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Significant contribution of the 3′→5′ exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ Walter J. Zahurancik, Seth J. Klein, and Zucai Suo Nucl. Acids Res. 2014 42: 13853-13860

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Structural basis for inhibition of DNA replication by aphidicolin Andrey G. Baranovskiy, Nigar D. Babayeva, Yoshiaki Suwa, Jianyou Gu, Youri I. Pavlov, and Tahir H. Tahirov Nucl. Acids Res. 2014 42: 14013-14021

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Protein Phosphatase 2A and Cdc7 Kinase Regulate the DNA Unwinding Element-binding Protein in Replication Initiation Yanzhe Gao, Jianhong Yao, Sumeet Poudel, Eric Romer, Lubna Abu-Niaaj, and Michael Leffak J. Biol. Chem. 2014; 289:35987-36000

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Accessory Replicative Helicases and the Replication of Protein-Bound DNA Jan-Gert Brüning, Jamieson L. Howard, Peter McGlynn Journal of Molecular Biology Volume 426, Issue 24, 12 December 2014, Pages 3917–3928

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Closing the MCM cycle at replication termination sites Armelle Lengronne, Philippe Pasero EMBO reports(2014)15,1226-1227

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Replication forks reverse at high frequency upon replication stress in Physarum polycephalum Chrystelle Maric, Marianne Bénard Chromosoma December 2014, Volume 123, Issue 6, pp 577-585

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CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition Mohammed El Dika, Katarzyna Laskowska-Kaszub, Magdalena Koryto, Damian Dudka, Claude Prigent, Jean-Pierre Tassan, Malgorzata Kloc, Zbigniew Polanski, Ewa Borsuk, Jacek Z. Kubiak Developmental Biology Volume 396, Issue 1, 1 December 2014, Pages 67–80

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Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C Melissa R. Marzahn, Jaclyn N. Hayner, Jennifer A. Meyer, Linda B. Bloom Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsVolume 1854, Issue 1, January 2015, Pages 31–38

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Replication protein A: Single-stranded DNA's first responder Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair Ran Chen andMarc S. Wold* BioEssays Volume 36, Issue 12, pages 1156–1161, December 2014

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PCNA mutation affects DNA repair not replication Catherine M Green, Emma L Baple & Andrew H Crosby Cell cycle 13 3157

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Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio Minori Shinya, Daiki Machiki, Thorsten Henrich, Yumiko Kubota, Haruhiko Takisawa & Satoru Mimura
pages Cell cycle 13 3271-3281

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Temporal separation of replication and transcription during S-phase progression Matthieu Meryet-Figuiere, Babak Alaei-Mahabadi, Mohamad Moustafa Ali, Sanhita Mitra, Santhilal Subhash, Gaurav Kumar Pandey, Erik Larsson & Chandrasekhar Kanduri Cell cycle 13 3241

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Checkpoint-independent scaling of the Saccharomyces cerevisiae DNA replication program Ariel Gispan, Miri Carmi and Naama Barkai BMC Biology 2014, 12:79

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Topologically associating domains are stable units of replication-timing regulation Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross C. Hardison, Tamer Kahveci, Bing Ren & David M. Gilbert Nature 515, 402–405 (20 November 2014)

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Genetic Variation Meets Replication Origins Ronald J. Hause, Jay Shendure Cell Volume 159, Issue 5, p973–974, 20 November 2014

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Genetic Variation in Human DNA Replication Timing Amnon Koren, Robert E. Handsaker, Nolan Kamitaki, Rosa Karlić, Sulagna Ghosh, Paz Polak, Kevin Eggan, Steven A. McCarroll Cell Volume 159, Issue 5, p1015–1026, 20 November 2014

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More Division of Labor at the Eukaryotic Replication Fork Brian S. Plosky Mol cell Volume 56, Issue 4, p467–468, 20 November 2014

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Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall Chuanhe Yu, Haiyun Gan, Junhong Han, Zhi-Xiong Zhou, Shaodong Jia, Andrei Chabes, Gianrico Farrugia, Tamas Ordog, Zhiguo Zhang Mol cell Volume 56, Issue 4, p551–563, 20 November 2014

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Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex Justine Witosch, Eva Wolf and Naoko Mizuno Nucl. Acids Res. (10 November 2014) 42 (20): 12912-12927.

