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The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε Alicja Winczura, Rowin Appanah, Michael H. Tatham, Ronald T. Hay, Giacomo De Piccoli PLoS Genet 15(11): e1008427

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Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication Xiangzhou Meng , Lei Wei , Xiao P. Peng, Xiaolan Zhao PLoS Genet 15(11): e1008426

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SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation Ivan Psakhye, Federica Castellucci, Dana Branzei Mol Cell VOLUME 76, ISSUE 4, P632-645.E6

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Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM Thomas C. R. Miller, Julia Locke, Julia F. Greiwe, John F. X. Diffley & Alessandro Costa Nature volume 575, pages704–710(2019)

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BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress Han-Sae Lee, Hye-Ran Seo, Shin-Ai Lee, Soohee Choi, Dongmin Kang, Jongbum Kwon Biochem J (2019) 476 (20): 3053-3066.

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DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication Roberto A. Donnianni, Xhi-Xiong Zhou, Scott A. Lujan, Amr Al-Zain, Valerie Garcia, Eleanor Glancy, Adam B. Burkholder, Thomas A. Kunkel, Lorraine S. Symington Mol Cell VOLUME 76, ISSUE 3, P371-381.E4

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Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45) Abbey L. Perl, Caitlin M. O'Connor, Pengyan Fa, Franklin Mayca Pozo, Junran Zhang, Youwei Zhang and Goutham Narl The Journal of Biological Chemistry 294, 17043-17059.

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Preparation for DNA replication: the key to a successful S phase Juanita C. Limas Jeanette Gowen Cook febs letters 59 Pages 2853-2867

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The Drosophila melanogaster PIF1 Helicase Promotes Survival During Replication Stress and Processive DNA Synthesis During Double-Strand Gap Repair Ece Kocak, Sarah Dykstra, Alexandra Nemeth, Catherine G. Coughlin, Kasey Rodgers and Mitch McVey GENETICS November 1, 2019 vol. 213 no. 3 835-847; https://www.genetics.org/content/213/3/835

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Checkpoint inhibition of origin firing prevents DNA topological stress Esther C. Morafraile1, Christine Hänni1, George Allen1, Theresa Zeisner, Caroline Clarke, Mark C. Johnson, Miguel M. Santos, Lauren Carroll, Nicola E. Minchell, Jonathan Baxter, Peter Banks, Dave Lydall and Philip Zegerman Genes & Dev. 2019. 33: 1539-1554

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Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication Thelma M. Escobar, Ozgur Oksuz, Ricardo Saldaña-Meyer, Nicolas Descostes, Roberto Bonasio, Danny Reinberg Cell VOLUME 179, ISSUE 4, P953-963.E11, OCTOBER 31, 2019

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RecQL4 tethering on the pre-replicative complex induces unscheduled origin activation and replication stress in human cells Gwangsu Shin, Dongsoo Jeong, Hyunsup Kim, Jun-Sub Im and Joon-Kyu Lee The Journal of Biological Chemistry 294, 16255-16265.

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Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity Tung T. Le, Xiang Gao, Seong ha Park, Jaeyoon Lee, James T. Inman, Joyce H. Lee, Jessica L. Killian, Ryan P. Badman, James M. Berger, Michelle D. Wang Cell VOLUME 179, ISSUE 3, P619-631.

Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae Joseph C. Sanchez, Anja Ollodart, Christopher R. L. Large, Courtnee Clough, Gina M. Alvino, Mitsuhiro Tsuchiya, Matthew Crane, Elizabeth X. Kwan, Matt Kaeberlein, Maitreya J. Dunham, M.K. Raghuraman and Bonita J. Brewer Genetics Volume 213 Issue 1, September 2019

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Metazoan DNA replication origins Olivier Ganier, Paulina Prorok, Ildem Akerman and MarcelMéchali Current Opinion in Cell Biology Volume 58, June 2019, Pages 134-141

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Origins of DNA replication Babatunde Ekundayo, Franziska Bleichert PLoS Genet 15(9): e1008320. https://doi.org/10.1371/journal.pgen.1008320

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Replication Licensing Aberrations, Replication Stress, and Genomic Instability Michalis Petropoulos, Spyridon Champeris Tsaniras, Stavros Taraviras, and Zoi Lygerou Trends in Biochemical Sciences, September 2019, Vol. 44, No. 9

