publication alert

Multi-step Loading of Human Minichromosome Maintenance Proteins in Live Human Cells* Ioanna-Eleni Symeonidou, Panagiotis Kotsantis, Vassilis Roukos, Maria-Anna Rapsomanik, Hernán E. Grecco, Philippe Bastiaens, Stavros Taraviras and Zoi Lygerou The Journal of Biological Chemistry, 288, 35852-35867.

publication alert

The dynamics of genome replication using deep sequencing Carolin A. Müller, Michelle Hawkins, Renata Retkute, Sunir Malla, Ray Wilson, Martin J. Blythe, Ryuichiro Nakato, Makiko Komata, Katsuhiko Shirahige, Alessandro P.S. de Moura, and Conrad A. Nieduszynski Nucl. Acids Res. 2013 42: e3

publication alert

Human Primpol1: a novel guardian of stalled replication forks Jun-Sub Im, Kyung Yong Lee, Laura W Dillon & Anindya Dutta EMBO reports (2013) 1412, 1104–1112

publication alert

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity Li Wan, Jiangman Lou, Yisui Xia, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou & Jun Huang EMBO Reports 14, 1104 (2013). doi:10.1038/embor.2013.159

publication alert

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template Neelsen, K. J., Zanini, I. M. Y., Mijic, S., Herrador, R., Zellweger, R., Ray Chaudhuri, A., Creavin, K. D., Blow, J. J., Lopes, M. Genes & Dev. 2013. 27: 2537-2542

publication alert

The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells Jeannine Gerhardt, Mark J. Tomishima, Nikica Zaninovic, Dilek Colak, Zi Yan, Qiansheng Zhan, Zev Rosenwaks, Samie R. Jaffrey, Carl L. Schildkraut. Molecular Cell, 27 November 2013

publication alert

A Role for USP7 in DNA Replication Jagannathan, M., Nguyen, T., Gallo, D., Luthra, N., Brown, G. W., Saridakis, V., Frappier, L. Mol. Cell. Biol. January 2014 vol. 34 no. 1 132-145

publication alert

Cell Division Cycle 7 Mediates Transforming Growth Factor-β-induced Smooth Muscle Maturation through Activation of Myocardin Gene Transcription Ning Shi and Shi-You Chen J. Biol. Chem. 2013; 288:34336-34342

publication alert

Opening pathways of the DNA clamps proliferating cell nuclear antigen and Rad9-Rad1-Hus1 Xiaojun Xu, Carlo Guardiani, Chunli Yan, and Ivaylo Ivanov Nucl. Acids Res. 2013 41: 10020-10031

publication alert

Mapping of active replication origins in vivo in thaum- and euryarchaeal replicons Erik A. Pelve, Willm Martens-Habbena, David A. Stahl and Rolf Bernander Molecular Microbiology Volume 90, Issue 3, pages 538–550, November 2013

publication alert

General and specific replication profiles are detected in normal human cells by genome-wide and single-locus molecular combing Elisa Palumbo, Elena Tosoni, Antonella Russo Experimental Cell Research Volume 319, Issue 20, 10 December 2013, Pages 3081–3093

publication alert

Repriming of DNA synthesis at stalled replication forks by human PrimPol Silvana Mourón, Sara Rodriguez-Acebes, María I Martínez-Jiménez, Sara García-Gómez, Sandra Chocrón, Luis Blanco & Juan Méndez Nature Structural & Molecular Biology 20, 1383–1389 (2013)

publication alert

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication Monica M. Olcina,Iosifina P. Foskolou,Selvakumar Anbalagan,Joana M. Senra,Isabel M. Pires,Yanyan Jiang, Anderson J. Ryan,Ester M. Hammond Molecular Cell, 21 November 2013

publication alert

PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome Sean G. Rudd,Lucy Glover,Stanislaw K. Jozwiakowski,David Horn,Aidan J. Doherty Molecular Cell, Volume 52, Issue 4, 554-565, 21

publication alert

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication Julie Bianchi,Sean G. Rudd,Stanislaw K. Jozwiakowski,Laura J. Bailey,Violetta Soura,Elaine Taylor,Irena Stevanovic,Andrew J. Green,Travis H. Stracker,Howard D. Lindsay,Aidan J. Doherty Molecular Cell, Volume 52, Issue 4, 566-573, 21

