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Implications of Translesion DNA Synthesis Polymerases on Genomic Stability and Human Health Jegadheeswari Venkadakrishnan, Ganesh Lahane, Arti Dhar, Wei Xiao, Krishna Moorthi Bhat, Tej K. PanditaORCID Icon & Audesh Bhat Mol Cell Biol 43 Pages 401-425

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NFIB facilitates replication licensing by acting as a genome organizer Wenting Zhang, Yue Wang, Yongjie Liu, Cuifang Liu, Yizhou Wang, Lin He, Xiao Cheng, Yani Peng, Lu Xia, Xiaodi Wu, Jiajing Wu, Yu Zhang, Luyang Sun, Ping Chen, Guohong Li, Qiang Tu, Jing Liang & Yongfeng Shang Nature Communications volume 14, Article number: 5076 (2023)

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How Pol α-primase is targeted to replisomes to prime eukaryotic DNA replication Morgan L. Jones, Valentina Aria, Yasemin Baris, Joseph T.P. Yeeles Mol Cell VOLUME 83, ISSUE 16, P2911-2924.E16

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Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates Jérémy Poulet-Benedetti, Caroline Tonnerre-Doncarli, Anne-Laure Valton, Marc Laurent, Marie Gérard, Natalja Barinova, Nikolaos Parisis, Florian Massip, Franck Picard & Marie-Noëlle Prioleau Nature Communications volume 14, Article number: 4843 (2023)

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Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3 Frederick Richards, Marta J. Llorca-Cardenosa, Jamie Langton, Sara C. Buch-Larsen, Noor F. Shamkhi, Abhishek Bharadwaj Sharma, Michael L. Nielsen & Nicholas D. Lakin Nature Communications volume 14, Article number: 4310 (2023)

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ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins Aina Maria Mas, Enrique Goñi, Igor Ruiz de los Mozos, Aida Arcas, Luisa Statello, Jovanna González, Lorea Blázquez, Wei Ting Chelsea Lee, Dipika Gupta, Álvaro Sejas, Shoko Hoshina, Alexandros Armaos, Gian Gaetano Tartaglia, Shou Waga, Jernej Ule, Eli Rothenberg, María Gómez & Maite Huarte Nature Communications volume 14, Article number: 4447 (2023)

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CST–Polα/Primase: the second telomere maintenance machine Sarah W Cai and Titia de Lange Genes and Dev. 37:1–15

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Changing protein–DNA interactions promote ORC binding-site exchange during replication origin licensing Annie Zhang, Larry J. Friedman, Jeff Gelles, and Stephen P. Bell PNAS 120 (30) e2305556120

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Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing Audra L. Amasino, Shalini Gupta, Larry J. Friedman, Jeff Gelles, and Stephen P. Bell PNAS 120 (29) e2221484120

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Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Su-Jung Kim, Chrystelle Maric, Lina-Marie Briu, Fabien Fauchereau, Giuseppe Baldacci, Michelle Debatisse, Stéphane Koundrioukoff, Jean-Charles Cadoret IJMS Volume 24 Issue 13 10.3390/ijms241310629

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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability Vincent Gaggioli, Calvin S. Y. Lo, Nazaret Reverón-Gómez, Zuzana Jasencakova, Heura Domenech, Hong Nguyen, Simone Sidoli, Andrey Tvardovskiy, Sidrit Uruci, Johan A. Slotman, Yi Chai, João G. S. C. Souto Gonçalves, Eleni Maria Manolika, Ole N. Jensen, David Wheeler, Sriram Sridharan, Sanjiban Chakrabarty, Jeroen Demmers, Roland Kanaar, Anja Groth & Nitika Taneja Nature Cell Biology volume 25, pages 1017–1032 (2023)

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Transient chromatin compaction in fork restart Susan M. Gasser Nature Cell Biology volume 25, pages 931–932 (2023)

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Interactions between Fkh1 monomers stabilize its binding to DNA replication origins Allan Reinapae, Ivar Ilves, Henel Jürgens, Signe Värv, Kersti Kristjuhan, Arnold Kristjuhan JBC VOLUME 299 105026, AUGUST 2023

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Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe Jinal A Patel, Camryn Zezelic, Julie Rageul, Joanne Saldanha, Arafat Khan, Hyungjin Kim Nucleic Acids Research 51, Pages 6246–6263