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Human PrimPol mutation associated with high myopia has a DNA replication defect Benjamin A. Keen, Laura J. Bailey, Stanislaw K. Jozwiakowski, and Aidan J. Doherty Nucl. Acids Res. 2014 42: 12102-12111

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FANCJ promotes DNA synthesis through G‐quadruplex structures Pau Castillo Bosch, Sandra Segura‐Bayona, Wouter Koole, Jane T van Heteren, James M Dewar, Marcel Tijsterman, Puck Knipscheer The EMBO Journal(2014)33,2521-2533

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Restriction of Replication Fork Regression Activities by a Conserved SMC Complex Xiaoyu Xue, Koyi Choi, Jaclyn Bonner, Tamara Chiba, Youngho Kwon, Yuanyuan Xu, Humberto Sanchez, Claire Wyman, Hengyao Niu, Xiaolan Zhao, Patrick Sung Mol cell Volume 56, Issue 3, p436–445,

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Geminin Inhibits a Late Step in the Formation of Human Pre-replicative Complexes Min Wu, Wenyan Lu, Ruth E. Santos, Mark G. Frattini, and Thomas J. Kelly J. Biol. Chem. 2014; 289:30810-30821

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Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes Nicolai B Larsen, Ian D Hickson, Hocine W Mankouri Cell cycle 13 2994-2998

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RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 Dafni-Eleftheria Pefani, Robert Latusek, Isabel Pires, Anna M. Grawenda, Karen S. Yee, Garth Hamilton, Louise van der Weyden, Fumiko Esashi, Ester M. Hammond & Eric O’Neill Nature Cell Biology 16, 962–971 (2014)

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Dicer Promotes Transcription Termination at Sites of Replication Stress to Maintain Genome Stability Stephane E. Castel, Jie Ren, Sonali Bhattacharjee, An-Yun Chang, Mar Sánchez, Alberto Valbuena, Francisco Antequera, Robert A. Martienssen Cell Volume 159, Issue 3, p572–583, 23 October 2014

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Polyubiquitylation drives replisome disassembly at the termination of DNA replication Sara Priego Moreno, Rachael Bailey, Nicholas Campion, Suzanne Herron, and Agnieszka Gambus Science 24 October 2014: 477-481.

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Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication Marija Maric, Timurs Maculins, Giacomo De Piccoli, and Karim Labib Science 24 October 2014: Vol. 346 no. 6208

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Terminating the replisome Stephen P. Bell Science 24 October 2014: Vol. 346 no. 6208 pp. 418-419

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Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome Indri Erliandri, Haiqing Fu, Megumi Nakano, Jung-Hyun Kim, Karen H. Miga,Mikhail Liskovykh, William C. Earnshaw, Hiroshi Masumoto, Natalay Kouprina, Mirit I. Aladjem, and Vladimir Larionov Nucl. Acids Res. 2014 42: 11502-11516

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Nucleotide Contributions to the Structural Integrity and DNA Replication Initiation Activity of Noncoding Y RNA 
 Iren Wang, Madzia P. Kowalski, Alexander R. Langley, Raphaël Rodriguez, Shankar Balasubramanian, Shang-Te Danny Hsu, and Torsten Krude Biochemistry, 2014, 53 (37), pp 5848–5863

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Chromatin Structure and Replication Origins: Determinants of Chromosome Replication and Nuclear Organization Owen K. Smith, Mirit I. Aladjem Journal of Molecular Biology Volume 426, Issue 20, 9 October 2014, Pages 3330–3341

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DNA replication timing: Coordinating genome stability with genome regulation on the X chromosome and beyond Amnon Koren BioEssaysVolume 36, Issue 10, pages 997–1004, October 2014

