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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites Shyam Twayana, Albino Bacolla, Angelica Barreto-Galvez, Ruth B. De-Paula, William C. Drosopoulos, Settapong T. Kosiyatrakul, Eric E. Bouhassira, John A. Tainer, Advaitha Madireddy, and Carl L. Schildkraut PNAS November 30, 2021 118 (48) e2106477118;

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The genetic architecture of DNA replication timing in human pluripotent stem cells Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark & Amnon Koren Nature Communications volume 12, Article number: 6746 (2021)

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Molecular Mechanisms of the RECQ4 Pathogenic Mutations Xiaohua Xu, Chou-Wei Chang, Min Li, Chao Liu and Yilun Liu Front. Mol. Biosci., 18 November 2021

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Replication timing analysis in polyploid cells reveals Rif1 uses multiple mechanisms to promote underreplication in Drosophila Souradip Das, Madison Caballero, Tatyana Kolesnikova, Igor Zhimulev, Amnon Koren, Jared Nordman Genetics, Volume 219, Issue 3, November 2021, iyab147,

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Error-prone, stress-induced 3′ flap–based Okazaki fragment maturation supports cell survival HAITAO SUN, ZHAONING LU, AMANPREET SINGH, YAJING ZHOU, ERIC ZHENG, MIAN ZHOU, JINHUI WANG, XIWEI WU, ZUNSONG HU, ZHAOHUI GU, JUDITH L. CAMPBELL, LI ZHENG, AND BINGHUI SHEN SCIENCE 2 Dec 2021,Vol 374, Issue 6572 pp. 1252-1258

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Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entry Yoko Hayashi-Takanaka, Yuichiro Hayashi, Yasuhiro Hirano, Atsuko Miyawaki-Kuwakado, Yasuyuki Ohkawa, Chikashi Obuse, Hiroshi Kimura, Tokuko Haraguchi, Yasushi Hiraoka Nucleic Acids Research, Volume 49, Issue 21, 2 December 2021, Pages 12152–12166

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The human telomeric proteome during telomere replication Chih-Yi Gabriela Lin, Anna Christina Näger, Thomas Lunardi, Aleksandra Vančevska, Gérald Lossaint, Joachim Lingner Nucleic Acids Research, Volume 49, Issue 21, 2 December 2021, Pages 12119–12135

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Structure of a human replisome shows the organisation and interactions of a DNA replication machine Morgan L Jones, Yasemin Baris, Martin R G Taylor, Joseph T P Yeeles EMBO J (2021)40:e108819

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A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes Michael Jenkyn-Bedford, Morgan L. Jones, Yasemin Baris, Karim P. M. Labib, Giuseppe Cannone, Joseph T. P. Yeeles & Tom D. Deegan Nature (2021)

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Unwinding of a DNA replication fork by a hexameric viral helicase Abid Javed, Balazs Major, Jonathan A. Stead, Cyril M. Sanders & Elena V. Orlova Nature Communications volume 12, Article number: 5535 (2021)

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Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus Diletta Ciardo, Olivier Haccard, Hemalatha Narassimprakash, David Cornu, Ida Chiara Guerrera, Arach Goldar, Kathrin Marheineke Nucleic Acids Research, Volume 49, Issue 17, 27 September 2021, Pages 9851–9869,

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Disruption of origin chromatin structure by helicase activation in the absence of DNA replication Rachel A. Hoffman, Heather K. MacAlpine and David M. MacAlpine Genes & Dev. 2021. 35: 1339-1355

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SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition Jian Ma, Qing Shi, Gaofeng Cui, Haoyue Sheng, Maria Victoria Botuyan, Yingke Zhou, Yuqian Yan, Yundong He, Liguo Wang, Yuzhuo Wang, Georges Mer, Dingwei Ye, Chenji Wang & Haojie Huang Nature Communications volume 12, Article number: 5779 (2021)

