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Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin

Elaine J. Gavin, Bo Song, Yuan Wang, Yaguang Xi, Jingfang Ju

PLoS ONE 3(12): e4054

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Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

Aaron S. Brewster, Ganggang Wang, Xian Yu, William B. Greenleaf, José María Carazo, Matthew Tjajadia, Michael G. Klein, and Xiaojiang S. Chen

PNAS December 23, 2008 vol. 105 no. 51 20191-20196

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The Methanothermobacter thermautotrophicus MCM Helicase Is Active as a Hexameric Ring

Jae-Ho Shin, Gun-Young Heo, and Zvi Kelman

J. Biol. Chem., Vol. 284, Issue 1, 540-546, January 2, 2009

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The Role of Dbf4/Drf1-Dependent Kinase Cdc7 in DNA-Damage Checkpoint Control

Toshiya Tsuji,Eric Lau,Gary G. Chiang1and Wei Jiang

Molecular Cell, Volume 32, Issue 6, 862-869, 26 December 2008

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Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1

Fulvia Terenzi, Paramananda Saikia and Ganes C Sen

The EMBO Journal (2008) 27, 3311–3321

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Structure of a Mutant Form of Proliferating Cell Nuclear Antigen That Blocks Translesion DNA Synthesis

Bret D. Freudenthal, S. Ramaswamy, Manju M. Hingorani and M. Todd Washington

Biochemistry, 2008, 47 (50), pp 13354–13361

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Binding of Drosophila Orc Proteins to Anaphase Chromosomes Requires Cessation of Mitotic Cyclin-Dependent Kinase Activity

Tina Baldinger and Manfred Gossen

Molecular and Cellular Biology, January 2009, p. 140-149, Vol. 29, No. 1

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Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

Vasundhara M. Navadgi-Patil and Peter M. Burgers

J. Biol. Chem., Vol. 283, Issue 51, 35853-35859, December 19, 2008

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Dpb11 activates the Mec1–Ddc2 complex

Daniel A. Mordes, Edward A. Nam, and David Cortez

PNAS December 2, 2008 vol. 105 no. 48 18730-18734

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Human Wrnip1 Is Localized in Replication Factories in a Ubiquitin-binding Zinc Finger-dependent Manner

Nicola Crosetto, Marzena Bienko, Richard G. Hibbert, Tina Perica, Chiara Ambrogio, Tobias Kensche, Kay Hofmann, Titia K. Sixma, and Ivan Dikic

J. Biol. Chem., Vol. 283, Issue 50, 35173-35185, December 12, 2008

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Lys-110 is essential for targeting PCNA to replication and repair foci, and the K110A mutant activates apoptosis

Byung Ju Kim and Hoyun Lee

Biology of the Cell (2008) 100, (675–686)

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Spatio-temporal dynamics of replication and transcription sites in the mammalian cell nucleus

Kishore S. Malyavantham, Sambit Bhattacharya, William D. Alonso, Raj Acharya and Ronald Berezney

Chromosoma Volume 117, Number 6 / December, 2008

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Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping

Megan G. Clareya, Michael Botchana, and Eva Nogalesa

Journal of Structural Biology Volume 164, Issue 3, December 2008, Pages 241-249

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Flexibility of Eukaryotic Okazaki Fragment Maturation through Regulated Strand Displacement Synthesis

Carrie M. Stith, Joan Sterling, Michael A. Resnick, Dmitry A. Gordenin, and Peter M. Burgers

J. Biol. Chem., Vol. 283, Issue 49, 34129-34140, December 5, 2008

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Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae

Junsuo Kan, Lan Zou, Jingjing Zhang, Rentian Wu, Ziyi Wang, and Chun Liang

J. Biol. Chem., Vol. 283, Issue 49, 33803-33807, December 5, 2008


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The Hsk1(Cdc7) Replication Kinase Regulates Origin Efficiency

Prasanta K. Patel, Naveen Kommajosyula, Adam Rosebrock, Aaron Bensimon,, Janet Leatherwood, John Bechhoefer, and Nicholas Rhind

Vol. 19, Issue 12, 5550-5558, December 2008

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PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step

Richard D. Hutton, Jennifer A. Roberts, J. Carlos Penedo and Malcolm F. White

Nucleic Acids Research, 2008, Vol. 36, No. 21 6720-6727

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RNA-dependent recruitment of the origin recognition complex

Julie Norseen, Andreas Thomae, Venkatesh Sridharan, Ashok Aiyar, Aloys Schepers and Paul M Lieberman

The EMBO Journal (2008) 27, 3024–3035

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Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomesin Meiosis I

Joao Matos,Jesse J. Lipp,Aliona Bogdanova,Sylvine Guillot,Elwy Okaz,Magno Junqueira,Andrej Shevchenko and Wolfgang Zachariae,

Cell, Volume 135, Issue 4, 662-678, 14 November 2008

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Enzymatic Mechanism Controls Redox-mediated Protein-DNA Interactions at the Replication Origin of Kinetoplast DNA Minicircles

Dotan Sela, Nurit Yaffe, and Joseph Shlomai

J. Biol. Chem., Vol. 283, Issue 46, 32034-32044,

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Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing in Saccharomyces cerevisiae

Jason A. Stewart, Adam S. Miller, Judith L. Campbell, and Robert A. Bambara

J. Biol. Chem., Vol. 283, Issue 46, 31356-31365,

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Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

Steffi Herold, 3, Andreas Hock, Barbara Herkert, Katrien Berns, Jasper Mullenders, Roderick Beijersbergen, Rene Bernards and Martin Eilers

The EMBO Journal (2008) 27, 2851–2861,

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Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

Li Zheng,Mian Zhou,Zhigang Guo,Huiming Lu,Limin Qian,Huifang Dai,Junzhuan Qiu,Elena Yakubovskaya,Daniel F. Bogenhagen,Bruce Demple andBinghui Shen,

Molecular Cell, Volume 32, Issue 3, 325-336, 7 November 2008

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Identification of the Xenopus DNA2 protein as a major nuclease for the 5'3' strand-specific processing of DNA ends

Shuren Liao, Thomas Toczylowski and Hong Yan

Nucleic Acids Research, 2008, Vol. 36, No. 19 6091-6100

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Dividing the workload at a eukaryotic replication fork

