publication alert

DNA replication timing alterations identify common markers between distinct progeroid diseases Juan Carlos Rivera-Muliaa, Romain Despratb, Claudia Trevilla-Garciaa, Daniela Cornacchiac, Hélène Schwererd, Takayo Sasakia, Jiao Simaa, Tyler Fellsa, Lorenz Studerc, Jean-Marc Lemaitreb,d,1, and David M. Gilbert PNAS December 19, 2017 vol. 114 no. 51

publication alert

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ Carine Tellier-Lebegue , Eléa Dizet , Emilie Ma, Xavier Veaute, Eric Coïc, Jean-Baptiste Charbonnier, Laurent Maloisel PLoS Genet 13(12): e1007119.

publication alert

Redox-sensitive alteration of replisome architecture safeguards genome integrity Kumar Somyajit, Rajat Gupta, Hana Sedlackova, Kai John Neelsen, Fena Ochs, Maj-Britt Rask, Chunaram Choudhary, Jiri Lukas Science 10 Nov 2017: Vol. 358, Issue 6364, pp. 797-802

publication alert

The need to regulate replication fork speed Belén Gómez-González, Andrés Aguilera Science 10 Nov 2017:Vol. 358, Issue 6364, pp. 722-723

publication alert

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model Yasunori Noguchi, Zuanning Yuan, Lin Bai, Sarah Schneider, Gongpu Zhao, Bruce Stillman, Christian Specka, and Huilin Li PNAS 114 E9529–E9538

publication alert

Initiation of DNA replication requires actin dynamics and formin activity Nikolaos Parisis, Liliana Krasinska, Bethany Harker, Serge Urbach, Michel Rossignol, Alain Camasses, James Dewar, Nathalie Morin, Daniel Fisher The EMBO Journal (2017) 36, 3212-3231

publication alert

MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication Akiko Kumagai and William G. Dunphy Mol. Biol. Cell November 1, 2017 vol. 28 no. 22 2998-3012

publication alert

PrimPol is required for replication reinitiation after mtDNA damage Rubén Torregrosa-Muñumer, Josefin M. E. Forslund, Steffi Goffart, Annika Pfeiffer, Gorazd Stojkovič, Gustavo Carvalho, Natalie Al-Furoukh, Luis Blanco, Sjoerd Wanrooij, and Jaakko L. O. Pohjoismäki PNAS 114 11398–11403

publication alert

publication alert

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress Haiyun Gan, Chuanhe Yu, Sujan Devbhandari, Sushma Sharma, Junhong Han, Andrei Chabes, Dirk Remus, Zhiguo Zhang Molecular Cell Volume 68, Issue 2, p446–455.e3, 19 October 2017

publication alert

Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast Joseph C. Sanchez, Elizabeth X. Kwan, Thomas J. Pohl, Haley M. Amemiya, M. K. Raghuraman, Bonita J. Brewer PLoS Genet13(10): e1007041.

publication alert

Both DNA Polymerases δ and ε Contact Active and Stalled Replication Forks Differently Chuanhe Yua, Haiyun Ganb and Zhiguo Zhang Mol. Cell. Biol. November 2017 vol. 37 no. 21 e00190-17

publication alert

The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis Mariko Nagata; Sonoko Ishino; Takeshi Yamagami; Hiromi Ogino; Jan-Robert Simons ... Nucleic Acids Research, Volume 45, Issue 18, 13 October 2017, Pages 10693–10705,

publication alert

Plant organellar DNA polymerases are replicative and translesion DNA synthesis polymerases Noe Baruch-Torres; Luis G. Brieba Nucleic Acids Research, Volume 45, Issue 18, 13 October 2017, Pages 10751–10763,

publication alert

Plant organellar DNA primase-helicase synthesizes RNA primers for organellar DNA polymerases using a unique recognition sequence Antolín Peralta-Castro; Noe Baruch-Torres; Luis G. Brieba Nucleic Acids Research, Volume 45, Issue 18, 13 October 2017, Pages 10764–10774,