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Specific basic patch‐dependent multimerization of Saccharomyces cerevisiae ORC on single‐stranded DNA promotes ATP hydrolysis Hironori Kawakami Ryuya Muraoka Eiji Ohashi Kenta Kawabata Shota Kanamoto Takeaki Chichibu Toshiki Tsurimoto Tsutomu Katayama Genes to Cells Volume24, Issue9 September 2019 Pages 608-618

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Involvement of G-quadruplex regions in mammalian replication origin activity Paulina Prorok, Marie Artufel, Antoine Aze, Philippe Coulombe, Isabelle Peiffer, Laurent Lacroix, Aurore Guédin, Jean-Louis Mergny, Julia Damaschke, Aloys Schepers, Benoit Ballester & Marcel Méchali Nature Communications volume 10, Article number: 3274 (2019)

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RIF1 promotes replication fork protection and efficient restart to maintain genome stability Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt & Arnab Ray Chaudhuri Nature Communications volume 10, Article number: 3287 (2019)

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Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Marta A. Garbacz & Thomas A. Kunkel Nature Communicationsvolume 10, Article number: 3992 (2019)

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Asymmetric histone inheritance via strand-specific incorporation and biased replication fork movement Matthew Wooten, Jonathan Snedeker, Zehra F. Nizami, Xinxing Yang, Rajesh Ranjan, Elizabeth Urban, Jee Min Kim, Joseph Gall, Jie Xiao & Xin Chen Nature Structural & Molecular Biologyvolume 26, pages732–743 (2019)

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Transcription-mediated replication hindrance: a major driver of genome instability Belén Gómez-González and Andrés Aguilera Genes & Dev. 2019. 33: 1008-1026

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Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes Melanie A Sparks, Saurabh P Singh, Peter M Burgers, Roberto Galletto Nucleic Acids Research, Volume 47, Issue 16, 19 September 2019, Pages 8595–8605,

Human replication protein A induces dynamic changes in single-stranded DNA and RNA structures Qing-Man Wang, Yan-Tao Yang, Yi-Ran Wang, Bo Gao, Xuguang Xi and Xi-Miao Hou The Journal of Biological Chemistry 294, 13915-13927.

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Replication fork pausing at protein barriers on chromosomes Kohji Hizume Hiroyuki Araki febs letters Volume593, Issue13Special Issue: The FEBS Congress Special Issue: Krakow July 2019 Pages 1449-1458

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Structural insight into the unique dsDNA binding topology of the human ORC2 wing helix domain Jiahai Zhang Qiong Guo Jun Gao Chao Xu Beibei Zhang Mingwei Li Jiaqi She Yunyu Shi Zhiyong Zhang Ke Ruan Jihui Wu Febs Journal Volume286, Issue14 July 2019 Pages 2726-2736

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Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase Michael R. Wasserman, Grant D. Schauer, Michael E. O’Donnell, Shixin Liu Cell VOLUME 178, ISSUE 3, P600-611

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DNA translocation mechanism of the MCM complex and implications for replication initiation Martin Meagher, Leslie B. Epling & Eric J. Enemark Nature Communicationsvolume 10, Article number: 3117 (2019)

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Replication fork stalling elicits chromatin compaction for the stability of stalling replication forks Gang Feng, Yue Yuan, Zeyang Li, Lu Wang, Bo Zhang, Jiechen Luo, Jianguo Ji, and Daochun Kong PNAS July 16, 2019 116 (29) 14563-14572

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An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication Tatiana N. Moiseeva, Yandong Yin, Michael J. Calderon, Chenao Qian, Sandra Schamus-Haynes, Norie Sugitani, Hatice U. Osmanbeyoglu, Eli Rothenberg, Simon C. Watkins, and Christopher J. Bakkenist PNAS July 2, 2019 116 (27) 13374-13383

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XLF extends its range from DNA repair to replication Yanira Gonzalez-Rodriguez, Samuel F. Bunting JCB 218 (7): 2075

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Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence Jacob Peter Matson,Amy M. House,Gavin D. Grant, Huaitong Wu, Joanna Perez, Jeanette Gowen Cook JCB 218 (7): 2169

