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Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish Dongyuan Ma, Lu Wang, Sifeng Wang, Ya Gao, Yonglong Wei, and Feng Liu PNAS December 18, 2012 vol. 109 no. 51 21040-21045

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Bypass of a protein barrier by a replicative DNA helicase Hasan Yardimci, Xindan Wang, Anna B. Loveland, Inger Tappin, David Z. Rudner, Jerard Hurwitz, Antoine M. van Oijen & Johannes C. Walter Nature 492, 205–209 (13 December 2012)

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The Involvement of Acidic Nucleoplasmic DNA-binding Protein (And-1) in the Regulation of Prereplicative Complex (pre-RC) Assembly in Human Cells Yongming Li, Haijie Xiao, Christelle de Renty, Aimee Jaramillo-Lambert, Zhiyong Han, Melvin L. DePamphilis, Kristy J. Brown, and Wenge Zhu J. Biol. Chem. 2012 287: 42469-42479.

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Human DNA Polymerase {epsilon} Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides A. Yasemin Goksenin, Walter Zahurancik, Kimberly G. LeCompte, David J. Taggart, Zucai Suo, and Zachary F. Pursell J. Biol. Chem. 2012 287: 42675-42684.

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The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability Isabelle Isoz, Ulf Persson, Kirill Volkov, and Erik Johansson Nucl. Acids Res. 2012 40: 11545-11553

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CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction Jiwon Huh and Helen Piwnica-Worms Mol. Cell. Biol. January 2013 33:213-226

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Trypanosoma bruceiOrc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching Imaan Benmerzouga, Jeniffer Concepción-Acevedo, Hee-Sook Kim, Anthula V. Vandoros, George A. M. Cross, Michele M. Klingbeil and Bibo Li Molecular Microbiology Volume 87, Issue 1, pages 196–210, January 2013

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Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells
 Keith Booher, Da-Wei Lin, Stacey L. Borrego and Peter Kaiser Cell Cycle 11 
Pages 4414 – 4423

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A Yeast GSK-3 Kinase Mck1 Promotes Cdc6 Degradation to Inhibit DNA Re-Replication Amy E. Ikui, Valentina Rossio, Lea Schroeder, Satoshi Yoshida PLoS Genet 8(12): e1003099

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Evolution of an MCM Complex in Flies That Promotes Meiotic Crossovers by Blocking BLM Helicase Kathryn P. Kohl, Corbin D. Jones, and Jeff Sekelsky Science 7 December 2012: 1363-1365.

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The role of PR-Set7 in replication licensing depends on Suv4-20h David B. Beck, Adam Burton, Hisanobu Oda, Céline Ziegler-Birling, Maria-Elena Torres-Padilla and Danny Reinberg Genes & Dev. 2012. 26: 2580-2589

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Continued DNA Synthesis in Replication Checkpoint Mutants Leads to Fork Collapse Sarah A. Sabatinos, Marc D. Green, and Susan L. Forsburg Mol. Cell. Biol. December 2012 32:4986-4997;

no postings this week

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Drosophila RecQ4 Is Directly Involved in Both DNA Replication and the Response to UV Damage in S2 Cells Gilles Crevel1, Nicole Vo1, Isabelle Crevel1, Sana Hamid1, Lily Hoa1, Seiji Miyata1,2, Sue Cotterill PLoS ONE 7(11): e49505

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Comparative analyses of the two proliferating cell nuclear antigens from the hyperthermophilic archaeon, Thermococcus kodakarensis Yumani Kuba, Sonoko Ishino, Takeshi Yamagami, Masahiro Tokuhara, Tamotsu Kanai, Ryosuke Fujikane, Hiromi Daiyasu, Haruyuki Atomi and Yoshizumi Ishino Genes to Cells Volume 17, Issue 11, pages 923–937,

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RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures Venkateswarlu Popuri, Deborah L. Croteau, Robert M. Brosh, Jr. and Vilhelm A. Bohr cell cycle 11, 4252 – 4265

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Origin of DNA replication at the human lamin B2 locus: OBR or ABR? Hoyun Lee and Julia Romero Cell cycle 11 4281 – 4283

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DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network Kenneth K. Karanja, Stephanie W. Cox, Julien P. Duxin, Sheila A. Stewart and Judith L. Campbell
 Cell cycle 11 3983 – 3996

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DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks Anna Mosbech, Ian Gibbs-Seymour, Konstantinos Kagias, Tina Thorslund, Petra Beli, Lou Povlsen, Sofie Vincents Nielsen, Stine Smedegaard, Garry Sedgwick, Claudia Lukas, Rasmus Hartmann-Petersen, Jiri Lukas, Chunaram Choudhary, Roger Pocock, Simon Bekker-Jensen & Niels Mailand Nature Structural & Molecular Biology 19, 1084–1092

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DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage Emily J Davis, Christophe Lachaud, Paul Appleton, Thomas J Macartney, Inke Näthke & John Rouse Nature Structural & Molecular Biology 19, 1093–1100

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Crystal structure of human CDC7 kinase in complex with its activator DBF4 Siobhan Hughes, Frédéric Elustondo, Andrea Di Fonzo, Frédéric G Leroux, Ai C Wong, Ambrosius P Snijders, Stephen J Matthews & Peter Cherepanov Nature Structural & Molecular Biology 19, 1101–1107 (

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The DNA Replication Factor RFC1 Is Required for Interference-Sensitive Meiotic Crossovers in Arabidopsis thaliana Yingxiang Wang, Zhihao Cheng, Jiyue Huang, Qian Shi, Yue Hong, Gregory P. Copenhaver, Zhizhong Gong, Hong Ma PLoS Genet 8(11): e1003039

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The Human Lagging Strand DNA Polymerase {delta} Holoenzyme Is Distributive Zhenxin Hu, Senthil K. Perumal, Hongjun Yue, and Stephen J. Benkovic J. Biol. Chem. 2012 287: 38442-38448.