publication alert

Pre‐initiation complex assembly functions as a molecular switch that splits the Mcm2‐7 double hexamer Mayumi Miyazawa‐Onami, Hiroyuki Araki, Seiji Tanaka EMBO Reports (2017) 18: 1752–1761

publication alert

Mrc1/Claspin: a new role for regulation of origin firing Hisao Masai, Chi-Chun Yang, Seiji Matsumoto Curr genetics Volume 63, Issue 5, October 2017813-815

publication alert

DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression Brian L. Hua and Terry L. Orr-Weaver GENETICS September 1, 2017 vol. 207 no. 1 29-47

publication alert

Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani Satya Prakash Yadav, Prashant Kumar Singh, Pradeep Sharma, Naseer Iqbal, Punit Kaur, Sujata Sharma, Tej P. Singh BBA proteins and proteomics 1865 Pages 1395-1405

publication alert

PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation Sheng-Qi Hou, Meng Ouyang, Andrew Brandmaier, Hongbo Hao and Wen H. Shen Bioessays 39

publication alert

Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction Agustin I. Seoane, David O. Morgan Current biology Volume 27, Issue 18, p2849–2855.e2, 25 September 2017

publication alert

Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome Jacob S. Lewis, Lisanne M. Spenkelink, Grant D. Schauer, Flynn R. Hill, Roxanna E. Georgescu, Michael E. O’Donnell, and Antoine M. van Oijen PNAS vol. 114 no. 40 > Jacob S. Lewis, 10630–10635

publication alert

The abundance of Fob1 modulates the efficiency of rRFBs to stall replication forks Alicia Castán; Pablo Hernández; Dora B. Krimer; Jorge B. Schvartzman Nucleic Acids Research, Volume 45, Issue 17, 29 September 2017, Pages 10089–10102,

publication alert

The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome Inyoung Lee, Gwang Su Kim, Jun Sung Bae, Jaeyoun Kim, Kunsoo Rhee and Deog Su Hwang J. Biol. Chem. 2017; 292:16267-16276

publication alert

Crystal structure of the human Polϵ B-subunit in complex with the C-terminal domain of the catalytic subunit Andrey G. Baranovskiy, Jianyou Gu, Nigar D. Babayeva, Igor Kurinov, Youri I. Pavlov and Tahir H. Tahirov J. Biol. Chem. 2017; 292:15717-15730

publication alert

Linchpin DNA-binding residues serve as go/no-go controls in the replication factor C-catalyzed clamp-loading mechanism Juan Liu, Yayan Zhou and Manju M. Hingorani J. Biol. Chem. 2017; 292:15892-15906

publication alert

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro Dekang Liu; Jane H. Frederiksen; Sascha E. Liberti; Anne Lützen; Guido Keijzers... Nucleic Acids Research, Volume 45, Issue 16, 19 September 2017, Pages 9427–9440

publication alert

STN1–POLA2 interaction provides a basis for primase-pol α stimulation by human STN1 Swapna Ganduri Neal F. Lue Nucleic Acids Research, Volume 45, Issue 16, 19 September 2017, Pages 9455–9466,

publication alert

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork Shankar Parajuli, Daniel C. Teasley, Bhavna Murali, Jessica Jackson, Alessandro Vindigni and Sheila A. Stewart J. Biol. Chem. 2017; 292:15216-15224

publication alert

Histone H4K20 tri‐methylation at late‐firing origins ensures timely heterochromatin replication Julien Brustel, Nina Kirstein, Fanny Izard, Charlotte Grimaud, Paulina Prorok, Christelle Cayrou, Gunnar Schotta, Alhassan F Abdelsamie, Jérôme Déjardin, Marcel Méchali, Giuseppe Baldacci, Claude Sardet, Jean‐Charles Cadoret, Aloys SchepersEric Julien The EMBO Journal (2017) 36: 2726–2741

publication alert

Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase Rubén Agudo Patricia A. Calvo María I. Martínez-Jiménez Luis Blanco Nucleic Acids Research, Volume 45, Issue 15, 6 September 2017, Pages 9046–9058,