Thomas A. Kunkel, and Peter M. Burgers

Trends in Cell Biology Volume 18, Issue 11, November 2008, Pages 521-527

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Caspase-mediated cleavage of importin-α increases its affinity for MCM and downregulates DNA synthesis by interrupting the binding of MCM to chromatin

Byung Ju Kim, and Hoyun Lee

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1783, Issue 12, December 2008, Pages 2287-2293

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Chromosome replication dynamics in the archaeon Sulfolobus acidocaldarius

Iain G. Duggina, Simon A. McCallum, and Stephen D. Bell

PNAS October 28, 2008 vol. 105 no. 43 16737-16742

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Mcm Subunits Can Assemble into Two Different Active Unwinding Complexes

Diane M. Kanter, Irina Bruck, and Daniel L. Kaplan

J. Biol. Chem., Vol. 283, Issue 45, 31172-31182, November 7, 2008

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Protein Phosphatase-1 Is Targeted to DNA Polymerase δ via an Interaction with the p68 Subunit

Yan Gao, Yajing Zhou, Bin Xie, Sufang Zhang, Amal Rahmeh, Hua-shan Huang, Marietta Y. W. T. Lee, and Ernest Y. C. Lee

Biochemistry, 47 (43), 11367–11376, 2008

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Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

Atsuko Niimi, Stephanie Brown, Simone Sabbioneda, Patricia L. Kannouche, Andrew Scott, Akira Yasui, Catherine M. Green, and Alan R. Lehmann

PNAS October 21, 2008 vol. 105 no. 42 16125-16130

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Making Connections at DNA Replication Forks: Mrc1 Takes the Lead

Karim Labib

Molecular Cell, Volume 32, Issue 2, 166-168, 24 October 2008

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Multiple Mechanisms Contribute to Schizosaccharomyces pombe Origin Recognition Complex-DNA Interactions

Christopher R. Houchens, Wenyan Lu, Ray-Yuan Chuang, Mark G. Frattini, Alex Fuller, Pam Simancek, and Thomas J. Kelly

J. Biol. Chem., Vol. 283, Issue 44, 30216-30224, October 31, 2008


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Genome-wide studies highlight indirect links between human replication origins and gene regulation

Jean-Charles Cadoret, Françoise Meisch, Vahideh Hassan-Zadeh, Isabelle Luyten, Claire Guillet, Laurent Duret, Hadi Quesneville, and Marie-Noëlle Prioleau

PNAS October 14, 2008 vol. 105 no. 41 15837-15842

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RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

Wei Fan and Jianyuan Luo

J. Biol. Chem., Vol. 283, Issue 43, 29037-29044, October 24, 2008

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DNA Polymerase Is Highly Processive with Proliferating Cell Nuclear Antigen and Undergoes Collision Release upon Completing DNA

Lance D. Langston and Mike O'Donnell

J. Biol. Chem., Vol. 283, Issue 43, 29522-29531, October 24, 2008

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Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

Ichiro Hiratani, Tyrone Ryba, Mari Itoh, Tomoki Yokochi, Michaela Schwaiger, Chia-Wei Chang, Yung Lyou, Tim M. Townes, Dirk Schübeler, David M. Gilbert

PLoS Biol 6(10): e245

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Hepatitis B Virus X Protein Increases the Cdt1-to-Geminin Ratio Inducing DNA Re-replication and Polyploidy

Lova Rakotomalala, Leo Studach, Wen-Horng Wang, Gerald Gregori, Ronald L. Hullinger, and Ourania Andrisani

J. Biol. Chem., Vol. 283, Issue 42, 28729-28740, October 17, 2008

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The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair

Weili Sun, Saikat Nandi, Fekret Osman, Jong Sook Ahn, Jovana Jakovleska, Alexander Lorenz, and Matthew C. Whitby

Molecular Cell, Vol 32, 118-128, 10 October 2008

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Mrc1 and DNA Polymerase ɛ Function Together in Linking DNA Replication and the S Phase Checkpoint

Huiqiang Lou, Makiko Komata, Yuki Katou, Zhiyun Guan, Clara C. Reis, Martin Budd, Katsuhiko Shirahige, and Judith L. Campbell

Molecular Cell, Vol 32, 106-117, 10 October 2008

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Spatial subunit distribution and in vitro functions of the novel trimeric PCNA complex from Sulfolobus tokodaii

Shuhong Lua, Zhuo Lia, Zhiyu Wanga, Xiaoqing Maa, Duohong Shenga, Jinfeng Nia and Yulong Shen

Biochemical and Biophysical Research Communications Volume 376, Issue 2, 14 November 2008, Pages 369-374

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Rtf1-Mediated Eukaryotic Site-Specific Replication Termination

T. Eydmann, E. Sommariva, T. Inagawa, S. Mian, A. J. S. Klar and J. Z. Dalgaard

Genetics, Vol. 180, 27-39, September 2008

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Rtt101 and Mms1 in budding yeast form a CUL4DDB1-like ubiquitin ligase that promotes replication through damaged DNA

Iram Waris Zaidi, Gwénaël Rabut, Ana Poveda, Hartmut Scheel, Johan Malmström, Helle Ulrich, Kay Hofmann, Philippe Pasero, Matthias Peter & Brian Luke

EMBO reports 9, 10, 1034–1040 (2008)

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Control of DNA polymerase stability by phosphorylation and ubiquitination during the cell cycle

Ursula Wimmer, Elena Ferrari, Peter Hunziker & Ulrich Hübscher

EMBO reports 9, 10, 1027–1033 (2008)

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HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

Benoit Miotto and Kevin Struhl

GENES & DEVELOPMENT 22:2633-2638, 2008

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Pif1 Helicase Directs Eukaryotic Okazaki Fragments toward the Two-nuclease Cleavage Pathway for Primer Removal

Marie L. Rossi, Jason E. Pike, Wensheng Wang, Peter M. J. Burgers, Judith L. Campbell, and Robert A. Bambara

J. Biol. Chem., Vol. 283, Issue 41, 27483-27493

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Publication Alert

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

Sylvain Courbet, Sophie Gay, Nausica Arnoult, Gerd Wronka, Mauro Anglana, Olivier Brison & Michelle Debatisse

Nature 455, 557-560 (25 September 2008)

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Intrinsic ssDNA Annealing Activity in the C-Terminal Region of WRN†

Meltem Muftuoglu, Tomasz Kulikowicz, Gad Beck, Jae Wan Lee, Jason Piotrowski, and Vilhelm A. Bohr

