24 December 2022
publication alert
Human DNA polymerase α has a strong mutagenic potential at the initial steps of DNA synthesis
Alisa E Lisova, Andrey G Baranovskiy, Lucia M Morstadt, Nigar D Babayeva, Tahir H Tahirov
Nucleic Acids Research, Volume 50, Issue 21, 28 November 2022, Pages 12266–12273,
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New insights into DNA polymerase mechanisms provided by time-lapse crystallography
Tyler M.Weaver, M. Todd Washington, Bret D.Freudenthal
Current Opinion in Structural Biology Volume 77, December 2022, 102465
publication alert
Pold4 is dispensable for mouse development, DNA replication and DNA repair
XuepingGu, Qinjin Dai, PengDu, Ning Li, Jiahui Li, Simiao Zeng, Shuyi Peng, Shengjun Tang, Lei Wang, Zhongcheng Zhou
Gene Volume 851, 30 January 2023, 147029
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Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation
Martin Meagher, Alexander Myasnikov, and Eric J. Enemark
Int. J. Mol. Sci. 2022, 23(23), 14678;
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Global landscape of replicative DNA polymerase usage in the human genome
Eri Koyanagi, Yoko Kakimoto, Tamiko Minamisawa, Fumiya Yoshifuji, Toyoaki Natsume, Atsushi Higashitani, Tomoo Ogi, Antony M. Carr, Masato T. Kanemaki & Yasukazu Daigaku
Nature Communications volume 13, Article number: 7221 (2022)
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The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells
Sameera Vipat, Dipika Gupta, Sagun Jonchhe, Hele Anderspuk, Eli Rothenberg & Tatiana N. Moiseeva
Nature Communications volume 13, Article number: 7099 (2022)
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Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions
Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann & Boris Pfander
Nature Communications volume 13, Article number: 7014 (2022)
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Trypanosoma brucei Mitochondrial DNA Polymerase POLIB Contains a Novel Polymerase Domain Insertion That Confers Dominant Exonuclease Activity
Stephanie B. Delzell, Scott W. Nelson, Matthew P. Frost, and Michele M. Klingbeil*
Biochemistry 23, 2751–2765 November 18, 2022
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Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics
Vlad-Stefan Raducanu, Muhammad Tehseen, Amani Al-Amodi, Luay I. Joudeh, Alfredo De Biasio & Samir M. Hamdan
Nature Communications volume 13, Article number: 6973 (2022)
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Cell division drives DNA methylation loss in late-replicating domains in primary human cells
Jamie L. Endicott, Paula A. Nolte, Hui Shen & Peter W. Laird
Nature Communications volume 13, Article number: 6659 (2022)
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Unexpected new insights into DNA clamp loaders
Huilin Li, Mike O'Donnell, Brian Kelch
Bioessays Volume44, Issue11 November 2022
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DNA replication timing: Biochemical mechanisms and biological significance
Nicholas Rhind
Bioassays Volume44, Issue11 November 2022
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Replicon hypothesis revisited
Hisao Masai
Biochemical and Biophysical Research Communications Volume 633, 10 December 2022, Pages 77-80
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Replicon-seq: seeing is believing
Cristian Polo Rivera
Tom D. Deegan
Trends in Genetics VOLUME 38, ISSUE 10, P987-988,
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Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L
Cuige Zhu, Mari Iwase, Ziqian Li, Faliang Wang, Annabel Quinet, Alessandro Vindigni & Jieya Shao
Nature Communications volume 13, Article number: 6531 (2022)
publication alert
Global early replication disrupts gene expression and chromatin conformation in a single cell cycle
Miguel M. Santos, Mark C. Johnson, Lukáš Fiedler & Philip Zegerman
Genome Biology volume 23, Article number: 217 (2022)
