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Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends Nikesh Patel, John M. Atack, L. David Finger, Jack C. Exell, Peter Thompson, Susan Tsutakawa, John A. Tainer, David M. Williams, and Jane A.Grasby Nucl. Acids Res. 2012 40: 4507-4519