Biochemistry, 47 (39), 10247–10254, 2008

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Thermoplasma acidophilum Cdc6 protein stimulates MCM helicase activity by regulating its ATPase activity

Gyri Teien Haugland, Nozomi Sakakibara, Angel L. Pey, Claire R. Rollor, Nils-Kåre Birkeland and Zvi Kelman,

Nucleic Acids Research, 2008, Vol. 36, No. 17 5602-5609

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Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage

Nasim Sabouri, Jörgen Viberg, Dinesh Kumar Goyal, Erik Johansson and Andrei Chabes

Nucleic Acids Research, 2008, Vol. 36, No. 17 5660-5667


Publication Alert

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts

Hélène Labit, Irène Perewoska, Thomas Germe, Olivier Hyrien and Kathrin Marheineke

Nucleic Acids Research, 2008, Vol. 36, No. 17 5623-5634

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Activation of the DNA Damage Checkpoint in Mutants Defective in DNA Replication Initiation

Ling Yin, Alexandra Monica Locovei, and Gennaro D'Urso

Mbc Vol. 19, Issue 10, 4374-4382, October 2008

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Recognition of Cisplatin−DNA Interstrand Cross-Links by Replication Protein A

Steve M. Patrick, Kristin Tillison, and Jeffrey M. Horn

Biochemistry, 47 (38), 10188–10196, 2008

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SUMO modification of PCNA is controlled by DNA

Joanne L Parker, Andrea Bucceri, Adelina A Davies, Katharina Heidrich, Hanna Windecker and Helle D Ulrich

The EMBO Journal (2008) 27, 2422–2431,

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Cyclin E-dependent localization of MCM5 regulates centrosome duplication

Rebecca L. Ferguson and James L. Maller

Journal of Cell Science 121, 3224-3232 (2008)

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Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability

Matthew L. Bochman, Stephen P. Bell, and Anthony Schwacha

Molecular and Cellular Biology, October 2008, p. 5865-5873, Vol. 28, No. 19

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Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast

Yanfei Zou and Xin Bi

Nucleic Acids Research, 2008, Vol. 36, No. 16 5189-5200

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The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase

Nives Selak, Csanád Z. Bachrati, Igor Shevelev, Tobias Dietschy, Barbara vanhttp://www.blogger.com/img/gl.link.gif Loon, Anette Jacob, Ulrich Hübscher, Joerg D. Hoheisel, Ian D. Hickson and Igor Stagljar

Nucleic Acids Research, 2008, Vol. 36, No. 16 5166-5179

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Expression and subcellular localization of ORC1 in Leishmania major

Diwakar Kumara, Agnideep Mukherjia and Swati Saha

Biochemical and Biophysical Research Communications Volume 375, Issue 1, 10 October 2008, Pages 74-79

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Asynchronous replication dynamics of imprinted and non-imprinted chromosome regions in early mouse embryos

Andreas Maya, Kurt Reifenbergb, Ulrich Zechnera and Thomas Haafa

Experimental Cell Research Volume 314, Issue 15, 10 September 2008, Pages 2788-2795

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Replication timing of extremely large genes on human chromosomes 11q and 21q

Yoshihisa Watanabea, Kiyoshi Shibatab, Toshimichi Ikemurac and Masato Maekawa

Gene Volume 421, Issues 1-2, 15 September 2008, Pages 74-80

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Mutagenic and Recombinagenic Responses to Defective DNA Polymerase Are Facilitated by the Rev1 Protein in pol3-t Mutants of Saccharomyces cerevisiae

Erica Mito, Janet V. Mokhnatkin, Molly C. Steele, Victoria L. Buettner, Steve S. Sommer, Glenn M. Manthey and Adam M. Bailis

Genetics, Vol. 179, 1795-1806, August 2008

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Functional Conservation of β-Hairpin DNA Binding Domains in the Mcm Protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae

Ronald P. Leon, Marianne Tecklenburg and Robert A. Sclafani

Genetics, Vol. 179, 1757-1768, August 2008,

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Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks

Naoki Nitani, Chie Yadani, Hayato Yabuuchi, Hisao Masukata, and Takuro Nakagawa

PNAS September 2, 2008 vol. 105 no. 35 12973-12978

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RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage

Rachel William Anantha, Elena Sokolova, and James A. Borowiec

PNAS September 2, 2008 vol. 105 no. 35 12903-12908

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Cell cycle progression requires the CDC-48UFD−1/NPL−4 complex for efficient DNA replication

Julien Mouysset, Alexandra Deichsel, Sandra Moser, Carsten Hoege, Anthony A. Hyman, Anton Gartner, and Thorsten Hoppe

PNAS September 2, 2008 vol. 105 no. 35 12879-12884

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Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage

Jonathan R. Hall, Hyun O. Lee, Brandon D. Bunker, Elizabeth S. Dorn, Greg C. Rogers, Robert J. Duronio, and Jeanette Gowen Cook

J. Biol. Chem., Vol. 283, Issue 37, 25356-25363, September 12, 2008

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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

Akira Motegi, Hung-Jiun Liaw, Kyoo-Young Lee, Henk P. Roest, Alex Maas, Xiaoli Wu, Helen Moinova, Sanford D. Markowitz, Hao Ding, Jan H. J. Hoeijmakers, and Kyungjae Myung

PNAS August 26, 2008 vol. 105 no. 34 12411-12416

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The origin recognition complex is dispensable for endoreplication in Drosophila

So Young Park and Maki Asano

PNAS August 26, 2008 vol. 105 no. 34 12343-12348

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Stochastic hybrid modeling of DNA replication across a complete genome

J. Lygeros, K. Koutroumpas, S. Dimopoulos, I. Legouras, P. Kouretas, C. Heichinger, P. Nurse, and Z. Lygerou

PNAS August 26, 2008 vol. 105 no. 34 12295-12300

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The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer

Sarah A. Compton, Gökhan Tolun, Ashwini S. Kamath-Loeb, Lawrence A. Loeb, and Jack D. Griffith

J. Biol. Chem., Vol. 283, Issue 36, 24478-24483, September 5, 2008

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Cdt1 Forms a Complex with the Minichromosome Maintenance Protein (MCM) and Activates Its Helicase Activity

Zhiying You and Hisao Masai

J. Biol. Chem., Vol. 283, Issue 36, 24469-24477, September 5, 2008


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Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition