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Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
Michael B. Heskett, Athanasios E. Vouzas, Leslie G. Smith, Phillip A. Yates, Christopher Boniface, Eric E. Bouhassira, Paul T. Spellman, David M. Gilbert & Mathew J. Thayer
Nature Communications volume 13, Article number: 6301 (2022)
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publication alert
Origin recognition complex harbors an intrinsic nucleosome remodeling activity
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell, and Shixin Liu
PNAS 119 (42) e2211568119
publication alert
Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes
Hana Polasek-Sedlackova, Thomas C. R. Miller, Jana Krejci, Maj-Britt Rask & Jiri Lukas
Nature Communications volume 13, Article number: 6090 (2022)
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DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis
Cong Wang, Jiyue Huang, Jun Zhang, Yue Yu, Gregory P. Copenhaver, Chenjiang You, and Yingxiang Wang
PNAS 119 (41) e2208441119
publication alert
Rpd3 regulates single-copy origins independently of the rDNA array by opposing Fkh1-mediated origin stimulation
Yiwei He, Meghan V. Petrie, Haiyang Zhang, Jared M. Peace, and Oscar M. Aparicio
PNAS 119 (40) e2212134119
publication alert
ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress
Xingxuan Wu, Shibin Xu, Peipei Wang,Zhao-Qi Wang, Hongxiang Chen, Xingzhi Xu , and Bin Peng
PNAS 119 (40) e2203783119
publication alert
The consequences of differential origin licensing dynamics in distinct chromatin environments
Liu Mei, Katarzyna M Kedziora, Eun-Ah Song, Jeremy E Purvis, Jeanette Gowen Cook
Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 9601–9620,
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Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities
Rachel L Dannenberg, Joseph A Cardina, Kara G Pytko, Mark Hedglin
Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 9893–9908,
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Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cells
Yann Benureau, Caroline Pouvelle, Pauline Dupaigne, Sonia Baconnais, Eliana Moreira Tavares, Gerard Mazón, Emmanuelle Despras, Eric Le Cam, Patricia L Kannouche
Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 9909–9929,
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3D chromatin connectivity underlies replication origin efficiency in mouse embryonic stem cells
Karolina Jodkowska, Vera Pancaldi, Maria Rigau, Ricardo Almeida, José M Fernández-Justel, Osvaldo Graña-Castro, Sara Rodríguez-Acebes, Miriam Rubio-Camarillo, Enrique Carrillo-de Santa Pau, David Pisano Fátima Al-Shahrour, Alfonso Valencia, María Gómez, Juan Méndez
Nucleic Acids Research, Volume 50, Issue 21, 28 November 2022, Pages 12149–12165,
22 September 2022
publication alert
Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM
Yun Quan, Qian-yi Zhang, Ann L. Zhou, Yuhao Wang, Jiaxi Cai, Yong-qi Gao, Huilin Zhou
PLoS Genet 18(6): e1010275.
publication alert
Telomere‐to‐telomere human DNA replication timing profiles
Dashiell J. Massey & Amnon Koren
Sci rep (2022) 12:9560
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Genome-wide mapping of individual replication fork velocities using nanopore sequencing
Bertrand Theulot, Laurent Lacroix, Jean-Michel Arbona, Gael A. Millot, Etienne Jean, Corinne Cruaud, Jade Pellet, Florence Proux, Magali Hennion, Stefan Engelen, Arnaud Lemainque, Benjamin Audit, Olivier Hyrien & Benoît Le Tallec
NATURE COMMUNICATIONS | (2022)13:3295
publication alert
Cohesin-mediated loop anchors confine the locations of human replication origins
Daniel J. Emerson, Peiyao A. Zhao, Ashley L. Cook, R. Jordan Barnett,Kyle N. Klein, Dalila Saulebekova, Chunmin Ge, Linda Zhou, Zoltan Simandi, Miriam K. Minsk, Katelyn R. Titus, Weitao Wang, Wanfeng Gong, Di Zhang, Liyan Yang, Sergey V. Venev, Johan H. Gibcus, Hongbo Yang, Takayo Sasaki, Masato T. Kanemaki, Feng Yue, Job Dekker, Chun-Long Chen, David M. Gilbert & Jennifer E. Phillips-Cremins
Nature | Vol606 | 23June2022
publication alert