publication alert

Mutant analysis of Cdt1's function in suppressing nascent strand elongation during DNA replication in Xenopus egg extracts Yuta Nakazaki, Takashi Tsuyama,Yutaro Azuma, Mikiko Takahashi, Shusuke Tada BBRC Volume 490, Issue 4, 2 September 2017, Pages 1375-1380

publication alert

Identification and characterization of ARS-like sequences as putative origin(s) of replication in human malaria parasite Plasmodium falciparum Meetu Agarwal,Krishanu Bhowmick,Kushal Shah,Annangarachari Krishnamachari,Suman Kumar Dhar Febs J. Volume 284, Issue 16 August 2017 Pages 2674–2695

publication alert

Retrotransposons are specified as DNA replication origins in the gene-poor regions of Arabidopsis heterochromatin Zaida Vergara Joana Sequeira-Mendes Jordi Morata Ramón Peiró Elizabeth Hénaff Celina Costas Josep M. Casacuberta Crisanto Gutierrez Nucleic Acids Research, Volume 45, Issue 14, 21 August 2017, Pages 8358–8368,

publication alert

Transcription-Replication Conflicts: Orientation Matters Yea-Lih Lin, Philippe Pasero Cell Volume 170, Issue 4, p603–604, 10 August 2017

publication alert

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses Stephan Hamperl, Michael J. Bocek, Joshua C. Saldivar, Tomek Swigut, Karlene A. Cimprich Cell Volume 170, Issue 4, p774–786.e19, 10 August 2017

publication alert

Replication-Transcription Conflicts Generate R-Loops that Orchestrate Bacterial Stress Survival and Pathogenesis Kevin S. Lang, Ashley N. Hall, Christopher N. Merrikh, Mark Ragheb, Hannah Tabakh, Alex J. Pollock, Joshua J. Woodward, Julia E. Dreifus, Houra Merrikh Cell Volume 170, Issue 4, p787–799.e18, 10 August 2017

publication alert

The Mcm2–7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing Masako Izumi, Takeshi Mizuno, Ken-ichiro Yanagi, Kazuto Sugimura, Katsuzumi Okumura, Naoko Imamoto, Tomoko Abe, and Fumio Hanaoka J. Biol. Chem. 2017; 292:13008-13021

publication alert

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading GIDEON COSTER, JOHN F. X. DIFFLEY Science 21 Jul 2017: Vol. 357, Issue 6348, pp. 314-318

publication alert

Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stability Koichi Utani, Haiqing Fu, Sang-Min Jang, Anna B. Marks, Owen K. Smith, Ya Zhang, Christophe E. Redon, Noriaki Shimizu, Mirit I. Aladjem Nucleic Acids Res (2017) 45 (13): 7807-7824.

publication alert

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing Yuanliang Zhai,Ningning Li, Hanlun Jiang, Xuhui Huang, Ning Gao, Bik Kwoon Tye Mol Cell Volume 67, Issue 2, p168–179, 20 July 2017

publication alert

A Comparative Analysis of Translesion DNA Synthesis Catalyzed by a High-Fidelity DNA Polymerase AnveshDasari, TejalDeodhar1 and Anthony J.Berdis Journal of Molecular Biology Volume 429, Issue 15, 21 July 2017, Pages 2308-2323

publication alert

Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition Clara Collart , James C. Smith , Philip Zegerman dev cell Volume 42, Issue 1, p82–96.e3, 10 July 2017

publication alert

A replication-time-controlling sequence element in Schizosaccharomyces pombe Vishnu P. TripathiDharani D. Dubey Chromosoma August 2017, Volume 126, Issue 4, pp 465–471

publication alert

Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation LingjunKong, HuilongYin and LiYuan Biochemical and Biophysical Research Communications Volume 489, Issue 4, 5 August 2017, Pages 497-502

publication alert

Mismatch repair regulates Cdt1 after UV damage Andreas Panagopoulos, Stavros Taraviras & Zoi Lygerou Cell Cycle Volume 16, 2017 - Issue 12

publication alert

A stitch in time: Replicate early and escape dosage compensation to express more María Gómez JCB 3 July 216 (7): 1869

publication alert

DNA replication timing influences gene expression level Carolin A. Müller,Conrad A. Nieduszynski JCB 3 July 216 (7): 1907

publication alert

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2–7 Patricia Perez-Arnaiz, Irina Bruck, Max K. Colbert, Daniel L. Kaplan Nucleic Acids Res (2017) 45 (12): 7261-7275.