publication alert

Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts Timothy J. Newman, Mohammed A. Mamun, Conrad A. Nieduszynski, and J. Julian Blow Nucl. Acids Res. 2013 41: 9705-9718

publication alert

Naked Replication Forks Break apRPArt Oscar Fernandez-Capetillo,André Nussenzweig Cell, Volume 155, Issue 5, 979-980

publication alert

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA Luis Ignacio Toledo, Matthias Altmeyer, Maj-Britt Rask, Claudia Lukas, Dorthe Helena Larsen, Lou Klitgaard Povlsen, Simon Bekker-Jensen, Niels Mailand, Jiri Bartek, Jiri Lukas Cell, Volume 155, Issue 5, 1088-1103

publication alert

ATR–Chk1–APC/CCdh1-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress Masayuki Yamada, Kenji Watanabe, Martin Mistrik1, Eva Vesela1, Iva Protivankova1, Niels Mailand, MyungHee Lee, Hisao Masai, Jiri Lukas and Jiri Bartek Genes & Dev. 2013. 27: 2459-2472

publication alert

The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability José M. Santos-Pereira1, Ana B. Herrero2, María L. García-Rubio1,4, Antonio Marín4, Sergio Moreno2,3 and Andrés Aguilera Genes & Dev. 2013. 27: 2445-2458

publication alert

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing Christophe Caillat, Dafni-Eleftheria Pefani, Peter J. Gillespie, Stavros Taraviras, J. Julian Blow, Zoi Lygerou, and Anastassis Perrakis J. Biol. Chem. 2013; 288:31624-31634

publication alert

Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry Bianca M. Sirbu, W. Hayes McDonald, Huzefa Dungrawala, Akosua Badu-Nkansah, Gina M. Kavanaugh, Yaoyi Chen, David L. Tabb, and David Cortez J. Biol. Chem. 2013; 288:31458-31467

journal issue alert

Journal of Molecular Biology Volume 425, Issue 23, Pages 4659-4856 (29 November 2013) Replicon Theory, Regulation of DNA Replication and Genomic Instability

publication alert

Alternative replication factor C protein, Elg1, maintains chromosome stability by regulating PCNA levels on chromatin Yasushi Shiomi*, Hideo Nishitani Genes to Cells Volume 18, Issue 11, pages 946–959, November 2013

publication alert

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells Sara García-Gómez,Aurelio Reyes,María I. Martínez-Jiménez,E. Sandra Chocrón,Silvana Mourón,Gloria Terrados,Christopher Powell,Eduardo Salido,Juan Méndez,Ian J. Holt,Luis Blanco Molecular Cell, 24 October 2013

publication alert

Knockdown of SCFSkp2 Function Causes Double-Parked Accumulation in the Nucleus and DNA Re-Replication in Drosophila Plasmatocytes Paul T. Kroeger Jr.,Douglas A. Shoue, 


Frank M. Mezzacappa, 


Gary F. Gerlach, 


Rebecca A. Wingert, 


Robert A. Schulz PLoS ONE 8(10): e79019.

publication alert

Degradation of p12 Subunit by CRL4^Cdt2 E3 Ligase Inhibits Fork Progression after DNA Damage Kenta Terai, Etsuko Shibata, Tarek Abbas, and Anindya Dutta J. Biol. Chem. 2013; 288:30509-30514

publication alert

Human Origin Recognition Complex Binds Preferentially to G-quadruplex-preferable RNA and Single-stranded DNA Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga,Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, and Shou Waga J. Biol. Chem. 2013; 288:30161-30171

publication alert

Control of DNA Replication by the Nucleus/Cytoplasm Ratio in Xenopus Christopher M. Murphy and W. Matthew Michael J. Biol. Chem. 2013; 288:29382-29393

publication alert

Dna2 Is Involved in CA Strand Resection and Nascent Lagging Strand Completion at Native Yeast Telomeres Martin E. Budd and Judith L. Campbell J. Biol. Chem. 2013; 288:29414-29429