Orc6 is a component of the replication fork and enables efficient mismatch repair
Yo-Chuen Lin, Dazhen Liu, Arindam Chakraborty, Lyudmila Y. Kadyrova, You Jin Song, Qinyu Hao, Jaba Mitra, Rosaline Y. C. Hsu, Mariam K. Arif, Sneha Adusumilli, Ting-Wei Liao, Taekjip Ha, Farid A. Kadyrov, Kannanganattu V. Prasanth, and Supriya G. Prasanth
PNAS May 27, 2022 119 (22) e2121406119
publication alert
HIRA-dependent boundaries between H3 variants shape early replication in mammals
Alberto Gatto, Audrey Forest, Jean-Pierre Quivy and Geneviève Almouzni
mol cell VOLUME 82, ISSUE 10, P1909-1923.E5,
19 September 2022
publication alert
Mechanism of replication origin melting nucleated by CMG helicase assembly
Jacob S. Lewis, Marta H. Gross, Joana Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F. X. Diffley & Alessandro Costa
Nature volume 606, pages 1007–1014 (2022)
publication alert
DNA Replication proteins in primary microcephaly syndromes
Melanie Tingler, Melanie Philipp, Martin D. Burkhalter
Biology of the Cell Volume114, Issue June 2022 Pages 143-159
publication alert
Insight into RNA–DNA primer length counting by human primosome
Andrey G Baranovskiy, Alisa E Lisova, Lucia M Morstadt, Nigar D Babayeva, Tahir H Tahirov
Nucleic Acids Research, Volume 50, Issue 11, 24 June 2022, Pages 6264–6270,
publication alert
Structures of the human CST-Polα–primase complex bound to telomere templates
Qixiang He, Xiuhua Lin, Bianca L. Chavez, Sourav Agrawal, Benjamin L. Lusk & Ci Ji Lim
Nature volume 608, pages 826–832 (2022)
publication alert
Reconstitution of a telomeric replicon organized by CST
Arthur J. Zaug, Karen J. Goodrich, Jessica J. Song, Ashley E. Sullivan & Thomas R. Cech
Nature volume 608, pages 819–825 (2022)
publication alert
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity
Xiaoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W. R. Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J. Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y. Sabio, Richa Verma, Raghvendra M. Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K. Chu, Stephen L. Wang, Daniel W. Kelly, Xin Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc G. T. Morris & Timothy A. Chan
Nature Genetics volume 54, pages 996–1012 (2022)
publication alert
Mutations in DNA polymerase δ subunit 1 co-segregate with CMD2-type resistance to Cassava Mosaic Geminiviruses
Yi-Wen Lim, Ben N. Mansfeld, Pascal Schläpfer, Kerrigan B. Gilbert, Narayanan N. Narayanan, Weihong Qi, Qi Wang, Zhenhui Zhong, Adam Boyher, Jackson Gehan, Getu Beyene, Zuh-Jyh Daniel Lin, Williams Esuma, Suhua Feng, Christelle Chanez, Nadine Eggenberger, Gerald Adiga, Titus Alicai, Steven E. Jacobsen, Nigel J. Taylor, Wilhelm Gruissem & Rebecca S. Bart
Nature Communications volume 13, Article number: 3933 (2022)
publication alert
Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST
Conner L. Olson, Alexandra T. Barbour & Deborah S. Wuttke
Nature Structural & Molecular Biology volume 29, pages 730–733 (2022)
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Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels
Stephanie R Barbari, Annette K Beach, Joel G Markgren, Vimal Parkash, Elizabeth A Moore, Erik Johansson, Polina V Shcherbakova
Nucleic Acids Research, Volume 50, Issue 14, 12 August 2022, Pages 8023–8040,
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Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state
Sarah W. Cai, John C. Zinder, Vladimir Svetlov, Martin W. Bush, Evgeny Nudler, Thomas Walz & Titia de Lange
Nature Structural & Molecular Biology volume 29, pages 813–819 (2022)
publication alert
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Sai Li, Michael R. Wasserman, Olga Yurieva, Lu Bai, Michael E. O’Donnell & Shixin Liu
Nature Communications volume 13, Article number: 4947 (2022)
publication alert
Yeast ORC sumoylation status fine-tunes origin licensing
Gemma Regan-Mochrie, Timothy Hoggard, Nikhil Bhagwat, Gerard Lynch, Neil Hunter, Dirk Remus, Catherine A. Fox and Xiaolan Zhao
Genes & Dev. 2022. 36: 807-821
