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Genetic Control of Replication through N1-methyladenine in Human Cells Juan Conde1, Jung-Hoon Yoon1, Jayati Roy Choudhury1, Louise Prakash and Satya Prakash2 Journal of Biological Chemistry, 290, 29794-29800

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Simultaneous measurement of passage through the restriction point and MCM loading in single cells T. W. Håland, E. Boye, T. Stokke, B. Grallert, and R. G. Syljuåsen Nucl. Acids Res. 2015 43: e150

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Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance Demis Menolfi, Axel Delamarre, Armelle Lengronne, Philippe Pasero, Dana Branze Mol cell Volume 60, Issue 6, p835–846, 17 December 2015

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Replication stress activates DNA repair synthesis in mitosis Sheroy Minocherhomji, Songmin Ying, Victoria A. Bjerregaard, Sara Bursomanno, Aiste Aleliunaite, Wei Wu, Hocine W. Mankouri, Huahao Shen, Ying Liu & Ian D. Hickson Nature 528, 286–290 (10 December 2015)

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M. Carmen Herrera, Silvia Tognetti, Alberto Riera, Juergen Zech, Pippa Clarke, Alejandra Fernández-Cid, and Christian Speck A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase Nucl. Acids Res. (02 December 2015) 43 (21): 10238-10250

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Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA Julien Gros, Charanya Kumar, Gerard Lynch, Tejas Yadav, Iestyn Whitehouse, Dirk Remus Mol cell Volume 60, Issue 5, p797–807, 3 December 2015

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DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene Ryan Griffin Thys and Yuh-Hwa Wang J. Biol. Chem. 2015; 290:28953-28962

no postings this week

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Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe Catarina A. Marques, Nicholas J. Dickens, Daniel Paape, Samantha J. Campbell and Richard McCulloch* Genome Biology (2015) 16:230

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Structural organization of human replication timing domains Rasha E. Boulos, Guénola Drillon, Françoise Argoul, Alain Arneodo, Benjamin Audit FEBS Letters Volume 589, Issue 20, Part A, 7 October 2015, Pages 2944–2957

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c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication Kaveri Sidhu, Vijay Kumar Biochimica et Biophysica Acta 1849 (2015) 1319–1328

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Rif1 binds to G quadruplexes and suppresses replication over long distances Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guillet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige & Hisao Masai Nature Structural & Molecular Biology 22, 889–897 (2015)

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Polymerase δ replicates both strands after homologous recombination–dependent fork restart - Izumi Miyabe, Ken'Ichi Mizuno, Andrea Keszthelyi, Yasukazu Daigaku, Meliti Skouteri, Saed Mohebi, Thomas A Kunkel, Johanne M Murray & Antony M Carr Nature Structural & Molecular Biology 22, 932–938 (2015)

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Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing Jordan R. Becker,Carles Pons,Hai Dang Nguyen,Michael Costanzo,Charles Boone,Chad L. Myers,Anja-Katrin Bielinsky PLoS Genet 11(11): e1005659

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The Replication Initiation Protein Sld3/Treslin Orchestrates the Assembly of the Replication Fork Helicase during S Phase Irina Bruck and Daniel L. Kaplan J. Biol. Chem. 2015; 290:27414-27424

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High-Resolution Profiling of Drosophila Replication Start Sites Reveals a DNA Shape and Chromatin Signature of Metazoan Origins Federico Comoglio, Tommy Schlumpf, Virginia Schmid, Remo Rohs, Christian Beisel, and Renato Paro Cell Reports 11, 821–834

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MCM ring hexamerization is a prerequisite for DNA-binding Clifford A. Froelich, Amanda Nourse, and Eric J. Enemark Nucl. Acids Res. 2015 43: 9553-9563

no publications this week

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no publications this week

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Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK-like kinase PK5 Abhijit S. Deshmukh, Meetu Agarwal1, Parul Mehra, Ashish Gupta, Nidhi Gupta, Christian D. Doerig and Suman Kumar Dhar Molecular MicrobiologyVolume 98, Issue 1, pages 17–33, October 2015