publication alert

A Novel Function of CRL4/Cdt2: REGULATION OF THE SUBUNIT STRUCTURE OF DNA POLYMERASE ? IN RESPONSE TO DNA DAMAGE AND DURING THE S PHASE Sufang Zhang, Hong Zhao, Zbiegniew Darzynkiewicz, Pengbo Zhou, Zhongtao Zhang, Ernest Y. C. Lee, and Marietta Y. W. T. Lee J. Biol. Chem. 2013; 288:29550-29561

publication alert

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication Jean-Baptiste Vannier, Sumit Sandhu, Mark IR. Petalcorin, Xiaoli Wu, Zinnatun Nabi, Hao Ding, and Simon J. Boulton Science 11 October 2013: Vol. 342 no. 6155 pp. 239-242

publication alert

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication Atsuya Nishiyama, Luna Yamaguchi, Jafar Sharif, Yoshikazu Johmura, Takeshi Kawamura, Keiko Nakanishi, Shintaro Shimamura, Kyohei Arita, Tatsuhiko Kodama, Fuyuki Ishikawa, Haruhiko Koseki & Makoto Nakanishi Nature 502, 249–253

publication alert

Kinetic Mechanism of DNA Polymerization Catalyzed by Human DNA Polymerase ε Walter J. Zahurancik, Seth J. Klein, and Zucai Suo Biochemistry, 2013, 52 (40), pp 7041–7049

publication alert

Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering Mairi Louise Kilkenny, Michael Anthony Longo, Rajika L. Perera, and Luca Pellegrini PNAS October 1, 2013 vol. 110 no. 40 15961-15966

publication alert

Dissection of the Beta-Globin Replication-Initiation Region Reveals Specific Requirements for Replicator Elements during Gene Amplification Naoya Okada, Noriaki Shimizu PLoS ONE 8(10): e77350

publication alert

Stochastic association of neighboring replicons creates replication factories in budding yeast Nazan Saner, Jens Karschau, Toyoaki Natsume, Marek Gierliński, Renata Retkute, Michelle Hawkins, Conrad A. Nieduszynski, J. Julian Blow, Alessandro P.S. de Moura, and Tomoyuki U. Tanaka JCB vol. 202 no. 7 1001-1012

publication alert

High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins Rodrigo Lombraña, Ricardo Almeida, Isabel Revuelta, Sofia Madeira, Gonzalo Herranz, Néstor Saiz, Ugo Bastolla & María Gómez The EMBO Journal 32, 2631 (2013)

publication alert

Cell cycle-dependent formation of Cdc45–Claspin complexes in human cells is compromized by UV-mediated DNA damage Ronan Broderick, Michael D. Rainey, Corrado Santocanale, Heinz P. Nasheuer FEBS Journal Volume 280, Issue 19, pages 4888–4902, October 2013

no postings this week

publication alert

A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast by Timothy Hoggard, Erika Shor, Carolin A. Müller, Conrad A. Nieduszynski, Catherine A. Fox PLoS Genet 9(9): e1003798.

publication alert

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts Elaine M. Taylor, Nicola M. Bonsu, R. Jordan Price, and Howard D. Lindsay Nucl. Acids Res. 2013 41: 7725-7737

publication alert

The Mini-Chromosome Maintenance (Mcm) Complexes Interact with DNA Polymerase α-Primase and Stimulate Its Ability to Synthesize RNA Primers Zhiying You, Mariarosaria De Falco, Katsuhiko Kamada, 
Francesca M. Pisani , 
Hisao Masai PLoS ONE 8(8): e72408.

publication alert

Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes Bruce Stillman PNAS August 27, 2013 vol. 110 no. 35 14120-14121

publication alert

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling Gérald Lossaint, Marion Larroque, Cyril Ribeyre, Nicole Bec, Christian Larroque, Chantal Décaillet, Kerstin Gari, Angelos Constantinou. Molecular Cell, 29 August 2013

publication alert

Titration of Four Replication Factors Is Essential for the Xenopus laevis Midblastula Transition Clara Collart, George E. Allen, Charles R. Bradshaw1, James C. Smith, Philip Zegerman Science 23 August 2013: Vol. 341 no. 6148 pp. 893-896

publication alert

Avoiding chromosome pathology when replication forks collide Christian J. Rudolph, Amy L. Upton, Anna Stockum, Conrad A. Nieduszynski & Robert G. Lloyd Nature 500, 608–611

publication alert

Cell Cycle-dependent Subcellular Translocation of the Human DNA Licensing Inhibitor Geminin Maria Dimaki, Georgia Xouri, Ioanna-Eleni Symeonidou, Chaido Sirinian, Hideo Nishitani, Stavros Taraviras, and Zoi Lygerou J. Biol. Chem. 2013 288: 23953-23963.