publication alert
Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication
Yaru Zhang, Marco Jost, Ryan A. Pak, Daniel Lu, Jing Li, Brett Lomenick, Spiros D. Garbis, Chi-Ming Li, Jonathan S. Weissman, James Russell Lipford, and Raymond J. Deshaies
PNAS 119 (36) e2205608119
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The DNA replication protein Orc1 from the yeast Torulaspora delbrueckii is required for heterochromatin formation but not as a silencer-binding protein
Haniam Maria, Laura N Rusche
Genetics, Volume 222, Issue 1, September 2022, iyac110,
publication alert
Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability
Zohreh Kianfard, Sarah A. Sabatinos
Volume44, Issue9 September 2022 2200141
publication alert
Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context
Toshihiro Matsukawa, Mianmian Yin, Timour Baslan, Yang Jo Chung, Dengchao Cao, Ryan Bertoli, Yuelin J. Zhu, Robert L. Walker, Amy Freeland, Erik Knudsen, Scott W. Lowe, Paul S. Meltzer, Peter D. Aplan
Faseb J September 2022 e22430
20 May 2022
publication alert
Fast and efficient DNA replication with purified human proteins
Yasemin Baris, Martin R. G. Taylor, Valentina Aria & Joseph T. P. Yeeles
Nature 18 May 2022
publication alert
MCM complexes are barriers that restrict cohesin-mediated loop extrusion
Bart J. H. Dequeker, Matthias J. Scherr, Hugo B. Brandão, Johanna Gassler, Sean Powell, Imre Gaspar, Ilya M. Flyamer, Aleksandar Lalic, Wen Tang, Roman Stocsits, Iain F. Davidson, Jan-Michael Peters, Karl E. Duderstadt, Leonid A. Mirny & Kikuë Tachibana
Nature (2022) 18/5
publication alert
Kronos scRT: a uniform framework for single-cell replication timing analysis
Stefano Gnan, Joseph M. Josephides, Xia Wu, Manuela Spagnuolo, Dalila Saulebekova, Mylène Bohec, Marie Dumont, Laura G. Baudrin, Daniele Fachinetti, Sylvain Baulande & Chun-Long Chen
Nature Communications volume 13, Article number: 2329 (2022)
publication alert
High-throughput analysis of single human cells reveals the complex nature of DNA replication timing control
Dashiell J. Massey & Amnon Koren
Nature Communications volume 13, Article number: 2402
publication alert
CDC7-independent G1/S transition revealed by targeted protein degradation
Jan M. Suski, Nalin Ratnayeke, Marcin Braun, Tian Zhang, Vladislav Strmiska, Wojciech Michowski, Geylani Can, Antoine Simoneau, Konrad Snioch, Mikolaj Cup, Caitlin M. Sullivan, Xiaoji Wu, Joanna Nowacka, Timothy B. Branigan, Lindsey R. Pack, James A. DeCaprio, Yan Geng, Lee Zou, Steven P. Gygi, Johannes C. Walter, Tobias Meyer & Piotr Sicinski
Nature volume 605, pages 357–365 (2022)
publication alert
Molecular basis for the initiation of DNA primer synthesis
Arthur W. H. Li, Katerina Zabrady, Lewis J. Bainbridge, Matej Zabrady, Sehr Naseem-Khan, Madison B. Berger, Peter Kolesar, G. Andrés Cisneros & Aidan J. Doherty
Nature (2022)04 May 2022
3 May 2022
publication alert
DNA replication fork speed underlies cell fate changes and promotes reprogramming
Tsunetoshi Nakatani, Jiangwei Lin, Fei Ji, Andreas Ettinger, Julien Pontabry, Mikiko Tokoro, Luis Altamirano-Pacheco, Jonathan Fiorentino, Elmir Mahammadov, Yu Hatano, Capucine Van Rechem, Damayanti Chakraborty, Elias R. Ruiz-Morales, Paola Y. Arguello Pascualli, Antonio Scialdone, Kazuo Yamagata, Johnathan R. Whetstine, Ruslan I. Sadreyev & Maria-Elena Torres-Padilla
Nature Genetics volume 54, pages 318–327 (2022)
publication alert
Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase
Jiaxuan Cheng, Ningning Li, Yunjing Huo, Shangyu Dang, Bik-Kwoon Tye, Ning Gao & Yuanliang Zhai
Nature Communications volume 13, Article number: 1396 (2022)
publication alert
Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome
Keisuke Oki, Mariko Nagata, Takeshi Yamagami, Tomoyuki Numata, Sonoko Ishino, Takuji Oyama, Yoshizumi Ishino
Nucleic Acids Research, Volume 50, Issue 7, 22 April 2022, Pages 3601–3615,
publication alert
Single-molecule mapping of replisome progression
Clémence Claussin, Jacob Vazquez, Iestyn Whitehouse
Mol cell Published:March 02, 2022
