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Checkpoint inhibition of origin firing prevents DNA topological stress Esther C. Morafraile1, Christine Hänni1, George Allen1, Theresa Zeisner, Caroline Clarke, Mark C. Johnson, Miguel M. Santos, Lauren Carroll, Nicola E. Minchell, Jonathan Baxter, Peter Banks, Dave Lydall and Philip Zegerman Genes & Dev. 2019. 33: 1539-1554