Publication Alert

Thermococcus kodakarensis encodes three MCM homologs but only one is essential

Miao Pan, Thomas J. Santangelo, Zhuo Li, John N. Reeve, and Zvi Kelman

Nucl. Acids Res. 2011 39: 9671-9680;

Publication Alert

Building a double hexamer of DNA helicase at eukaryotic replication origins

Karim Labib

The EMBO Journal (2011), 30,4853 – 4855

Publication Alert

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2–7 helicases

Thomas J Takara and Stephen P Bell

The EMBO Journal (2011), 30,4885 – 4896

Publication Alert

Drug-Sensitive DNA Polymerase δ Reveals a Role for Mismatch Repair in Checkpoint Activation in Yeast

Linda J. Reha-Krantz, Md. Shahjahan P. Siddique, Kelly Murphy, Andrea Tam, Michelle O’Carroll, Sam Lou, Amy Schultz, and Charles Boone

Genetics December 2011 189:1211-1224

Publication Alert

Purification and functional inactivation of the fission yeast MCMMCM–BP complex

Juan-juan Li, Jasmin Schnick, Jacqueline Hayles, Stuart A. MacNeill

Febs lett 24 3850-3855

Publication Alert

Biochemical and genetical analyses of the three mcm genes from the hyperthermophilic archaeon, Thermococcus kodakarensis

Sonoko Ishino, Seiji Fujino, Hiroya Tomita, Hiromi Ogino, Koichi Takao, Hiromi Daiyasu, Tamotsu Kanai, Haruyuki Atomi and Yoshizumi Ishino

Genes to Cells Volume 16, Issue 12 pages 1176–1189

Publication Alert

Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos

Jolanta Kisielewska and J. Julian Blow

Development 2012 139:63-74

Publication Alert

Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

Davide Mantiero, Amanda Mackenzie, Anne Donaldson and Philip Zegerman

The EMBO Journal (2011) 30, 4805 – 4814

Publication Alert

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Marie Regairaz, Yong-Wei Zhang, Haiqing Fu, Keli K. Agama, Nalini Tata, Surbhi Agrawal, Mirit I. Aladjem, and Yves Pommier

JCB vol. 195 no. 5 739-749

Publication Alert

Abundance of Prereplicative Complexes (Pre-RCs) Facilitates Recombinational Repair under Replication Stress in Fission Yeast

Kentaro Maki, Takahiro Inoue, Atsushi Onaka, Hiroko Hashizume, Naoko Somete, Yuko Kobayashi, Shigefumi Murakami, Chikako Shigaki, Tatsuro S. Takahashi, Hisao Masukata, and Takuro Nakagawa

J. Biol. Chem. 2011 286: 41701-41710.

Publication Alert

Function of the origin recognition complex 1 (ORC1) outside DNA replication in Drosophila

So Young Park and Maki Asano

Cell cycle Volume 10 November 15, 2011 Pages 3957 - 3963

Publication Alert

The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

Vasundhara M. Navadgi-Patil, Sandeep Kumar, and Peter M. Burgers

J. Biol. Chem. 2011 286: 40999-41007.

Publication Alert

Decreased MCM2-6 in Drosophila S2 Cells Does Not Generate Significant DNA Damage or Cause a Marked Increase in Sensitivity to Replication Interference

Isabelle Crevel, Gilles Crevel, Thierry Gostan, Christelle de Renty, Vincent Coulon, Sue Cotterill

PLoS ONE 6(11): e27101

Publication Alert

DNA Replication Timing Is Maintained Genome-Wide in Primary Human Myoblasts Independent of D4Z4 Contraction in FSH Muscular Dystrophy

Benjamin D. Pope, Koji Tsumagari, Dana Battaglia, Tyrone Ryba, Ichiro Hiratani, Melanie Ehrlich, David M. Gilbert

PLoS ONE 6(11): e27413

Publication Alert

Plk1 Phosphorylation of Orc2 Promotes DNA Replication under Conditions of Stress

Bing Song, X. Shawn Liu, Korbin Davis, and Xiaoqi Liu

Mol. Cell. Biol. December 2011 31:4844-4856

Publication Alert

Phosphorylation of MCM3 Protein by Cyclin E/Cyclin-dependent Kinase 2 (Cdk2) Regulates Its Function in Cell Cycle

Junhui Li, Min Deng, Qian Wei, Ting Liu, Xiaomei Tong, and Xin Ye

J. Biol. Chem. 2011 286: 39776-39785.

Publication Alert

P50, the Small Subunit of DNA Polymerase Delta, Is Required for Mediation of the Interaction of Polymerase Delta Subassemblies with PCNA

Yujue Wang, Qian Zhang, Huiqing Chen, Xiao Li, Weijun Mai, Keping Chen, Sufang Zhang, Ernest Y. C. Lee, Marietta Y. W. T. Lee, Yajing Zhou

PLoS ONE 6(11): e27092

Publication Alert

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

Narottam Acharya, Roland Klassen, Robert E. Johnson, Louise Prakash, and Satya Prakash

PNAS 2011 108 (44) 17927-17932

Publication Alert

Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation

Seiji Matsumoto, Motoshi Hayano, Yutaka Kanoh, and Hisao Masai

J. cell biol. 195:387-401.

Publication Alert

Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation

Nozomi Sugimoto, Takashi Yugawa, Masayoshi Iizuka, Tohru Kiyono, and
Masatoshi Fujita