publication alert
Mapping replication forks, one replicon at a time
Nicholas Rhind
Mol Cell VOLUME 82, ISSUE 7, P1246-1248, APRIL 07, 2022
publication alert
Stable G-quadruplex DNA structures promote replication-dependent genome instability
S. Dean Rider Jr.,Rujuta Yashodhan Gadgi, David C. Hitch, Resha Shrestha, Kazuo Shin-ya, Michael Leffak
JBC in press
7 March 2022
publication alert
The inner workings of replisome-dependent control of DNA damage tolerance
Tianpeng Zhang and Roger A. Greenberg
Genes & Dev. 2022. 36: 103-105
publication alert
Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance
Valeria Dolce, Sabrina Dusi, Michele Giannattasio, Chinnu Rose Joseph, Marco Fumasoni and Dana Branzei
Genes & Dev. 2022. 36: 167-179
publication alert
A DNA replication-independent function of pre-replication complex genes during cell invasion in C. elegans.
Lattmann E, Deng T, Walser M, Widmer P, Rexha-Lambert C, Prasad V, et al.
PLoS Biol 20(2): e3001317.
publication alert
Prereplication complex proteins get caught moonlighting.
Coller HA
PLoS Biol 20(2): e3001549.
publication alert
The fork protection complex recruits FACT to reorganize nucleosomes during replication
Barbara Safaric, Erika Chacin, Matthias J Scherr, Lional Rajappa, Christian Gebhardt, Christoph F Kurat, Thorben Cordes, Karl E Duderstadt
Nucleic Acids Research, Volume 50, Issue 3, 22 February 2022, Pages 1317–1334,
publication alert
A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6
Jan Marten Schmidt, Ran Yang, Ashish Kumar, Olivia Hunker, Jan Seebacher & Franziska Bleichert
Nature Communications volume 13, Article number: 1059 (2022)
publication alert
Genomic patterns of transcription–replication interactions in mouse primary B cells
Commodore P St Germain, Hongchang Zhao, Vrishti Sinha, Lionel A Sanz, Frédéric Chédin, Jacqueline H Barlow
Nucleic Acids Research, Volume 50, Issue 4, 28 February 2022, Pages 2051–2073,
publication alert
Transcription-replication coordination revealed in single live cells
Ioannis Tsirkas, Daniel Dovrat, Manikandan Thangaraj, Ineke Brouwer, Amit Cohen, Zohar Paleiov, Michael M Meijler, Tineke Lenstra, Amir Aharoni
Nucleic Acids Research, Volume 50, Issue 4, 28 February 2022, Pages 2143–2156,
publication alert
Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress
Rebecca L. Kelly, Amelia M. Huehls, Annapoorna Venkatachalam, Catherine J. Huntoon, Yuichi J. Machida,Larry M. Karnitz
JBC in press
21 February 2022
publication alert
Dbf4-Dependent Kinase: DDK-ated to post-initiation events in DNA replication
Andrew Dolson, Safia Mahabub Sauty, Kholoud Shaban & Krassimir Yankulov
Cell Cycle Volume 20, 2021 - Issue 22
publication alert
Preventing excess replication origin activation to ensure genome stability
Bhushan L. Thakur, Anagh Ray, Christophe E. Redon,Mirit I. Aladjem
TIGS | VOLUME 38, ISSUE 2, P169-181, FEBRUARY 01, 2022
publication alert
In silico reconstitution of DNA replication. Lessons from single-molecule imaging and cryo-tomography applied to single-particle cryo-EM
Julia F.Greiwe, GiuliaZanetti, Thomas C.R.Mille, AlessandroCosta
Current Opinion in Structural Biology Volume 72, February 2022, Pages 279-286
publication alert
The yeast Dbf4 Zn2+ finger domain suppresses single-stranded DNA at replication forks initiated from a subset of origins
Jeff Bachant, Elizabeth A. Hoffman, Chris Caridi, Constance I. Nugent & Wenyi Feng
Current Genetics (2022)
publication alert
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint
Lili Li, Jie Wang, Zijia Yang, Yiling Zhao, Hui Jiang, Luguang Jiang, Wenya Hou, Risheng Ye, Qun He, Martin Kupiec, Brian Luke, Qinhong Cao, Zhi Qi, Zhen Li, Huiqiang Lou
The EMBO Journal (2022)41:e108290
publication alert
Yeast Stn1 promotes MCM to circumvent Rad53 control of the S phase checkpoint
Hovik Gasparayan, Chris Caridi, Jeff Julius, Wenyi Feng, Jeff Bachant & Constance I. Nugent
Current Genetics (2022)
publication alert
A novel link between the DNA replication machinery and chromatin assembly
J Cell Sci (2022) 135 (2): e135_e0202.