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Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes Amaya Alzu, Rodrigo Bermejo, Martina Begnis, Chiara Lucca, Daniele Piccini, Walter Carotenuto, Marco Saponaro, Alessandra Brambati, Andrea Cocito, Marco Foiani,Giordano Liberi Cell, Volume 151, Issue 4, 835-846

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A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis Bruce N. Bagley, Thomas M. Keane, Vilena I. Maklakova, Jonathon G. Marshall, Rachael A. Lester, Michelle M. Cancel, Alex R. Paulsen, Laura E. Bendzick, Raha A. Been, Scott C. Kogan, Robert T. Cormier, Christina Kendziorski, David J. Adams, Lara S. Collier PLoS Genet 8(11): e1003034.

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DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei Alwine Gassen, Doris Brechtefeld, Niklas Schandry, J. Manuel Arteaga-Salas, Lars Israel, Axel Imhof, and Christian J. Janzen Nucl. Acids Res. 2012 40: 10302-10311

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Phosphorylation of Serine 51 Regulates the Interaction of Human DNA Ligase I with Replication Factor C and Its Participation in DNA Replication and Repair Zhimin Peng, Zhongping Liao, Barbara Dziegielewska, Yoshi Matsumoto, Stefani Thomas, Yunhu Wan, Austin Yang, and Alan E. Tomkinson J. Biol. Chem. 2012 287: 36711-36719.

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3D chromatin conformation correlates with replication timing and is conserved in resting cells Benoit Moindrot, Benjamin Audit, Petra Klous, Antoine Baker, Claude Thermes, Wouter de Laat, Philippe Bouvet, Fabien Mongelard, and Alain Arneodo Nucl. Acids Res. 2012 40: 9470-9481

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Geminin Regulates the Transcriptional and Epigenetic Status of Neuronal Fate-Promoting Genes during Mammalian Neurogenesis Dhananjay Yellajoshyula, Jong-won Lim, Dominic M. Thompson Jr, Jacob S. Witt, Ethan S. Patterson and Kristen L. Kroll Mol. Cell. Biol. November 2012 vol. 32 no. 22 4549-4560

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RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT Mitsuaki Fujimoto, Eiichi Takaki, Ryosuke Takii, Ke Tan, Ramachandran Prakasam, Naoki Hayashida, Shun-ichiro Iemura, Tohru Natsume, Akira Nakai Molecular Cell, Volume 48, Issue 2, 182-194, 30 August 2012

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Orc2 protects ORCA from ubiquitin-mediated degradation Zhen Shen and Supriya G. Prasanth
Pages Cell cycle 11 3578 – 3589

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Replication timing in a single human chromosome 11 transferred into the Chinese hamster ovary (CHO) cell line Yoshihisa Watanabe, Yasuhiro Kazuki, Mitsuo Oshimura, Toshimichi Ikemura, Masato Maekawa Gene Volume 510, Issue 1, 15 November 2012, Pages 1–6

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DNA Replication Origin Function Is Promoted by H3K4 Di-methylation in Saccharomyces cerevisiae Lindsay F. Rizzardi, Elizabeth S. Dorn, Brian D. Strahl, and Jeanette Gowen Cook Genetics October 2012 192:371-384;

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Impact of Individual Proliferating Cell Nuclear Antigen-DNA Contacts on Clamp Loading and Function on DNA Yayan Zhou and Manju M. Hingorani J. Biol. Chem. 2012 287: 35370-35381.

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The epigenetic control of E-box and Myc-dependent chromatin modificationsregulate the licensing of lamin B2 origin during cell cycle Manickavinayaham Swarnalatha, Anup Kumar Singh, and Vijay Kumar Nucl. Acids Res. 2012 40: 9021-9035 Open Access

no postings this week

publication alert

Segregation of Replicative DNA Polymerases during S Phase: DNA POLYMERASE{epsilon}, BUT NOT DNA POLYMERASES {alpha}/{delta}, ARE ASSOCIATED WITH LAMINS THROUGHOUT S PHASE IN HUMAN CELLS Markku Vaara, Harri Itkonen, Tomi Hillukkala, Zhe Liu, Heinz-Peter Nasheuer, Daniel Schaarschmidt, Helmut Pospiech, and Juhani E. Syvaoja J. Biol. Chem. 2012 287: 33327-33338.

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Replication Fork Stalling and Checkpoint Activation by a PKD1 Locus Mirror Repeat Polypurine-Polypyrimidine (Pu-Py) Tract Guoqi Liu, Shere Myers, Xiaomi Chen, John J. Bissler, Richard R. Sinden, and Michael Leffak J. Biol. Chem. 2012 287: 33412-33423.

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Nuclear-to-cytoplasmic Relocalization of the Proliferating Cell Nuclear Antigen (PCNA) during Differentiation Involves a Chromosome Region Maintenance 1 (CRM1)-dependent Export and Is a Prerequisite for PCNA Antiapoptotic Activity in Mature Neutrophils Dikra Bouayad, Magali Pederzoli-Ribeil, Julie Mocek, Celine Candalh, Jean-Benoit Arlet, Olivier Hermine, Nathalie Reuter, Noelie Davezac, and Veronique Witko-Sarsat J. Biol. Chem. 2012 287: 33812-33825.

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The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif Oliver Ohlenschlager, Anja Kuhnert, Annerose Schneider, Sebastian Haumann,Peter Bellstedt, Heidi Keller, Hans-Peter Saluz, Peter Hortschansky, Frank Hanel, Frank Grosse, Matthias Gorlach, and Helmut Pospiech Nucl. Acids Res. 2012 40: 8309-8324

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CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation Ingegerd Elvers, Anna Hagenkort, Fredrik Johansson, Tatjana Djureinovic, Anne Lagerqvist, Niklas Schultz, Ivaylo Stoimenov, Klaus Erixon, and Thomas Helleday Nucl. Acids Res. 2012 40: 8440-8448

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Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption Halfdan Beck, Viola Nähse-Kumpf, Marie Sofie Yoo Larsen, Karen A. O'Hanlon, Sebastian Patzke, Christian Holmberg, Jakob Mejlvang, Anja Groth, Olaf Nielsen, Randi G. Syljuåsen, and Claus Storgaard Sørensen Mol. Cell. Biol. October 2012 32:4226-4236