J. Biol. Chem. 2011;286 39200-39210

Publication Alert

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression

Suzanne A. Hartforda, Yunhai Luoa, Teresa L. Southarda, Irene M. Minb, John T. Lisb, and John C. Schimenti

PNAS October 25, 2011 vol. 108 no. 43 17702-17707

no postings this week

Publication Alert

Cloning of the Flap Endonuclease-1 Gene in Bombyx mori and Identification of an Antiapoptotic Function

Min-Hui Pan, Juan Du, Jin-Ye Zhang, Mao-Hua Huang, Ting Li, Hong-Juan Cui, Cheng Lu

DNA and Cell Biology. October 2011, 30(10): 763-770.

Publication Alert

Enabling Association of the GINS Protein Tetramer with the Mini Chromosome Maintenance (Mcm)2-7 Protein Complex by Phosphorylated Sld2 Protein and Single-stranded Origin DNA

Irina Bruck, Diane M. Kanter, and Daniel L. Kaplan

J. Biol. Chem. 2011 286: 36414-36426.

Publication Alert

CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication

André Franz, Michael Orth, Paul A. Pirson, Remi Sonneville, J. Julian Blow, Anton Gartner, Olaf Stemmann, Thorsten Hoppe

Molecular Cell, Volume 44, Issue 1, 85-96,

Publication Alert

JNK1 Phosphorylation of Cdt1 Inhibits Recruitment of HBO1 Histone Acetylase and Blocks Replication Licensing in Response to Stress

Benoit Miotto, Kevin Struhl

Molecular Cell, Volume 44, Issue 1, 72-84

Publication Alert

R-loop-mediated genomic instability is caused by impairment of replication fork progression

Wenjian Gan, Zhishuang Guan, Jie Liu, Ting Gui, Keng Shen, James L. Manley, and Xialu Li

Genes Dev. October 1, 2011 25:

Publication Alert

G-quadruplex-induced instability during leading-strand replication

Judith Lopes, Aurèle Piazza, Rodrigo Bermejo, Barry Kriegsman, Arianna Colosio, Marie-Paule Teulade-Fichou, Marco Foiani and Alain Nicolas

The EMBO Journal (2011), 30,4033 - 4046,

Publication Alert

Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins

Jane C. Kim and Terry L. Orr-Weaver

PNAS October 4, 2011 vol. 108 no. 40 16681-16686

Publication Alert

Flexible tethering of primase and DNA Pol {alpha} in the eukaryotic primosome

Rafael Nunez-Ramirez, Sebastian Klinge, Ludovic Sauguet, Roberto Melero, Maria A. Recuero-Checa, Mairi Kilkenny, Rajika L. Perera, Begona Garcia-Alvarez, Richard J. Hall, Eva Nogales, Luca Pellegrini, and Oscar Llorca

Nucl. Acids Res. 2011 39: 8187-8199

no postings this week

Publication Alert

Drosophila P elements preferentially transpose to replication origins

Allan C. Spradlinga, Hugo J. Bellena, and Roger A. Hoskins

PNAS September 20, 2011 vol. 108 no. 38 15948-15953

Publication Alert

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

Yu V. Fu,Hasan Yardimci,David T. Long,Angelo Guainazzi,Vladimir P. Bermudez,Jerard Hurwitz,Antoine van Oijen,Orlando D. Schärer,Johannes C. Walter

Cell, Volume 146, Issue 6, 931-941, 16 September 2011

Publication Alert

The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Pol{zeta}/Rev1-dependent Translesion DNA Synthesis

Neeru M. Sharma, Olga V. Kochenova, and Polina V. Shcherbakova

J. Biol. Chem. 2011 286: 33557-33566.

Publication Alert

Schizosaccharomyces pombe Minichromosome Maintenance-binding Protein (MCM-BP) Antagonizes MCM Helicase

Lin Ding and Susan L. Forsburg

J. Biol. Chem. 2011 286: 32918-32930.

Publication Alert

Mutation Rates across Budding Yeast Chromosome VI Are Correlated with Replication Timing

Gregory I. Lang1 and Andrew W. Murray

Genome Biol Evol (2011) 3

Publication Alert

In Vitro Gap-directed Translesion DNA Synthesis of an Abasic Site Involving Human DNA Polymerases {epsilon}, {lambda}, and {beta}

Giuseppe Villani, Ulrich Hubscher, Nadege Gironis, Sinikka Parkkinen, Helmut Pospiech, Igor Shevelev, Giulia di Cicco, Enni Markkanen, Juhani E.Syvaoja, and Nicolas Tanguy Le Gac

J. Biol. Chem. 2011 286: 32094-32104.

Publication Alert

The Cdc45-Mcm2-7-GINS Protein Complex in Trypanosomes Regulates DNA Replication and Interacts with Two Orc1-like Proteins in the Origin Recognition Complex

Hung Quang Dang and Ziyin Li

J. Biol. Chem. 2011 286: 32424-32435.

Publication Alert

The Karyopherin Kap95 and the C-Termini of Rfa1, Rfa2, and Rfa3 Are Necessary for Efficient Nuclear Import of Functional RPA Complex Proteins in Saccharomyces cerevisiae

Kenneth D. Belanger, Amanda L. Griffith, Heather L. Baker, Jeanne N. Hansen, Laura A. Simmons Kovacs, Justin S. Seconi, Andrew C. Strine

DNA and Cell Biology. September 2011, 30(9): 641-651.