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Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation Daniel Dovrata, Joseph L. Stodol, Peter M. J. Burgers, and Amir Aharoni PNAS September 30, 2014 vol. 111 no. 39 14118-14123

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Dynamics of DNA Replication during Premeiosis and Early Meiosis in Wheat María-Dolores ReyPilar Prieto PLoS ONE 9(10): e107714

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BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork David T. Long, Vladimir Joukov, Magda Budzowska, Johannes C. Walter Mol cell Volume 56, Issue 1, p174–185, 2 October 2014

no postings this week

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Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells Timothy W. R. Kelso, Karen Baumgart, Jan Eickhoff, Thomas Albert, Claudia Antrecht, Sarah Lemcke, Bert Klebl and Michael Meisterernst Mol. Cell. Biol. October 2014 vol. 34 no. 19 3675

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Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation Sukhyun Kang, Megan D. Warner, Stephen P. Bell Mol cell Volume 55, Issue 5, p655–665,

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Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase Gideon Coster, Jordi Frigola, Fabienne Beuron, Edward P. Morris, John F.X. Diffley Mol cell Volume 55, Issue 5, p666–677, 4 September 2014

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Diffusion of Human Replication Protein A along Single-Stranded DNA Binh Nguyen, Joshua Sokoloski, Roberto Galletto, Elliot L. Elson, Marc S. Wold, Timothy M. Lohman Journal of Molecular Biology Volume 426, Issue 19, 23 September 2014, Pages 3246–3261

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The Interaction between Checkpoint Kinase 1 (Chk1) and the Minichromosome Maintenance (MCM) Complex Is Required for DNA Damage-induced Chk1 Phosphorylation Xiangzi Han, Aaron Aslanian, Kang Fu, Toshiya Tsuji, and Youwei Zhang J. Biol. Chem. 2014; 289:24716-24723

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Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation Jeannine Gerhardt, Nikica Zaninovic, Qiansheng Zhan, Advaitha Madireddy, Sarah L. Nolin, Nicole Ersalesi, Zi Yan, Zev Rosenwaks, and Carl L. Schildkraut JCB vol. 206 no. 5 599-607

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Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery Anar K. Murphy, Michael Fitzgerald, Teresa Ro, Jee Hyun Kim, Ariana I. Rabinowitsch, Dipanjan Chowdhury, Carl L. Schildkraut, and James A. Borowiec JCB vol. 206 no. 4 493-507 August 11, 2014

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Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork Roxana E Georgescu, Lance Langston, Nina Y Yao, Olga Yurieva, Dan Zhang, Jeff Finkelstein, Tani Agarwal & Mike E O'Donnell Nature Structural & Molecular Biology 21, 664–670 (2014)

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Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells Will Yarosh and Allan C. Spradling Genes & Dev. 2014. 28: 1840-1855

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CRL4Cdt2 E3 Ubiquitin Ligase and Proliferating Cell Nuclear Antigen (PCNA) Cooperate to Degrade Thymine DNA Glycosylase in S Phase Etsuko Shibata, Ashraf Dar, and Anindya Dutta J. Biol. Chem. 2014; 289:23056-23064

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Temporospatial Coordination of Meiotic DNA Replication and Recombination via DDK Recruitment to Replisomes Hajime Murakami, Scott Keeney Cell Volume 158, Issue 4, p861–873, 14 August 2014

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The C-terminal Domain of the DNA Polymerase Catalytic Subunit Regulates the Primase and Polymerase Activities of the Human DNA Polymerase α-Primase Complex Yinbo Zhang, Andrey G. Baranovskiy, Tahir H. Tahirov, and Youri I. Pavlov J. Biol. Chem. 2014; 289:22021-22034

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The N-terminus of Mcm10 is important for interaction with the 9-1-1 clampand in resistance to DNA damage Robert C. Alver, Tianji Zhang, Ajeetha Josephrajan, Brandy L. Fultz, Chance J. Hendrix, Sapna Das-Bradoo, and Anja-Katrin Bielinsky Nucl. Acids Res. 2014 42: 8389-8404