publication alert
SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication
Caitlin Connolly,Saori Takahashi,Hisashi Miura,Ichiro Hiratani,Nick Gilbert,Anne D. Donaldson,Shin-Ichiro Hiraga
J Cell Sci (2022) 135 (2): jcs258991.
publication alert
Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability
Taha Mohamed, Madison B. Adolph, David Cortez
JBC in press
publication alert
Proline-specific aminopeptidase P prevents replication-associated genome instability
Nicola Silva, Maikel Castellano-Pozo, Kenichiro Matsuzaki, Consuelo Barroso, Monica Roman-Trufero, Hannah Craig, Darren R. Brooks, R. Elwyn Isaac, Simon J. Boulton, Enrique Martinez-Perez
PLoS Genet 18(1): e1010025.
publication alert
Stimulation of adaptive gene amplification by origin firing under replication fork constraint
Alex J Whale, Michelle King, Ryan M Hull, Felix Krueger, Jonathan Houseley
Nucleic Acids Research, Volume 50, Issue 2, 25 January 2022, Pages 915–936,
publication alert
Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ
Joseph M Dahl, Natalie Thomas, Maxwell A Tracy, Brady L Hearn, Lalith Perera, Scott R Kennedy, Alan J Herr, Thomas A Kunkel
Nucleic Acids Research, Volume 50, Issue 2, 25 January 2022,
24 January 2022
publication alert
How asymmetric DNA replication achieves symmetrical fidelity
Zhi-Xiong Zhou, Scott A. Lujan, Adam B. Burkholder, Jordan St. Charles, Joseph Dahl, Corinne E. Farrell, Jessica S. Williams & Thomas A. Kunkel
Nature Structural & Molecular Biology volume 28, pages 1020–1028 (2021)
publication alert
Blm helicase facilitates rapid replication of repetitive DNA sequences in early Drosophila development
Jolee M Ruchert, Morgan M Brady, Susan McMahan, Karly J Lacey, Leigh C Latta, Jeff Sekelsky, Eric P Stoffregen
Genetics, Volume 220, Issue 1, January 2022, iyab169
publication alert
Geminin is essential for DNA re-replication in the silk gland cells of silkworms
Tai-HangLiu, Xiao-Long Dong, Peng Chen, QianZhang, Xiao-LinZhou, ChengLu, Min-HuiPan
Experimental Cell Research Volume 410, Issue 1, 1 January 2022, 112951
publication alert
Water skating: How polymerase sliding clamps move on DNA
Huilin Li, Fengwei Zheng, Mike O’Donnell
Febs JournalVolume288, Issue24 December 2021 Pages 7256-7262
publication alert
CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism
Nina Y. Yao, Dan Zhang, Olga Yurieva, and Michael E. O’Donnell
PNAS January 25, 2022 119 (4) e2119580119
publication alert
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase
Julia F. Greiwe, Thomas C. R. Miller, Julia Locke, Fabrizio Martino, Steven Howell, Anne Schreiber, Andrea Nans, John F. X. Diffley & Alessandro Costa
Nature Structural & Molecular Biology volume 29, pages 10–20 (2022)
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