Taro Masuda-Sasa, Piotr Polaczek, Xiao P. Peng, Lu Chen, and Judith L. Campbell

J. Biol. Chem., Vol. 283, Issue 36, 24359-24373, September 5, 2008

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The replicative DNA polymerase of herpes simplex virus 1 exhibits apurinic/apyrimidinic and 5′-deoxyribose phosphate lyase activities

Federica Bogani and Paul E. Boehmer

PNAS August 19, 2008 vol. 105 no. 33 11709-11714

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Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase

Alessandro Costa, Gijs van Duinen, Barbara Medagli, James Chong, Nozomi Sakakibara, Zvi Kelman, Satish K Nair, Ardan Patwardhan and Silvia Onesti

The EMBO Journal (2008) 27, 2250–2258

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DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1

R. A. M. de Bruin, T. I. Kalashnikova, A. Aslanian, J. Wohlschlegel, C. Chahwan, J. R. YatesIII, P. Russell, and C. Wittenberg

PNAS August 12, 2008 vol. 105 no. 32 11230-11235

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In Xenopus Egg Extracts, DNA Replication Initiates Preferentially at or near Asymmetric AT Sequences

Slavica Stanojcic, Jean-Marc Lemaitre, Konstantin Brodolin, Etienne Danis, and Marcel Mechali

Molecular and Cellular Biology, September 2008, p. 5265-5274, Vol. 28, No. 17

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Reduced Levels of DNA Polymerase delta Induce Chromosome Fragile Site Instability in Yeast

Francene J. Lemoine, Natasha P. Degtyareva, Robert J. Kokoska,2 and Thomas D. Petes

Molecular and Cellular Biology, September 2008, p. 5359-5368, Vol. 28, No. 17

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A Dynamic Stochastic Model for DNA Replication Initiation in Early Embryos

Arach Goldar, Hélène Labit, Kathrin Marheineke, Olivier Hyrien

PLoS ONE 3(8): e2919

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Formation of Noncanonical DNA Structures Mediated by Human ORC4, a Protein Component of the Origin Recognition Complex

Dragana Stefanovic, Jelena Kusic, Aleksandra Divac, and Branko Tomic

Biochemistry, 47 (33), 8760–8767

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The N-Terminal Domain of the Drosophila Retinoblastoma Protein Rbf1 Interacts with ORC and Associates with Chromatin in an E2F Independent Manner

Joseph Ahlander, Xiao-Bo Chen, Giovanni Bosco

PLoS ONE 3(7): e2831

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Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro

Masaya TAKEHARA, Masaki MAKISE, Hitomi TAKENAKA, Teita ASANO and Tohru MIZUSHIMA1

Biochem. J. (2008) 413 (535–543)

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Plasmodium falciparum origin recognition complex subunit 5: functional characterization and role in DNA replication foci formation

Ashish Gupta, Parul Mehra and Suman Kumar Dhar*

Molecular Microbiology Volume 69 Issue 3, Pages 646 – 665

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The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

Zhiqiang Chen, Christian Speck, Patricia Wende, Chunyan Tang, Bruce Stillman, and Huilin Li

PNAS July 29, 2008 vol. 105 no. 30 10326-10331

Publication Alert

Analysis of Chromosome III Replicators Reveals an Unusual Structure for the ARS318 Silencer Origin and a Conserved WTW Sequence within the Origin Recognition Complex Binding Site

FuJung Chang, James F. Theis, Jeremy Miller, Conrad A. Nieduszynski, Carol S. Newlon, and Michael Weinreich

Molecular and Cellular Biology, August 2008, p. 5071-5081, Vol. 28, No. 16

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Checkpoint effects and telomere amplification during DNA re-replication in fission yeast

Katie L Mickle, Anna Oliva, Joel A Huberman and Janet Leatherwood

BMC Molecular Biology 2007, 8:119

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Checkpoint independence of most DNA replication origins in fission yeast

Katie L Mickle , Sunita Ramanathan, Adam Rosebrock, Anna Oliva, Amna Chaudari, Chulee Yompakdee, Donna Scott, Janet Leatherwood and Joel A Huberman

BMC Molecular Biology 2007, 8:112

Publication Alert

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

Irina Voineagu, Vidhya Narayanan, Kirill S. Lobachev, and Sergei M. Mirkin

PNAS July 22, 2008 vol. 105 no. 29 9936 –9941

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Catalysis of Strand Annealing by Replication Protein A Derives from Its Strand Melting Properties

Jeremy D. Bartos, Lyndsay J. Willmott, Sara K. Binz, Marc S. Wold, and Robert A. Bambara

J. Biol. Chem., Vol. 283, Issue 31, 21758-21768, August 1, 2008

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Regulatory Functions of the N-terminal Domain of the 70-kDa subunit of Replication Protein A (RPA)

Sara K. Binz and Marc S. Wold

J. Biol. Chem., Vol. 283, Issue 31, 21559-21570, August 1, 2008

Publication Alert

Schizosaccharomyces Pombe NOC3 is essential for ribosome biogenesis and cell division but not DNA replication

Christopher R. Houchens, Audrey Perreault, François Bachand, and Thomas J. Kelly

Eukaryotic Cell doi:10.1128/EC.00119-08

Publication Alert

The Mcm2-7 Complex Has In Vitro Helicase Activity

Matthew L. Bochman and Anthony Schwacha

Molecular Cell, Vol 31, 287-293, 25 July 2008

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MCM9 Binds Cdt1 and Is Required for the Assembly of Prereplication Complexes

Malik Lutzmann and Marcel Méchali

Molecular Cell, Vol 31, 190-200, 25 July 2008

Publication Alert

Isolation of a Drosophila amplification origin developmentally activated by transcription

Fang Xie and Terry L. Orr-Weaver

PNAS July 15, 2008 vol. 105 no. 28 9651-9656

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Identifying a property of origins of DNA synthesis required to support plasmids stably in human cells

Chen-Yu Wang and Bill Sugden

PNAS July 15, 2008 vol. 105 no. 28 9639-9644

Publication Alert

Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae

Shawn J. Szyjka, Jennifer G. Aparicio, Christopher J. Viggiani, Simon Knott, Weihong Xu1, Simon Tavaré, and Oscar M. Aparicio

GENES & DEVELOPMENT 22:1906-1920, 2008

Publication Alert

Cdc7–Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts

Tatsuro S. Takahashi1, Abhijit Basu, Vladimir Bermudez, Jerard Hurwitz, and Johannes C. Walter