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CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis Ornella Cazzalini, Sabrina Sommatis, Micol Tillhon, Ilaria Dutto, Angela Bachi, Alexander Rapp, Tiziana Nardo, A. Ivana Scovassi, Daniela Necchi, M. Cristina Cardoso, Lucia A. Stivala, and Ennio Prosperi Nucl. Acids Res. 2014 42: 8433-8448

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Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins Si Xie, Yao Lu, Jean Jakoncic, Hongzhe Sun, Jiang Xia and Chengmin Qian FEBS Journal Volume 281, Issue 15, pages 3382–3396, August 2014

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Noncoding RNAs in the regulation of DNA replication Xin Quan Ge, Haifan Lin TIBS Volume 39, Issue 8, August 2014, Pages 341–343

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Conformational Dynamics of Thermus aquaticus DNA Polymerase I during Catalysis Cuiling Xu, Brian A. Maxwell, Zucai Suo Journal of Molecular Biology Volume 426, Issue 16, 12 August 2014, Pages 2901–2917

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DNA polymerase α interacts with PrSet7 and mediates H4K20 monomethylation in Drosophila Ritsuko Sahashi, Gilles Crevel1, Jaroslaw Pasko, Osamu Suyari, Rika Nagai, Mario Martinez Saura, Masamitsu Yamaguchi and Sue Cotterill July 15, 2014 J Cell Sci 127, 3066-3078

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Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms Catherine J. Potenski, Hengyao Niu, Patrick Sung & Hannah L. Klein Nature 511, 251–254 (10 July 2014)

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NCOA4 Transcriptional Coactivator Inhibits Activation of DNA Replication Origins Roberto Bellelli, Maria Domenica Castellone, Teresa Guida, Roberto Limongello, Nina Alayne Dathan, Francesco Merolla, Anna Maria Cirafici, Andrea Affuso, Hisao Masai, Vincenzo Costanzo6, Domenico Grieco, Alfredo Fusco, Massimo Santoro, Francesca Carlomagno Mol cell Volume 55, Issue 1, p123–137, 3 July 2014

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SCF-FBXO31 E3 Ligase Targets DNA Replication Factor Cdt1 for Proteolysis in the G2 Phase of Cell Cycle to Prevent Re-replication Pegah Johansson, Jessie Jeffery, Fares Al-Ejeh, Renèe B. Schulz, David F. Callen, Raman Kumar, and Kum Kum Khanna J. Biol. Chem. 2014; 289:18514-18525

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Dephosphorylation of Orc2 by protein phosphatase 1 promotes the binding of the origin recognition complex to chromatin Kyung Yong Lee, June Sung Bae, Sangwook Yoon, Deog Su Hwang BBRC 48 Pages 385-389

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DNA replication: damage tolerance at the assembly line András Blastyák Trends in Biochemical Sciences Volume 39, Issue 7, July 2014, Pages 301–304

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Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair Jordan R Becker, Hai Dang Nguyen, Xiaohan Wang and Anja-Katrin Bielinsky Cell cycle Pages 1737 – 1748

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Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion Mário Gomes-Pereira, James D. Hilley, Fernando Morales, Berit Adam, Helen E. James and Darren G. Monckton Nucl. Acids Res. (2014) 42 (11): 7047-7056.

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Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells Sergi Aranda1, Dorothea Rutishauser and Patrik Ernfors Nucl. Acids Res. (2014) 42 (11): 6972-6986

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Regulatory Mechanisms That Prevent Re-initiation of DNA Replication Can Be Locally Modulated at Origins by Nearby Sequence Elements Christopher D. Richardson, Joachim J. Li PLoS Genet 10(6): e1004358

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A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome Aline C. Simon, Jin C. Zhou, Rajika L. Perera, Frederick van Deursen, Cecile Evrin, Marina E. Ivanova, Mairi L. Kilkenny, Ludovic Renault, Svend Kjaer, Dijana Matak-Vinković, Karim Labib, Alessandro Costa & Luca Pellegrini Nature 510, 293–297

