. (20 April 2016) 44 (7): 3317-3329.

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DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction Sana I. Algasaier, Jack C. Exell, Ian A. Bennet, Mark J. Thompson, Victoria J. B. Gotham, Steven J. Shaw, Timothy D. Craggs, L. David Finger, and Jane A. Grasby J. Biol. Chem. 2016; 291:8258-826

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Direct non transcriptional role of NF-Y in DNA replication Paolo Benatti, Silvia Belluti, Benoit Miotto, Julia Neusiedler, Diletta Dolfini, Marjorie Drac, Valentina Basile, Etienne Schwob, Roberto Mantovani, J. Julian Blow, Carol Imbriano BBA 1879 Pages 673-685

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The Eukaryotic Replisome Goes Under the Microscope Mike O’Donnell, Huilin Li Current biology Volume 26, Issue 6, pR247–R256

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USP7 is a SUMO deubiquitinase essential for DNA replication Emilio Lecona, Sara Rodriguez-Acebes, Julia Specks, Andres J Lopez-Contreras, Isabel Ruppen, Matilde Murga, Javier Muñoz, Juan Mendez & Oscar Fernan dez-Capetillo Nat Struct Mol Biol nsmb 23 270 - 277

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DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, and Chuanmao Zhang J Cell Sci 2016 129: 1429-1440

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DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, Chuanmao Zhang J Cell Sci 2016 129: 1429-1440; doi: 10.1242/jcs.178723

no postings this week

no postins ths week

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Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex Max E. Douglas and John F. X. Diffley J. Biol. Chem. 2016; 291:5879-5888

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A new MCM modification cycle regulates DNA replication initiation Lei Wei & Xiaolan Zhao Nature Structural & Molecular Biology 23, 209–216 (2016)

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Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation Zuanning Yuan, Lin Bai, Jingchuan Sun, Roxana Georgescu, Jun Liu, Michael E O'Donnell & Huilin Li Nature Structural & Molecular Biology 23, 217–224 (2016)

no postings this week

publication alert

Insight into the Human DNA Primase Interaction with Template-Primer Andrey G. Baranovskiy, Yinbo Zhang, Yoshiaki Suwa, Jianyou Gu, Nigar D. Babayeva, Youri I. Pavlov and Tahir H. Tahirov Journal of Biological Chemistry, 291, 4793-4802

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Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools Danielle L. Watt, Robert J. Buckland, Scott A. Lujan, Thomas A. Kunkel and Andrei Chabes Nucl. Acids Res. (29 February 2016) 44 (4): 1669-1680.

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Response to Burgers et al. Robert E. Johnson2, Roland Klassen23, Louise Prakash, Satya Prakash Mol cell Volume 61, Issue 4, p494–495, 18 February 2016

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Who Is Leading the Replication Fork, Pol ε or Pol δ? Peter M.J. Burgers, Dmitry Gordenin, Thomas A. Kunkel Mol cell Volume 61, Issue 4, p492–493, 18 February 2016

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The N Terminus of the Retinoblastoma Protein Inhibits DNA Replication via a Bipartite Mechanism Disrupted in Partially Penetrant Retinoblastomas Sergiy I. Borysova, Brook S. Nepon-Sixta,b and Mark G. Alexandrow Mol. Cell. Biol. March 2016 vol. 36 no. 5 832-845

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The LMO2 oncogene regulates DNA replication in hematopoietic cells Marie-Claude Sincennesa, Magali Humbert, Benoît Grondin, Véronique Lisi, Diogo F. T. Veiga, André Haman, Christophe Cazaux, Nazar Mashtalir, EL Bachir Affar, Alain Verreault, and Trang Hoanga Pnas 113 no. 5 1393–1398,

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Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication Mayumi Haruta, Midori Shimada, Atsuya Nishiyama, Yoshikazu Johmura, Benoît Le Tallec, Michelle Debatisse, Makoto Nakanishi Biochemical and Biophysical Research Communications Volume 469, Issue 4, 22 January 2016, Pages 960–966

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Excess Cdt1 inhibits nascent strand elongation by repressing the progression of replication forks in Xenopus egg extracts Yuta Nakazaki, Takashi Tsuyama, Masayuki Seki, Mikiko Takahashi, Takemi Enomoto, Shusuke Tada Biochemical and Biophysical Research Communications Volume 470, Issue 2, 5 February 2016, Pages 405–410

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MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication Debra L. Evans, Haoxing Zhang, Hyoungjun Ham, Huadong Peib, SeungBaek Lee, JungJin Kim, Daniel D. Billadeau & Zhenkun Lou Cell cycle pages 95-105

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Stability of blocked replication forks in vivo Karla A. Mettrick and Ian Grainge Nucl. Acids Res. 2016 44: 657-668

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Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway Federica Calì, Sanjay Kumar Bharti, Roberta Di Perna, Robert M. Brosh, Jr, and Francesca M. Pisani Nucl. Acids Res. 2016 44: 705-717

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Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner Sumanprava Giri, Arindam Chakraborty, Kizhakke M. Sathyan, Kannanganattu V. Prasanth, Supriya G. Prasanth J Cell Sci 2016 129: 417-429

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BRPF3‐HBO1 regulates replication origin activation and histone H3K14 acetylation Yunpeng Feng, Arsenios Vlassis, Céline Roques, Marie‐Eve Lalonde, Cristina González‐Aguilera, Jean‐Philippe Lambert, Sung‐Bau Lee, Xiaobei Zhao, Constance Alabert, Jens V Johansen, Eric Paquet, Xiang‐Jiao Yang, Anne‐Claude Gingras, Jacques Côté, Anja Groth The EMBO Journal (2016) 35, 176-192

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Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program Rossana Foti, Stefano Gnan, Daniela Cornacchia8, Vishnu Dileep, Aydan Bulut-Karslioglu9, Sarah Diehl, Andreas Buness, Felix A. Klein, Wolfgang Huber, Ewan Johnstone, Remco Loos, Paul Bertone, David M. Gilbert, Thomas Manke, Thomas Jenuwein, Sara C.B. Buonomo Mol cell Volume 61, Issue 2, p260–273, 21 January 2016

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Mechanism of Archaeal MCM Helicase Recruitment to DNA Replication Origins Rachel Y. Samson, Priyanka D. Abeyrathne, Stephen D. Bell Mol cell Volume 61, Issue 2, p287–296, 21 January 2016

no publications this week

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Mcm10 coordinates the timely assembly and activation of the replication fork helicase Patricia Perez-Arnaiz, Irina Bruck, and Daniel L. Kaplan Nucl. Acids Res. 2016 44: 315-329

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PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells Davide Schiavone, Stanislaw K. Jozwiakowski, Marina Romanello, Guillaume Guilbaud, Thomas A. Guilliam, Laura J. Bailey, Julian E. Sale, Aidan J. Doherty Molecular Cell 61, 161–169,

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The architecture of a eukaryotic replisome Jingchuan Sun, Yi Shi, Roxana E Georgescu, Zuanning Yuan, Brian T Chait, Huilin Li & Michael E O'Donnell NATURE STRUCTURAL & MOLECULAR BIOLOGY 22, 976–982 (2015)