GENES & DEVELOPMENT 22:1894-1905, 2008

Publication Alert

The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1

Naoki Takahashi1, Tim Lammens, Véronique Boudolf1, Sara Maes1, Takeshi Yoshizumi, Geert De Jaeger, Erwin Witters, Dirk Inzé1 and Lieven De Veylder

The EMBO Journal (2008) 27, 1840–1851,

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Asymmetric bidirectional replication at the human DBF4 origin

Julia Romero & Hoyun Lee

Nature Structural & Molecular Biology 15, 722 - 729 (2008) 


Publication Alert

Temporal Profiling of the Chromatin Proteome Reveals System-wide Responses to Replication Inhibition

Guennadi A. Khoudoli, Peter J. Gillespie, Graeme Stewart, Jens S. Andersen, Jason R. Swedlow, and J. Julian Blow

Current Biology, Vol 18, 838-843, 03 June 2008

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Prediction of replication time zones at single nucleotide resolution in the human genome

Feng Gaoa and Chun-Ting Zhang

Febs letters Volume 582, Issue 16, 9 July 2008, Pages 2441-2444

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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

Arkaitz Ibarra, Etienne Schwob, and Juan Méndez

PNAS July 1, 2008 vol. 105 no. 26 8956-8961

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Cellular Functions of Human RPA1: MULTIPLE ROLES OF DOMAINS IN REPLICATION, REPAIR, AND CHECKPOINTS

Stuart J. Haring, Aaron C. Mason, Sara K. Binz, and Marc S. Wold

J. Biol. Chem., Vol. 283, Issue 27, 19095-19111, July 4, 2008


Publication Alert

Cdc6 Determines Utilization of p21WAF1/CIP1-dependent Damage Checkpoint in S Phase Cells

Qiuming Kan, Shigeki Jinno, Kohei Kobayashi, Hanako Yamamoto, and Hiroto Okayama1

J. Biol. Chem., Vol. 283, Issue 26, 17864-17872, June 27, 2008

Publication Alert

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

Venkateswarlu Popuri, Csanád Z. Bachrati, Laura Muzzolini, Georgina Mosedale, Silvia Costantini, Elisa Giacomini, Ian D. Hickson, and Alessandro Vindigni

J. Biol. Chem., Vol. 283, Issue 26, 17766-17776, June 27, 2008


Publication Alert

The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles

Norman Zielke, Silvia Querings, Carmen Rottig, Christian Lehner, and Frank Sprenger

GENES & DEVELOPMENT 22:1690-1703, 2008

Publication Alert

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

Jonathan Baxter, and John F.X. Diffley

Molecular Cell, Vol 30, 790-802, 20 June 2008

Publication Alert

Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2–7 complex

Douglas I. Lin, Priya Aggarwal, and J. Alan Diehl

PNAS | June 10, 2008 | vol. 105 | no. 23 | 8079-8084

Publication Alert

A Conserved Proliferating Cell Nuclear Antigen-interacting Protein Sequence in Chk1 Is Required for Checkpoint Function

Jennifer Scorah, Meng-Qiu Dong, John R. Yates, III, Mary Scott, David Gillespie, and Clare H. McGowan

J. Biol. Chem., Vol. 283, Issue 25, 17250-17259, June 20, 2008

Publication Alert

Nucleolar Localization and Dynamic Roles of Flap Endonuclease 1 in Ribosomal DNA Replication and Damage Repair

Zhigang Guo, Limin Qian, Ren Liu, Huifang Dai, Mian Zhou, Li Zheng, and Binghui Shen*

Molecular and Cellular Biology, July 2008, p. 4310-4319, Vol. 28, No. 13

Publication Alert (review)

How ATR turns on: TopBP1 goes on ATRIP with ATR

Anna E. Burrows and Stephen J. Elledge

GENES & DEVELOPMENT 22:1416-1421, 2008

Publication Alert

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

Daniel A. Mordes, Gloria G. Glick, Runxiang Zhao, and David Cortez

GENES & DEVELOPMENT 22:1478-1489, 2008

Publication Alert

Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum

Liliana Mancio-Silva, Ana Paola Rojas-Meza, Miguel Vargas, Artur Scherf, and Rosaura Hernandez-Rivas2

Journal of Cell Science 121, 2046-2053 (2008)

Publication Alert

Structural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain

Wei Liu1, Biagio Pucci, Mosè Rossi, Francesca M. Pisani and Rudolf Ladenstein

Nucleic Acids Research 2008 36(10):3235-3243;

Publication Alert

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint

J M Kim, N Kakusho, M Yamada, Y Kanoh, N Takemoto and H Masai

Oncogene (2008) 27, 3475–3482

Publication Alert

Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin

Iwao Kukimoto, Seiichiro Mori, Hidetaka Sato, Takamasa Takeuchi and Tadahito Kanda

FEBS Journal Volume 275 Issue 12 Page 3123-3135, June 2008

Publication Alert

HMGB1 protein inhibits DNA replication in vitro: A role of the acetylation and the acidic tail

Dessislava Topalovaa, Iva Ugrinovaa, Iliya G. Pasheva and Evdokia A. Pasheva

The International Journal of Biochemistry & Cell Biology Volume 40, Issue 8, 2008, Pages 1536-1542

Publication Alert (review)

RecQ helicases: guardian angels of the DNA replication fork

Csanád Z. Bachrati1 and Ian D. Hickson1

Chromosoma Volume 117, Number 3 / June, 2008

Publication Alert

Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit

Anthony J. Davis, Zhen Yan, Bobbie Martinez, and Marc C. Mumby

J. Biol. Chem., Vol. 283, Issue 23, 16104-16114, June 6, 2008

Publication Alert

Cds1 Controls the Release of Cdc14-like Phosphatase Flp1 from the Nucleolus to Drive Full Activation of the Checkpoint Response to Replication Stress in Fission Yeast

Helena Díaz-Cuervo, and Avelino Bueno

MBC Vol. 19, Issue 6, 2488-2499, June 2008

Publication Alert

Claspin Promotes Normal Replication Fork Rates in Human Cells

Eva Petermann, Thomas Helleday, and Keith W. Caldecott

MBC Vol. 19, Issue 6, 2373-2378, June 2008

Publication alert

Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two
mechanisms

Razidlo DF, Lahue RS

DNA Repair (Amst). 2008 Apr 2;7(4):633-40. Epub 2008 Mar 5

Publication Alert

A DNA Polymerase α Accessory Protein, Mcl1, Is Required for Propagation of Centromere Structures in Fission Yeast

Toyoaki Natsume1, Yasuhiro Tsutsui, Takashi Sutani, Elaine M. Dunleavy, Alison L. Pidoux, Hiroshi Iwasaki, Katsuhiko Shirahige, Robin C. Allshire, Fumiaki Yamao

PLoS ONE 3(5): e2221.