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Replication dynamics in fission and budding yeasts through DNA polymerase tracking Enrique Vazquez and Francisco Antequera Volume 37, Issue 10, pages 1067–1073, October 2015

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Tethering of SCFDia2 to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase Timurs Maculins, Pedro Junior Nkosi, Hiroko Nishikawa, Karim Labib Current Biology volume 25, Issue 17, p2254–2259, 31 August 2015

no publications this week

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The mechanism of DNA replication termination in vertebrates James M. Dewar, Magda Budzowska & Johannes C. Walter Nature 525, 345–350 (17 September 2015)

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The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication Maryna Levikova and Petr Cejka Nucl. Acids Res. 2015 43: 7888-7897

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Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases Yuji Masuda, Rie Kanao, Kentaro Kaji, Haruo Ohmori, Fumio Hanaoka, and Chikahide Masutani Nucl. Acids Res. 2015 43: 7898-7910

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The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability Huzefa Dungrawala, Kristie L. Rose, Kamakoti P. Bhat, Kareem N. Mohni, Gloria G. Glick, Frank B. Couch, David Cortez Mol cell Volume 59, Issue 6, p998–1010, 17 September 2015

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Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase Rémi Buisson, Jessica L. Boisvert, Cyril H. Benes, Lee Zou Mol cell Volume 59, Issue 6, p1011–1024, 17 September 2015

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Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase Irina Bruck and Daniel L. Kaplan PNAS vol. 112 no. 36 11223

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Pre-steady-state Kinetic Analysis of a Family D DNA Polymerase from Thermococcus sp. 9°N Reveals Mechanisms for Archaeal Genomic Replication and Maintenance Kelly M. Schermerhorn and Andrew F. Gardner J. Biol. Chem. 2015; 290:21800-21810

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Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation Philip Zegerman Chromosoma September 2015, Volume 124, Issue 3, pp 309-321

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MCM2 binding to histones H3–H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork Camille Clément & Geneviève Almouzni Nature Structural & Molecular Biology 22, 587–589 (2015)

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A unique binding mode enables MCM2 to chaperone histones H3–H4 at replication forks Hongda Huang, Caroline B Strømme, Giulia Saredi, Martina Hödl, Anne Strandsby, Cristina González-Aguilera, Shoudeng Chen, Anja Groth & Dinshaw J Patel Nature Structural & Molecular Biology 22, 618–626 (2015)

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Initiation of replication in Xenopus egg extracts at a spatially defined origin Kyung Yong Leea & Anindya Duttaa* Cell Cycle Volume 14, Issue 15, 2015 page 2391

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Activation of new replication foci under conditions of replication stress P Rybak, A Waligórska, Ł Bujnowicz, A Hoang & JW Dobrucki Cell Cycle Volume 14, Issue 16, 2015 pages 2634-2647

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Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes Thomas A. Guilliam, Benjamin A. Keen, Nigel C. Brissett, and Aidan J. Doherty Nucl. Acids Res. 2015 43: 6651-6664

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Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences Mary E. Tarantino, Katharina Bilotti, Ji Huang, and Sarah Delaney J. Biol. Chem. 2015; 290:21154-21162

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TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells Rune Troelsgaard Pedersen, Thomas Kruse, Jakob Nilsson, Vibe H. Oestergaard, and Michael Lisby Jcb 210:565-582.

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Structure of the eukaryotic MCM complex at 3.8 Å Ningning Li, Yuanliang Zhai, Yixiao Zhang, Wanqiu Li, Maojun Yang, Jianlin Lei, Bik-Kwoon Tye & Ning Gao Nature 524, 186–191 (13 August 2015)

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DNA replication: Strand separation unravelled Matthew L. Bochman & Anthony Schwacha Nature 524, 166–167 (13 August 2015)

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And‐1 coordinates with Claspin for efficient Chk1 activation in response to replication stress Jing Hao, Christelle de Renty, Yongming Li, Haijie Xiao, Michael G Kemp, Zhiyong Han, Melvin L DePamphilis, Wenge Zhu EMBO J Volume 34, Issue 15 04 August 2015 | pp 1987 – 2110

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Checkpoint Activation of an Unconventional DNA Replication Program in Tetrahymena Pamela Y. Sandoval, Po-Hsuen Lee, Xiangzhou Meng, Geoffrey M. Kapler PLoS Genet 11(7): e1005405.