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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases Philip S. Robinson, Tim H. H. Coorens, Claire Palles, Emily Mitchell, Federico Abascal, Sigurgeir Olafsson, Bernard C. H. Lee, Andrew R. J. Lawson, Henry Lee-Six, Luiza Moore, Mathijs A. Sanders, James Hewinson, Lynn Martin, Claudia M. A. Pinna, Sara Galavotti, Raheleh Rahbari, Peter J. Campbell, Iñigo Martincorena, Ian Tomlinson & Michael R. Stratton Nature Genetics volume 53, pages 1434–1442 (2021)

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POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes Luigi Magrin, Daniele Fanale, Chiara Brando, Alessia Fiorino, Lidia Rita Corsini, Roberta Sciacchitano, Clarissa Filorizzo, Alessandra Dimino, Antonio Russo & Viviana Bazan Oncogene volume 40, pages 5893–5901 (2021)

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The Fkh1 Forkhead associated domain promotes ORC binding to a subset of DNA replication origins in budding yeast Timothy Hoggard, Allison J Hollatz, Rachel E Cherney, Melissa R Seman, Catherine A Fox Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10207–10220,

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Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions Io Yamamoto, Hidenori Nakaoka, Masahiro Takikawa, Sanki Tashiro, Junko Kanoh, Tomoichiro Miyoshi, Fuyuki Ishikawa Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10465–10476,

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The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase Kimberlie A Wittig, Courtney G Sansam, Tyler D Noble, Duane Goins, Christopher L Sansam Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10507–10523,

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Frequency and patterns of ribonucleotide incorporation around autonomously replicating sequences in yeast reveal the division of labor of replicative DNA polymerases Penghao Xu, Francesca Storici Nucleic Acids Research, Volume 49, Issue 18, 11 October 2021, Pages 10542–10557,

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Anatomy and evolution of a DNA replication origin Yutaka Yamamoto, Eric A. Gustafson, Michael S. Foulk, Heidi S. Smith & Susan A. Gerbi Chromosoma volume 130, pages 199–214 (2021)

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DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity Qian Du, Grady C. Smith, Phuc Loi Luu, James M. Ferguson, Nicola J. Armstrong, C. Elizabeth Caldon, Elyssa M. Campbell, Shalima S. Nair, Elena ZotenkoCathryn M. Gould,Michael Buckley, Kee-Ming Chia, Neil Portman, Elgene Lim, Dominik Kaczorowski, Chia-Ling Chan, Kirston Barton, Ira W. Deveson, Martin A. Smith, Joseph E. Powell, Ksenia Skvortsova, Clare Stirzaker, Joanna Achinger-Kawecka, Susan J. Clark Cell reports ARTICLE| VOLUME 36, ISSUE 12, 109722, SEPTEMBER 21, 2021

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Who gets a license: DNA synthesis in quiescent cells re‐entering the cell cycle Po‐Hsuen Lee · Mary Ann Osley Current Genetics (2021) 67:539–543

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TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans Yisui Xia , Ryo Fujisawa , Tom D Deegan , Remi Sonneville & Karim P M Labib The EMBO Journal (2021) 40: e108053

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A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes Vivek M. Shastri, Veena Subramanian and Kristina H. Schmidt Nucleic Acids Research, 2021, Vol. 49, No. 15 8699–8713

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A CDK-regulated chromatin segregase promoting chromosome replication Erika Chacin, Priyanka Bansal, Karl-Uwe Reusswig, Luis M. Diaz-Santin, Pedro Ortega, Petra Vizjak, Belen Gómez-González , Felix Müller-Planitz, Andrés Aguilera , Boris Pfander ,Alan C. M. Cheung & Christoph F. Kurat NATURE COMMUNICATIONS | (2021)12:5224 |

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Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans Eric J. Foss, Smitha Sripathy, Tonibelle Gatbonton-Schwager, Hyunchang Kwak, Adam H. Thiesen, Uyen Lao, Antonio Bedalov PLoS Genet 17(9): e1009714.

