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Assembly of a homohexameric minichromosome maintenance complex is dependent on ATP and DNA Oliver W. Noble ∙ Clement Degut∙ Michael R. Hodgkinson ∙ James P.J. Chong ∙ Michael J. Plevin Journal of Biological Chemistry,

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Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki Volume599, Issue24 December 2025 Pages 3669-3684

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The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein Salla Keskitalo, Boglarka Zambo, Dicle Malaymar Pinar, Antti Tuhkala, Kari Salokas, Tanja Turunen, Norbert Deutsch, Norman Davey, Zsuzsanna Dosztányi, Markku Varjosalo & Gergo Gogl  Nature Communications ,

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License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication Victoria Frisbie, Franziska Bleichert Bio essays. Volume48, Issue1 January 2026 e70095

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Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer Rosanna Wilkins, Eva Petermann J Cell Sci (2025) 138 (23): jcs264148.

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Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions Joshua Tomkins, Lucy V. Edwardes, Sarah V. Faull, Matthew Peach, Peter J. Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J. Julian Blow, Alexis R. Barr, Anna Barnard& Christian Speck  Nat Commun (2025).

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Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication Xiaoxuan Zhu, Atabek Bektash, Yuki Hatoyama, Sachiko Muramatsu, Shin-Ya Isobe, Chikashi Obuse, Atsushi Toyoda, Yasukazu Daigaku, Chun-Long Chen & Masato T. Kanemaki  Nature Communications volume 16, Article number: 10069 (2025)

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Spatial mapping of DNA synthesis reveals dynamics and geometry of human replication nanostructures Michael Hawgood Bruno Urién Ana Agostinho Praghadhesh Thiagarajan Giovanni Giglio, Yiqiu Yang Xue Zhang Gemma Quijada Matilde Fonseca Jiri Bartek1 Hans Blom & Bennie Lemmens EMBO J 44, 7263–7294 (2025).

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The A, B, C, D’s of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy Leonardo Betancurt-Anzola , Killian C O’Connell , Vladimir Potapov , Jennifer L Ong , Nathan A Tanner , Ludovic Sauguet , Kelly M Zatopek Nucleic Acids Research, Volume 53, Issue 21, 26 November 2025, gkaf1143,

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A novel MCMDC2 variant causes meiotic arrest and non-obstructive azoospermia in a consanguineous Chinese family Qi Fang, Lanxi Ran, Song Liu, Jianyong Di, Ye Liu, Fengqin Xu & Binbin Wang Journal of Human Genetics volume 70,  pages 661–665 (2025)

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Mechanistic coupling of enzymatic activities at the replisome Malisha U. Welikala ∙ Lauren J. Butterworth ∙ Rashini Y. Beragama Arachchi ∙ Michael A. Trakselis Journal of Biological Chemistry, Volume 301, Issue 11, 110761

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Replication timings affect the frequency of chromosomal translocation Promeet Halder & Mrinal Srivastava Nature Reviews Cancer volume 25, 886 (2025)

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H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability Filip D Duzanic, Vaishnavi Mohana-Natarajan, Samuele Fisicaro, Collin Bakker, Moses Aouami, Gabriel Amaral, Massimo Lopes, Nitika Taneja & Lorenza Penengo EMBO J 44, 6598–6625 (2025).

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Turning the replisome around. Petryk, N. Nat Rev Mol Cell Biol 26, 908 (2025).

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Unexpected molecular mechanism of Orc6-based Meier–Gorlin syndrome: insights from a humanized Drosophila model Maxim Balasov, Katarina Akhmetova, Igor Chesnokov Genetics, Volume 231, Issue 3, November 2025, iyaf203,

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HIRA defines early replication initiation zones independently of their genome compartment Tina Karagyozova, Alberto Gatto, Audrey Forest, Jean-Pierre Quivy, Rocío Nunez-Vazquez, Marc A. Martí-Renom, Leonid A. Mirny & Geneviève Almouzni  Nature Communications volume 16, Article number: 9715 (2025)

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MCM5 UFMylation regulates replication origin firing and fork progression, Zheng Li, Xingxuan Wu, Liu Liu, Shaohong Rao, Yanting Liao, Mengting Liu, Bin Peng, Qiongdan Zhang, Yisui Xia , Yuanliang Zhai, ShunichiTakeda, and Xingzhi Xu EMBO J (2025) 44: 6019 - 6050

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Leading and lagging strand abasic sites differentially affect vertebrate replisome progression but involve analogous bypass mechanisms Matthew T Cranford, Steven N Dahmen, David Cortez, James M Dewar Nucleic Acids Research, Volume 53, Issue 18, 14 October 2025, gkaf975,

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ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation Ying Pang, Meng Cheng, Jingzhe Wang, Rui Wang, Xu Chen, Chunyu Zhang, Yuntong Yang, Tongjie Ji, Min Liu, Jing Zhang, Chunlong Zhong Nucleic Acids Research, Volume 53, Issue 18, 14 October 2025, gkaf939,

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Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression Marta Milan, Valeria Runfola, Manthan Patel, Lucia Falbo, Roberta Noberini, Chiara Soriani, Simona Rodighiero, Tiziana Bonaldi, Vincenzo Costanzo, Madapura M Pradeepa Paola Scaffidi Nucleic Acids Research, Volume 53, Issue 18, 14 October 2025,

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CRL4DCAF12 regulation of MCMBP ensures optimal licensing of DNA replication Anoop Kumar Yadav, Alikhan Abdirov, Katarina Ondruskova, Simran Negi, Kristina Jamrichova, Karolina Kolarova, Nikol Dibus, Jana Krejci, Hana Polasek-Sedlackova & Lukas Cermak  Nature Communications volume 16, Article number: 9391 (2025)

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Dynamic association of H3K36me3 with pericentromeric heterochromatin regulates its replication time Sunil Kumar Pradhan , Hui Zhang, Ksenia G Kolobynina, Alexander Rapp , Maria Arroyo, and M Cristina Cardoso EMBO Rep (2025) 26: 4950 - 4976

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An Orc6 tether mediates ORC binding-site switching during replication origin licensing David Driscoll, Larry J. Friedman , Jeff Gelles, and Stephen P. Bell PNAS 122 (41) e2510685122 https://doi.org/10.1073/pnas.2510685122