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RPA prevents G‐rich structure formation at lagging‐strand telomeres to allow maintenance of chromosome ends Julien Audry, Laetitia Maestroni, Emmanuelle Delagoutte, Tiphaine Gauthier, Toru M Nakamura, Yannick Gachet, Carole Saintomé, Vincent Géli, and Stéphane Coulon The EMBO Journal (2015) 34: 1942–1958

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Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae Amr Al-Zain, Lea Schroeder, Alina Sheglov, and Amy E. Ikui Mol. Biol. Cell July 15, 2015 vol. 26 no. 14 2609-2619

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Control of Cdc6 accumulation by Cdk1 and MAPK is essential for completion of oocyte meiotic divisions in Xenopus Enrico M. Daldello, Tran Le, Robert Poulhe, Catherine Jessus, Olivier Haccard and Aude Dupré July 15, 2015 J Cell Sci 128, 2482-2496.

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BLM helicase facilitates telomere replication during leading strand synthesis of telomeres William C. Drosopoulos, Settapong T. Kosiyatrakul, and Carl L. Schildkraut JCB vol. 210 no. 2 191-208

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Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes Bruce Stillman Mol cell Volume 59, Issue 2, p139–141, 16 July 2015

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A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands Robert E. Johnson, Roland Klassen, Louise Prakash, Satya Prakash Mol cell Volume 59, Issue 2, p163–175, 16 July 2015

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Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein Jared T. Nordman and Terry L. Orr-Weaver BioEssays Volume 37, Issue 8, pages 856–861, August 2015

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Behavior of replication origins in Eukaryota – spatio-temporal dynamics of licensing and firing Marcelina W Musiałek & Dorota Rybaczek Cell cycle pages 2251-2264

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HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest Bizhan Romani, Nima Shaykh Baygloo, Mohammad Reza Aghasadeghi, and Elham Allahbakhshi J. Biol. Chem. 2015; 290:17380-17389

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Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture Nozomi Sugimoto, Kazumitsu Maehara, Kazumasa Yoshida, Shuhei Yasukouchi, Satoko Osano, Shinya Watanabe, Masahiro Aizawa, Takashi Yugawa, Tohru Kiyono, Hitoshi Kurumizaka, Yasuyuki Ohkawa, and Masatoshi Fujita Nucl. Acids Res. 2015 43: 5898-5911

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DNA Polymerase α Subunit Residues and Interactions Required for Efficient Initiation Complex Formation Identified by a Genetic Selection Janet C. Lindow, Paul R. Dohrmann, and Charles S. McHenry J. Biol. Chem. 2015; 290:16851-16860

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Okazaki fragment maturation involves α‐segment error editing by the mammalian FEN1/MutSα functional complex Songbai Liu, Guojun Lu, Shafat Ali, Wenpeng Liu, Li Zheng, Huifang Dai, Hongzhi Li, Hong Xu, Yuejin Hua, Yajing Zhou, Janice Ortega, Guo‐Min Li, Thomas A Kunkel, Binghui Shen The EMBO Journal (2015) 34: 1829–1843

no postings this week

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Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair Jessica L. Alexander, M. Inmaculada Barrasa, Terry L. Orr-Weaver Current biology Volume 25, Issue 12, p1654–1660, 15 June 2015

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RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin Furqan Sami , Xing Lu , Swetha Parvathaneni , Rabindra Roy , Ronald K. Gary , Sudha Sharma Biochemical Journal Jun 01, 2015, 468 (2) 227-244;

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FEN1-mediated α-segment error editing during Okazaki fragment maturation Shafat Ali, Li Zheng & Binghui Shen Cell Cycle Volume 14, Issue 12, 2015 page 1767

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Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis Faiza M Kalfalah, Elke Berg, Morten O Christensen, René M Linka, Wilhelm G Dirks, Fritz Boege & Christian Mielke Cell Cycle Volume 14, Issue 11, 2015 pages 1704-1715

no postings this week

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Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit Yoshiaki Suwa, Jianyou Gu, Andrey G. Baranovskiy, Nigar D. Babayeva, Youri I. Pavlov and Tahir H. Tahirov The Journal of Biological Chemistry, 290, 14328-14337.