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Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required forthe stability and repair of stalled replication forks Emma Bolderson, Eva Petermann, Laura Croft, Amila Suraweera, Raj K. Pandita, Tej K. Pandita, Thomas Helleday, Kum Kum Khanna, and Derek J. Richard Nucl. Acids Res. 2014 42: 6326-6336

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The histone variant H2A.Bbd is enriched at sites of DNA synthesis Viola Sansoni, Corella S. Casas-Delucchi, Malini Rajan, Andreas Schmidt, Clemens Bönisch, Andreas W. Thomae, Martin S. Staege, Sandra B. Hake, M. Cristina Cardoso, and Axel Imhof Nucl. Acids Res. 2014 42: 6405-6420

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Intrinsic stability and oligomerization dynamics of DNA processivity clamps Jennifer K. Binder, Lauren G. Douma, Suman Ranjit, David M. Kanno, Manas Chakraborty, Linda B. Bloom, and Marcia Levitus Nucl. Acids Res. 2014 42: 6476-6486

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Rif1 Regulates Initiation Timing of Late Replication Origins throughout the S. cerevisiae Genome Jared M. Peace, 
Anna Ter-Zakarian, 
Oscar M. Aparicio PLoS ONE 9(5): e98501

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Polymerase Stalling during Replication, Transcription and Translation Ellen R. Edenberg, Michael Downey, David Toczyski current biology Volume 24, Issue 10, pR445–R452, 19 May 2014

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The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast Kazumasa Yoshida, Julien Bacal, Damien Desmarais, Ismaël Padioleau, Olga Tsaponina, Andrei Chabes, Véronique Pantesco, Emeric Dubois, Hugues Parrinello, Magdalena Skrzypczak, Krzysztof Ginalski, Armelle Lengronne, Philippe Pasero Mol cell Volume 54, Issue 4, p691–697, 22 May 2014

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Rad52/Rad59-dependent Recombination as a Means to Rectify Faulty Okazaki Fragment Processing Miju Lee, Chul-Hwan Lee, Annie Albert Demin, Palinda Ruvan Munashingha, Tamir Amangyeld, Buki Kwon, Tim Formosa, and Yeon-Soo Seo J. Biol. Chem. 2014; 289:15064-15079

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A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression Spencer W. Luebben, Tsuyoshi Kawabata, Charles S. Johnson, M. Gerard O'Sullivan, and Naoko Shima Nucl. Acids Res. 2014 42: 5605-5615

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The Spatiotemporal Program of DNA Replication Is Associated with Specific Combinations of Chromatin Marks in Human Cells Franck Picard, Jean-Charles Cadoret, Benjamin Audit, 
Alain Arneodo, 
Adriana Alberti, 
Christophe Battail, 

Laurent Duret, Marie-Noelle Prioleau PLoS Genet 10(5): e1004282

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Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A Anastasia Tsaalbi-Shtylik, Jill Moser, Leon H. F. Mullenders, Jacob G. Jansen and Niels de Wind Nucl. Acids Res. (2014) 42 (7): 4406-4413

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Drosophila Mcm10 Is Required for DNA Replication and Differentiation in the Compound Eye Nicole Vo, Ayano Taga, 

Yasuhiro Inaba,


Hideki Yoshida, 
Sue Cotterill, Masamitsu Yamaguchi PLoS ONE 9(3): e93450

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Crystal Structure of the Shrimp Proliferating Cell Nuclear Antigen: Structural Complementarity with WSSV DNA Polymerase PIP-Box Jesus S. Carrasco-Miranda, 

Alonso A. Lopez-Zavala, Aldo A. Arvizu-Flores, Karina D. Garcia-Orozco, Vivian Stojanoff, Enrique Rudiño-Piñera, Luis G. Brieba ,Rogerio R. Sotelo-Mundo PLoS ONE 9(4): e94369.

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A PCNA-Derived Cell Permeable Peptide Selectively Inhibits Neuroblastoma Cell Growth Long Gu, Shanna Smith, 

Caroline Li, Robert J. Hickey, Jeremy M. Stark,

Gregg B. Fields,

Walter H. Lang, John A. Sandoval, Linda H. Malkas PLoS ONE 9(4): e94773.