Publication Alert

Replication-timing-correlated spatial chromatin arrangements in cancer and in primate interphase nuclei

Florian Grasser, Michaela Neusser, Heike Fiegler, Tobias Thormeyer, Marion Cremer, Nigel P. Carter, Thomas Cremer, and Stefan Müller,

Journal of Cell Science 121, 1876-1886 (2008)

Site update

*****Most of the pages on dnareplication.net have recently been updated. In addition to our weekly update of the interactive pages new proteins have been added and updates have been made to the existing protein entries. We have also added a search function and a site index. Please let us know of any problems. The model will also shortly be updated - any suggestions will be welcome (26.5.8)*****

Publication Alert

DNA replication timing of the human β-globin domain is controlled by histone modification at the origin

Alon Goren, Amalia Tabib, Merav Hecht, and Howard Cedar

GENES & DEVELOPMENT 22:1319-1324, 2008

Publication Alert

DNA Combing Reveals Intrinsic Temporal Disorder in the Replication of Yeast Chromosome VI

Daniel M. Czajkowsky, Jie Liu, Joyce L. Hamlin and Zhifeng Shao

Journal of Molecular Biology Volume 375, Issue 1, 4 January 2008, Pages 12-19

Publication Alert (review)

DNA Polymerases at the Replication Fork in Eukaryotes

Bruce Stillman

Molecular Cell, Vol 30, 259-260, 09 May 2008

Publication Alert

Flap Endonuclease 1 Contributes to Telomere Stability

Abhishek Saharia, Lionel Guittat, Sandra Crocker, Adeline Lim, Martin Steffen, Shashikant Kulkarni, and Sheila A. Stewart

Current Biology, Vol 18, 496-500, 08 April 2008

Publication Alert

The role of the Saccharomyces cerevisiae Cdc7–Dbf4 complex in the replication checkpoint

Hiroo Ogia, Cheng-Zhong Wanga, Wataru Nakaic, Yasuo Kawasakia and Hiroshi Masumoto

Gene Volume 414, Issues 1-2, 15 May 2008, Pages 32-40

Publication Alert

Human Replication Protein A Melts a DNA Triple Helix Structure in a Potent and Specific Manner

Yuliang Wu, Nina Rawtani, Arun Kalliat Thazhathveeti, Mark K. Kenny, Michael M. Seidman, and Robert M. Brosh, Jr

Biochemistry, 47 (18), 5068–5077, 2008. 10.1021/bi702102d

Publication Alert

Chk1 and Claspin potentiate PCNA ubiquitination

Xiaohong H. Yang, Bunsyo Shiotani, Marie Classon, and Lee Zou

GENES & DEVELOPMENT 22:1147-1152, 2008

Publication Alert

Interplay between S-Cyclin-dependent Kinase and Dbf4-dependent Kinase in Controlling DNA Replication through Phosphorylation of Yeast Mcm4 N-Terminal Domain

Alain Devault, Elisabeth Gueydon, and Etienne Schwob

MBC Vol. 19, Issue 5, 2267-2277, May 2008

Publication Alert

The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication

Dale K. Shumaker, Liliana Solimando, Kaushik Sengupta, Takeshi Shimi, Stephen A. Adam, Antje Grunwald, Sergei V. Strelkov, Ueli Aebi, M. Cristina Cardoso, and Robert D. Goldman

The Journal of Cell Biology, Vol. 181, No. 2, 269-280

Publication Alert

An ARS Element Inhibits DNA Replication through a SIR2-Dependent Mechanism

Amber Crampton, FuJung Chang, Donald L. Pappas Jr., Ryan L. Frisch, and Michael Weinreich

Molecular Cell, Vol 30, 156-166, 25 April 2008

Publication Alert

Division of Labor at the Eukaryotic Replication Fork

Stephanie A. Nick McElhinny, Dmitry A. Gordenin, Carrie M. Stith, Peter M.J. Burgers, and Thomas A. Kunkel

Molecular Cell, Vol 30, 137-144, 25 April 2008

Publication Alert

Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair

Meltem Muftuoglu, Rika Kusumoto, Elzbieta Speina, Gad Beck, Wen-Hsing Cheng, Vilhelm A. Bohr

PLoS ONE 3(4): e1918

Publication Alert

Regulation of polymerase exchange between Pol and Pol by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

Zhihao Zhuang, Robert E. Johnson, Lajos Haracska, Louise Prakash, Satya Prakash, and Stephen J. Benkovic

PNAS | April 8, 2008 | vol. 105 | no. 14 | 5361-5366

Publication Alert

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1

Lara N. Bennett, Conor Larkin, David A. Gillespie and Paul R. Clarke

Biochemical and Biophysical Research Communications Volume 369, Issue 3, 9 May 2008, Pages 973-976

Publication Alert

On the mechanism of loading the PCNA sliding clamp by RFC

Isabelle Dionne, Nicola J. Brown, Roger Woodgate and Stephen D. Bell

Molecular MicrobiologyVolume 68 Issue 1 Page 216-222, April 2008

Publication Alert

A topoisomerase II-dependent mechanism for resetting replicons at the S–M-phase transition

Olivier Cuvier, Slavica Stanojcic, Jean-Marc Lemaitre, and Marcel Mechali

GENES & DEVELOPMENT 22:860-865, 2008

Publication Alert

ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6

Qiuming Kan, Shigeki Jinno, Hanako Yamamoto, Kohei Kobayashi, and Hiroto Okayama

PNAS | March 25, 2008 | vol. 105 | no. 12 | 4757-4762

Publication Alert

DNA Damage-induced Ubiquitylation of RFC2 Subunit of Replication Factor C Complex

