Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae Joseph C. Sanchez, Anja Ollodart, Christopher R. L. Large, Courtnee Clough, Gina M. Alvino, Mitsuhiro Tsuchiya, Matthew Crane, Elizabeth X. Kwan, Matt Kaeberlein, Maitreya J. Dunham, M.K. Raghuraman and Bonita J. Brewer Genetics Volume 213 Issue 1, September 2019