publication alert

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts Vincent Gaggioli, Barbara Le Viet, Thomas Germe, and Olivier Hyrien Nucl. Acids Res. 2013 41: 7313-7331

publication alert

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA Jingchuan Sun, Cecile Evrin, Stefan A Samel, Alejandra Fernández-Cid, Alberto Riera, Hironori Kawakami, Bruce Stillman, Christian Speck & Huilin Li Nature Structural & Molecular Biology 20, 944–951

publication alert

The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties Roberta Di Perna, Valentina Aria, Mariarosaria De Falco, Vincenzo Sannino, Andrei L. Okorokov, Francesca M. Pisani and Mariarita De Felice Biochem. J. (2013) 454 (333–343)

publication alert

Concerted interaction between origin recognition complex (ORC), nucleosomes and replication origin DNA ensures stable ORC–origin binding Kohji Hizume, Masaru Yagura and Hiroyuki Araki Genes to Cells Volume 18, Issue 9, pages 764–779, September 2013

no postings this week

no postings this week

publication alert

FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery Indrajit Chaudhury, Archana Sareen, Maya Raghunandan, and Alexandra Sobeck Nucl. Acids Res. 2013 41: 6444-6459

publication alert

Activation of a human chromosomal replication origin by protein tethering Xiaomi Chen, Guoqi Liu, and Michael Leffak Nucl. Acids Res. 2013 41: 6460-6474

publication alert

ATR phosphorylates SMARCAL1 to prevent replication fork collapse Frank B. Couch, Carol E. Bansbach, Robert Driscoll, Jessica W. Luzwick, Gloria G. Glick, Rémy Bétous, Clinton M. Carroll, Sung Yun Jung, Jun Qin, Karlene A. Cimprich and David Cortez Genes & Dev. 2013. 27: 1610-1623

publication alert

Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication Andrea Ballabenia, Raffaella Zamponib, Jodene K. Moorea, Kristian Helinc,d, and Marc W. Kirschner PNAS July 23, 2013 vol. 110 no. 30 E2848-E2853

publication alert

Over Expression of Minichromosome Maintenance Genes is Clinically Correlated to Cervical Carcinogenesis Mitali Das, Babu Prasad, 
X

Suresh Singh Yadav, 


H. B. Govardhan,


Lakshmi Kant Pandey, 


Sunita Singh, 


Satyajit Pradhan,Gopeshwar Narayan PLoS ONE 8(7): e69607

publication alert

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy Michael N Weedon, Sian Ellard, Marc J Prindle, Richard Caswell, Hana Lango Allen, Richard Oram, Koumudi Godbole, Chittaranjan S Yajnik, Paolo Sbraccia, Giuseppe Novelli, Peter Turnpenny, Emma McCann, Kim Jee Goh, Yukai Wang, Jonathan Fulford, Laura J McCulloch, David B Savage, Stephen O'Rahilly, Katarina Kos, Lawrence A Loeb, Robert K Semple & Andrew T Hattersley Nature Genetics 45, 947–950 (2013)

no postings this week

publication alert

Phosphorylation of Minichromosome Maintenance Protein 7 (MCM7) by Cyclin/Cyclin-dependent Kinase Affects Its Function in Cell Cycle Regulation Qian Wei, Junhui Li, Ting Liu, Xiaomei Tong, and Xin Ye J. Biol. Chem. 2013 288: 19715-19725.

publication alert

Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response Bachar H. Hassan, Laura A. Lindsey-Boltz, Michael G. Kemp, and Aziz Sancar J. Biol. Chem. 2013 288: 18903-18910.