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Defects in the origin licensing checkpoint stresses cells exiting G0 J. Julian Blow JCB 218 (7): 2080

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XLF and H2AX function in series to promote replication fork stability Bo-Ruei Chen,Annabel Quinet,Andrea K. Byrum, Jessica Jackson,Matteo Berti,Saravanabhavan Thangavel, Andrea L. Bredemeyer, Issa Hindi, Nima Mosammaparast, Jessica K. Tyler, Alessandro Vindigni, Barry P. Sleckman JCB 218 (7): 2113

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ATP-dependent helicase activity is dispensable for the physiological functions of Recql4 Wilson Castillo-Tandazo, Monique F. Smeets, Vincent Murphy, Rui Liu, Charlotte Hodson, Jo ̈ rg Heierhorst, Andrew J. Deans, Carl R. Walkley PLoS Genet 15 (7): e1008266

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DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis Duyen T. Bui and Joachim J. Li GENETICS June 1, 2019 vol. 212 no. 2 445-460;

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Linking the organization of DNA replication with genome maintenance Balveer SinghPei-Yun Jenny Wu Current Genetics June 2019, Volume 65, Issue 3, pp 677–683

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Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ Josyter Beek Vimal Parkash Göran O Bylund Pia Osterman A Elisabeth Sauer-Eriksson Erik Johansson Nucleic Acids Research, Volume 47, Issue 11, 20 June 2019, Pages 5712–5722,

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Evolution of replication origins in vertebrate genomes: rapid turnover despite selective constraints Florian Massip Marc Laurent Caroline Brossas José Miguel Fernández-Justel María Gómez Marie-Noelle Prioleau Laurent Duret Franck Picard Nucleic Acids Research, Volume 47, Issue 10, 04 June 2019, Pages 5114–5125,

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Replication dynamics of individual loci in single living cells reveal changes in the degree of replication stochasticity through S phase Bénédicte Duriez Sabarinadh Chilaka Jean-François Bercher Eslande Hercul Marie-Noëlle Prioleau Nucleic Acids Research, Volume 47, Issue 10, 04 June 2019, Pages 5155–5169,

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Mammalian CST averts replication failure by preventing G-quadruplex accumulation Miaomiao Zhang Bing Wang Tingfang Li Rui Liu Yingnan Xiao Xin Geng Guang Li Qiang Liu Carolyn M Price Yang Liu ... Show more Nucleic Acids Research, Volume 47, Issue 10, 04 June 2019, Pages 5243–5259,

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Replication-Coupled DNA Repair David Cortez Mol cell VOLUME 74, ISSUE 5, P866-876, JUNE 06, 2019

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Centromere maintenance during DNA replication Masatoshi Hara & Tatsuo Fukagawa Nature Cell Biology 21, 669–671 (2019)

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DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres Yael Nechemia-Arbely, Karen H. Miga, Ofer Shoshani, Aaron Aslanian, Moira A. McMahon, Ah Young Lee, Daniele Fachinetti, John R. Yates III, Bing Ren & Don W. Cleveland Nature Cell Biology 21, 743–754 (2019) |

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Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes Mi-Sun Kang, Eunjin Ryu, Seung-Won Lee, Jieun Park, Na Young Ha, Jae Sun Ra, Yeong Jae Kim, Jinwoo Kim, Mohamed Abdel-Rahman, Su Hyung Park, Kyoo-young Lee, Hajin Kim, Sukhyun Kang & Kyungjae Myung Nature Communications 10, Article number: 2420 (2019)

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The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet & Marcel Méchali Nature Communications 10, Article number: 2426 (2019)

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The mechanism of DNA unwinding by the eukaryotic replicative helicase Daniel R. Burnham, Hazal B. Kose, Rebecca B. Hoyle & Hasan Yardimci Nature Communications 10, Article number: 2159 (2019)

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The interaction networks of the budding yeast and human DNA replication-initiation proteins Rentian Wu , Aftab Amin n, Ziyi Wang, Yining Huang , Marco Man-Hei Cheung , Zhiling Yu, Wei Yang & Chun Liang cell cycle Pages 723-741

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Human NOC3 is essential for DNA replication licensing in human cells Man-Hei Cheung, Aftab Amin, Rentian Wu, Yan Qin, Lan Zou, Zhiling Yu Cell cycle Pages 605-620