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A highly divergent archaeo-eukaryotic primase from the Thermococcus nautilus plasmid, pTN2 Sukhvinder Gill, Mart Krupovic, Nicole Desnoues, Pierre Béguin, Guennadi Sezonov and Patrick Forterre Nucl. Acids Res. (2014) 42 (6): 3707-3719

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G4 motifs affect origin positioning and efficiency in two vertebrate replicators Anne‐Laure Valton, Vahideh Hassan‐Zadeh, Ingrid Lema, Nicole Boggetto, Patrizia Alberti, Carole Saintomé, Jean‐François Riou, Marie‐Noëlle Prioleau Embo Volume 33, Issue 7 01 April 2014 | pp 665 – 779

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Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance Shunsuke Kusunoki and Yukio Ishimi FEBS JournalVolume 281, Issue 4, pages 1057–1067, February 2014

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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components Constance Alabert, Jimi-Carlo Bukowski-Wills, Sung-Bau Lee, Georg Kustatscher, Kyosuke Nakamura, Flavia de Lima Alves, Patrice Menard, Jakob Mejlvang, Juri Rappsilber & Anja Groth Nature Cell Biology 16, 281–293 (2014)

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Prereplicative complexes assembled in vitro support origin‐dependent and independent DNA replication Kin Fan On, Fabienne Beuron, David Frith, Ambrosius P Snijders, Edward P Morris, John F X Diffley Embo Volume 33, Issue 618 March 2014 pp 529 – 664

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Origin plasticity during budding yeast DNA replication in vitro Julien Gros, Sujan Devbhandari, Dirk Remus Embo Volume 33, Issue 6 18 March 2014 pp 529 – 664

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PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase Linda Clijsters and Rob Wolthuis J Cell Sci 127, 1336-1345

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Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication Yannick Jacob, Elisa Bergamin, Mark T. A. Donoghue, Vanessa Mongeon, Chantal LeBlanc, Philipp Voigt, Charles J. Underwood, Joseph S. Brunzelle, Scott D. Michaels, Danny Reinberg, Jean-François Couture, Robert A. Martienssen Science 14 March 2014: Vol. 343 no. 6176 pp. 1249-1253

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The 1.8-Å Crystal Structure of the N-Terminal Domain of an Archaeal MCM as a Right-Handed Filament Yang Fu1, Ian M. Slaymaker1, Junfeng Wang, Ganggang Wang, Xiaojiang S. Chen Journal of Molecular Biology Volume 426, Issue 7, 3 April 2014, Pages 1512–1523

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The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation Cecile Evrin, Alejandra Fernández-Cid, Alberto Riera, Juergen Zech, Pippa Clarke, M. Carmen Herrera, Silvia Tognetti, Rudi Lurz, and Christian Speck Nucl. Acids Res. 2014 42: 2257-2269

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Multiple replication origins with diverse control mechanisms in Haloarcula hispanica Zhenfang Wu, Jingfang Liu, Haibo Yang, Hailong Liu, and Hua Xiang Nucl. Acids Res. 2014 42: 2282-2294

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DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding Anna Szambowska, Ingrid Tessmer, Petri Kursula, Christian Usskilat, Piotr Prus, Helmut Pospiech, and Frank Grosse Nucl. Acids Res. 2014 42: 2308-2319

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Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage Shoichi Kubota, Yasunori Fukumoto, Kenichi Ishibashi, Shuhei Soeda, Sho Kubota, Ryuzaburo Yuki, Yuji Nakayama, Kazumasa Aoyama, Noritaka Yamaguchi, and Naoto Yamaguchi J. Biol. Chem. 2014; 289:5730-5746

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Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates Timothy D. Craggs, Richard D. Hutton, Alfonso Brenlla, Malcolm F. White and J. Carlos Penedo Nucl. Acids Res. (2014) 42 (3): 1857-1872.