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Small tandem DNA duplications result from CST- guided Pol α-primase action at DNA break termini Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel & Marcel Tijsterman NATURE COMMUNICATIONS | (2021)12:4843 |

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Fused in sarcoma (FUS) regulates DNA replication timing and kinetics Weiyan Jia, Sang Hwa Kim, Mark A. Scalf, Peter Tonzi, Robert J. Millikin, William M. Guns, Lu Liu, Adam S. Mastrocola, Lloyd M. Smith, Tony T. Huang, Randal S. Tibbetts JBC

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LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components Yilin Fan, Marielle S. Köberlin, Nalin Ratnayeke, Chad Liu, Madhura Deshpande, Jeannine Gerhardt, Tobias Meyer J Cell Biol (2021) 220 (8): e202009147.

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First come, first served: Mammalian recombination is timed to replication Jason A. Halliwell, Eva R. Hoffmann Cell VOLUME 184, ISSUE 16, P4112-4114, AUGUST 05, 2021

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Meiotic recombination mirrors patterns of germline replication in mice and humans Florencia Pratto, Kevin Brick, Gang Cheng, Kwan-Wood Gabriel Lam, Jeffrey M. Cloutier, Daisy Dahiya, Stephen R. Wellard, Philip W. Jordan, R. Daniel Camerini-Otero CELL VOLUME 184, ISSUE 16, P4251-4267.E20, AUGUST 05, 2021

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Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices Michaela Ihle, Stephanie Biber, Insa S Schroeder, Christine Blattner, Miriam Deniz, Giovanna Damia, Vanesa Gottifredi, Lisa Wiesmüller Nucleic Acids Research, Volume 49, Issue 13, 21 July 2021, Pages 7457–7475,

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The emerging determinants of replication fork stability Tanay Thakar, George-Lucian Moldovan Nucleic Acids Research, Volume 49, Issue 13, 21 July 2021, Pages 7224–7238,

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DNA molecular combing-based replication fork directionality profiling Marion Blin, Laurent Lacroix, Nataliya Petryk, Yan Jaszczyszyn, Chun-Long Chen, Olivier Hyrien and Benoˆıt Le Tallec Nucleic Acids Research, 2021, Vol. 49, No. 12 e69

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Transcription shapes DNA replication initiation to preserve genome integrity Yang Liu, Chen Ai, Tingting Gan, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao, Qing Li, Xiong Ji & Jiazhi Hu Genome Biology volume 22, Article number: 176 (2021)

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Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse Grazia Pellicanò, Mohammed Al Mamun, Dolores Jurado-Santiago, Sara Villa-Hernández, Xingyu Yin, Michele Giannattasio, Michael C. Lanz, Marcus B. Smolka, Joseph Yeeles, Katsuhiko Shirahige, Miguel García-Díaz, Rodrigo Bermejo MOL CELL ARTICLE| VOLUME 81, ISSUE 13, P2778-2792.E4, JULY 01, 2021

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Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication Helena Santos-Rosa, Gonzalo Millán-Zambrano, Namshik Han, Tommaso Leonardi, Marie Klimontova, Simona Nasiscionyte, Luca Pandolfini, Kostantinos Tzelepis, Till Bartke, Tony Kouzarides MOL CELL VOLUME 81, ISSUE 13, P2793-2807.E8, JULY 01, 2021

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Dynamics of replication origin over-activation Haiqing Fu, Christophe E. Redon, Bhushan L. Thakur, Koichi Utani, Robin Sebastian, Sang-Min Jang, Jacob M. Gross, Sara Mosavarpour, Anna B. Marks, Sophie Z. Zhuang, Sarah B. Lazar, Mishal Rao, Shira T. Mencer, Adrian M. Baris, Lorinc S. Pongor & Mirit I. Aladjem Nature Communications volume 12, Article number: 3448 (2021)