Publication Alert

DNA Replication: Mammalian Treslin–TopBP1 Interaction Mirrors Yeast Sld3–Dpb11

Adam C. Mueller, Mignon A. Keaton, Anindya Dutta

Current biology Volume 21, Issue 16, R638-R640, 23 August 2011

Publication Alert

Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality

Han Jeong Lim1, Yoon Jeon1, Chang Hwan Jeon, Jong Hyun Kim, Ho Lee

Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchVolume 1813, Issue 10, October 2011, Pages 1777-1783

no postings this week

Publication Alert

Coordinated protein and DNA remodeling by human HLTF on stalled replication fork

Yathish Jagadheesh Achar, David Balogh, and Lajos Haracska

PNAS August 23, 2011 no. 34 14073-14078 


Publication Alert

The Histone Chaperone Facilitates Chromatin Transcription (FACT) Protein Maintains Normal Replication Fork Rates

Takuya Abe, Kazuto Sugimura, Yoshifumi Hosono, Yasunari Takami, Motomu Akita, Akari Yoshimura, Shusuke Tada, Tatsuo Nakayama, Hiromu Murofushi, Katsuzumi Okumura, Shunichi Takeda, Masami Horikoshi, Masayuki Seki, and Takemi Enomoto

J. Biol. Chem. 2011 286: 30504-30512.

Publication Alert

High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements

FuJung Chang, Caitlin D. May, Timothy Hoggard, Jeremy Miller, Catherine A.Fox, and Michael Weinreich

Nucl. Acids Res. 2011 39: 6523-6535

Publication Alert

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier

Sevil Sofueva, Fekret Osman, Alexander Lorenz, Roland Steinacher, Stefania Castagnetti, Jennifer Ledesma, and Matthew C. Whitby

Nucl. Acids Res. 2011 39: 6568-6584

Publication Alert

Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

Brian W. Graham, Grant D. Schauer, Sanford H. Leuba, and Michael A. Trakselis

Nucl. Acids Res. 2011 39: 6585-6595

Publication Alert

Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage

Brent E. Stead, Christopher J. Brandl, and Megan J. Davey

Nucl. Acids Res. 2011 39: 6998-7008

Publication Alert

UV stalled replication forks restart by re-priming in human fibroblasts

Ingegerd Elvers, Fredrik Johansson, Petra Groth, Klaus Erixon, and Thomas Helleday

Nucl. Acids Res. 2011 39: 7049-7057

no postings this week

Publication Alert

Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions

Syuzi Uno and Hisao Masai

Genes to Cells Volume 16, Issue 8, pages 842–856, August 2011

Publication Alert

How dormant origins promote complete genome replication

J. Julian Blow, Xin Quan Ge and Dean A. Jackson

Trends in Biochemical Sciences Volume 36, Issue 8, August 2011, Pages 405-414

Publication Alert

Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans

Dominik Boos, Luis Sanchez-Pulido, Mathieu Rappas, Laurence H. Pearl, Antony W. Oliver, Chris P. Ponting, John F.X. Diffley

Current Biology, Volume 21, Issue 13, 1152-1157, 23 June 2011

Publication Alert

Studies on Human DNA Polymerase {epsilon} and GINS Complex and Their Role in DNA Replication

Vladimir P. Bermudez, Andrea Farina, Vineetha Raghavan, Inger Tappin, and Jerard Hurwitz

J. Biol. Chem. 2011;286 28963-28977

Publication Alert

The Werner and Bloom Syndrome Proteins Help Resolve Replication Blockage by Converting (Regressed) Holliday Junctions to Functional Replication Forks

Amrita Machwe, Rajashree Karale, Xioahua Xu, Yilun Liu, and David K. Orren

Biochemistry, 2011, 50 (32), pp 6774–6788

Publication Alert

A novel DNA nuclease is stimulated by association with the GINS complex

Zhuo Li, Miao Pan, Thomas J. Santangelo, Wiebke Chemnitz, Wei Yuan, James L. Edwards, Jerard Hurwitz, John N. Reeve, and Zvi Kelman

Nucl. Acids Res. 2011 39: 6114-6123

Publication Alert

Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation

Estrella Guarino, Marianne E. A. Shepherd, Israel Salguero, Hui Hua, Rachel S. Deegan, and Stephen E. Kearsey

Nucl. Acids Res. 2011 39: 5978-5990

Publication Alert

DNA replication initiation patterns and spatial dynamics of the human ribosomal RNA gene loci

Daniela S. Dimitrova

August 15, 2011 J Cell Sci 124, 2743-2752

no postings this week

Publication Alert

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

Rodrigo Bermejo, Thelma Capra, Rachel Jossen, Arianna Colosio, Camilla Frattini, Walter Carotenuto, Andrea Cocito, Ylli Doksani, Hannah Klein, Belén Gómez-González, Andrés Aguilera, Yuki Katou, Katsuhiko Shirahige, Marco Foiani