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Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate Feng-Ling Tsaia, Sriram Vijayraghavana, Joseph Prinz, Heather K. MacAlpine, David M. MacAlpine and Anthony Schwacha Mol. Cell. Biol. June 2015 vol. 35 no. 12 2131-2143

no postings this week

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The Roles of Family B and D DNA Polymerases in Thermococcus Species 9°N Okazaki Fragment Maturation* Lucia Greenough, Zvi Kelman and Andrew F. Gardner The Journal of Biological Chemistry, 290, 12514-12522.

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Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin Jeannine Gerhardt, Gulfem D. Guler, Ellen Fanning Experimental Cell Research Volume 334, Issue 2, 10 June 2015, Pages 283–293

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Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation Xiangzi Han, Franklin Mayca Pozo, Jacob N. Wisotsky, Benlian Wang, James W. Jacobberger, and Youwei Zhang J. Biol. Chem. 2015; 290:12370-12378

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Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells Nihan Kara, Manzar Hossain, Supriya G. Prasanth, and Bruce Stillman J. Biol. Chem. 2015; 290:12355-12369

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Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis Janice Ortega, Jessie Y. Li,Sanghee Lee, Dan Tong, Liya Gu, and Guo-Min Li PNAS 112 no. 18, 5667–5672

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Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system Ruth Stucke, Néstor García-Rodríguez, Andrés Aguilera, and Ralf Erik Wellinger PNAS vol. 112 no. 18 5779–5784

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The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-Molecule Level Daniel Duzdevich, Megan D. Warner, Simina Ticau, Nikola A. Ivica, Stephen P. Bell, Eric C. Greene Mol cell Volume 58, Issue 3, p483–494,

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Regulation of yeast DNA polymerase δ-mediated strand displacement synthesis by 5′-flaps Katrina N. Koc, Joseph L. Stodola, Peter M. Burgers, and Roberto Galletto Nucl. Acids Res. 2015 43: 4179-4190

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Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing Gheorghe Chistol, Johannes C. Walter Cell Volume 161, Issue 3, p429–430, 23 April 2015

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Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading Simina Ticau, Larry J. Friedman, Nikola A. Ivica, Jeff Gelles, Stephen P. Bell Cell Volume 161, Issue 3, p513–525, 23 April 2015

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ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress Yu-Hung Chen, Mathew J.K. Jones, Yandong Yin, Sarah B. Crist, Luca Colnaghi, Robert J. Sims, Eli Rothenberg, Prasad V. Jallepalli, Tony T. Huang Mol cell Volume 58, Issue 2, p323–338, 16 April 2015

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The Human RNA Polymerase I Transcription Terminator Complex Acts as a Replication Fork Barrier That Coordinates the Progress of Replication with rRNA Transcription Activity Yufuko Akamatsu and Takehiko Kobayashi Mol. Cell. Biol. May 2015 vol. 35 no. 10 1871-1881

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Cyclin‐A–CDK2‐mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication Nikki A. Copeland*, Heather E. Sercombe, Rosemary H. C. Wilson‡ and Dawn Coverley J Cell Sci 128, 1518-1527

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Replisome Function During Replicative Stress Is Modulated by Histone H3 Lysine 56 Acetylation Through Ctf4 Pierre Luciano, Pierre-Marie Dehé, Stéphane Audebert, Vincent Géli, and Yves Corda Genetics April 1, 2015 vol. 199 no. 4 1047-1063

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RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells Jun-Sub Im, Soon-Young Park, Won-Ho Cho, Sung-Ho Bae, Jerard Hurwitz & Joon-Kyu Lee Cell Cycle Volume 14,pages 1001-1009