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The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes Yang Liu, Lu Wang, Xin Xu, Yue Yuan, Bo Zhang, Zeyang Li, Yuchen Xie, Rui Yan, Zeqi Zheng, Jianguo Ji, Johanne M. Murray, Antony M. Carr, and Daochun Kong PNAS June 15, 2021 118 (24) e2019183118;

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Regulation of DNA duplication by the mTOR signaling pathway Zhengfu He, Peter J. Houghton, Terence M. Williams & Changxian Shen Cell cycle 20 Issue 8 Pages 742-751

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The intrinsically disordered N-terminal region of mouse DNA polymerase alpha mediates its interaction with POT1a/b at telomeres Takeshi Mizuno, Kei Hirabayashi, Sae Miyazawa, Yurika Kobayashi, Kenta Shoji, Masakazu Kobayashi, Fumio Hanaoka, Naoko Imamoto, Hidetaka Torigoe Genes to cells Volume26, Issue6 June 2021 Pages 360-380

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Unchecked nick ligation can promote localized genome re-replication Erik Johansson and John F.X. Diffley VOLUME 31, ISSUE 11, PR710-R711, JUNE 07, 2021

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The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ Denis A Kiktev, Margaret Dominska, Tony Zhang, Joseph Dahl, Elena I Stepchenkova, Piotr Mieczkowski, Peter M Burgers, Scott Lujan, Adam Burkholder, Thomas A Kunkel and Thomas D Petes Nucleic Acids Research, Volume 49, Issue 10, 4 June 2021, Pages 5623–5636,

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Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitro Max E Douglas, John F X Diffley Nucleic Acids Research, Volume 49, Issue 10, 4 June 2021, Pages 5671–5683,

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Rtt105 promotes high-fidelity DNA replication and repair by regulating the single-stranded DNA-binding factor RPA Xuejie Wang, Yang Dong, Xiaocong Zhao,Jinbao Li, Jordan Lee, Zhenxin Yan, Shuangshuang Yang, Wenqiang Wu, Ximiao Hou, Guangxue Liu, Yueyue Zhang, Lun Song, Gang Cai, Qing Li, Grzegorz Ira, Xinghua Zhang, and Xuefeng Chen PNAS June 22, 2021 118 (25) e2106393118;

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Interdomain connecting loop and J loop structures determine cross-species compatibility of PCNA Premlata Kumari, Rajivgandhi Sundaram, Kodavati Manohar, Dileep Vasudevan, Narottam Acharya JBC ARTICLES IN PRESS, 100911

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DNA replication origins retain mobile licensing proteins Humberto Sánchez, Kaley McCluskey, Theo van Laar, Edo van Veen, Filip M. Asscher, Belén Solano, John F. X. Diffley & Nynke H. Dekker NATURE COMMUNICATIONS (2021)12:1908

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Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles Mareike Herzog, Elisa Alonso-Perez, Israel Salguero, Jonas Warringer, David J Adams, Stephen P Jackson, Fabio Puddu Nucleic Acids Research, Volume 49, Issue 7, 19 April 2021, Pages 3919–3931

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Computational modeling of chromosome re-replication in mutant strains of fission yeast Béla Novák and John J. Tyson Molecular Biology of the CellVol. 32, No. 9 Published Online:19 Apr 2021

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Replication timing maintains the global epigenetic state in human cells Kyle N. Klein1, Peiyao A. Zhao1, Xiaowen Lyu2, Takayo Sasaki1, Daniel A. Bartlett, Amar M. Singh, Ipek Tasan, Meng Zhang, Lotte P. Watts, Shin-ichiro Hiraga, Toyoaki Natsume, Xuemeng Zhou, Timour Baslan, Danny Leung, Masato T. Kanemaki, Anne D. Donaldson, Huimin Zhao, Stephen Dalton, Victor G. Corces, David M. Gilbert Science 23 Apr 2021:Vol. 372, Issue 6540, pp. 371-378

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N-terminal region of RecQ4 inhibits non-homologous end joining and chromatin association of the Ku heterodimer in Xenopus egg extracts Takashi Tsuyama, Kumiko Fujita, Ryosuke Sasaki, Shiori Hamanaka, Yuki Sotoyama, Akira Ogawa, Kana Kusuzaki, Yutaro Azuma, Shusuke Tada Gene Volume 787, 30 June 2021, 145647

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Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins Seiji Tanaka Genetics, Volume 217, Issue 1, January 2021, Pages 1–11

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Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii Ikui AE, Ueki N, Pecani K, Cross F PLoS Genet 17(4): e1009471.