publication alert

Two Geminin homologs regulate DNA replication in silkworm, Bombyx mori Xiao-Fang Tang, Xiang-Yun Chen, Chun-Dong Zhang, Yao-Feng Li, Tai-Hang Liu, Xiao-Lin Zhou, show all Cell cycle Pages 830-840

publication alert

Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex Zhiying You, Hisao Masai Nucleic Acids Res (2017) 45 (11): 6494-6506.

publication alert

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion Luis Toledo , Kai John Neelsen, Jiri Lukas Mol cell Volume 66, Issue 6, p735–749, 15 June 2017

publication alert

The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome Chengcheng Guan, Jun Li, Dapeng Sun, Yingfang Liu, and Huanhuan Liang J. Biol. Chem. 2017; 292:9627-9636

publication alert

Proliferating cell nuclear antigen (PCNA) contributes to the high-order structure and stability of heterochromatin in Saccharomyces cerevisiae Bi, X., Ren, Y. & Kath, M. Chromosome Res (2017) 25: 89

publication alert

Ctf4 Prevents Genome Rearrangements by Suppressing DNA Double-Strand Break Formation and Its End Resection at Arrested Replication Forks Mariko Sasaki, Takehiko Kobayashi Mol Cell Volume 66, Issue 4, p533–545.e5, 18 May 2017

publication alert

Flexible DNA Path in the MCM Double Hexamer Loaded on DNA Kohji Hizume, Hiroaki Kominami, Kei Kobayashi, Hirofumi Yamada, and Hiroyuki Araki Biochemistry, 2017, 56 (19), pp 2435–2445

publication alert

Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase Cody M. Rogers, Joseph Che-Yen Wang, Hiroki Noguchi, Tsuyoshi Imasaki, Yuichiro Takagi, Matthew L. Bochman Nucleic Acids Res (2017) 45 (9): 5217-5230.

publication alert

PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast Yasukazu Daigaku ,Thomas J. Etheridge,Yuka Nakazawa,Mayumi Nakayama,Adam T. Watson,Izumi Miyabe,Tomoo Ogi, PLoS Genet 13(5): e1006789.

publication alert

Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges Anissia Ait Saada, Ana Teixeira-Silva, Ismail Iraqui, Audrey Costes, Julien Hardy, Giulia Paoletti, Karine Fréon, Sarah A.E. Lambert http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30232-0

publication alert

Terminating the replication helicase Vincent Gaggioli & Philip Zegerman Nature Cell Biology 19, 410–412

publication alert

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis Remi Sonneville, Sara Priego Moreno, Axel Knebel, Clare Johnson, C. James Hastie, Anton Gartner, Agnieszka Gambus & Karim Labib Nature Cell Biology 19, 468–479 (2017)

publication alert

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism John J Reynolds, Louise S Bicknell, Paula Carroll, Martin R Higgs, Ranad Shaheen, Jennie E Murray, Dimitrios K Papadopoulos, Andrea Leitch, Olga Murina, Žygimantė Tarnauskaitė, Sarah R Wessel, Anastasia Zlatanou, Audrey Vernet, Alex von Kriegsheim, Rachel M A Mottram, Clare V Logan, Hannah Bye, Yun Li, Alexander Brean, Sateesh Maddirevula, Rachel C Challis, Kassiani Skouloudaki, Agaadir Almoisheer, Hessa S Alsaif, Ariella Amar, Natalie J Prescott, Michael B Bober, Angela Duker, Eissa Faqeih, Mohammed Zain Seidahmed, Saeed Al Tala, Abdulrahman Alswaid, Saleem Ahmed, Jumana Yousuf Al-Aama, Janine Altmüller, Mohammed Al Balwi, Angela F Brady, Luciana Chessa, Helen Cox, Rita Fischetto, Raoul Heller, Bertram D Henderson, Emma Hobson, Peter Nürnberg, E Ferda Percin, Angela Peron, Luigina Spaccini, Alan J Quigley, Seema Thakur, Carol A Wise, Grace Yoon, Maha Alnemer, Pavel Tomancak, Gökhan Yigit, A Malcolm R Taylor, Martin A M Reijns, Michael A Simpson, David Cortez, Fowzan S Alkuraya, Christopher G Mathew, Andrew P Jackson & Grant S Stewart Nature Genetics 49, 537–549 (2017)

