4 June 2025
Publication alert
The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme
Feng Wang, Qing He, Michael E. O’Donnell, and Huilin Li
PNAS 122 (22) e2507232122
3 June 2025
Publication alert
Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing get actual link when it comes out
Christian Speck, Luitpold Maximilian Reuter
Bioessays. 2025 May 19:e70018.
Publication alert
Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones
Jamie T. Carrington, Rosemary H. C. Wilson, Eduardo de La Vega, Sathish Thiyagarajan, Tom Barker, Leah Catchpole, Alex Durrant, Vanda Knitlhoffer, Chris Watkins, Karim Gharbi & Conrad A. Nieduszynski
Genome Biology volume 26, Article number: 122 (2025)
Publication alert
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA
Yeonoh Shin ∙ Mark Hedglin ∙ Katsuhiko S. Murakami
Journal of Biological Chemistry, Volume 301, Issue 4, 108342
Publication alert
A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate
Sandra Koit1 ∙ Nele Tamberg ∙ Allan Reinapae ∙ Lauri Peil ∙ Arnold Kristjuhan ∙ Ivar Ilves
Journal of Biological Chemistry, Volume 301, Issue 4, 108408
Publication alert
Effects of CDC45 mutations on DNA replication and genome stability
Milena Denkiewicz-Kruk, Deepali Chaudhry, Alina Krasilia, Malgorzata Jedrychowska, Iwona J. Fijalkowska, Michal Dmowski
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1872, Issue 5, June 2025, 119936
Publication alert
Multigenerational cell tracking of DNA replication and heritable DNA damage
Andreas Panagopoulos, Merula Stout, Sinan Kilic, Peter Leary, Julia Vornberger, Virginia Pasti, Antonio Galarreta, Aleksandra Lezaja, Kyra Kirschenbühler, Ralph Imhof, Hubert Rehrauer, Urs Ziegler & Matthias Altmeyer
Nature.
Publication alert
DNA replication timing reveals genome-wide features of transcription and fragility
Francisco Berkemeier, Peter R. Cook & Michael A. Boemo
Nature Communications volume16, Article number: 4658 (2025)
Publication alert
USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown & Michael J. Emanuele
Nature Communications volume 16, Article number: 4575 (2025
Publication alert
The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection
Kimberly Calugaru , Eun Young Yu , Sophie Huang , Nayim González-Rodríguez , Javier Coloma , Neal F Lue
Nucleic Acids Research, Volume 53, Issue 7, 24 April 2025,
Publication alert
Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome
Suzanne E Hile , Matthias H Weissensteiner , Kara G Pytko , Joseph Dahl , Eduard Kejnovsky , Iva Kejnovská , Mark Hedglin , Ilias Georgakopoulos-Soares , Kateryna D Makova , Kristin A Eckert
Nucleic Acids Research, Volume 53, Issue 8, 8 May 2025,
Publication alert
Human DNA replication initiation sites are specified epigenetically by oxidation of 5-methyl-deoxycytidine
Torsten Krude , Jiaming Bi , Rachel Doran , Rebecca A Jones , James C Smith
Nucleic Acids Research, Volume 53, Issue 8, 8 May 2025,
13 May 2025
publication alert
DNA bending mediated by ORC is essential for replication licensing in budding yeast
Wai Hei Lam, Daqi Yu, Qiongdan Zhang, and Shangyu Dang
PNAS April 4, 2025 122 (14) e2502277122
publication alert
Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome
Emma E Fletcher, Morgan L Jones, and Joseph T P Yeeles
EMBO J(2025)44: 2298 - 2322
publication alert
RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization
Tsunetoshi Nakatani ∙ Tamas Schauer ∙ Mrinmoy Pal ∙ Julia Zorn ∙ David M. Gilbert ∙ Maria-Elena Torres-Padilla
Dev Cell
publication alert
Selective interactions at pre-replication complexes categorize baseline and dormant origins