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Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast Atsutoshi Tazumi, Masayoshi Fukuura, Ryuichiro Nakato, Ami Kishimoto, Tomokazu Takenaka, Shiho Ogawa, Ji-hoon Song, Tatsuro S. Takahashi, Takuro Nakagawa, Katsuhiko Shirahige and Hisao Masukat Genes & Dev. 2012. 26: 2050-2062

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Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis Tomás Aparicio, Diego Megías and Juan Méndez CHROMOSOMA 121, Number 5 (2012), 499-507

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Genome Rearrangements Caused by Depletion of Essential DNA Replication Proteins in Saccharomyces cerevisiae Edith Cheng, Jessica A. Vaisica, Jiongwen Ou, Anastasia Baryshnikova, Yong Lu, Frederick P. Roth, and Grant W. Brown Genetics September 2012 192:147-160

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Geminin is required for mitotic proliferation of spermatogonia Kelly A. Barrya, Kathryn M. Schultza, Christopher J. Payneb, Thomas J. McGarry Developmental Biology 371, Issue 1, 1 November 2012, Pages 35–46

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RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity Deborah L. Croteau, Marie L. Rossi, Jennifer Ross, Lale Dawut, Christopher Dunn, Tomasz Kulikowicz, Vilhelm A. Bohr BBA) - Molecular Basis of Disease 1822, Issue 11, November 2012, Pages 1727–1734

publication alert

Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma M E Rusiniak, D Kunnev, A Freeland, G K Cady and S C Pruitt Oncogene 31: 4034-4044

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Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation L Martin, M Rainey, C Santocanale and L B Gardner Oncogene 31: 4076-4084;

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Rif1 choreographs DNA replication timing Mirit I Aladjem The EMBO Journal (2012), 31, 3650 - 3652;

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Rif1 regulates the replication timing domains on the human genome Satoshi Yamazaki, Aii Ishii, Yutaka Kanoh, Masako Oda, Yasumasa Nishito and Hisao Masai The EMBO Journal (2012), 31, 3667 - 3677;

publication alert

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells Daniela Cornacchia, Vishnu Dileep, Jean-Pierre Quivy, Rossana Foti, Federico Tili, Rachel Santarella-Mellwig, Claude Antony, Geneviève Almouzni, David M Gilbert and Sara B C Buonomo The EMBO Journal (2012), 31, 3678 - 3690

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An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks Anna Maria Hegnauer, Nicole Hustedt, Kenji Shimada, Brietta L Pike, Markus Vogel, Philipp Amsler, Seth M Rubin, Fred van Leeuwen, Aude Guénolé, Haico van Attikum, Nicolas H Thomä and Susan M Gasser The EMBO Journal (2012), 31, 3768 - 3783

no postings this week

publication alert

Mcm8 and Mcm9 Form a Complex that Functions in Homologous Recombination Repair Induced by DNA Interstrand Crosslinks Kohei Nishimura, Masamichi Ishiai, Kazuki Horikawa, Tatsuo Fukagawa, Minoru Takata, Haruhiko Takisawa, Masato T. Kanemaki Molecular Cell, Volume 47, Issue 4, 511-522, 05 July 2012

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MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination Malik Lutzmann, Corinne Grey, Sabine Traver, Olivier Ganier, Apolinar Maya-Mendoza, Noemie Ranisavljevic, Florence Bernex, Atsuya Nishiyama, Nathalie Montel, Elodie Gavois, Luc Forichon, Bernard de Massy, Marcel Méchali Molecular Cell, Volume 47, Issue 4, 523-534, 05 July 2012

publication alert

Human CST promotes telomere duplex replication and general replication restart after fork stalling Jason A Stewart, Feng Wang, Mary F Chaiken, Christopher Kasbek, Paul D Chastain II, Woodring E Wright and Carolyn M Price The EMBO Journal (2012), 31, 3537 - 3549

publication alert

Dual effect of heat shock on DNA replication and genome integrity Artem K. Velichko, Nadezhda V. Petrova, Omar L. Kantidze, and Sergey V. Razin Mol. Biol. Cell 2012 23:17 3450-3460;

publication alert

Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus Peer Papior, José M. Arteaga-Salas, Thomas Günther, Adam Grundhoff, and Aloys Schepers J. Cell Biol. 2012;198 509-528,

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Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication Manzar Hossain and Bruce Stillman Genes Dev. August 15, 2012 26: 1797-1810;

publication alert

Control over DNA replication in time and space Ioanna-Eleni Symeonidou, Stavros Taraviras, Zoi Lygerou FEBS Letters Volume 586, Issue 18 , Pages 2803-2812, 31 August 2012

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Replication origins run (ultra) deep David M Gilbert Nature Structural & Molecular Biology 19, 740–742 (2012)

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Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences Rama Rao Damerla, Kelly E. Knickelbein, Steven Strutt, Fu-Jun Liu, Hong Wang and Patricia L. Opresko Cell cycle Volume 11, Issue 16 August 15, 2012 Pages 3036 – 3044

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An orc1 allele with a mutated APC motif is female sterile with amplification defects So Young Park and Maki Asano

 Cell cycle 11 Pages 2828 - 2832

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Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage Jennifer Chea, Sufang Zhang, Hong Zhao, Zhongtao Zhang, Ernest Y.C. Lee, Zbigniew Darzynkiewicz and Marietta Y.W.T. Lee
 Cell cycle 11 Pages 2885 - 2895

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Transfecting DNA is frequently inserted near DNA replication origins Gennady Kholodii, Olga Dantsevich and Vyacheslav Tarantul Cell cycle 11 
Pages 2956 - 2958

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Chromatin architectures at fission yeast transcriptional promoters and replication origins Robert M. Givens, William K. M. Lai, Jason M. Rizzo, Jonathan E. Bard, Piotr A. Mieczkowski, Janet Leatherwood, Joel A. Huberman, and Michael J.Buck Nucl. Acids Res. 2012 40: 7176-7189

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CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10 Manpreet Kaur, Md. Muntaz Khan, Ananya Kar, Aparna Sharma, and Sandeep Saxena Nucl. Acids Res. 2012 40: 7332-7346 Open Access

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The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures Colleen Barefield and Jan Karlseder Nucl. Acids Res. 2012 40: 7358-7367 Open Access