Junya Tomida, Yuji Masuda, Hidekazu Hiroaki, Tomoko Ishikawa, Ihnyoung Song, Toshiki Tsurimoto, Satoshi Tateishi, Tadahiro Shiomi, Yasuhiro Kamei, Jinhyeong Kim, Kenji Kamiya, Cyrus Vaziri, Haruo Ohmori, and Takeshi Todo

J. Biol. Chem., Vol. 283, Issue 14, 9071-9079, April 4, 2008

Publication Alert

Ubiquitylation of Proliferating Cell Nuclear Antigen and Recruitment of Human DNA Polymerase η

Nana Nikolaishvili-Feinberg, G. Scott Jenkins, Kathleen R. Nevis, Dean P. Staus, Cameron O. Scarlett, Keziban Ünsal-Kaçmaz, William K. Kaufmann, and Marila Cordeiro-Stone

Biochemistry, 47 (13), 4141–4150,

Publication Alert

Orchestration of the S-phase and DNA damage checkpoint pathways by replication forks from early origins

Julie M. Caldwell, Yinhuai Chen, Kaila L. Schollaert, James F. Theis, George F. Babcock, Carol S. Newlon, and Yolanda Sanchez

The Journal of Cell Biology, Vol. 180, No. 6, 1073-1086

Publication Alert

Plx1 is required for chromosomal DNA replication under stressful conditions

Kristina Trenz, Alessia Errico and Vincenzo Costanzo

The EMBO Journal (2008) 27, 876–885,

Publication Alert

Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus

Liliana Krasinska, Emilie Besnard, Emilie Cot, Christiane Dohet, Marcel Méchali, Jean-Marc Lemaitre, and Daniel Fisher,

The EMBO Journal (2008) 27, 758–769,

Publication Alert

Identification of Novel Human Cdt1-binding Proteins by a Proteomics Approach: Proteolytic Regulation by APC/CCdh1


Nozomi Sugimoto, Issay Kitabayashi, Satoko Osano, Yasutoshi Tatsumi, Takashi Yugawa, Mako Narisawa-Saito, Akio Matsukage, Tohru Kiyono, and Masatoshi Fujita

MBC Vol. 19, Issue 3, 1007-1021, March 2008

Publication Alert

Phosphorylation of the C subunit (p66) of human DNA polymerase δ

Laure Lemmensa, Serge Urbachb, Renaud Prudentc, Claude Cochetc, Giuseppe Baldaccia, and Patrick Hughesa

Biochemical and Biophysical Research Communications Volume 367, Issue 2, 7 March 2008, Pages 264-270

Publication Alert

Insight into initiator-DNA interactions: a lesson from the archaeal ORC

Shusuke Tada, Lena R. Kundu, Takemi Enomoto

Bioessays Volume 30, Issue 3 , Pages 208 – 211

Publication Alert

A Role for Chd1 and Set2 in Negatively Regulating DNA Replication in Saccharomyces cerevisiae

Debabrata Biswas, Shinya Takahata, Hua Xin, Rinku Dutta-Biswas, Yaxin Yu, Tim Formosa and David J. Stillman

Genetics, Vol. 178, 649-659, February 2008, Copyright © 2008


Publication Alert

Dpb2p, a Noncatalytic Subunit of DNA Polymerase , Contributes to the Fidelity of DNA Replication in Saccharomyces cerevisiae

Malgorzata Jaszczur, Krzysztof Flis, Justyna Rudzka, Joanna Kraszewska, Martin E. Budd, Piotr Polaczek, Judith L. Campbell, Piotr Jonczyk and Iwona J. Fijalkowska

Genetics, Vol. 178, 633-647, February 2008, Copyright © 2008

Publication Alert

Once in a lifetime: strategies for preventing re-replication in prokaryotic and eukaryotic cells

Olaf Nielsen & Anders Løbner-Olesen

EMBO reports 9, 2, 151–156 (2008)

Publication Alert

Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein
Nozomi Sakakibara, Rajesh Kasiviswanathan, Eugene Melamud, Mimi Han, Frederick P. Schwarz, and Zvi Kelman

Nucleic Acids Research 2008 36(4):1309-1320

Publication Alert

A chemical method for fast and sensitive detection of DNA synthesis in vivo

Adrian Salic, and Timothy J. Mitchison

PNAS | February 19, 2008 | vol. 105 | no. 7 | 2415-2420

Publication Alert

Ku is involved in cell growth, DNA replication and G1-S transition

Emmanouil Rampakakis, Domenic Di Paola and Maria Zannis-Hadjopoulos

Journal of Cell Science 121, 590-600 (2008)

Publication Alert

Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins

Andreas W. Thomae, Dagmar Pich, Jan Brocher, Mark-Peter Spindler, Christian Berens, Robert Hock, Wolfgang Hammerschmidt, and Aloys Schepers

PNAS | February 5, 2008 | vol. 105 | no. 5 | 1692-1697

Publication Alert

Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing

Zhao-Qiu Wu and Xiaoqi Liu

PNAS | February 12, 2008 | vol. 105 | no. 6 | 1919-1924

Publication Alert

Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability

Julie M. Bailis, Douglas D. Luche, Tony Hunter, and Susan L. Forsburg

Molecular and Cellular Biology, March 2008, p. 1724-1738, Vol. 28, No. 5

Publication Alert

RFCCtf18 and the Swi1-Swi3 Complex Function in Separate and Redundant Pathways Required for the Stabilization of Replication Forks to Facilitate Sister Chromatid Cohesion in Schizosaccharomyces pombe

Alison B. Ansbach, Chiaki Noguchi, Ian W. Klansek, Mike Heidlebaugh, Toru M. Nakamura, and Eishi Noguchi

MBC Vol. 19, Issue 2, 595-607, February 2008

Publication Alert

Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint

Benoît Froget, Joël Blaisonneau, Sarah Lambert, and Giuseppe Baldacci

MBC Vol. 19, Issue 2, 445-456, February 2008

Publication Alert

14-3-3 Cruciform-binding proteins as regulators of eukaryotic DNA replication

Maria Zannis-Hadjopoulosa, , Wafaa Yahyaouia and Mario Callejoa

Trends in Biochemical Sciences Volume 33, Issue 1, January 2008, Pages 44-50

Publication Alert

Werner syndrome helicase activity is essential in maintaining fragile site stability

Livia Maria Pirzio, Pietro Pichierri, Margherita Bignami, and Annapaola Franchitto

The Journal of Cell Biology, Vol. 180, No. 2, 305-314

Publication Alert

Mutational specificity and genetic control of replicative bypass of an abasic site in yeast