Cell, Volume 146, Issue 2, 233-246, 22 July 2011

Publication Alert

Coordination of DNA replication and histone modification by the Rik1–Dos2 complex

Fei Li1, Rob Martienssen2 & W. Zacheus Cande

Nature 475, 244–248

Publication Alert

CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast

Masayoshi Fukuuraa, Koji Nagaob, Chikashi Obuseb, Tatsuro S. Takahashia, Takuro Nakagawaa, and Hisao Masukataa

MBoC 22, Issue 14, 2620-2633, July 15, 2011

Publication Alert

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

Ryan C. Heller, Sukhyun Kang, Wendy M. Lam, Shuyan Chen, Clara S. Chan, Stephen P. Bell

Cell, Volume 146, Issue 1, 80-91, 8 July 201

Publication Alert

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

Efrat Ozeri-Galai, Ronald Lebofsky, Ayelet Rahat, Assaf C. Bester, Aaron Bensimon, Batsheva Kerem

Molecular Cell, Volume 43, Issue 1, 122-131, 8 July 201

Publication Alert

Characterization of the Endonuclease and ATP-dependent Flap Endo/Exonuclease of Dna2

Barbara K. Fortini, Subhash Pokharel, Piotr Polaczek, Lata Balakrishnan, Robert A. Bambara, and Judith L. Campbell

J. Biol. Chem. 2011 286: 23763-23770.

Publication Alert

Assembly of the Human Origin Recognition Complex Occurs through Independent Nuclear Localization of Its Components

Soma Ghosh, Alex P. Vassilev, Junmei Zhang, Yingming Zhao, and Melvin L. DePamphilis

J. Biol. Chem. 2011 286: 23831-23841.

Publication Alert

Mms1 and Mms22 stabilize the replisome during replication stress

Jessica A. Vaisica, Anastasija Baryshnikova, Michael Costanzo, Charles Boone, and Grant W. Brown

Mol. Biol. Cell 2011 22: 2396-2408

Publication Alert

The Phosphorylation Network for Efficient Activation of the DNA Replication Checkpoint in Fission Yeast

Ming Yue, Amanpreet Singh, Zhuo Wang, and Yong-jie Xu

J. Biol. Chem. 2011 286: 22864-22874.

Publication Alert

Molecular Mechanism of Activation of Human Cdc7 Kinase: BIPARTITE INTERACTION WITH Dbf4/ACTIVATOR OF S PHASE KINASE (ASK) ACTIVATION SUBUNIT STIMULATES ATP BINDING AND SUBSTRATE RECOGNITION

Ryo Kitamura, Rino Fukatsu, Naoko Kakusho, Yong-Soon Cho, Chika Taniyama, Satoshi Yamazaki, Gaik-theng Toh, Kazuo Yanagi, Naoko Arai, Ho-Jin Chang, and Hisao Masai

J. Biol. Chem. 2011 286: 23031-23043.

Publication Alert

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

Akiko Kumagai, Anna Shevchenko, Andrej Shevchenko, and William G. Dunphy

JCB vol. 193 no. 6 995-1007

Publication Alert

Analysis of protein dynamics at active, stalled, and collapsed replication forks

Bianca M. Sirbu, Frank B. Couch, Jordan T. Feigerle, Srividya Bhaskara, Scott W. Hiebert, and David Cortez

Genes Dev. June 15, 2011 25: 1320-1327

Publication Alert

MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

Maimon E. Hubbi, Weibo Luo, Jin H. Baek, Gregg L. Semenza

Molecular Cell, Volume 42, Issue 5, 700-712, 10 June 2011

Publication Alert

A novel heterotetrameric structure of the crenarchaeal PCNA2–PCNA3 complex

Akito Kawaia, Hiroshi Hashimotod, Shigesada Higuchia, Masaru Tsunodac, Mamoru Satod, Kazuo T. Nakamurab and Shuichi Miyamoto

Journal of Structural Biology Volume 174, Issue 3, June 2011, Pages 443-450

Publication Alert

Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication

Lena R. Kundua, Masayuki Sekia, Nanae Watanabea, Hiromu Murofushib, Asako Furukohric, Shou Wagad, Alan J. Scoree, J. Julian Blowe, Masami Horikoshif, Takemi Enomotoa, g and Shusuke Tada

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1813, Issue 6, June 2011, Pages 1129-1136

Publication Alert

The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase

Li Phing Liew and Stephen D. Bell1

Biochem. J. (2011) 436 (409–414)

Publication Alert

Characterization of functional domains in human Claspin

Özdemirhan Serçin and Michael G. Kemp

Cell cycle Volume 10, Issue 10 May 15, 2011 Pages 1599 - 1606

no postings this week

Publication Alert

Architectures of archaeal GINS complexes, essential DNA replication initiation factors

Takuji Oyama , Sonoko Ishino , Seiji Fujino , Hiromi Ogino , Tsuyoshi Shirai , Kouta Mayanagui , Mihoko Saito , Naoko Nagasawa , Yoshizumi Ishino and Kosuke Morikawa