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RecQ4 promotes the conversion of the pre-initiation complex at a site-specific origin for DNA unwinding in Xenopus egg extracts Yosuke Sanuki, Yumiko Kubota, Masato T Kanemaki, Tatsuro S Takahashi, Satoru Mimura & Haruhiko Takisawa 
Cell Cycle Volume 14,pages 1010-1023

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Role of swi7H4 Mutant Allele of DNA Polymerase α in the DNA Damage Checkpoint Response Saman Khan, Shakil Ahmed PLoS ONE 10(3): e0124063

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G-quadruplexes Significantly Stimulate Pif1 Helicase-catalyzed Duplex DNA Unwinding Xiao-Lei Duan, Na-Nv Liu, Yan-Tao Yang, Hai-Hong Li, Ming Li, Shuo-Xing Dou and Xu-Guang Xi The Journal of Biological Chemistry, 290, 7722-7735

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Dpb11 Protein Helps Control Assembly of the Cdc45·Mcm2-7·GINS Replication Fork Helicase* Nalini Dhingra, Irina Bruck, Skye Smith, Boting Ning and Daniel L. Kaplan Journal of Biological Chemistry, 290, 7586-7601

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Molecular biology: DNA replication reconstructed Michael Weinreich Nature 519, 418–419 (26 March 2015)

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Regulated eukaryotic DNA replication origin firing with purified proteins Joseph T. P. Yeeles, Tom D. Deegan, Agnieszka Janska, Anne Early & John F. X. Diffley Nature 519, 431–435 (26 March 2015)

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Crystal structure of the eukaryotic origin recognition complex Franziska Bleichert, Michael R. Botchan & James M. Berger Nature 519, 321–326

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DNA Induces Conformational Changes in a Recombinant Human Minichromosome Maintenance Complex Emma L. Hesketh, Richard P. Parker-Manuel, Yuriy Chaban, Rabab Satti, Dawn Coverley, Elena V. Orlova§ and James P. J. Chong Journal of Biological Chemistry, 290, 7973-7979

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H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing Beatrice Rondinelli, Hélène Schwerer, Elena Antonini, Marco Gaviraghi, Alessio Lupi, Michela Frenquelli, Davide Cittaro, Simona Segalla, Jean-Marc Lemaitre, and Giovanni Tonon Nucl. Acids Res. 2015 43: 2560-2574

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Single molecule analysis of Trypanosoma brucei DNA replication dynamics Simone Guedes Calderano, William C. Drosopoulos, Marina Mônaco Quaresma, Catarina A. Marques, Settapong Kosiyatrakul, Richard McCulloch, Carl L. Schildkraut, and Maria Carolina Elias Nucl. Acids Res. 2015 43: 2655-2665

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Replication fork integrity and intra-S phase checkpoint suppress gene amplification Anna Kondratova, Takaaki Watanabe, Michael Marotta, Matthew Cannon, Anca M. Segall, David Serre, and Hisashi Tanaka Nucl. Acids Res. 2015 43: 2678-2690

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High-affinity DNA-binding Domains of Replication Protein A (RPA) Direct SMARCAL1-dependent Replication Fork Remodeling Kamakoti P. Bhat, Rémy Bétous and David Cortez The Journal of Biological Chemistry, 290, 4110-4117.

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Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle Sara K Powell, Heather K MacAlpine, Joseph A Prinz, Yulong Li, Jason A Belsky, David M MacAlpine EMBO J Volume 34,12 February 2015 | pp 425 - 577

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Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules Shinichiro Niimi, Shiho Arakawa-Takeuchi, Baasanjav Uranbileg, Jun-ha Park, Shigeki Jinno and Hiroto Okayama The Journal of Biological Chemistry, 287, 18573-18583.