publication alert

Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells Masaki Hosogane, Lena Bosu, Emiko Fukumoto, Hidetoshi Yamada, Soichiro Sato and Keiko Nakayama Genes to cells 22 (4) 360-375 (17)

publication alert

Rescue from replication stress during mitosis Michalis Fragkos & Valeria Naim Cell cycle Volume 16, 2017 Pages 613-633

publication alert

CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome Jin Chuan Zhou, Agnieszka Janska,Panchali Goswami, Ludovic Renault, Ferdos Abid Ali, Abhay Kotecha, John F. X. Diffley, and Alessandro Costa Proc. Nat.Acad.Sci. vol. 114 no. 16 4141–4146,

publication alert

Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe Ling Guan, Peng He, Fang Yang, Yuan Zhang, Yunfei Hu, Jienv Ding, Yu Hua, Yi Zhang, Qiong Ye, Jiazhi Hu, Tao Wang, Changwen Jin, and Daochun Kong J. Biol. Chem. 2017; 292:6056-6075

publication alert

Cdc45-induced loading of human RPA onto single-stranded DNA Anna Szambowska Ingrid Tessmer Piotr Prus Bernhard Schlott Helmut Pospiech Frank Grosse Nucleic Acids Res (2017) 45 (6): 3217-3230.

publication alert

Non-coding Y RNAs associate with early replicating euchromatin in concordance with the origin recognition complex Eyemen Kheir, Torsten Krude J Cell Sci 2017 130: 1239-1250

publication alert

Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers Bin Zhu, Longfei Wang, Hitoshi Mitsunobu, Xueling Lu, Alfredo J. Hernandez, Yukari Yoshida-Takashima, Takuro Nunoura, Stanley Tabor, and Charles C. Richardson PNAS vol. 114 no. 12 E2310–E2318

publication alert

Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in S. cerevisiae A. Zachary Ostrow, Reza Kalhor, Yan Gan, Sandra K. Villwock, Christian Linke, Matteo Barberis, Lin Chen, and Oscar M. Aparicio PNAS 114 no. 12 E2411–E2419,

publication alert

Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells Bochao Liu, Jiazhi Hu, Jingna Wang and Daochun Kong The Journal of Biological Chemistry 292, 4777-4788.

publication alert

Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase Seiji Matsumoto, Yutaka Kanoh, Michie Shimmoto, Motoshi Hayano, Kyosuke Ueda, Rino Fukatsu, Naoko Kakusho and Hisao Masai Mol. Cell. Biol. April 2017 vol. 37 no. 7 e00355-16

publication alert

CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination James M. Dewar, Emily Low, Matthias Mann, Markus Räschle and Johannes C. Walter Genes & Dev. 2017. 31: 275-290

publication alert

The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity Aditya Mojumdar, Matteo De March, Francesca Marino, and Silvia Onesti J. Biol. Chem. 2017; 292:4176-4184

publication alert

Ribosomal Protein S3 Negatively Regulates Unwinding Activity of RecQ-like Helicase 4 through Their Physical Interaction Ajay Vitthal Patil and Tao-Shih Hsieh J. Biol. Chem. 2017; 292:4313-4325 F

publication alert

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation Shin‐ichiro Hiraga, Tony Ly, Javier Garzón, Zuzana Hořejší, Yoshi‐nobu Ohkubo, Akinori Endo, Chikashi Obuse, Simon J Boulton, Angus I Lamond, Anne D Donaldson EMBO Reports (2017) 18: 403–419

publication alert

Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization Yating Wang Abid Khan Anna B. Marks Owen K. Smith Sumanprava Giri Yo-Chuen Lin Rachel Creager David M. MacAlpine Kannanganattu V. Prasanth Mirit I. Aladjem Supriya G. Prasanth Nucleic Acids Res (2017) 45 (5): 2490-2502.