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A role for chromatin remodellers in replication of damaged DNA Atsuko Niimi, Anna L. Chambers, Jessica A. Downs, and Alan R. Lehmann Nucl. Acids Res. 2012 40: 7393-7403 Open Access

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Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1 Jason W. Gloor, Lata Balakrishnan, Judith L. Campbell, and Robert A. Bambara Nucl. Acids Res. 2012 40: 6774-6786 Open Access

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Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex Ivar Ilves, Nele Tamberg, and Michael R. Botchan PNAS August 14, 2012 vol. 109 no. 33 13163-13170

publication alert

DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast Tetsuya Handa, Mai Kanke, Tatsuro S. Takahashi, Takuro Nakagawa, and Hisao Masukata Mol. Biol. Cell 2012 23:16 3240-3253

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Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress Alberto Ciccia, Amitabh V. Nimonkar, Yiduo Hu, Ildiko Hajdu, Yathish Jagadheesh Achar, Lior Izhar, Sarah A. Petit, Britt Adamson, John C. Yoon, Stephen C. Kowalczykowski, David M. Livingston, Lajos Haracska, Stephen J. Elledge Molecular Cell, Volume 47, Issue 3, 396-409

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The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress Jingsong Yuan, Gargi Ghosal, Junjie Chen Molecular Cell, Volume 47, Issue 3, 410-42

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Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression Zhigang Guo, Julie Kanjanapangka, Na Liu, Songbai Liu, Changwei Liu, Zhenxing Wu, Yingjie Wang, Tiffany Loh, Claudia Kowolik, Joonas Jamsen, Mian Zhou, Khue Truong, Yuan Chen, Li Zheng, Binghui Shen Molecular Cell, Volume 47, Issue 3, 444-456

publication alert

Entropy Involved in Fidelity of DNA Replication J. Ricardo Arias-Gonzalez PLoS ONE 7(8): e42272

publication alert

Regulation of DNA Replication Timing on Human Chromosome by a Cell-Type Specific DNA Binding Protein SATB1 Masako Oda, Yutaka Kanoh, Yoshihisa Watanabe, Hisao Masai PLoS ONE 7(8): e42375

publication alert

Structural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase {alpha}-Primase Bo Zhou, Diana R. Arnett, Xian Yu, Aaron Brewster, Gregory A. Sowd, Charlies L. Xie, Stefan Vila, Dahai Gai, Ellen Fanning, and Xiaojiang S. Chen J. Biol. Chem. 2012 287: 26854-26866.

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ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote Artem Y. Lyubimov, Alessandro Costa, Franziska Bleichert, Michael R. Botchan, and James M. Berger PNAS July 24, 2012 vol. 109 no. 30 11999-12004

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Brc1-dependent recovery from replication stress Kirstin L. Bass, Johanne M. Murray, and Matthew J. O'Connell J Cell Sci 2012 125:2753-2764

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Claspin as a biomarker of Human Papillomavirus-related High Grade lesions of uterine cervix Benevolo M, Musio A, Vocaturo A, Donà M, Rollo F, Terrenato I, Carosi M, Pescarmona E, Vocaturo G, Mottolese M Journal of Translational Medicine 2012, 10:132

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RMI1 Promotes DNA Replication Fork Progression and Recovery from Replication Fork Stress Jay Yang, Lara O'Donnell, Daniel Durocher and Grant W. Brown Mol. Cell. Biol. August 2012 vol. 32 no. 15

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Dynamic Association of ORCA with Prereplicative Complex Components Regulates DNA Replication Initiation Zhen Shen, Arindam Chakraborty, Ankur Jain, Sumanprava Giri, Taekjip Ha, Kannanganattu V. Prasanth, and Supriya G. Prasanth Mol. Cell. Biol. August 2012 32:3107-3120

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Novel DNA damage checkpoint in mitosis: Mitotic DNA damage induces re-replication without cell division in various cancer cells Sun-Yi Hyun, Eliot M. Rosen, Young-Joo Jang BBRC 423 Pages 593-599

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The Prereplication Complex Recruits XEco2 to Chromatin to Promote Cohesin Acetylation in Xenopus Egg Extracts Torahiko L. Higashi, Megumi Ikeda, Hiroshi Tanaka, Takuro Nakagawa, Masashige Bando, Katsuhiko Shirahige, Yumiko Kubota, Haruhiko Takisawa, Hisao Masukata, Tatsuro S. Takahashi Current Biology, Volume 22, Issue 11, 977-988, 03 May 2012

publication alert

Replication timing and its emergence from stochastic processes John Bechhoefer1, Nicholas Rhind TIGS

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Regulation of DNA Replication within the Immunoglobulin Heavy-Chain Locus During B Cell Commitment Agnieszka Demczuk, Michel G. Gauthier, Ingrid Veras, Settapong Kosiyatrakul, Carl L. Schildkraut, Meinrad Busslinger, John Bechhoefer, Paolo Norio PLoS Biol 10(7): e1001360

publication alert

A Conserved Motif in the C-terminal Tail of DNA Polymerase {alpha} Tethers Primase to the Eukaryotic Replisome Mairi L. Kilkenny, Giacomo De Piccoli, Rajika L. Perera, Karim Labib, and Luca Pellegrini J. Biol. Chem. 2012 287: 23740-23747.

publication alert

Epstein-Barr Nuclear Antigen 1 (EBNA1)-dependent Recruitment of Origin Recognition Complex (Orc) on oriP of Epstein-Barr Virus with Purified Proteins: STIMULATION BY Cdc6 THROUGH ITS DIRECT INTERACTION WITH EBNA1 Kenji Moriyama, Naoko Yoshizawa-Sugata, Chikashi Obuse, Toshiki Tsurimoto,and Hisao Masai J. Biol. Chem. 2012 287: 23977-23994.