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Lagging-strand replication shapes the mutational landscape of the genome Martin A. M. Reijns, Harriet Kemp, James Ding, Sophie Marion de Procé, Andrew P. Jackson & Martin S. Taylor Nature 518, 502–506 (26 February 2015)

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Crystal Structure of the Human Primase Andrey G. Baranovskiy, Yinbo Zhang, Yoshiaki Suwa, Nigar D. Babayeva, Jianyou Gu, Youri I. Pavlov, and Tahir H. Tahirov J. Biol. Chem. 2015; 290:5635-5646

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A fresh start for stalled forks Mitch Leslie J. Cell Biol. 2015; 208:495

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DNA2 drives processing and restart of reversed replication forks in human cells Saravanabhavan Thangavel, Matteo Berti, Maryna Levikova, Cosimo Pinto, Shivasankari Gomathinayagam, Marko Vujanovic, Ralph Zellweger, Hayley Moore, Eu Han Lee, Eric A. Hendrickson, Petr Cejka, Sheila Stewart, Massimo Lopes, and Alessandro Vindigni J. Cell Biol. 2015; 208:545-562,

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Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells Ralph Zellweger, Damian Dalcher, Karun Mutreja, Matteo Berti, Jonas A. Schmid, Raquel Herrador, Alessandro Vindigni, and Massimo Lopes J. Cell Biol. 2015; 208:563-579

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Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex Marco Fumasoni, Katharina Zwicky, Fabio Vanoli, Massimo Lopes, Dana Branzei Mol cell Volume 57, Issue 5, p812–823, 5 March 2015

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Switch on the engine: how the eukaryotic replicative helicase MCM2–7 becomes activated Silvia Tognetti, Alberto Riera, Christian Speck Chromosoma March 2015, Volume 124, Issue 1, pp 13-26Pages 13-26

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DNA replication in nurse cell polytene chromosomes of Drosophila melanogaster otu mutants Dmitry E. Koryakov ad Igor F. Zhimulev Chromosoma March 2015, Volume 124, Issue 1, pp 95-106

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Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity Sarah K. Deng, Huan Chen and Lorraine S. Symington BioEssays Volume 37, Issue 3, pages 305–313, March 2015

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Ribonucleotides in DNA: hidden in plain sight Sue Jinks-Robertson & Hannah L Klein Nature Structural & Molecular Biology 22, 176–178 (2015)

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Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation Anders R Clausen, Scott A Lujan, Adam B Burkholder, Clinton D Orebaugh, Jessica S Williams, Maryam F Clausen, Ewa P Malc, Piotr A Mieczkowski, David C Fargo, Duncan J Smith & Thomas A Kunkel Nature Structural & Molecular Biology 22, 185–191 (2015)

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A global profile of replicative polymerase usage - Yasukazu Daigaku, Andrea Keszthelyi, Carolin A Müller, Izumi Miyabe, Tony Brooks, Renata Retkute, Mike Hubank, Conrad A Nieduszynski & Antony M Carr Nature Structural & Molecular Biology 22, 192–198 (2015)

no postings this week

publication alert

Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork Nicolas Richet, Danni Liu, Pierre Legrand, Christophe Velours, Armelle Corpet, Albane Gaubert, May Bakail, Gwenaelle Moal-Raisin, Raphael Guerois, Christel Compper, Arthur Besle, Berengère Guichard, Genevieve Almouzni, and Françoise Ochsenbein Nucl. Acids Res. 2015 43: 1905-1917

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Dynamic loading and redistribution of the Mcm2‐7 helicase complex through the cell cycle Sara K Powell, Heather K MacAlpine, Joseph A Prinz, Yulong Li, Jason A Belsky, David M MacAlpine Embo j Volume 34, Issue 4 12 February 2015 | pp 425 – 577

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Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication Emma L Hesketh, John RP Knight, Rosemary HC Wilson, James PJ Chong & Dawn Coverley Cell Cycle Volume 14, Issue 3, 2015

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Opening the gate to DNA replication Alberto Rieraa & Christian Speck Cell cycle 14 6-8

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DNA-protein interaction dynamics at the Lamin B2 replication origin Luca Puzzi, Laura Marchetti, Fiorenzo A Peverali, Giuseppe Biamonti & Mauro Giacca
 Cell cycle 14 pages 64-73