BMC Biology 2011, 9:28

http://www.biomedcentral.com/1741-7007/9/28/abstract

Publication Alert

Dynamic interaction of Y RNAs with chromatin and initiation proteins during human DNA replication

Alice Tianbu Zhang, Alexander R. Langley, Christo P. Christov, Eyemen Kheir, Thomas Shafee, Timothy J. Gardiner and Torsten Krude

J Cell Sci 124, 2058-2069

Publication Alert

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

Katrin Paeschke, John A. Capra, Virginia A. Zakian

Cell, Volume 145, Issue 5, 678-691, 27 May 2011


Publication Alert

Mrc1 Marks Early-Firing Origins and Coordinates Timing and Efficiency of Initiation in Fission Yeast

Motoshi Hayano, Yutaka Kanoh, Seiji Matsumoto, and Hisao Masai

Mol. Cell. Biol. June 2011 31: 2380-2391

Publication Alert

Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2-7 Complex,Allowing the GINS Tetramer to Bind the Mcm2-7 Complex

Irina Bruck and Daniel L. Kaplan

J. Biol. Chem. 2011 286: 18602-18613.

Publication Alert

Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast

Tamon Tanaka, Toshiko Umemori, Shizuko Endo, Sachiko Muramatsu, Masato Kanemaki, Yoichiro Kamimura1, Chikashi Obuse and Hiroyuki Araki

The EMBO Journal (2011) 30, 2019 – 2030

Publication Alert

Timeless Links Replication Termination to Mitotic Kinase Activation

Jayaraju Dheekollu, Andreas Wiedmer, James Hayden, David Speicher, Anthony L. Gotter, Tim Yen, Paul M. Lieberman

PLoS ONE 6(5): e19596

Publication Alert

Preferential Localization of Human Origins of DNA Replication at the 5′-Ends of Expressed Genes and at Evolutionarily Conserved DNA Sequences

Manuel S. Valenzuela, Yidong Chen, Sean Davis, Fan Yang, Robert L. Walker, Sven Bilke, John Lueders, Melvenia M. Martin, Mirit I. Aladjem, Pierre P. Massion, Paul S. Meltzer

PLoS ONE 6(5): e17308

Publication Alert

Activity of FEN1 Endonuclease on Nucleosome Substrates Is Dependent upon DNA Sequence but Not Flap Orientation

Indu Jagannathan, Sharon Pepenella, and Jeffrey J. Hayes

J. Biol. Chem. 2011 286: 17521-17529.

Publication Alert

The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation

Hui-Yong Lian, E. Douglas Robertson, Shin-ichiro Hiraga, Gina M. Alvino, David Collingwood, Heather J. McCune, Akila Sridhar, Bonita J. Brewer, M. K. Raghuraman, and Anne D. Donaldson

Mol. Biol. Cell 2011 22: 1753-1765

Publication Alert

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB

Shixuan Liua, Maxim Balasovb, Hongfei Wanga, Lijie Wua, Igor N. Chesnokovb,1, and Yingfang Liu

PNAS May 3, 2011 vol. 108 no. 18 7373-7378

Publication Alert

Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition

Tetsuya Gotoha, , , Takeo Kishimotob and Jill C. Sible

Developmental Biology Volume 353, Issue 2, 15 May 2011, Pages 302-308

Publication Alert

Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog

Valerie S. Yang, Stephanie A. Carter, Sarah J. Hyland, Kikuë Tachibana-Konwalski, Ronald A. Laskey, Michael A. Gonzalez Curren

Current Biology, Volume 21, Issue 8, 692-699, 14 April 2011

Publication Alert

Molecular determinants of origin discrimination by Orc1 initiators in archaea

Erin C. Dueber, Alessandro Costa, Jacob E. Corn, Stephen D. Bell, and James M. Berger

Nucl. Acids Res. 2011 39: 3621-3631

Publication Alert

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

Doryen Bubeck, Martin A. M. Reijns, Stephen C. Graham, Katy R. Astell, E. Yvonne Jones, and Andrew P. Jackson

Nucl. Acids Res. 2011 39: 3652-3666

no postings this week

Publication Alert

Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation

Eugen C. Minca and David Kowalski

Nucl. Acids Res. (2011) 39 (7): 2610-2623.

Publication Alert

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing

Diane M. Kanter and Daniel L. Kaplan

Nucl. Acids Res. (2011) 39 (7): 2580-2592.

Publication Alert

Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone

Yoav Lubelsky, Takayo Sasaki, Marjorie A. Kuipers, Isabelle Lucas, Michelle M. Le Beau, Sandra Carignon, Michelle Debatisse, Joseph A. Prinz, Jonathan H. Dennis, and David M. Gilbert

Nucl. Acids Res. 2011 39: 3141-3155

Publication Alert

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

Susan E. Tsutakawa, Scott Classen, Brian R. Chapados, Andrew S. Arvai, L. David Finger, Grant Guenther, Christopher G. Tomlinson, Peter Thompson, Altaf H. Sarker, Binghui Shen, Priscilla K. Cooper, Jane A. Grasby, John A. Tainer

Cell, Volume 145, Issue 2, 198-211, 15 April 2011

Publication Alert

GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding

Irina Bruck and Daniel L. Kaplan

J. Biol. Chem. 2011 286: 14157-14167.

Publication Alert

Replication-Fork Stalling and Processing at a Single Psoralen Interstrand Crosslink in Xenopus Egg Extracts

Cyrille Le Breton, Magali Hennion, Paola B. Arimondo, Olivier Hyrien

PLoS ONE 6(4): e18554.