publication alert

DNA Replication Checkpoint Signaling Depends on a Rad53–Dbf4 N-Terminal Interaction in Saccharomyces cerevisiae Ying-Chou Chen, Jessica Kenworthy, Carrie Gabrielse, Christine Hänni, Philip Zegerman, and Michael Weinreich Genetics June 2013 194:389-401;

publication alert

Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases Chia Yee Tan, Thilo Hagen The International Journal of Biochemistry & Cell Biology Volume 45, Issue 7, July 2013, Pages 1489–1498

publication alert

INK4a/ARF limits the expansion of cells suffering from replication stress Angela Monasor, Matilde Murga, Andres J. Lopez-Contreras, Carolina Navas, Gonzalo Gomez, David G. Pisano and Oscar Fernandez-Capetillo Cell cycle 12 Pages 1948 – 1954

publication alert

Brc1 links replication stress response and centromere function Si Young Lee, Paul Russell Cell cycle 12 1665 – 1671

no postings this week

no postings this week

publication alert

Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle Haiqing Fu, 


Alika K. Maunakea, Melvenia M. Martin,


Liang Huang, 


Ya Zhang, 


Michael Ryan, 


RyangGuk Kim, Chii Meil Lin, 


Keji Zhao, 


Mirit I. Aladjem PLoS Genet 9(6): e1003542

publication alert

Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction Seiji Tanakaa,b, Yayoi Komedaa, Toshiko Umemoria, Yumiko Kubotac, Haruhiko Takisawac and Hiroyuki Araki Mol. Cell. Biol. July 2013 vol. 33 no. 13 2614-2622

publication alert

Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome Nadezhda E. Vorobyeva, Marina U. Mazina, Anton K. Golovnin, Daria V. Kopytova, Dmitriy Y. Gurskiy, Elena N. Nabirochkina, Sofia G. Georgieva, Pavel G. Georgiev, and Aleksey N. Krasnov Nucl. Acids Res. 2013 41: 5717-5730

publication alert

Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment Toyoaki Natsume, Carolin A. Müller, Yuki Katou, Renata Retkute, Marek Gierliński, Hiroyuki Araki, J. Julian Blow, Katsuhiko Shirahige, Conrad A. Nieduszynski, Tomoyuki U. Tanaka Molecular Cell, Volume 50, Issue 5, 661-674

publication alert

Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells Dominik Boos, Mona Yekezare, John F. X. Diffley Science 24 May 2013: Vol. 340 no. 6135 pp. 981-984

publication alert

Pif1 family helicases suppress genome instability at G-quadruplex motifs Katrin Paeschke, Matthew L. Bochman, P. Daniela Garcia, Petr Cejka, Katherine L. Friedman, Stephen C. Kowalczykowski & Virginia A. Zakian Nature 497, 458–462 (23 May 2013)

publication alert

Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions with Distinct Mcm2-7 Protein Subunits Matthew D. Ramer, Evelyin S. Suman, Hagen Richter, Karen Stanger, Martina Spranger, Nicole Bieberstein, and Bernard P. Duncker J. Biol. Chem. 2013 288: 14926-14935.

publication alert

Coordinated Processing of 3' Slipped (CAG)n/(CTG)n Hairpins by DNA Polymerases {beta} and {delta} Preferentially Induces Repeat Expansions Nelson L. S. Chan, Jinzhen Guo, Tianyi Zhang, Guogen Mao, Caixia Hou, Fenghua Yuan, Jian Huang, Yanbin Zhang, Jianxin Wu, Liya Gu, and Guo-Min Li J. Biol. Chem. 2013 288: 15015-15022.