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Yeast DNA Polymerase ϵ Catalytic Core and Holoenzyme Have Comparable Catalytic Rates Rais A. Ganai, Pia Osterman, and Erik Johansson J. Biol. Chem. 2015; 290:3825-3835

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Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication Cai Guo, Akiko Kumagai, Katharina Schlacher, Anna Shevchenko, Andrej Shevchenko, William G. Dunphy Mol cell Volume 57, Issue 3, p492–505, 5 February 2015

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Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly Jason A. Belsky, Heather K. MacAlpine, Yoav Lubelsky, Alexander J. Hartemink and David M. MacAlpine Genes & Dev. 2015. 29: 212-224

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Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement Tatjana Petojevic, James J. Pesavento, Alessandro Costa, Jingdan Liang, Zhijun Wang, James M. Berger, and Michael R. Botchan PNAS 2015 112 (3) E249-E258;

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Switching between polymerase and exonuclease sites in DNA polymerase ε Rais A. Ganai, Göran O. Bylund, and Erik Johansson Nucl. Acids Res. 2015 43: 932-942

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Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins Thomas A. Guilliam, Stanislaw K. Jozwiakowski, Aaron Ehlinger, Ryan P. Barnes, Sean G. Rudd, Laura J. Bailey, J. Mark Skehel, Kristin A. Eckert,Walter J. Chazin, and Aidan J. Doherty Nucl. Acids Res. 2015 43: 1056-1068

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The Dbf4-Cdc7 Kinase Promotes Mcm2-7 Ring Opening to Allow for Single-stranded DNA Extrusion and Helicase Assembly Irina Bruck and Daniel L. Kaplan1 The Journal of Biological Chemistry, 290, 1210-1221.

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Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function Jingchuan Sun,Alejandra Fernandez-Cid, Alberto Riera, Silvia Tognetti, Zuanning Yuan, Bruce Stillman, Christian Speck and Huilin Li1, Genes & Dev. 2014. 28: 2291-2303

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Characterization of a Drosophila Ortholog of the Cdc7 Kinase: A ROLE FOR Cdc7 IN ENDOREPLICATION INDEPENDENT OF CHIFFON Robert Stephenson, Marcus R. Hosler, Navnath S. Gavande, Arun K. Ghosh, and Vikki M. Weake J. Biol. Chem. 2015; 290:1332-1347

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The DNA Replication Licensing Factor Miniature Chromosome Maintenance 7 Is Essential for RNA Splicing of Epidermal Growth Factor Receptor, c-Met, and Platelet-derived Growth Factor Receptor Zhang-Hui Chen, Yan P. Yu, George Michalopoulos, Joel Nelson, and Jian-Hua Luo J. Biol. Chem. 2015; 290:1404-1411

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Human CST abundance determines recovery from diverse forms of DNA damage and replication stress Feng Wang, Jason Stewart & Carolyn M Price cell cycle 13 3488-3498

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RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain R.S. Pavania,C. Fernandesb, A.M. Perezc, E.J.R. Vasconcelos, J.L. Siqueira-Neto, M.R. Fontes, M.I.N. Cano FEBS Letters Volume 588, Issue 24, 20 December 2014, Pages 4740–4748

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Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner Gwang Su Kim, Jeeheon Kang, Sung Woong Bang, Deog Su Hwang Biochemical and Biophysical Research Communications Volume 456, Issue 3, 16 January 2015, Pages 763–767

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The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus Giuseppe Cannone, Yuli Xu, Thomas R. Beattie, Stephen D. Bell and Laura Spagnolo Biochem. J. (2015) 465 (239–245)

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Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21WAF1, Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells Hong Zhao, Sufang Zhang, Dazhong Xu, Marietta YWT Lee, Zhongtao Zhang, Ernest YC Lee & Zbigniew Darzynkiewicz
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Developmental Regulation of the Tetrahymena thermophila Origin Recognition Complex Po-Hsuen Lee, Xiangzhou Meng, Geoffrey M. Kapler PLoS Genet 11(1): e1004875

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ASAR15, A cis-Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15 Nathan Donley, Leslie Smith, Mathew J. Thayer PLoS Genet 11(1): e1004923