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CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans Vincent Gaggioli, Eva Zeiser, David Rivers, Charles R. Bradshaw, Julie Ahringer and Philip Zegerman JCB vol. 204 no. 4 507-522

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Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex Shin-ichiro Hiraga, Gina M. Alvino, FuJung Chang, Hui-yong Lian, Akila Sridhar, Takashi Kubota, Bonita J. Brewer, Michael Weinreich, M.K. Raghuraman and Anne D. Donaldson Genes & Dev. 2014. 28: 372-383

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The dual roles of geminin during trophoblast proliferation and differentiation Christelle de Renty, Kotaro J. Kaneko, Melvin L. DePamphilis Developmental Biology Volume 387, Issue 1, 1 March 2014, Pages 49–63

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Two nuclear export signals of Cdc6 are differentially associated with CDK-mediated phosphorylation residues for cytoplasmic translocation In Sun Hwang, Sang Uk Woo, Ji-Woong Park, Seung Ki Lee, Hyungshin Yim BBA MOL CELL RES 1843 Pages 223-233

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ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication Satoko Iwahori, Daisuke Kohmon, Junya Kobayashi, Yuhei Tani, Takashi Yugawa, Kenshi Komatsu, Tohru Kiyono, Nozomi Sugimoto and Masatoshi Fujita Cell cycle 13 471 – 481

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no postings this week

publication alert

The Replication Initiation Protein Sld2 Regulates Helicase Assembly Irina Bruck and Daniel L. Kaplan J. Biol. Chem. 2014 289: 1948-1959

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DNA replication and spindle checkpoints cooperate during S phase to delay mitosis and preserve genome integrity Maria M. Magiera, Elisabeth Gueydon, and Etienne Schwob JCB 204:165-175

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The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing Rebecca A. Frum, Shilpa Singh, Catherine Vaughan, Nitai D. Mukhopadhyay, Steven R. Grossman, Brad Windle, Sumitra Deb and Swati Palit Deb Nucl. Acids Res. (2014) 42 (2): 926-940

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The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression Marietta YWT Lee, Sufang Zhang, Szu Hua Sharon Lin, Xiaoxiao Wang, Zbigniew Darzynkiewicz, Zhongtao Zhang and Ernest YC Lee Cell cycle 13 Pages 23 – 31

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Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ Matthew Hogg, Pia Osterman, Göran O Bylund, Rais A Ganai, Else-Britt Lundström, A Elisabeth Sauer-Eriksson & Erik Johansson Nature Structural & Molecular Biology 21, 49–55 (2014)

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Prereplication-complex formation: a molecular double take? Hasan Yardimci & Johannes C Walter Nature Structural & Molecular Biology 21, 20–25 (2014

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Look Ma, no PCNA: how DNA polymerase ε synthesizes long stretches of DNA without a processivity factor Karl E Zahn & Sylvie Doublié Nature Structural & Molecular Biology 21, 12–14 (2014)

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Causes and consequences of replication stress Michelle K. Zeman & Karlene A. Cimprich Nature Cell Biology 16, 2–9 (2014)

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New histone supply regulates replication fork speed and PCNA unloading Jakob Mejlvang, Yunpeng Feng, Constance Alabert, Kai J. Neelsen, Zuzana Jasencakova, Xiaobei Zhao, Michael Lees, Albin Sandelin, Philippe Pasero, Massimo Lopes, and Anja Groth JCB vol. 204 no. 1 29-43

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An Iron–Sulfur Cluster in the Polymerase Domain of Yeast DNA Polymerase ε Rinku Jain, Eva S. Vanamee, Boris G. Dzikovski, Angeliki Buku, Robert E. Johnson, Louise Prakash, Satya Prakash, Aneel K. Aggarwal Journal of Molecular Biology Volume 426, Issue 2, 23 January 2014, Pages 301–308

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Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase Sivaraja Vaithiyalingam, Diana R. Arnett, Amit Aggarwal1, Brandt F. Eichman, Ellen Fanning, Walter J. Chazin Journal of Molecular Biology Volume 426, Issue 3, 6 February 2014, Pages 558–569