publication alert

MCM Loading—An Open-and-Shut Case? Rachel Y. Samson, Stephen D. Bell Mol cell Volume 50, Issue

publication alert

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly Alejandra Fernández-Cid, Alberto Riera, Silvia Tognetti, M. Carmen Herrera, Stefan Samel, Cecile Evrin, Christian Winkler, Emanuela Gardenal, Stefan Uhle, Christian Speck Molecular Cell, Volume 50, Issue 4, 577-588, 18 April 2013

publication alert

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins Huan Chen, Michael Lisby, Lorraine S. Symington Molecular Cell, Volume 50, Issue 4, 589-600, 23 May 2013

publication alert

Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint Michael D. Rainey, Brendan Harhen, Guan-Nan Wang, Paul V. Murphy and Corrado Santocanale Cell cycle 12 
Pages 1560 – 1568

publication alert

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity Weiqiang Lin, Shilpa Sampathi, Huifang Dai, Changwei Liu, Mian Zhou, Jenny Hu, Qin Huang, Judith Campbell, Kazuo Shin-Ya, Li Zheng, Weihang Chai and Binghui Shen The EMBO Journal 32, 1425 – 1439

no postings this week

publication alert

The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase {epsilon} and Stimulates Its Synthetic Activity Valentina Aria, Mariarita De Felice, Roberta Di Perna, Shuji Uno, Hisao Masai, Juhani E. Syvaoja, Barbara van Loon, Ulrich Hubscher, and Francesca M. Pisani J. Biol. Chem. 2013 288: 12742-12752.

publication alert

The level of origin firing inversely affects the rate of replication fork progression Yuan Zhong, Tittu Nellimoottil, Jared M. Peace, Simon R.V. Knott, Sandra K. Villwock, Janis M. Yee, Jeffrey M. Jancuska, Sanket Rege, Marianne Tecklenburg, Robert A. Sclafani, Simon Tavaré, and Oscar M. Aparicio JCB vol. 201 no. 3 373-383

publication alert

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis Valérie Bergoglio, Anne-Sophie Boyer, Erin Walsh, Valeria Naim, Gaëlle Legube, Marietta Y.W.T. Lee, Laurie Rey, Filippo Rosselli, Christophe Cazaux, Kristin A. Eckert, and Jean-Sébastien Hoffmann JCB vol. 201 no. 3 395-408

publication alert

Controlling DNA replication origins in response to DNA damage – inhibit globally, activate locally Mona Yekezare, Belén Gómez-González and John F. X. Diffley J Cell Sci 126, 1297-1306

publication alert

PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase δ, η, and ζ activities Jian Lia,b, Donald L. Holzschua,b, and Tomohiko Sugiyama PNAS May 7, 2013 vol. 110 no. 19 7672-7677

publication alert

The Elg1 Replication Factor C-like Complex Functions in PCNA Unloading during DNA Replication Takashi Kubota, Kohei Nishimura, Masato T. Kanemaki, Anne D. Donaldson Molecular Cell, Volume 50, Issue 2, 273-280, 14 March 2013

publication alert

Genetic and Biochemical Assays Reveal a Key Role for Replication Restart Proteins in Group II Intron Retrohoming Jun Yao, 


David M. Truong, Alan M. Lambowitz PLoS Genet 9(4): e1003469.

publication alert

Silvia Onesti, Stuart A. MacNeill Structure and evolutionary origins of the CMG complex Chromosoma Volume 122, Issue 1-2, pp 47-53

publication alert

Dpb2 Integrates the Leading-Strand DNA Polymerase into the Eukaryotic Replisome Sugopa Sengupta, Frederick van Deursen, Giacomo de Piccoli, Karim Labib Current Biology, Volume 23, Issue 7, 543-552, 14 March 2013


publication alert

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation Agnieszka Gambus and J. Julian Blow Cell cycle Volume 12, Issue 8 April 15, 2013

publication alert

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation Samuel T. Fatoba, Silvia Tognetti, Melissa Berto, Elisabetta Leo, Claire M. Mulvey, Jasminka Godovac-Zimmermann, Yves Pommier, and Andrei L. Okorokov Nucl. Acids Res. 2013 41: 4065-4079

publication alert

Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks Mari Fujita, 
Hiroyuki Sasanuma, Kimiyo N. Yamamoto, Hiroshi Harada, 
Aya Kurosawa, 


Noritaka Adachi, 
Masato Omura, Masahiro Hiraoka, Shunichi Takeda, 
Kouji Hirota PLoS ONE 8(4): e60043

publication alert

ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin Replication Gregory A. Sowd, Nancy Yan Li, 