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Actin nucleators safeguard replication forks by limiting nascent strand degradation Jadwiga Nieminuszczy, Peter R Martin, Ronan Broderick, Joanna Krwawicz, Alexandra Kanellou, Camelia Mocanu, Vicky Bousgouni, Charlotte Smith, Kuo-Kuang Wen, Beth L Woodward, Chris Bakal, Fiona Shackley, Andrés Aguilera, Grant S Stewart, Yatin M Vyas, Wojciech Niedzwiedz Nucleic Acids Research, Volume 51, Pages 6337–6354,

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Go along to get along: Integrator at active replication forks defuses co-directional transcription-replication conflicts Leticia Dinatto,Peter C. Stirling Mol Cell ISSUE 13, P2161-2163, JULY 06, 2023

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Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability Rahul Bhowmick, Kavi P.M. Mehta, Mads Lerdrup, David Cortez Mol Cell 83,P2357-2366

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A look into the dynamic process of proofreading in DNA polymerase-γ at near-atomic resolution Nature Structural & Molecular Biology volume 30, pages 722–723 (2023)

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Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity Joon Park, Geoffrey K. Herrmann, Patrick G. Mitchell, Michael B. Sherman & Y. Whitney Yin Nature Structural & Molecular Biology volume 30, pages 812–823 (2023)

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H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins Yingying Zou, Jiayao Pei, Haizhen Long, Liting Lan, Kejian Dong, Tingting Wang, Ming Li, Zhexuan Zhao, Lirun Zhu, Gangxuan Zhang, Xin Jin, Yang Wang, Zengqi Wen, Min Wei & Yunpeng Feng Nature Structural & Molecular Biology volume 30, pages 800–811 (2023)

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Distinct Interaction Modes for the Eukaryotic RNA Polymerase Alpha-like Subunits Alana E. Belkevich, Haleigh G. Pascual, Aula M. Fakhouri, David G. Ball & Bruce A. Knutson Mol Cell Biol 43 Pages 269-282

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DNA polymerase ε leading strand signature mutations result from defects in its proofreading activity Robert E. Johnson, Louise Prakash, and Satya Prakash JBC 299 104293 June 2023,

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Cell-type specificity of the human mutation landscape with respect to DNA replication dynamics Madison Caballero, Dominik Boos, Amnon Koren Mol Cell VOLUME 3, ISSUE 6, 100315

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Structures of human primosome elongation complexes Qixiang He, Andrey G. Baranovskiy, Lucia M. Morstadt, Alisa E. Lisova, Nigar D. Babayeva, Benjamin L. Lusk, Ci Ji Lim & Tahir H. Tahirov Nature Structural & Molecular Biology volume 30, pages 579–583 (2023)

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Human primase hangs on the primer–template and Polα to facilitate primer termination. He et al Nat Struct Mol Biol 30, 575–576 (2023).

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CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands Clément Rouillon, Bruna V Eckhardt, Leonie Kollenstart, Fabian Gruss, Alexander E E Verkennis, Inge Rondeel, Peter H L Krijger, Giulia Ricci, Alva Biran, Theo van Laar, Charlotte M Delvaux de Fenffe, Georgiana Luppens, Pascal Albanese, Koichi Sato, Richard A Scheltema, Wouter de Laat, Puck Knipscheer, Nynke H Dekker, Anja Groth, Francesca Mattiroli Nucleic Acids Research, Volume 51, Pages 3770–3792

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DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao & Xinghuan Wang Nature Communications volume 14, Article number: 2421 (2023)

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Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk Mariève J. Rocque, Vilde Leipart, Ashish Kumar Singh, Pilar Mur, Maren F. Olsen, Lars F. Engebretsen, Edgar Martin-Ramos, Rosa Aligué, Pål Sætrom, Laura Valle, Finn Drabløs, Marit Otterlei & Wenche Sjursen MGG volume 298, pages 555–566 (2023)

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RAD51 bypasses the CMG helicase to promote replication fork reversal WENPENG LIU, YUICHIRO SAITO, JESSICA JACKSON, RAHUL BHOWMICK, MASATO T. KANEMAKI, ALESSANDRO VINDIGNI, AND DAVID CORTEZ SCIENCE 380 pp. 382-387

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Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts Brittany N. Vandenberg, Marian F. Laughery, Cameron Cordero, Dalton Plummer, Debra Mitchell, Jordan Kreyenhagen, Fatimah Albaqshi, Alexander J. Brown, Piotr A. Mieczkowski, John J. Wyrick & Steven A. Roberts Nature Communications volume 14, Article number: 2576 (2023)

