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Replisome passage through the cohesin ring Samson Glaser ∙ Maxim I. Molodtsov ∙ John F.X. Diffley∙ Frank Uhlmann Cell Volume 188, Issue 20P5618-5631.E14October 02, 2025

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Structural obstruction to full DNA replication in terminally differentiated skeletal muscle cells Sara Zribi, Gladio Joel Giannitelli , Laura Bernardini, Federica Censi Serena Camerini, Lucia Bertuccini , Francesca Iosi , Emilia Giannella, Massimo Sanchez, Elisa Consoli , Andrea Casagrande , Alessandra Cenci , Giovanna Floridia Antonio Novelli , Alessandro Giuliani , Vincenzo Costanzo , Marco Crescenzi and Deborah Pajalunga Embo rep (2025). 26: 4633 - 4655.

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PARP1 auto-modification promotes faithful Okazaki fragment processing and limits replication fork speed Jonas D. Elsborg ∙ Sebastian H.N. Munk ∙ Alba Adelantado-Rubio ∙ Ramóna Pék ∙ Zita Fábian ∙ Victor Imburchia ∙ Siham Zentout ∙ Ivo A. Hendriks ∙ Sara C. Buch-Larsen ∙ Rebecca Smith ∙ Jiri Bartek ∙ Julien P. Duxin ∙ Sébastien Huet ∙ Apolinar Maya-Mendoza ∙ Michael L. Nielsen. Mol cell Volume 85, Issue 19P3562-3575.E10October 02, 2025

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Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Masashi Minamino1∙ John F.X. Diffley∙ Frank Uhlmann Mol Cell

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DNA polymerase α-primase can function as a translesion DNA polymerase Ryan Mayle , Roxana Georgescu and Michael E. O’Donnell PNASA 122 (37) e2517556122

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Mutational analysis of the Drosophila CMG helicase reveals relationships among chromosome integrity and the maintenance of spindle and centrosome structure Lucia Graziadio, Livia Scatolini, Elisabetta Bucciarelli, Grazia Daniela Raffa, Silvia Bonaccorsi, Maurizio Gatti Genetics, Volume 231, Issue 1, September 2025, iyaf124,

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The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication Kyohei Matsuhashi, Kei K. Ito, Kaho Nagai, Akira Sanada, Koki Watanabe, Kasuga Takumi, Atsushi Toyoda, Masamitsu Fukuyama, Shohei Yamamoto, Takumi Chinen, Grant S. Stewart, Shoji Hata & Daiju Kitagawa  Nature Communications 16, Article number: 7799 (2025)

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The human primosome requires replication protein A when copying DNA with inverted repeats Andrey G Baranovskiy , Lucia M Morstadt , Eduardo E Romero , Nigar D Babayeva , Tahir H Tahirov Nucleic Acids Research, Volume 53, Issue 15, 28 August 2025, gkaf799,

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Replication program of a single-chromosome budding yeast strain Jade Pellet , Laurent Lacroix , Bertrand Theulot , Emma Simonin Chavignier , Alan Tourancheau , Florence Proux , Sylvie Hermann-Le Denmat , Gael A Millot , Benoît Le Tallec , Olivier Hyrien Nucleic Acids Research, Volume 53, Issue 15, 28 August 2025, gkaf754,

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RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization Tsunetoshi Nakatani ∙ Tamas Schauer ∙ Mrinmoy Pal ∙ Andreas Ettinger ∙ Luis Altamirano-Pacheco ∙ Julia Zorn ∙ David M. Gilbert ∙ Maria-Elena Torres-Padilla Dev Cell Volume 60, Issue 16P2149-2162.E7August 18, 2025

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Master transcription-factor binding sites constitute the core of early replication control elements Jesse L Turner, Laura Hinojosa-Gonzalez, Takayo Sasaki Satoshi Uchino , Athanasios Vouzas, Mariella S Soto , Abhijit Chakraborty, Karen EAlexander, Cheryl A Fitch, Amber N Brown Ferhat Ay, and David M Gilbert EMBO J (2025) 44: 4499 - 4524

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ecDNA replication is disorganized and vulnerable to replication stress Jedrzej J Jaworski , Pauline L Pfuderer , Pawel Czyz , Gianluca Petris , Michael A Boemo , Julian E Sale Nucleic Acids Research, Volume 53, Issue 14, 12 August 2025, gkaf711,

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Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and pattern Tyler D. Noble, Courtney G. Sansam, Kimberlie A. Wittig, Blanka Majchrzycka & Christopher L. Sansam Genome Biology volume 26, Article number: 194 (2025)

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A human high-fidelity DNA polymerase holoenzyme has a wide range of lesion bypass activities Rachel L Dannenberg , Joseph A Cardina , Helen Washington , Shijun Gao , Marc M Greenberg , Mark Hedglin Nucleic Acids Research, Volume 53, Issue 13, 22 July 2025, gkaf646,

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USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance Mengfan Tang , Siting Li , Ziqiang Zhu , Chao Wang , Shuai Ding , Huimin Zhang , Min Huang , Sarah Keast , Zhen Chen , Ling Yin , Litong Nie , Dan Su , Xu Feng , Junjie Chen Nucleic Acids Research, Volume 53, Issue 12, 8 July 2025, gkaf544,

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Dynamics of replication timing during mammalian development Tsunetoshi Nakatani. Trends in Genetics, Volume 41, Issue 7, 568 - 576