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Dynamics of Replication Fork Progression Following Helicase–Polymerase Uncoupling in Eukaryotes Martin R.G.TaylorJoseph T.P.Yeeles Journal of Molecular Biology Volume 431, Issue 10, 3 May 2019, Pages 2040-2049

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PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells Laura J Bailey Julie Bianchi Aidan J Doherty Nucleic Acids Research, Volume 47, Issue 8, 07 May 2019, Pages 4026–4038

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Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks Julie Rageul Jennifer J Park Ukhyun Jo Alexandra S Weinheimer Tri T M Vu Hyungjin Kim Nucleic Acids Research, Volume 47, Issue 8, 07 May 2019, Pages 3996–4010

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The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity Marta A Garbacz Phillip B Cox Sushma Sharma Scott A Lujan Andrei Chabes Thomas A Kunkel Nucleic Acids Research, Volume 47, Issue 8, 07 May 2019, Pages 3986–3995

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Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes Tom D. Deegan, Jonathan Baxter, María Ángeles, Ortiz Bazán, Joseph T.P. Yeeles, Karim P.M. Labib mol cell VOLUME 74, ISSUE 2, P231-244.E9,

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Role of Cdc23/Mcm10 in generating the ribonucleotide imprint at the mat1 locus in fission yeast Balveer Singh Kamlesh K Bisht Udita Upadhyay Avinash Chandra Kushwaha Jagpreet Singh Nanda Suchita Srivastava Jai Kumar Saini Amar J S Klar Jagmohan Singh Nucleic Acids Research, Volume 47, Issue 7, 23 April 2019, Pages 3422–3433

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Ssu72 phosphatase is a conserved telomere replication terminator Jose Miguel Escandell, Edison SM Carvalho, Maria Gallo‐Fernandez, Clara C Reis, Samah Matmati, Inês Matias Luís, Isabel A Abreu, Stéphane Coulon, Miguel Godinho Ferreira The EMBO Journal (2019) 38, e100476

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Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen Mark Hedglin, Mahesh Aitha, Anthony Pedley and Stephen J. Benkovic The Journal of Biological Chemistry 294, 5157-5168

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Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo Malik Kahli Joseph S Osmundson Rani Yeung Duncan J Smith Author Notes Nucleic Acids Research, Volume 47, Issue 4, 28 February 2019, Pages 1814–1822

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DNA polymerase η contributes to genome-wide lagging strand synthesis Katrin Kreisel Martin K M Engqvist Josephine Kalm Liam J Thompson Martin Boström Clara Navarrete John P McDonald Erik Larsson Roger Woodgate Anders R Clausen Nucleic Acids Research, Volume 47, Issue 5, 18 March 2019, Pages 2425–2435,

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Bayesian inference of origin firing time distributions, origin interference and licencing probabilities from Next Generation Sequencing data Alina Bazarova Conrad A Nieduszynski Ildem Akerman Nigel J Burroughs Nucleic Acids Research, Volume 47, Issue 5, 18 March 2019, Pages 2229–2243

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The p12 subunit of human polymerase δ uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA) Amaia Gonzalez-Magaña, Alain Ibáñez de Opakua, Miguel Romano-Moreno, Javier Murciano-Calles, Nekane Merino, Irene Luque, Adriana L. Rojas, Silvia Onesti, Francisco J. Blanco and Alfredo De Biasio The Journal of Biological Chemistry 294, 3947-3956.

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Dynamics of DNA replication in a eukaryotic cell Thomas Kelly and A. John Callegari PNAS March 12, 2019 116 (11) 4973-4982

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Mathematical description of eukaryotic chromosome replication Huilin Li and Michael E. O’Donnell PNAS March 12, 2019 116 (11) 4776-4778

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Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements Lin Deng,R. Alex Wu,Remi Sonneville,Olga V. Kochenova,Karim Labib,David Pellman,Johannes C. Walter Molecular CELL VOLUME 73, ISSUE 5, P915-929.E6, MARCH 07, 2019

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Female-biased embryonic death from inflammation induced by genomic instability Adrian J. McNairn, Chen-Hua Chuang, Jordana C. Bloom, Marsha D. Wallace & John C. Schimenti Nature volume 567, pages105–108 (2019)