Vincent Pagès, Robert E. Johnson, Louise Prakash, and Satya Prakash

PNAS | January 29, 2008 | vol. 105 | no. 4 | 1170-1175

Publication Alert

DNA Polymerase Is Preferentially Recruited during Homologous Recombination To Promote Heteroduplex DNA Extension

Laurent Maloisel, Francis Fabre, and Serge Gangloff,

Molecular and Cellular Biology, February 2008, p. 1373-1382, Vol. 28, No. 4

Publication Alert

Domain Architecture and Biochemical Characterization of Vertebrate Mcm10

Patrick D. Robertson, Eric M. Warren, Haijiang Zhang, David B. Friedman, Jeffrey W. Lary, James L. Cole, Antonin V. Tutter, Johannes C. Walter, Ellen Fanning, and Brandt F. Eichman

J. Biol. Chem., Vol. 283, Issue 6, 3338-3348, February 8, 2008

Publication Alert

Overreplication of short DNA regions during S phase in human cells

María Gómez and Francisco Antequera

GENES & DEVELOPMENT 22:375-385, 2008

Publication Alert

The GINS Complex from Pyrococcus furiosus Stimulates the MCM Helicase Activity*

Takehiro Yoshimochi, Ryosuke Fujikane, Miyuki Kawanami, Fujihiko Matsunaga, and Yoshizumi Ishino

J. Biol. Chem., Vol. 283, Issue 3, 1601-1609, January 18, 2008

Publication Alert

A homologous recombination defect affects replication-fork progression in mammalian cells

Fayza Daboussi, Sylvain Courbet, Simone Benhamou, Patricia Kannouche, Malgorzata Z. Zdzienicka, Michelle Debatisse and Bernard S. Lopez

Journal of Cell Science 121, 162-166 (2008)

Publication Alert

Structure of a Sliding Clamp on DNA

Roxana E. Georgescu, Seung-Sup Kim, Olga Yurieva, John Kuriyan, Xiang-Peng Kong, and Mike O'Donnell

Cell, Vol 132, 43-54, 11 January 2008

Publication Alert

Template Switching: From Replication Fork Repair to Genome Rearrangements

Dana Branzei and Marco Foiani

Cell 131, December 28, 2007 1227 – 1230

Publication Alert

A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders

Jennifer A. Lee, Claudia M.B. Carvalho, and James R. Lupski

Cell 131, 1235–1247, December 28, 2007

Publication Alert

Remodeling of the Human Papillomavirus Type 11 Replication Origin into Discrete Nucleoprotein Particles and Looped Structures by the E2 Protein

Jeonggu Sim, Sezgin Ozgur, Biing Yuan Lin, Jei-Hwa Yu2, Thomas R. Broker, Louise T. Chow and Jack Griffith

Journal of Molecular Biology Volume 375, Issue 4, 25 January 2008, Pages 1165-1177

Publication Alert

Regulation of Rtt107 Recruitment to Stalled DNA Replication Forks by the Cullin Rtt101 and the Rtt109 Acetyltransferase

Tania M. Roberts, Iram Waris Zaidi, Jessica A. Vaisica, Matthias Peter, and Grant W. Brown

mol biol cell Vol. 19, Issue 1, 171-180, January 2008

Publication Alert

Ciz1, a p21Cip1/ Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog

Anna Łukasik, Katarzyna A. Uniewicz, Marta Kulis and Piotr Kozlowski

FEBS Journal 275 (2008) 332–340

Publication Alert

Hbo1 Links p53-Dependent Stress Signaling to DNA Replication Licensing

Masayoshi Iizuka, Olga F. Sarmento, Takao Sekiya, Heidi Scrable, C. David Allis, and M. Mitchell Smith

Molecular and Cellular Biology, January 2008, p. 140-153, Vol. 28, No. 1

Publication Alert

DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication

Berndt Müller, Jane Blackburn, Carmen Feijoo, Xiujie Zhao, and Carl Smythe

The Journal of Cell Biology, Vol. 179, No. 7, 1385-1398

Publication Alert

A conserved mechanism for replication origin recognition
and binding in archaea

Alan I. MAJERN´IK and James P. J. CHONG

Biochem. J. (2008) 409, 511–518

Publication Alert

Characterization of the interaction between the human DNA topoisomerase IIβ -binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

Uta SCHMIDT, Yvonne WOLLMANN , Claudia FRANKE, Frank GROSSE, Hans-Peter SALUZ and Frank H ANEL

Biochem. J. (2008) 409, 169–177

Publication Alert

Regulation of Replication Fork Progression Through Histone Supply and Demand

Anja Groth, Armelle Corpet, Adam J. L. Cook, Daniele Roche, Jiri Bartek, Jiri Lukas, Geneviève Almouzni

Science 21 December 2007:
Vol. 318. no. 5858, pp. 1928 – 1931

Publication Alert

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

Hanada K, Budzowska M, Davies SL, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson ID, Kanaar R.

Nat Struct Mol Biol. 2007 Nov;14(11):1096-104

Publication Alert

Identification of Mutations That Decrease the Stability of a Fragment of Saccharomyces cerevisiae Chromosome III Lacking Efficient Replicators

James F. Theis, Ann Dershowitz, Carmela Irene, Clelia Maciariello, Michael L. Tobin, Giordano Liberi, Sahba Tabrizifard, Malgorzata Korus, Lucia Fabiani and Carol S. Newlon

Genetics, Vol. 177, 1445-1458
doi:10.1534/genetics.107.074690

Publication Alert

Tetrahymena ORC contains a ribosomal RNA fragment that participates in rDNA origin recognition

Mohammad M Mohammad, Taraka R Donti, J Sebastian Yakisich, Aaron G Smith and Geoffrey M Kapler

EMBO Journal (2007) 26, 5048–5060, doi:10.1038/sj.emboj.7601919

Post doctoral opportunities

Cell cycle and DNA damage regulation of the Cdt1 replication licensing factor

Function of Cut8 in DNA repair

Two post-doctoral positions, funded by Cancer Research UK, are available in these two areas. For further details of projects see tinyurl.com/26ye48; also Ralph et al. 7:1134, Kearsey et al. Mol Cell Biol 27:1558. Informal enquiries to stephen.kearsey@zoo.ox.ac.uk (Dept Zoology, University of Oxford).