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Okazaki Fragment Processing-independent Role for Human Dna2 Enzyme during DNA Replication Julien P. Duxin, Hayley R. Moore, Julia Sidorova, Kenneth Karanja, Yuchi Honaker, Benjamin Dao, Helen Piwnica-Worms, Judith L. Campbell, Raymond J.Monnat, Jr., and Sheila A. Stewart J. Biol. Chem. 2012 287: 21980-21991.

publication alert

The role of N-terminus of Plasmodium falciparum ORC1 in telomeric localization and var gene silencing Abhijit S. Deshmukh, Sandeep Srivastava, Susann Herrmann, Ashish Gupta, Pallabi Mitra, Tim Wolf Gilberger, and Suman Kumar Dhar Nucl. Acids Res. 2012 40: 5313-5331

publication alert

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation Kathleen Klotz-Noack, Debbie McIntosh, Nicholas Schurch, Norman Pratt, and J. Julian Blow J Cell Sci 2012 125:2436-2445

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RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress Siddharth De, Jyoti Kumari, Richa Mudgal, Priyanka Modi, Shruti Gupta, Kazunobu Futami, Hideyuki Goto, Noralane M. Lindor, Yasuhiro Furuichi, Debasisa Mohanty, and Sagar Sengupta J Cell Sci 2012 125:2509-2522

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The Prereplication Complex Recruits XEco2 to Chromatin to Promote Cohesin Acetylation in Xenopus Egg Extracts Torahiko L. Higashi, Megumi Ikeda, Hiroshi Tanaka, Takuro Nakagawa, Masashige Bando, Katsuhiko Shirahige, Yumiko Kubota, Haruhiko Takisawa, Hisao Masukata, Tatsuro S. Takahashi Curret Biology 12 issue 10 p977

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DNA Replication: Pif1 Pulls the Plug on Stalled Replication Forks Kenji Shimada, Susan M. Gasser Current biology Volume 22, Issue 10 pR404

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Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore–microtubule attachment Dileep Varma, Srikripa Chandrasekaran, Lynsie J. R. Sundin, Karen T. Reidy, Xiaohu Wan, Dawn A. D. Chasse, Kathleen R. Nevis, Jennifer G. DeLuca, E. D. Salmon & Jeanette Gowen Cook Nature Cell Biology 14, 593–603 (2012)

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Physical Links Between the Nuclear Envelope Protein Mps3, Three Alternate Replication Factor C Complexes, and a Variant Histone in Saccharomyces cerevisiae Jared Haas, Amanda Lemoncelli, Christina Morozov, Karl Franke, John Dominder, Lisa M. Antoniacci DNA and Cell Biology. June 2012, 31(6): 917-924.

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The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing Jiazhi Hu,Lei Sun,Fenfen Shen,Yufei Chen,Yu Hua,Yang Liu,Mian Zhang,Yiren Hu,Qingsong Wang,Wei Xu,Fei Sun,Jianguo Ji,Johanne M. Murray,Antony M. Carr,Daochun Kong cell, Volume 149, Issue 6, 1221-1232, 8 June 2012

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Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells Chen-Hua Chuang, Dian Yang, Gongshi Bai, Amy Freeland, Steven C. Pruitt, and John C. Schimenti Nucl. Acids Res. 2012 40: 4914-4924

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Structural basis for homeodomain recognition by the cell-cycle regulator Geminin Bo Zhou, Changdong Liu, Zhiwen Xu, and Guang Zhu PNAS June 5, 2012 vol. 109 no. 23 8931-8936

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Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability Jordi Querol-Audía, Chunli Yan, Xiaojun Xu, Susan E. Tsutakawa, Miaw-Sheue Tsai, John A. Tainer, Priscilla K. Cooper, Eva Nogalesa, and Ivaylo Ivanov PNAS May 29, 2012 vol. 109 no. 22 8528-8533

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Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules Shinichiro Niimi, Shiho Arakawa-Takeuchi, Baasanjav Uranbileg, Jun-ha Park, Shigeki Jinno, and Hiroto Okayama J. Biol. Chem. 2012 287: 18573-18583.

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Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4Cdt2-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation Yasushi Shiomi, Akiyo Hayashi, Takashi Ishii, Kaori Shinmyozu, Jun-ichi Nakayama, Kaoru Sugasawa, and Hideo Nishitani Mol. Cell. Biol. June 2012 32:2279-2288;

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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen Israel Salguero, Estrella Guarino, Marianne E.A. Shepherd, Tom D. Deegan, Courtney G. Havens, Stuart A. MacNeill, Johannes C. Walter, Stephen E. Kearsey Current Biology, Volume 22, Issue 8, 720-726

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Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends Nikesh Patel, John M. Atack, L. David Finger, Jack C. Exell, Peter Thompson, Susan Tsutakawa, John A. Tainer, David M. Williams, and Jane A.Grasby Nucl. Acids Res. 2012 40: 4507-4519

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Flexible tethering of primase and DNA Pol {alpha} in the eukaryotic primosome Rafael Nunez-Ramirez, Sebastian Klinge, Ludovic Sauguet, Roberto Melero, Maria A. Recuero-Checa, Mairi Kilkenny, Rajika L. Perera, Begona Garcia-Alvarez, Richard J. Hall, Eva Nogales, Luca Pellegrini, and Oscar Llorca Nucl. Acids Res. 2012 40: 4726

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Characterization of DNA Primase Complex Isolated from the Archaeon, Thermococcus kodakaraensis Wiebke Chemnitz Galal, Miao Pan, Zvi Kelman, and Jerard Hurwitz J. Biol. Chem. 2012 287: 16209-16219.

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Effects of Friedreich's ataxia GAA repeats on DNA replication in mammaliancells Gurangad S. Chandok, Mayank P. Patel, Sergei M. Mirkin, and Maria M. Krasilnikova Nucl. Acids Res. 2012 40: 3964-3974 Open Access

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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation Frederick van Deursen, Sugopa Sengupta, Giacomo De Piccoli, Alberto Sanchez-Diaz and Karim Labib The EMBO Journal (2012), 31,2195 – 2206

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Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components Mai Kanke, Yukako Kodama, Tatsuro S Takahashi, Takuro Nakagawa and Hisao Masukata The EMBO Journal (2012), 31,2182 – 2194

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Depletion of Cellular Pre-Replication Complex Factors Results in Increased Human Cytomegalovirus DNA Replication Tamara Evans Braun, Emma Poole, John Sinclair PLoS ONE 7(5): e36057