Publication Alert

Crystal structure of the C-terminal domain of human DNA primase large subunit: Implications for the mechanism of the primase-polymerase α switch

Vinod B. Agarkar, Nigar D. Babayeva, Youri I. Pavlov and Tahir H. Tahirov

Cell cycle Volume 10, Issue 6 March 15, 2011 Pages 926 - 931

Publication Alert

Subtle interactions between heterochromatin and DNA replication timing

Joel A. Huberman

Cell cycle Volume 10, Issue 6 March 15, 2011 Pages 873 - 878

Publication Alert

Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing

Koji L. Ode, Koichi Fujimoto, Yumiko Kubota, Haruhiko Takisawa

Genes to Cells Volume 16, Issue 4, pages 380–396, April 2011

Publication Alert

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

Alessandro Costa, Ivar Ilves, Nele Tamberg, Tatjana Petojevic, Eva Nogales, Michael R Botchan & James M Berger

Nature Structural & Molecular Biology 18, 471–477 (2011)

Publication Alert

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

Duane L Guernsey, Makoto Matsuoka, Haiyan Jiang, Susan Evans, Christine Macgillivray, Mathew Nightingale, Scott Perry, Meghan Ferguson, Marissa LeBlanc, Jean Paquette, Lysanne Patry, Andrea L Rideout, Aidan Thomas, Andrew Orr, Chris R McMaster, Jacques L Michaud, Cheri Deal, Sylvie Langlois, Duane W Superneau, Sandhya Parkash, Mark Ludman, David L Skidmore & Mark E Samuels

Nature Genetics 43, 360–364 (2011)

Publication Alert

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

Louise S Bicknell, Sarah Walker, Anna Klingseisen, Tom Stiff, Andrea Leitch, Claudia Kerzendorfer, Carol-Anne Martin, Patricia Yeyati, Nouriya Al Sanna, Michael Bober, Diana Johnson, Carol Wise, Andrew P Jackson, Mark O'Driscoll & Penny A Jeggo

Nature Genetics 43, 350–355 (2011)

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Mapping the FEN1 interaction domain with hTERT

Shilpa Sampathi and Weihang Chai

Biochemical and Biophysical Research Communications Volume 407, Issue 1, 1 April 2011, Pages 34-38

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C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability

Jerome Korzeliusa, 1, Inge Thea, Suzan Ruijtenberga, Vincent Portegijsa, Huihong Xuc, H. Robert Horvitzb and Sander van den Heuvel

Developmental Biology Volume 350, Issue 2, 15 February 2011, Pages 358-369

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RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo

Ryan J. Bourgoa, Ursula Ehmerb, Julien Sageb, and Erik S. Knudsena

MBoC Vol. 22, Issue 7, 931-939, April 1, 2011

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MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

Agnieszka Gambus, Guennadi A. Khoudoli, Richard C. Jones, and J. Julian Blow

J. Biol. Chem. 2011 286: 11855-11864.

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A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission

Juan A. Bernal and Ashok R. Venkitaraman

JCB vol. 192 no. 6 969-978

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A distinct first replication cycle of DNA introduced in mammalian cells

Gurangad S. Chandok, Kalvin K. Kapoor, Rachel M. Brick, Julia M. Sidorova, and Maria M. Krasilnikova

Nucl. Acids Res. 2011 39: 2103-2115

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Polymerase Epsilon Is Required To Maintain Replicative Senescence,

Abhyuday M. Deshpande, Iglika G. Ivanova, Vasil Raykov, Yuan Xue, and Laura Maringele

Molecular and Cellular Biology, April 2011, p. 1637-1645, Vol. 31, No. 8

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The high fidelity and unique error signature of human DNA polymerase epsilon

Dagmara A. Korona, Kimberly G. LeCompte, and Zachary F. Pursell

Nucl. Acids Res. 2011 39: 1763-1773

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The effect of the intra-S-phase checkpoint on origins of replication in human cells

Neerja Karnani and Anindya Dutta1

Genes & Dev. 2011. 25: 621-633

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Nuclear Mitochondrial DNA Activates Replication in Saccharomyces cerevisiae

Laurent Chatre, Miria Ricchetti

PLoS ONE 6(3): e17235

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Geminin-Deficient Neural Stem Cells Exhibit Normal Cell Division and Normal Neurogenesis

Kathryn M. Schultz, Ghazal Banisadr, Ruben O. Lastra1, Tammy McGuire, John A. Kessler, Richard J. Miller, Thomas J. McGarry

PLoS ONE 6(3): e17736.