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DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability Yo-Chuen Lin, Dazhen Liu, Arindam Chakraborty, Virgilia Macias, Eileen Brister, Jay Sonalkar, Linyuan Shen, Jaba Mitra, Taekjip Ha, Andre Kajdacsy-Balla, Kannanganattu V. Prasanth & Supriya G. Prasanth Mol Cell Biol 43 Pages 143-156

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Pif1 family helicases promote mutation avoidance during DNA replication Zhi-Xiong Zhou, Cindy Follonier, Scott A Lujan, Adam B Burkholder, Virginia A Zakian, Thomas A Kunkel Nucleic Acids Research, Volume 50, Issue 22, 9 December 2022, Pages 12844–12855

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The human pre-replication complex is an open complex Jian Li,Jiangqing Dong,Weitao Wang,Daqi Yu,Xinyu Fan,Yan Chit Hui,Clare S.K. Lee,Wai Hei Lam,Nathan Alary,Yang Yang,Yingyi Zhang,Qian Zhao,Chun-Long Chen,Bik-Kwoon Tye,Shangyu Dang,Yuanliang Zhai Cell VOLUME 186, ISSUE 1, P98-111.E21, JANUARY 05, 2023

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CDT1, a licensing factor that limits rereplication Gergely Rona and Michele Pagano Mol Cell VOLUME 83, ISSUE 1, P1-3, JANUARY 05, 2023

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Dephosphorylation of the pre-initiation complex is critical for origin firing Fiona Jenkinson,Kang Wei Tan,Barbara Schöpf,Miguel M. Santos,Philip Zegerman Mol Cell VOLUME 83, ISSUE 1, P12-25.E10, JANUARY 05, 2023

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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis Nalin Ratnayeke,Yasemin Baris,Mingyu Chung,Joseph T.P. Yeeles,Tobias Meyer Mol Cell VOLUME 83, ISSUE 1, P26-42.E13, JANUARY 05, 2023

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Replication fork uncoupling causes nascent strand degradation and fork reversal Tamar Kavlashvili, Wenpeng Liu, Taha M. Mohamed, David Cortez & James M. Dewar Nature Structural & Molecular Biology volume 30, pages 115–124 (2023)

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Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry Xiangzhou Meng, Clémence Claussin, Gemma Regan-Mochrie1, Iestyn Whitehouse and Xiaolan Zhao Gnes and Dev January 26, 2023,

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Origins of DNA replication in eukaryotes Yixin Hu and Bruce Stillman Mol Cell VOLUME 83, ISSUE 3, P352-372, FEBRUARY 02, 2023

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Rapid profiling of DNA replication dynamics using mass spectrometry–based analysis of nascent DNA Mohamed E. Ashour,Andrea K. Byrum ,Alice Meroni ,Jun Xia ,Saurabh Singh ,Roberto Galletto ,Susan M. Rosenberg ,Alessandro Vindigni ,Nima Mosammaparast J Cell Biol (2023) 222 (4): e202207121.

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A replication fork determinant for the establishment of sister chromatid cohesion Masashi Minamino,Céline Bouchoux,Berta Canal,John F.X. Diffley,Frank Uhlmann Cell VOLUME 186, ISSUE 4, P837-849.E11,

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Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon Roman Jaksik, David A. Wheeler & Marek Kimmel BMC Biology volume 21, Article number: 41 (2023)

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DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation Xiaohua Xu, Chou-Wei Chang, Min Li, Kenneth Omabe, Nhung Le, Yi-Hsuan Chen, Feng Liang & Yilun Liu Nature Communications volume 14, Article number: 1233 (2023)

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Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition Zaida Vergara, María S. Gomez, Bénédicte Desvoyes, Joana Sequeira-Mendes, Kinda Masoud, Celina Costas, Sandra Noir, Elena Caro, Victoria Mora-Gil, Pascal Genschik & Crisanto Gutierrez Nature Communications volume 14, Article number: 1270 (2023)

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The evolution of the human DNA replication timing program Alexa N. Bracci, Anissa Dallmann, Qiliang Ding, Melissa J. Hubisz, Madison Caballero, and Amnon Koren PNAS February 27, 2023 120 (10) e2213896120

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Mismatch repair operates at the replication fork in direct competition with mismatch extension by DNA polymerase δ Roland Klassen,Venkat Gangavarapu,Robert E. Johnson,Louise Prakash, Satya Prakash JBC VOLUME 299, ISSUE 4, 104598, APRIL 2023