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Genome-wide identification and characterization of replication origins by deep sequencing Jia Xu, Yoshimi Yanagisawa, Alexander M Tsankov, Christopher Hart, Keita Aoki, Naveen Kommajosyula, Kathleen E Steinmann, James Bochicchio, Carsten Russ, Aviv Regev, Oliver J Rando, Chad Nusbaum, Hironori Niki, Patrice Milos, Zhiping Weng and Nicholas Rhind Genome Biology 2012, 13:R27

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Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy Ronan Broderick, Sivaramakrishnan Ramadurai, Katalin Tóth, Denisio M. Togashi, Alan G. Ryder, Jörg Langowsk3, Heinz Peter Nasheuer PLoS ONE 7(4): e35537

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Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts Benedicte Recolin, Siem Van Der Laan, and Domenico Maiorano Nucl. Acids Res. 2012 40: 3431-3442

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Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication Chandanamali Punchihewa, Akira Inoue, Asami Hishiki, Yoshihiro Fujikawa, Michele Connelly, Benjamin Evison, Youming Shao, Richard Heath, Isao Kuraoka, Patrick Rodrigues, Hiroshi Hashimoto, Masanobu Kawanishi, Mamoru Sato, Takashi Yagi, and Naoaki Fujii J. Biol. Chem. 2012 287: 14289-14300.

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The Nucleosome Binding Protein HMGN1 Interacts with PCNA and Facilitates Its Binding to Chromatin Yuri V. Postnikov, Toshihiro Kurahashi, Ming Zhou, and Michael Bustin Mol. Cell. Biol. May 2012 32:1844-1854

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Regulation and spatial organization of PCNA in Trypanosoma brucei

Doris Kaufmanna, Alwine Gassena, Andreas Maiser, Heinrich Leonhardt, Christian J. Janzen

Biochemical and Biophysical Research Communications Volume 419, Issue 4, Pages 698–702

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Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA

Yongxin Yu, Chunying Song, Qiongyi Zhang, Peter A. DiMaggio, Benjamin A. Garcia, Autumn York, Michael F. Carey, Michael Grunstein

Molecular Cell, Volume 46, Issue 1, 7-17, 13 April 2012

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Altered Replication in Human Cells Promotes DMPK (CTG)n · (CAG)n Repeat Instability

Guoqi Liu, Xiaomi Chen, Yanzhe Gao, Todd Lewis, Joanna Barthelemy, and Michael Leffak

Mol. Cell. Biol. May 2012 32:1618-1632

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DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1

Anna Travesa, Dwight Kuo, Robertus A M de Bruin, Tatyana I Kalashnikova, Marisela Guaderrama, Kevin Thai, Aaron Aslanian, Marcus B Smolka, John R Yates III, Trey Ideker and Curt Wittenberg

The EMBO Journal (2012), 31,1811 – 1822

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Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes

Francisco M Bastos de Oliveira, Michael R Harris, Pijus Brazauskas, Robertus A M de Bruin and Marcus B Smolka

The EMBO Journal (2012), 31,1798 – 1810

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RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts

Pierre Luciano, Stéphane Coulon, Virginie Faure, Yves Corda, Julia Bos, Steven J Brill, Eric Gilson, Marie-Noelle Simon and Vincent Géli

The EMBO Journal (2012) 31, 2034 - 2046

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Structural insights into the Cdt1-mediated MCM2–7 chromatin loading

Changdong Liu, Rentian Wu, Bo Zhou, Jiafeng Wang, Zhun Wei, Bik K. Tye, Chun Liang, and Guang Zhu

Nucl. Acids Res. (2012) 40(7): 3208-3217

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Human telomeres replicate using chromosome-specific, rather than universal, replication programs

William C. Drosopoulos, Settapong T. Kosiyatrakul, Zi Yan, Simone G. Calderano, and Carl L. Schildkraut

JCB vol. 197 no. 2 253-266

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The Werner Syndrome Exonuclease Facilitates DNA Degradation and High Fidelity DNA Polymerization by Human DNA Polymerase δ

Ashwini S. Kamath-Loeb, Jiang-Cheng Shen, Michael W. Schmitt, and Lawrence A. Loeb

J. Biol. Chem. 2012 287: 12480-12490

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ATM Protein Physically and Functionally Interacts with Proliferating Cell Nuclear Antigen to Regulate DNA Synthesis

Armin M. Gamper, Serah Choi, Yoshihiro Matsumoto, Dibyendu Banerjee, Alan E. Tomkinson and Christopher J. Bakkenist

The Journal of Biological Chemistry, 287, 12445-12454.

Phosphorylation of ORC2 Protein Dissociates Origin Recognition Complex from Chromatin and Replication Origins

Kyung Yong Lee, Sung Woong Bang, Sang Wook Yoon, Seung-Hoon Lee, Jong-Bok Yoon and Deog Su Hwang

The Journal of Biological Chemistry, 287, 11891-11898

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Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1

Yiru Zhang, Yuqian Xing, Lei Zhang, Yang Mei, Kazuo Yamamoto, Tak W. Mak, and Han You,

PNAS April 10, 2012 vol. 109 no. 15 5717-5722

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Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase ε in rolling circle DNA synthesis

Young-Hoon Kang, Wiebke Chemnitz Galal, Andrea Farina, Inger Tappin, and Jerard Hurwitz

PNAS 2012 109 (16) 6042-6047

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The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

Alex J. Kuo, Jikui Song, Peggie Cheung, Satoko Ishibe-Murakami, Sayumi Yamazoe, James K. Chen, Dinshaw J. Patel & Or Gozani

Nature 484, 115–119

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Evaluation of MCM-2 Expression in TMA Cervical Specimens

Alcina F. Nicol1, José R. Lapa e Silva, Cynthia B. Cunha, Sergio M. Amaro-Filho, Nathalia Oliveira, Beatriz Grinsztejn, Ruth Khalil, Fabio Russomano, Andrea Pires, Jonathan E. Golub, Gerard J. Nuovo

PLoS ONE 7(4): e32936

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Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

Hiroshi Arakawa, Theresa Bednar, Minli Wang, Katja Paul, Emil Mladenov, Alena A. Bencsik-Theilen and George Iliakis

Nucl. Acids Res. (2012) 40 (6): 2599-2610

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Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