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The capacity of origins to load mcm establishes replication timing patterns. Dukaj L, Rhind N PLoS Genet 17(3): e1009467.

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Single-strand DNA breaks cause replisome disassembly Kyle B. Vrtis, James M. Dewar, Gheorghe Chistol, R. Alex Wu, Thomas G.W. Graham, Johannes C. Walter mol cell VOLUME 81, ISSUE 6, P1309-1318.E6, MARCH 18, 2021

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CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle Fabrizio Villa, Ryo Fujisawa, Johanna Ainsworth, Kohei Nishimura, Michael Lie‐A‐Ling, Georges Lacaud, Karim PM Labib EMBO Rep (2021)22:e52164

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TopBP1 assembles nuclear condensates to switch on ATR signaling Camilla Frattini, Alexy Promonet, Emile Alghoul, Sophie Vidal-Eychenie, Marie Lamarque, Marie-Pierre Blanchard, Serge Urbach, Jihane Basbous, Angelos Constantinou Mol Cell VOLUME 81, ISSUE 6, P1231-1245.E8, MARCH 18, 2021

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TopBP1 comes into focus William G. Dunphy Mol Cell VOLUME 81, ISSUE 6, P1126-1127, MARCH 18, 2021

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The eukaryotic replisome tolerates leading‐strand base damage by replicase switching Thomas A Guilliam andJoseph TP Yeeles EMBO J (2021)40:e107037

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RPA-mediated recruitment of Bre1 couples histone H2B ubiquitination to DNA replication and repair Guangxue Liu, Jiaqi Yan, Xuejie Wang, Junliang Chen, View ORCID ProfileXin Wang, Yang Dong, Simin Zhang, Xiaoli Gan, Jun Huang, and Xuefeng Chen PNAS February 23, 2021 118 (8) e2017497118

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A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56. Gershon L, Kupiec M PLoS Genet 17(2): e1009391.

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Chromosomal coordination and differential structure of asynchronous replicating regions Britny Blumenfeld, Hagit Masika, Marganit Farago, Yishai Yehuda, Lamia Halaseh, Oriya Vardi, Rachel Rapoport, Rena Levin-Klein, Howard Cedar, Yehudit Bergman & Itamar Simon NATURE COMMUNICATIONS | (2021)12:1035 |

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SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing Ryonosuke Taniguchi, Koichi Utani, Bhushan Thakur, Kazuho Ishine, Mirit I. Aladjem, Noriaki Shimizu Show footnotes jbc 52

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Replication dynamics of recombination-dependent replication forks Karel Naiman, Eduard Campillo-Funollet, Adam T. Watson, Alice Budden, Izumi Miyabe & Antony M. Carr Nature Communications volume 12, Article number: 923 (2021)

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication Mathew J.K. Jones, Camille Gelot, Stephanie Munk, Amnon Koren, Yoshitaka Kawasoe, Kelly A. George, Ruth E. Santos, Jesper V. Olsen, Steven A. McCarroll, Mark G. Frattini, Tatsuro S. Takahashi, Prasad V. Jallepalli Mol Cell ARTICLE| VOLUME 81, ISSUE 3, P426-441.E8,

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Humanizing the yeast origin recognition complex Clare S. K. Lee, Ming Fung Cheung, Jinsen Li, Yongqian Zhao, Wai Hei Lam, Vincy Ho, Remo Rohs, Yuanliang Zhai, Danny Leung & Bik-Kwoon Tye Nature Communications volume 12, Article number: 33 (2021)