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PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ Tanumoy Mondol Joseph L Stodola Roberto Galletto Peter M Burgers Nucleic Acids Research, Volume 47, Issue 4, 28 February 2019, Pages 1977–1986

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DNA replication from two different worlds Huilin Li, Michael E. O'Donnell Science 22 Feb 2019: Vol. 363, Issue 6429, pp. 814-815

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Helicase Subunit Cdc45 Targets the Checkpoint Kinase Rad53 to Both Replication Initiation and Elongation Complexes after Fork Stalling mol cell VOLUME 73, ISSUE 3, P562-573.E3, FEBRUARY 07, 2019 Geylani Can, Anastasia Christine Kauerhof, Dominik Macak,Philip Zegerman

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Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication Jiao Sima,Abhijit Chakraborty,Vishnu Dileep,Peter Fraser,Ferhat Ay,David M. Gilbert Cell VOLUME 176, ISSUE 4, P816-830.E18, FEBRUARY 07, 2019

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Replication Timing Becomes Intertwined with 3D Genome Organization Jian Ma, Zhijun Duan Cell VOLUME 176, ISSUE 4, P681-684, FEBRUARY 07, 2019

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Both a Unique Motif at the C Terminus and an N-Terminal HEAT Repeat Contribute to G-Quadruplex Binding and Origin Regulation by the Rif1 Protein Shunsuke Kobayashi,Rino Fukatsu,Yutaka Kanoh,Naoko Kakusho,Seiji Matsumoto,Shigeru Chaen,Hisao Masai Mol Cell Biol 39:e00364-18

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The catalytic subunit of DNA polymerase δ is a nucleocytoplasmic shuttling protein Yuehong Shen, Kexin Wang, Robert Z.Qi Experimental Cell Research Volume 375, Issue 2, 15 February 2019, Pages 36-40

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Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication and transcription Hee-Sook Kim Nucleic Acids Research, Volume 47, Issue 2, 25 January 2019, Pages 634–647

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The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair Justin L. Sparks, Gheorghe Chistol, Alan O. Gao, Markus Räschle, Nicolai B. Larsen, Matthias Mann, Julien P. Duxin, Johannes C. Walter Mol cell VOLUME 176, ISSUE 1, P167-181.E21, JANUARY 10, 2019

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Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression Ryan Mayle, Lance Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, and Michael E. O’Donnell PNAS January 15, 2019 116 (3) 798-803

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Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins Valentina Aria, Joseph T.P. Yeeles Mol cell VOLUME 73, ISSUE 2, P199-211.E10, JANUARY 17, 2019

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The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair Justin L. Sparks,Gheorghe Chistol,Alan O. Gao,Markus Räschle,Nicolai B. Larsen,Matthias Mann,Julien P. Duxin,Johannes C. Walter CellVOLUME 176, ISSUE 1, P167-181.E21, JANUARY 10, 2019

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A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template Julien Boudet, Jean-Christophe Devillier, Thomas Wiegand, Beat H. Meier, Georg Lipps, Frédéric H.-T. Allain cell VOLUME 176, ISSUE 1, P154-166.E13, JANUARY 10, 2019

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Resting cells rely on the DNA helicase component MCM2 to build cilia Teresa Casar Tena Lars D Maerz Karol Szafranski Marco Groth Tamara J Blätte Cornelia Donow Sabrina Matysik Paul Walther Penelope A Jeggo Martin D Burkhalter Melanie Philipp Nucleic Acids Research, Volume 47, Issue 1, 10 January 2019, Pages 134–151,

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Transcription shapes DNA replication initiation and termination in human cells Yu-Hung Chen, Sarah Keegan, Malik Kahli, Peter Tonzi, David Fenyö, Tony T. Huang & Duncan J. Smith Nature Structural & Molecular Biology volume 26, pages67–77 (2019)

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Transcription-dependent regulation of replication dynamics modulates genome stability Marion Blin, Benoît Le Tallec, Viola Nähse, Mélanie Schmidt, Caroline Brossas, Gael A. Millot, Marie-Noëlle Prioleau & Michelle Debatisse Nature Structural & Molecular Biology volume 26, pages58–66 (2019)