Athanasia Stathopoulou, Vassilis Roukos, Chariklia Petropoulou, Panagiotis Kotsantis, Nickolas Karantzelis, Hideo Nishitani, Zoi Lygerou2, Stavros Taraviras

PLoS ONE 7(3): e34621

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Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

Courtney G. Havens, Nadia Shobnam, Estrella Guarino, Richard C. Centore, Lee Zou, Stephen E. Kearsey and Johannes C. Walter

Journal of Biological Chemistry, 287,

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Embryonic onset of late replication requires Cdc25 down-regulation

Jeffrey A. Farrell, Antony W. Shermoen, Kai Yuan, and Patrick H. O'Farrell

Genes Dev. April 1, 2012 26: 714-725

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Preventing Replication Stress to Maintain Genome Stability: Resolving Conflicts between Replication and Transcription

Rodrigo Bermejo, Mong Sing Lai, Marco Foiani

Molecular Cell, Volume 45, Issue 6, 710-718

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Intrinsic coupling of lagging-strand synthesis to chromatin assembly

Duncan J. Smith & Iestyn Whitehouse

Nature 483, 434–438 (22 March 2012)

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Forced binding of the origin of replication complex to chromosomal sites in Drosophila S2 cells creates an origin of replication

Gilles Crevel and Sue Cotterill

J Cell Sci 2012 125:965-972

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DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

Nasim Sabouri, Karin R. McDonald, Christopher J. Webb, Ileana M. Cristea and Virginia A. Zakian

Genes & Dev. 2012. 26: 581-593

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Mcm10 Plays a Role in Functioning of the Eukaryotic Replicative DNA Helicase, Cdc45-Mcm-GINS

George Watase, Haruhiko Takisawa, Masato T. Kanemaki

Current Biology, Volume 22, Issue 4, 343-349, 26 January 2012

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Replication fork dynamics and the DNA damage response

Rebecca M. Jones and Eva Petermann

Biochem. J. (2012) 443 (13–26

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Modeling Inhomogeneous DNA Replication Kinetics

Michel G. Gauthier, Paolo Norio, John Bechhoefer

PLoS ONE 7(3): e32053

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USF Binding Sequences from the HS4 Insulator Element Impose Early Replication Timing on a Vertebrate Replicator

Vahideh Hassan-Zadeh, Sabarinadh Chilaka, Jean-Charles Cadoret, Meiji Kit-Wan Ma, Nicole Boggetto, Adam G. West, Marie-Noëlle Prioleau

PLoS Biol 10(3): e1001277

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Do replication forks control late origin firing in Saccharomyces cerevisiae?

Emilie Ma, Olivier Hyrien, and Arach Goldar

Nucl. Acids Res. 2012 40: 2010-2019

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Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

Giacomo De Piccoli, Yuki Katou, Takehiko Itoh, Ryuichiro Nakato, Katsuhiko Shirahige, Karim Labib

Molecular Cell, Volume 45, Issue 5, 696-704, 09 February 2012

no postings this week

Publication Alert

Physical and Functional Interactions of Caenorhabditis elegansWRN-1 Helicase with RPA-1

Moonjung Hyun, Sojin Park, Eunsun Kim, Do-Hyung Kim, Se-Jin Lee, Hyeon-Sook Koo, Yeon-Soo Seo, and Byungchan Ahn

Biochem 51 1336–1345

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Cdc6 Protein Activates p27KIP1-bound Cdk2 Protein Only after the Bound p27 Protein Undergoes C-terminal Phosphorylation

Baasanjav Uranbileg, Hanako Yamamoto, Jung-ha Park, Atish R. Mohanty, Shiho Arakawa-Takeuchi, Shigeki Jinno, and Hiroto Okayama

J. Biol. Chem. 2012 287: 6275-6283.

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Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility

Lyad Zamir, Marianna Zaretsky, Yearit Fridman, Hadas Ner-Gaon, Eitan Rubin, and Amir Aharoni

PNAS 2012 109 (7) E406–E414

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dNTP pools determine fork progression and origin usage under replication stress

Jérôme Poli, Olga Tsaponina, Laure Crabbé, Andrea Keszthelyi, Véronique Pantesco, Andrei Chabes, Armelle Lengronne and Philippe Pasero

The EMBO Journal (2012), 31,883 – 894

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Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

Marta B Davidson, Yuki Katou, Andrea Keszthelyi, Tina L Sing, Tian Xia, Jiongwen Ou, Jessica A Vaisica, Neroshan Thevakumaran, Lisette Marjavaara, Chad L Myers, Andrei Chabes, Katsuhiko Shirahige and Grant W Brown

The EMBO Journal (2012), 31,895 – 907

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Differential requirement for the N-terminal catalytic domain of the DNA polymerase ε p255 subunit in the mitotic cell cycle and the endocycle Original Research Article


Osamu Suyari, Mieko Kawai, Hiroyuki Ida, Hideki Yoshida, Kengo Sakaguchi, Masamitsu Yamaguchi

Gene 465 Pages 104-114

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Replication Timing: The Early Bird Catches the Worm pR81

Max E. Douglas, John F.X. Diffley

Current Biology, Volume 22, Issue 3, R81-R82, 7 February 2012

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In Vivo Binding of Orc2 to a Region of the Chicken Lysozyme GAS41 Origin Containing Multiple Sp1-Binding Sites

Katrin Hübner, Loc Phi-van

DNA and Cell Biology. February 2012, 31(2): 180-186.