Ellen Fanning PLoS Pathog 9(4): e1003283

publication alert

A solution to release twisted DNA during chromosome replication by coupled DNA polymerases Isabel Kurth, Roxana E. Georgescu & Mike E. O'Donnell Nature 496, 119–122

publication alert

ATPase-dependent quality control of DNA replication origin licensing Jordi Frigola, Dirk Remus, Amina Mehanna & John F. X. Diffley Nature 495, 339–343 (21 March 2013)

publication alert

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates Kai J. Neelsen, Isabella M.Y. Zanini, Raquel Herrador, and Massimo Lopes J. Cell Biology 200:699-708.

publication alert

CUL4B promotes replication licensing by up-regulating the CDK2–CDC6 cascade Yongxin Zou, Jun Mi, Wenxing Wang, Juanjuan Lu, Wei Zhao, Zhaojian Liu, Huili Hu, Yang Yang, Xiaoxing Gao, Baichun Jiang, Changshun Shao, and Yaoqin Gong J. Cell Biology 200:743-756.

publication alert

Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast Lindsey N. Williams, Alan J. Herr and Bradley D. Preston Genetics March 1, 2013 vol. 193 no. 3 751-770

publication alert

Identification, quantification, and evolutionary analysis of a novel isoform of MCM9 Original Research Elizabeth P. Jeffries, William I. Denq, Jonathan C. Bartko, Michael A. Trakselis Gene Volume 519, Issue 1, 25 April 2013, Pages 41–49

publication alert

Hypothesis: Local dNTP depletion as the cause of microsatellite repeat instability during replication Michael Leffak BioEssays Volume 35, Issue 4, page 305, April 2013

publication alert

Inhibition of DNA synthesis facilitates expansion of low-complexity repeats:Is strand slippage stimulated by transient local depletion of specific dNTPs? Andrei Kuzminov BioEssays Volume 35, Issue 4, pages 306–313, April 2013

publication alert

Chromosome Biology: Conflict Management for Replication and Transcription James M. Dewar, Johannes C. Walter Current Biology, Volume 23, Issue 5, R200-R202

publication alert

Enigmatic roles of Mcm10 in DNA replication Yee Mon Thu, Anja-Katrin Bielinsky Tibs Volume 38, Issue 4, April 2013, Pages 184–194

publication alert

Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication Yan Li and Hiroyuki Araki Genes to Cells Volume 18, Issue 4, pages 266–277, April 2013

publication alert

Novel Interaction of the Bacterial-Like DnaG Primase with the MCM Helicase in Archaea Robert J. Bauer, Brian W. Graham, Michael A. Trakselis Journal of Molecular Biology Volume 425, Issue 8, 26 April 2013, Pages 1259–1273

publication alert

The N-terminal 45-kDa Domain of Dna2 Endonuclease/Helicase Targets the Enzyme to Secondary Structure DNA Chul-Hwan Lee, Miju Lee, Hyo-Jin Kang, Do-Hyung Kim, Young-Hoon Kang, Sung-Ho Bae, and Yeon-Soo Seo J. Biol. Chem. 2013 288: 9468-9481.

publication alert

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure Rebekka A. Schwab1, Jadwiga Nieminuszczy1,2, Kazuo Shin-ya3, and Wojciech Niedzwiedz JCB vol. 201 no. 1 33-48

publication alert

Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains Niels Van der Aa, Jiqiu Cheng, Ligia Mateiu, Masoud Zamani Esteki, Parveen Kumar, Eftychia Dimitriadou, Evelyne Vanneste, Yves Moreau, Joris Robert Vermeesch, and Thierry Voet Nucl. Acids Res. 2013 41: e66

publication alert

Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome Tom Stiff, Meryem Alagoz,Diana Alcantara, Emily Outwin, Han G. Brunner, Ernie M. H. F. Bongers, Mark O'Driscoll, Penny A. Jeggo PLoS Genet 9(3): e1003360

publication alert

Cdc45 Protein-Single-stranded DNA Interaction Is Important for Stalling the Helicase during Replication Stress Irina Bruck and Daniel L. Kaplan J. Biol. Chem. 2013 288: 7550-7563.