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Human TopBP1 localization to the mitotic centrosome mediates mitotic progression

Sung Woong Banga, Min Ji Koa, Sukhyun Kanga, Gwang Su Kima, Dongmin Kangb, JooHun Leec and Deog Su Hwanga

Experimental Cell Research Volume 317, Issue 7, 15 April 2011, Pages 994-1004

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The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells: Role of the N-terminal region of RECQL4 in cells

Takuya Abe, Akari Yoshimura, Yoshifumi Hosono, Shusuke Tada, c, Masayuki Seki and Takemi Enomoto

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1813, Issue 3, March 2011, Pages 473-479

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Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks

Celina Costas, Maria de la Paz Sanchez, Hume Stroud, Yanchun Yu, Juan Carlos Oliveros, Suhua Feng, Alberto Benguria, Irene López-Vidriero, Xiaoyu Zhang, Roberto Solano, Steven E Jacobsen & Crisanto Gutierrez

Nature Structural & Molecular Biology 18, 395–400 (2011)

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Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

Tsuyoshi Kawabata, Spencer W. Luebben, Satoru Yamaguchi, Ivar Ilves, Ilze Matise, Tavanna Buske, Michael R. Botchan, Naoko Shima

Molecular Cell, Volume 41, Issue 5, 543-553, 4 March 2011

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A Role for Dormant Origins in Tumor Suppression

Kathleen Klotz-Noack and J. Julian Blow

Molecular Cell, Volume 41, Issue 5, 495-496,

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Eukaryotic Lagging Strand DNA Replication Employs a Multi-pathway Mechanism That Protects Genome Integrity

Lata Balakrishnan and Robert A. Bambara

J. Biol. Chem. 2011 286: 6865-6870.

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Reduced Stability and Increased Dynamics in the Human Proliferating Cell Nuclear Antigen (PCNA) Relative to the Yeast Homolog

Alfredo De Biasio, Ricardo Sánchez, Jesús Prieto, Maider Villate, Ramón Campos-Olivas, Francisco J. Blanco

PLoS ONE 6(2): e16600

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CDK prevents Mcm2–7 helicase loading by inhibiting Cdt1 interaction with Orc6

Shuyan Chen and Stephen P. Bell

Genes Dev. February 15, 2011 25: 363-372

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Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

Avvaru N Suhasini, Nina A Rawtani, Yuliang Wu, Joshua A Sommers, Sudha Sharma, Georgina Mosedale, Phillip S North, Sharon B Cantor, Ian D Hickson and Robert M Brosh Jr

The EMBO Journal (2011), 30, 692 - 705

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Crystal structures of two active proliferating cell nuclear antigens (PCNAs) encoded by Thermococcus kodakaraensis

Jane E. Ladner, Miao Pan, Jerard Hurwitz, and Zvi Kelman

PNAS February 15, 2011 vol. 108 no. 7 2711-2716

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TopBP1 Deficiency Causes an Early Embryonic Lethality and Induces Cellular Senescence in Primary Cells

Yoon Jeon, Eun Ko, Kyung Yong Lee, Min Ji Ko, Seo Young Park, Jeeheon Kang, Chang Hwan Jeon, Ho Lee, and Deog Su Hwang

J. Biol. Chem. 2011 286: 5414-5422.

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Replication protein A safeguards genome integrity by controlling NER incision events

René M. Overmeer, Jill Moser, Marcel Volker, Hanneke Kool, Alan E. Tomkinson, Albert A. van Zeeland, Leon H.F. Mullenders, and Maria Fousteri

JCB vol. 192 no. 3 401-415

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Amplification of a plasmid bearing a mammalian replication initiation region in chromosomal and extrachromosomal contexts

Seiyu Harada, Naoki Sekiguchi, and Noriaki Shimizu

Nucl. Acids Res. 2011 39: 958-969

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Functional regulation of FEN1 nuclease and its link to cancer

Li Zheng, Jia Jia, L. David Finger, Zhigang Guo, Cindy Zer,and Binghui Shen

Nucl. Acids Res. 2011 39: 781-794;

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Replication-compromised cells require the mitotic checkpoint to prevent tetraploidization

Zilai Zhang, Sumit Arora, Yanjiao Zhou, Athena Cherry and Teresa S.-F. Wang

CHROMOSOMA Volume 120, Number 1, 73-82

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Regulation of DNA replication by chromatin structures: accessibility and recruitment

Makoto T. Hayashi and Hisao Masukata

CHROMOSOMA Volume 120, Number 1, 39-46,

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Replication timing of pseudo-NORs

Evgeny Smirnov, Dušan Cmarko, Lubomír Kováčik, Guy M. Hagen, Alexey Popov, Otakar Raška, José-Luis Prieto, Boris Ryabchenko, Filipa Amim, Brian McStay and Ivan Rašk

Journal of Structural Biology Volume 173, Issue 2, February 2011, Pages 213-218

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Lysine Residue 185 of Rad1 Is a Topological but Not a Functional Counterpart of Lysine Residue 164 of PCNA

Niek Wit, Peter H. L. Krijger, Paul C. M. van den Berk, Heinz Jacobs

PLoS ONE 6(1): e16669.