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Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids Henriette Stoy, Katharina Zwicky, Danina Kuster, Kevin S Lang, Jana Krietsch, Magdalena P. Crossley, Jonas A. Schmid, Karlene A. Cimprich, Houra Merrikh & Massimo Lopes Nature Structural & Molecular Biology volume 30, pages 348–359 (2023)

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The evolving tale of Pol2 function Matthew Gallitto and Zhiguo Zhang Genes and Dev April 1, 2023, 37 (7-8)

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Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry Xiangzhou Meng, Clémence Claussin, Gemma Regan-Mochrie, Iestyn Whitehouse and Xiaolan Zhao Genes & Dev. 2023. 37: 74-79

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The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress Zhe Han, Martin Andrš, Bindhu K Madhavan, Serap Kaymak, Alba Sulaj, Zoltan Kender, Stefan Kopf, Lars Kihm, Rainer Pepperkok, Pavel Janscak, Peter Nawroth, Varun Kumar Nucleic Acids Research, Volume 51, Issue 5, 21 March 2023, Pages 2298–2318,

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ORChestra coordinates the replication and repair music Dazhen Liu, Jay Sonalkar, Supriya G. Prasanth Bioessays Volume45, Issue4 April 2023 2200229

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Replication timing and transcriptional control: beyond cause and effect — part IV Athanasios E Vouzas , David M Gilbert Current Opinion in Genetics & Development Volume 79, April 2023, 102031

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DDK promotes DNA replication initiation: Mechanistic and structural insights Ningning Li, Ning Gao, Yuanliang Zhai Current Opinion in Structural Biology Volume 78, February 2023, 102504

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Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival Haitao Sun,Lingzi Ma,Ya-Fang Tsai,Tharindu Abeywardana,Binghui Shen, Li Zheng Trends in Cell Biol VOLUME 33, ISSUE 3, P221-234, MARCH 2023

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The in vivo measurement of replication fork velocity and pausing by lag-time analysis Dean Huang, Anna E. Johnson, Brandon S. Sim, Teresa W. Lo, Houra Merrikh & Paul A. Wiggins Nature Communications volume 14, Article number: 1762 (2023)

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RNA:DNA hybrids from Okazaki fragments contribute to establish the Ku-mediated barrier to replication-fork degradation Charlotte Audoynaud,Kamila Schirmeisen,Anissia Ait Saada,Armelle Gesnik,Paloma Fernández-Varela, Virginie Boucherit,Virginie Ropars,Anusha Chaudhuri,Karine Fréon,Jean-Baptiste Charbonnier,Sarah A.E. Lambert Mol Cell VOLUME 83, ISSUE 7, P1061-1074.E6, APRIL 06, 2023

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GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail Ling Chen , Qidong Cai, Rui Yang, Haiyan Wang, Huli Ling, Tiansheng Li, Na Liu, Zuli Wang, Jingyue Sun, Tania Tao, Ying Shi, Ya Cao, Xiang Wang, Desheng Xiao, Shuang Liu, and Yongguang Tao PNAS April 5, 2023 120 (15) e2219585120

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Replication licensing during S phase: breaking the law to prevent breaking DNA David M. Gilbert Nature Structural & Molecular Biology volume 30, pages 406–408 (2023)

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Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation Olivier Brison, Stefano Gnan, Dana Azar, Stéphane Koundrioukoff, Rodrigo Melendez-Garcia, Su-Jung Kim, Mélanie Schmidt, Sami El-Hilali, Yan Jaszczyszyn, Anne-Marie Lachages, Claude Thermes, Chun-Long Chen & Michelle Debatisse Nature Structural & Molecular Biology volume 30, pages 539–550 (2023)

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Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation Daniel Ramírez Montero, Humberto Sánchez, Edo van Veen, Theo van Laar, Belén Solano, John F. X. Diffley & Nynke H. Dekker Nature Communications volume 14, Article number: 2082 (2023)

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Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex Kiyoshi Yamaguchi, Saya Nakagawa,Akari Saku,Yumiko Isobe,Rui Yamaguchi,Paul Sheridan,Kiyoko Takane,Tsuneo Ikenoue,Chi Zhu,Masashi Miura,Yuya Okawara,Satoru Nagatoishi,Hiroko Kozuka-Hata,Masaaki Oyama,Susumu Aikou,Yuka Ahiko,Dai Shida,Kouhei Tsumoto,Satoru Miyano,Seiya Imoto,Yoichi Furukawa iScience VOLUME 26, ISSUE 4,106563, APRIL 21, 2023