publication alert

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization Cecile Evrin, Alejandra Fernández-Cid, Juergen Zech, M. Carmen Herrera, Alberto Riera, Pippa Clarke, Shlomo Brill, Rudi Lurz, and Christian Speck Nucl. Acids Res. 2013 41: 3162-3172

publication alert

Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology Ian M. Slaymaker, Yang Fu, Daniel B. Toso, Nimna Ranatunga, Aaron Brewster, Susan L. Forsburg, Z. Hong Zhou, and Xiaojiang S. Chen Nucl. Acids Res. 2013 41: 3446-3456

publication alert

The Fission Yeast Minichromosome Maintenance (MCM)-binding Protein (MCM-BP), Mcb1, Regulates MCM Function during Prereplicative Complex Formation in DNA Replication Venny Santosa, Sabrina Martha, Noriaki Hirose, and Katsunori Tanaka J. Biol. Chem. 2013 288: 6864-6880.

publication alert

SCFFbxw15 Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation Chunbin Zou, Yan Chen, Rebecca M. Smith, Courtney Snavely, Jin Li, Tiffany, A. Coon, Bill B. Chen, Yutong Zhao, and Rama K. Mallampalli J. Biol. Chem. 2013 288: 6306-6316.

publication alert

Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis Hui Hua, Mandana Namdar, Olivier Ganier, Juraj Gregan, Marcel Méchali, and Stephen E. Kearsey Mol. Biol. Cell 2013 24:5 578-587

publication alert

A Substitution in the Fingers Domain of DNA Polymerase {delta} Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site Marc J. Prindle, Michael W. Schmitt, Fabio Parmeggiani, and Lawrence A. Loeb J. Biol. Chem. 2013 288: 5572-5580.

publication alert

Chromatin-dependent and -independent regulation of DNA replication origin activation in budding yeast Marko Lõoke, Kersti Kristjuhan, Signe Värv & Arnold Kristjuhan EMBO reports (2013), 14,191 – 198

publication alert

Translocation and Stability of Replicative DNA Helicases upon Encountering DNA-Protein Cross-links Toshiaki Nakano, Mayumi Miyamoto-Matsubara, Mahmoud I. Shoulkamy, Amir M. H. Salem, Seung Pil Pack, Yukio Ishimi, and Hiroshi Ide J. Biol. Chem. 2013 288: 4649-4658.

publication alert

Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases Won-Ho Cho, Young-Hoon Kang, Yun-Young An, Inger Tappin, Jerard Hurwitz, and Joon-Kyu Lee, PNAS February 12, 2013 vol. 110 no. 7 2523-2527

publication aler

Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase {delta} for Degradation in Response to DNA Damage Sufang Zhang, Yajing Zhou, Ali Sarkeshik, John R. Yates III, Timothy M. Thomson, Zhongtao Zhang, Ernest Y. C. Lee and Marietta Y. W. T. Lee J. Biol. Chem. 2013 288: 2951.

publication alert

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability Jacqueline H. Barlow, Robert B. Faryabi, Elsa Callén, Nancy Wong, Amy Malhowski, Hua Tang Chen, Gustavo Gutierrez-Cruz, Hong-Wei Sun, Peter McKinnon, George Wright, Rafael Casellas, Davide F. Robbiani, Louis Staudt, Oscar Fernandez-Capetillo, André Nussenzweig Cell, Volume 152, Issue 3, 620-632, 24 January 2013

publication alert

Location, location, location: it's all in the timing for replication origins Oscar M. Aparicio Genes & Dev. 2013. 27: 117-128

publication alert

Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination Kenneth J. Finn and 


Joachim J. Li PLoS Genet 9(1): e1003192

publication alert

Phosphoinositide 3-kinase beta controls replication factor C assembly and function Javier Redondo-Muñoz, María Josefa Rodríguez, Virginia Silió, Vicente Pérez-García, José María Valpuesta, and Ana C. Carrera Nucl. Acids Res. 2013 41: 855-868

publication alert

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication Erin Walsh, Xiaoxiao Wang, Marietta Y. Lee, Kristin A. Eckert Journal of Molecular Biology Volume 425, Issue 2, 23 January 2013, Pages 232–243

publication alert

A Role for H2B Ubiquitylation in DNA Replication Kelly M. Trujillo, Mary Ann Osley Molecular Cell, Volume 48, Issue 5, 734-746, 25 October 2012