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Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

Anne Letessier, Gaël A. Millot, Stéphane Koundrioukoff, Anne-Marie Lachagès, Nicolas Vogt, R. Scott Hansen, Bernard Malfoy, Olivier Brison & Michelle Debatisse

Nature 470, 120–123 (03 February 2011)

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MCM3AP Is Transcribed from a Promoter within an Intron of the Overlapping Gene for GANP

Vihandha O. Wickramasinghe, Paul I.A. McMurtrie, Jackie Marr, Yoko Amagase, Sarah Main, Anthony D. Mills, Ronald A. Laskey and Yoshinori Takei

Journal of Molecular Biology Volume 406, Issue 3, 25 February 2011, Pages 355-361

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Replication infidelity via a mismatch with Watson–Crick geometry

Katarzyna Bebenek, Lars C. Pedersen, and Thomas A. Kunkel

PNAS February 1, 2011 vol. 108 no. 5 1862-1867

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Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex

Kouta Mayanagi, Shinichi Kiyonari, Hirokazu Nishida, Mihoko Saito, Daisuke Kohda, Yoshizumi Ishino, Tsuyoshi Shiraid, and Kosuke Morikawae

PNAS February 1, 2011 vol. 108 no. 5 1845-1849

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Crystal Structure of SUMO-Modified Proliferating Cell Nuclear Antigen

Bret D. Freudenthal1, John E. Brogie1, Lokesh Gakhar, Christine M. Kondratick and M. Todd Washington

Journal of Molecular Biology Volume 406, Issue 1, 11 February 2011, Pages 9-17

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Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage

Amrita Machwe, Enerlyn Lozada, Marc S. Wold, Guo-Min Li, and David K. Orren

J. Biol. Chem. 2011 286: 3497-3508.

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A Dbf4 Mutant Contributes to Bypassing the Rad53-mediated Block of Origins of Replication in Response to Genotoxic Stress

Alba Duch, Gloria Palou, Zophonias O. Jonsson, Roger Palou, Enrique Calvo,James Wohlschlegel, and David G. Quintana

J. Biol. Chem. 2011 286: 2486-2491.

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Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

Dorjbal Dorjsuren, Daemyung Kim, David J. Maloney, David M. Wilson, III, and Anton Simeonov

Nucl. Acids Res. 2011 39: e11

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DNA is a co-factor for its own replication in Xenopus egg extracts

Ronald Lebofsky, Antoine M. van Oijen, and Johannes C. Walter

Nucl. Acids Res. 2011 39: 545-555

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Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage

Vassilis Roukos, Ali Kinkhabwala, Julien Colombelli, Panagiotis Kotsantis, Stavros Taraviras, Hideo Nishitani, Ernst Stelzer, Philippe Bastiaens and Zoi Lygerou

Journal of Cell Science 124, 422-434 (2011)

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MCM-BP regulates unloading of the MCM2–7 helicase in late S phase

Atsuya Nishiyama, Lori Frappier, and Marcel Méchali

Genes Dev. January 15, 2011 25: 165-175;

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Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload

Marjorie A. Kuipers, Timothy J. Stasevich, Takayo Sasaki, Korey A. Wilson, Kristin L. Hazelwood, James G. McNally, Michael W. Davidson, and David M. Gilbert

JCB vol. 192 no. 1 29-41

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The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells

Jingjing Zhang, Lan Yu, Xing Wu, Lan Zou, Kelvin K.L. Sou, Zhun Wei, Xue Cheng, Guang Zhu and Chun Liang

Cell cycle 9, Issue 24 December 15, 2010 Pages 4848 – 4857

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Replication termination and chromosome dimer resolution in the archaeon Sulfolobus solfataricus

Iain G Duggin, Nelly Dubarry and Stephen D Bell

The EMBO Journal (2011) 30, 145 – 153

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Proliferating Cell Nuclear Antigen-dependent Rapid Recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged Sites after UV Irradiation in HeLa Cells

Takashi Ishii, Yasushi Shiomi, Toshihiro Takami, Yusuke Murakami, Naho Ohnishi, and Hideo Nishitani

J. Biol. Chem. 2010 285: 41993-42000.

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An Alternative Pathway for Okazaki Fragment Processing: RESOLUTION OF FOLD-BACK FLAPS BY Pif1 HELICASE

Jason E. Pike, Ryan A. Henry, Peter M. J. Burgers, Judith L. Campbell, and Robert A. Bambara

J. Biol. Chem. 2010 285: 41712-41723.

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The Transcription Elongation Factor Bur1-Bur2 Interacts with Replication Protein A and Maintains Genome Stability during Replication Stress

Emanuel Clausing, Andreas Mayer, Sittinan Chanarat, Barbara Muller, Susanne M. Germann, Patrick Cramer, Michael Lisby, and Katja Strasser

J. Biol. Chem. 2010 285: 41665-41674.

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Dbf4 Regulates the Cdc5 Polo-like Kinase through a Distinct Non-canonical Binding Interaction

Ying-Chou Chen and Michael Weinreich

J. Biol. Chem. 2010 285: 41244-41254.

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Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

Xin Quan Ge and J. Julian Blow

JCB vol. 191 no. 7 1285-1297

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Cyclin A Promotes S-Phase Entry via Interaction with the Replication Licensing Factor Mcm7

Taku Chibazakura, Kazuhiro Kamachi, Mayu Ohara, Shoji Tane, Hirofumi Yoshikawa, and James M. Roberts

Molecular and Cellular Biology, January 2011, p. 248-255, Vol. 31, No. 2

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DNA Replication: Making Two Forks from One Prereplication Complex

Michael Botchan, James Berger

Molecular Cell, Volume 40, Issue 6, 860-861, 22 December 2010