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Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase Min June Yang, Haeun Lee, Donguk Kang, Chin-Ju Park Febs J Volume292, Issue12 June 2025 Pages 3151-3164

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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells Agostina P. Bertolin ∙ Berta Canal ∙ Mona Yekezare ∙ Anne Early ∙ Jingkun Zeng ∙ Rachael Instrell ∙ Michael Howell ∙ John F.X. Diffley Molecular Cell, Volume 85, Issue 13, 2474 - 2486.e6

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The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks Berta Canal ∙ Agostina P. Bertolin ∙ Giselle C. Lee ∙ Lucy S. Drury ∙ Masashi Minamino ∙ John F.X. Diffley Molecular Cell, Volume 85, Issue 13, 2462 - 2473.e6

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DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication Sara Rodríguez-Acebes, Rodrigo Martín-Rufo, Alicia Gómez-Moya, Scott B. Churcher, Alejandro Fernández-Llorente, Guillermo de la Vega-Barranco, Alejandra Perona, Pilar Oroz, Elena Martín-Doncel, Luis Ignacio Toledo, Juan Méndez & Emilio Lecona  Nature Communications volume 16, Article number: 5706 (2025)

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BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication Dongxu Li, Zhi-Min Zhang, Liu Mei, Yao Yu, Yiran Guo, Samuel G. Mackintosh, Jianbin Chen, David F. Allison, Arum Kim, Aaron J. Storey, Ricky D. Edmondson, Stephanie D. Byrum, Alan J. Tackett, Ling Cai, Jeanette G. Cook, Jikui Song & Gang Greg Wang  Nature Communications volume16, Article number: 5502 (2025)

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USP37 protects mammalian cells during DNA replication stress by counteracting CUL2LRR1 and TRAIP Fabrizio Villa ∙ Johanna Ainsworth ∙ Karim P.M. Labib Cell Reports, Volume 44, Issue 6, 115739

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Loss of G1-phase CDK-inhibition biases instability between genomic regions by unevenly reducing activity among replication origins Fábia Gomes ∙ Fernando Devesa ∙ Pilar Ayuda-Durán ∙ Pablo Aza ∙ Arantxa Agote-Arán ∙ Debora Cavero ∙ Azman Embarc-Buh ∙ Ana González ∙ Rodrigo Bermejo ∙ Arturo Calzada iScience, Volume 28, Issue 6, 112757

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USP37 prevents premature disassembly of stressed replisomes by TRAIP Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter & Stephen P. Jackson  Nature Communications volume 16, Article number: 5333 (2025)

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An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins Rajkumar Dhanaraju, Rachel Y. Samson, Xu Feng, Alessandro Costa, Giovanni Gonzalez-Gutierrez & Stephen D. Bell  Nature Communications volume 16, Article number: 5230 (2025)

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BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function Kyrie Pappas, Matteo Ferrari, Perianne Smith, Subhiksha Nandakumar, Zahra Khan, Serina B. Young, Justin LaClair, Marco Vincenzo Russo, Emmet Huang-Hobbs, Nikolaus Schultz, Wassim Abida, Wouter Karthaus, Maria Jasin and Charles L. Sawyers PNAS June 3, 2025122 (23) e2426743122

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The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme Feng Wang, Qing He, Michael E. O’Donnell, and Huilin Li PNAS 122 (22) e2507232122

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Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing get actual link when it comes out Christian Speck, Luitpold Maximilian Reuter Bioessays. 2025 May 19:e70018.

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Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones Jamie T. Carrington, Rosemary H. C. Wilson, Eduardo de La Vega, Sathish Thiyagarajan, Tom Barker, Leah Catchpole, Alex Durrant, Vanda Knitlhoffer, Chris Watkins, Karim Gharbi & Conrad A. Nieduszynski  Genome Biology volume 26, Article number: 122 (2025)

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Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA Yeonoh Shin ∙ Mark Hedglin ∙ Katsuhiko S. Murakami Journal of Biological Chemistry, Volume 301, Issue 4, 108342

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USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown & Michael J. Emanuele  Nature Communications volume 16, Article number: 4575 (2025

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Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome Suzanne E Hile , Matthias H Weissensteiner , Kara G Pytko , Joseph Dahl , Eduard Kejnovsky , Iva Kejnovská , Mark Hedglin , Ilias Georgakopoulos-Soares , Kateryna D Makova , Kristin A Eckert Nucleic Acids Research, Volume 53, Issue 8, 8 May 2025,

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RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization Tsunetoshi Nakatani ∙ Tamas Schauer ∙ Mrinmoy Pal ∙ Julia Zorn ∙ David M. Gilbert ∙ Maria-Elena Torres-Padilla Dev Cell

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Selective interactions at pre-replication complexes categorize baseline and dormant origins Bhushan L. Thakur, Christophe E. Redon, Haiqing Fu, Robin Sebastian, Nana A. Kusi, Sophie Z. Zhuang, Lorinc S. Pongor, Vilhelm A. Bohr & Mirit I. Aladjem Nature Communications volume 16, Article number: 4140 (2025)

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Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei Marija Krasiļņikova, Catarina A. Marques, Emma M. Briggs, Craig Lapsley, Graham Hamilton, Dario Beraldi, Kathryn Crouch & Richard McCulloch Nature Communications volume 16, Article number: 751 (2025)

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