publication alert

Revealing the role of the product metal in DNA polymerase β catalysis Lalith Perera Bret D. Freudenthal William A. Beard Lee G. Pedersen Samuel H. Wilson Nucleic Acids Res (2017) 45 (5): 2736-2745.

publication alert

DNA Replication: How Does a Sliding Clamp Slide? Nina Y. Yao, Mike O’Donnell Current biol Volume 27, Issue 5, pR174–R176, 6 March 2017

publication alert

Unearthing worm replication origins Takayo Sasaki & David M Gilbert Nature Structural & Molecular Biology 24, 195–196 (2017)

publication alert

The gastrula transition reorganizes replication-origin selection in Caenorhabditis elegans Marta Rodríguez-Martínez, Natalia Pinzón, Charles Ghommidh, Emmanuelle Beyne, Hervé Seitz, Christelle Cayrou & Marcel Méchali Nature Structural & Molecular Biology 24 290–299 (2017)

publication alert

Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer Yuanliang Zhai, Erchao Cheng, Hao Wu, Ningning Li, Philip Yuk Kwong Yung, Ning Gao & Bik-Kwoon Tye Nature Structural & Molecular Biology 24 300-308

publication alert

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing Simina Ticau, Larry J Friedman, Kanokwan Champasa, Ivan R Corrêa Jr, Jeff Gelles & Stephen P Bell Nature Structural & Molecular Biology 24 309–315 (2017)

publication alert

Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1 Zuanning Yuan, Alberto Riera, Lin Bai, Jingchuan Sun, Saikat Nandi, Christos Spanos, Zhuo Angel Chen, Marta Barbon, Juri Rappsilber, Bruce Stillman, Christian Speck & Huilin Li Nature Structural & Molecular Biology 24 316–324 (2017)

publication alert

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1 Hai Dang Nguyen, Tribhuwan Yadav, Sumanprava Giri, Borja Saez, Timothy A. Graubert, Lee Zou Molecular cell Volume 65, Issue 5, p832–847.e4, 2 March 2017

publication alert

Mechanisms for initiating cellular DNA replication Franziska Bleichert, Michael R. Botchan, James M. Berger Science Vol 355, Issue 6327 24 February 2017

publication alert

The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport ELIZABETH O’BRIEN, MARILYN E. HOLT, MATTHEW K. THOMPSON, LAUREN E. SALAY, AARON C. EHLINGER, WALTER J. CHAZIN, JACQUELINE K. BARTON Science Vol 355, Issue 6327 24 February 2017

publication alert

A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase Irina Bruck, Nalini Dhingra, and Daniel L. Kaplan J. Biol. Chem. 2017; 292:3062-3073

publication alert

Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA Amit Ketkar, Markus Voehler, Tresor Mukiza, and Robert L. Eoff J. Biol. Chem. 2017; 292:3154-3163

no postings this week

publication alert

Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation Nicole Vo Dang Ngoc Anh Suong Natsuki Yoshino Hideki Yoshida Sue Cotterill Masamitsu Yamaguchi Nucleic Acids Res (2017) 45 (3): 1233-1254.

publication alert

Disentangling polydispersity in the PCNA−p15PAF complex, a disordered, transient and multivalent macromolecular assembly Tiago N. Cordeiro Po-chia Chen Alfredo De Biasio Nathalie Sibille Francisco J. Blanco Jochen S. Hub Ramon Crehuet Pau Bernadó Nucleic Acids Res (2017) 45 (3): 1501-1515.