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Mimosine arrests the cell cycle prior to the onset of DNA replication by preventing the binding of human Ctf4/And-1 to chromatin via Hif-1α activation in HeLa cells

Soon-Young Park, Jun-Sub Im, Sung-Rye Park, Sang-Eun Kim, Hoe-Jeong Wang and Joon-Kyu Lee

Cell cycle Volume 11, Issue 4 February 15, 2012 Pages 761 - 766

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Cdc6 is required for meiotic spindle assembly in Xenopus oocytes

Yadushyla Narasimhachar, Daniel R. Webster, David L. Gard and Martine Coué

Cell cycle Volume 11, Issue 3 February 1, 2012 Pages 524 – 531

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Molecular architecture of a multifunctional MCM complex

June Sanchez-Berrondo, Pablo Mesa, Arkaitz Ibarra, Maria I. Martinez-Jimenez, Luis Blanco, Juan Mendez, Jasminka Boskovic, and Guillermo Montoya

Nucl. Acids Res. 2012 40: 1366-1380

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Overcoming natural replication barriers: differential helicase requirements

Ranjith P. Anand, Kartik A. Shah, Hengyao Niu, Patrick Sung, Sergei M. Mirkin, and Catherine H. Freudenreich

Nucl. Acids Res. 2012 40: 1091-1105 Open Access

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Repair-specific Functions of Replication Protein A

Cathy S. Hass, Koonyee Lam, and Marc S. Wold

J. Biol. Chem. 2012 287: 3908-3918.

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Structural and Functional Insights into the DNA Replication Factor Cdc45 Reveal an Evolutionary Relationship to the DHH Family of Phosphoesterases

Ivet Krastanova, Vincenzo Sannino, Heinz Amenitsch, Opher Gileadi, Francesca M. Pisani, and Silvia Onesti

J. Biol. Chem. 2012 287: 4121-4128.

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The MCM-associated protein MCM-BP is important for human nuclear morphology

Madhav Jagannathan, Amos M. Sakwe, Tin Nguyen, and Lori Frappier

J Cell Sci 2012 125:133-143

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Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex

Rentian Wu, Jiafeng Wang, and Chun Liang

J Cell Sci 2012 125:209-219

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Rif1 is a global regulator of timing of replication origin firing in fission yeast

Motoshi Hayano, Yutaka Kanoh, Seiji Matsumoto, Claire Renard-Guillet, Katsuhiko Shirahige, and Hisao Masai

Genes Dev. January 15, 2012 26: 137-150

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A Central Swivel Point in the RFC Clamp Loader Controls PCNA Opening and Loading on DNA

Miho Sakato, Mike O'Donnell, Manju M. Hingorani

Journal of Molecular Biology, Volume 416, Issue 2, 17 February 2012, Pages 163–175

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The dynamics of replication licensing in live Caenorhabditis elegans embryos

Remi Sonneville, Matthieu Querenet, Ashley Craig, Anton Gartner, and J. Julian Blow

JCB vol. 196 no. 2 233-246

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Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae

Simon R.V. Knott,Jared M. Peace,A. Zachary Ostrow,Yan Gan,Alexandra E. Rex,Christopher J. Viggiani,Simon Tavaré,Oscar M. Aparicio

Cell, Volume 148, Issue 1, 99-111, 20 January 2012

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Replication Factor C Is a More Effective Proliferating Cell Nuclear Antigen (PCNA) Opener than the Checkpoint Clamp Loader, Rad24-RFC

Jennifer A. Thompson, Melissa R. Marzahn, Mike O'Donnell, and Linda B. Bloom

J. Biol. Chem. 2012 287: 2203-2209.

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Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

Seiji Tanaka, Ryuichiro Nakato, Yuki Katou, Katsuhiko Shirahige, Hiroyuki Araki

Current Biology, Volume 21, Issue 24, 2055-2063,

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RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

Yoshitami Hashimoto, Fabio Puddu & Vincenzo Costanzo

Nature Structural & Molecular Biology 19, 17–24 (2012)

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Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin

Corella S. Casas-Delucchi, Joke G. van Bemme, Sebastian Haase, Henry D. Herce, Danny Nowak, Daniela Meilinger, Jeffrey H. Stear, Heinrich Leonhardt and M. Cristina Cardoso

Nucl. Acids Res. (2012) 40 (1): 159-169

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Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast

Elisa de Castro, Ignacio Soriano, Laura Marín, Rebeca Serrano, Luis Quintales and Francisco Antequera

The EMBO Journal (2012) 31, 124 - 137

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Phosphorylation of the p68 Subunit of Pol δ Acts as a Molecular Switch To Regulate Its Interaction with PCNA

Amal A. Rahmeh, Yajing Zhou, Bin Xie, Hao Li, Ernest Y. C. Lee, and Marietta Y. W. T. Lee

Biochemistry, 2012, 51 (1), pp 416–424

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RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance

Avik K. Ghosh, Marie L. Rossi, Dharmendra Kumar Singh, Christopher Dunn, Mahesh Ramamoorthy, Deborah L. Croteau, Yie Liu, and Vilhelm A. Bohr

J. Biol. Chem. 2012 287: 196-209.

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Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

Maria Sideridou, Roubini Zakopoulou, Konstantinos Evangelou, Michalis Liontos, Athanassios Kotsinas, Emmanouil Rampakakis, Sarantis Gagos, Kaoru Kahata, Kristina Grabusic, Kalliopi Gkouskou, Ioannis P. Trougakos1, Evangelos Kolettas, Alexandros G. Georgakilas, Sinisa Volarevic, Aristides G. Eliopoulos, Maria Zannis-Hadjopoulos, Aristidis Moustakas, and Vassilis G. Gorgoulis

JCB vol. 195 no. 7 1123-1140

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Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin

Corella S. Casas-Delucchi, Joke G. van Bemmel, Sebastian Haase, Henry D. Herce, Danny Nowak, Daniela Meilinger, Jeffrey H. Stear, Heinrich Leonhardt, and M. Cristina Cardoso

Nucl. Acids Res. 2012 40: 159-169

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The RecQ4 Orthologue Hrq1 Is Critical for DNA Interstrand Cross-Link Repair and Genome Stability in Fission Yeast

Lynda M. Groococka, John Pruddena, J. Jefferson P. Perrya,b and Michael N. Boddy

Mol. Cell. Biol. January 2012 vol. 32 no. 2

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Cdc7-Dbf4 Is a Gene-Specific Regulator of Meiotic Transcription in Yeast

Hsiao-Chi Lo, Ryan C. Kunz, Xiangyu Chen, Allison Marullo, Steven P. Gygi, and Nancy M. Hollingsworth

Mol. Cell. Biol. January 2012 32:541-557

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Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex

Jun Liu, Kristopher McConnell, Michael Dixon, and Brian R. Calvi

Mol. Biol. Cell 2012 23:1 200-212;