publication alert

Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog Adrian J. McNairn, Vera D. Rinaldi, John C. Schimenti Genetics February 2017 205: 529-537

publication alert

Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes Joseph S Osmundson, Jayashree Kumar, Rani Yeung & Duncan J Smith Nature Structural & Molecular Biology 24, 162–170 (2017)

publication alert

A long noncoding RNA in DNA replication and chromosome dynamics Francesco P. Marchese & Maite Huarte Cell cycle 16 Pages 151-152

publication alert

DNA replication stress: NoCut to the rescue Nuno Amaral, Nicola Brownlow & Manuel Mendoza Cell cycle 16 Pages 233-234

publication alert

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork Katherine N. Choe2, George-Lucian Moldovan Molecular Cell Volume 65, Issue 3, p380–392, 2 February 2017

publication alert

Recruitment of Fkh1 to replication origins requires precisely positioned Fkh1/2 binding sites and concurrent assembly of the pre- replicative complex Allan Reinapae, Kristiina Jalakas, Nikita Avvakumov, Marko Lõoke, Kersti Kristjuhan, Arnold Kristjuhan PLoS Genet 13(1): e1006588.

publication alert

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation Roxana Georgescu, Zuanning Yuan, Lin Bai, Ruda de Lun Almeida Santos, Jingchuan Sun, Dan Zhang, Olga Yurieva, Huilin Lic and Michael E. O’Donnell PNAS 2017 114 (5) E697-E706

publication alert

RPA binds histone H3-H4 and functions in DNA replication–coupled nucleosome assembly Shaofeng Liu, Zhiyun Xu, He Leng, Pu Zheng, Jiayi Yang, Kaifu Chen, Jianxun Feng, Qing Li Science Vol 355, Issue 6323 27 January 2017

publication alert

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication Rentian Wu, Zhiquan Wang, Honglian Zhang, Haiyun Gan, and Zhiguo Zhang Nucl. Acids Res. 2017 45: 169-180

publication alert

SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences Eric J. Fossa, Uyen Laoa, Emily Dalrymplea, Robin L. Adriansea, Taylor Loea, and Antonio Bedalov PNAS vol. 114 no. 3, 552–557,

publication alert

Thinking Outside the Cell: Replicating Replication In Vitro Rhiannon R. Aguilar, Jessica K. Tyler Molecular cell Volume 65, Issue 1, p5–7, 5 January 2017

publication alert

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication Joseph T.P. Yeeles, Agnieska Janska, Anne Early, John F.X. Diffley Mol cell Volume 65, Issue 1, p105–116, 5 January 2017

publication alert

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates Christoph F. Kurat, Joseph T.P. Yeeles, Harshil Patel, Anne Early, John F.X. Diffley Mol cell Volume 65, Issue 1, p117–130, 5 January 2017

publication alert

Chromatin Constrains the Initiation and Elongation of DNA Replication Sujan Devbhandari, Jieqing Jiang, Charanya Kumar, Iestyn Whitehouse, Dirk Remus Mol cell Volume 65, Issue 1, p131–141, 5 January 2017

publication alert

Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6 Harri M. Itkonen, Jukka Kantelinen, Markku Vaara, Sinikka Parkkinen, Bernhard Schlott, Frank Grosse, Minna Nyström, Juhani E. Syväoja, Helmut Pospiech febs letters 590, Pages: 4233–4241

publication alert

TRF2 recruits ORC through TRFH domain dimerization Mitsunori Higaa, Tatsunori Kushiyamaa, Seiichiro Kurashigea, Daisuke Kohmona, Kouki Enokitania, Satoko Iwahorib, Nozomi Sugimotoa, Kazumasa Yoshidaa, Masatoshi Fujitaa Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1864, Issue 1, January 2017, Pages 191–201

publication alert

SUV4-20 activity in the preimplantation mouse embryo controls timely replication André Eid, Diego Rodriguez-Terrones, Adam Burton, and Maria-Elena Torres-Padilla GENES & DEVELOPMENT 30:2513–2526