Bhushan L. Thakur, Christophe E. Redon, Haiqing Fu, Robin Sebastian, Nana A. Kusi, Sophie Z. Zhuang, Lorinc S. Pongor, Vilhelm A. Bohr & Mirit I. Aladjem
Nature Communications volume 16, Article number: 4140 (2025)
publication alert
Chromatin-centric insights into DNA replication
Yang Liu ∙ Zhengrong Zhangding ∙ Xuhao Liu ∙ Jiazhi Hu
Trends in Genetics, Volume 41, Issue 5, 412 - 424
publication alert
The Depletion of TRAIP Results in the Retention of PCNA on Chromatin During Mitosis Leads to Inhibiting DNA Replication Initiation
Yasushi Shiomi, Akiyo Hayashi, Yuichiro Saito, Masato T. Kanemaki, Hideo Nishitani
Genes to Cells, 2025; 30:e70006
2 April 2025
publication alert
Z-form DNA-RNA hybrid blocks DNA replication
Shiyu Wang, Yan Xu
Nucleic Acids Research, Volume 53, Issue 5, 24 March 2025, gkaf135,
publication alert
A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate
Sandra Koit, ∙ Nele Tamberg ∙ Allan Reinapae ∙ Lauri Peil ∙ Arnold Kristjuhan ∙ Ivar Ilves
Journal of Biological Chemistry, Volume 0, Issue 0, 108408
publication alert
The Shu complex interacts with the replicative helicase to prevent mutations and aberrant recombination
Adeola A Fagunloye , Alessio De Magis , Jordan H Little , Isabela Contreras, Tanis J Dorwart , Braulio Bonilla , Kushol Gupta , Nathan Clark , Theresa Zacheja, Katrin Paeschke and Kara A Bernstein
EMBO J(2025)44: 1512 - 1539
publication alert
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA
Yeonoh Shin ∙ Mark Hedglin ∙ Katsuhiko S. Murakami
Journal of Biological Chemistry, Volume 301, Issue 4, 108342
publication alert
Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes
Mariko Sasaki, Takehiko Kobayashi
Nucleic Acids Research, Volume 53, Issue 3, 10 February 2025, gkaf014,
publication alert
Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus
Diletta Ciardo, Olivier Haccard, Francesco de Carli, Olivier Hyrien, Arach Goldar, Kathrin Marheineke
Nucleic Acids Research, Volume 53, Issue 3, 10 February 2025, gkaf007,
publication alert
DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion
Mili Das, Suzanne E Hile, Jennifer Brewster, Jan Leendert Boer, Rachel Bezalel-Buch, Qiong Guo, Wei Yang, Peter M Burgers, Kristin A Eckert, Catherine H Freudenreich
Nucleic Acids Research, Volume 53, Issue 3, 10 February 2025, gkae1254,
publication alert
Replication-IDentifier links epigenetic and metabolic pathways to the replication stress response
Sophie C. van der Horst, Leonie Kollenstart, Amandine Batté , Sander Keizer, Kees Vreeken, Praveen Pandey, Andrei Chabes & Haico van Attikum
Nature Communications | (2025)16:1416
publication alert
The double life of mammalian DNA replication origins
Olivier Hyrien, Guillaume Guilbaud and Torsten Krude
Genes & Dev. 2025.
publication alert
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei
Marija Krasiļņikova, Catarina A. Marques, Emma M. Briggs, Craig Lapsley, Graham Hamilton, Dario Beraldi, Kathryn Crouch & Richard McCulloch
Nature Communications volume 16, Article number: 751 (2025)
publication alert
Sequence specificity of an essential nuclear localization sequence in Mcm3
Ziyi Wang, Yun Jing Zhang, Qian-yi Zhang, Kate Bilsborrow, Matthew Leslie, Raymond T. Suhandynata, Huilin Zhou
PLoS Genet 21(1): e1011499.
publication alert
Unidirectional MCM translocation away from ORC drives origin licensing
Agata Butryn, Julia F. Greiwe & Alessandro Costa
Nature Communications volume 16, Article number: 782 (2025)
publication alert
A tale of two strands: Decoding chromatin replication through strand-specific sequencing
Zhiming Li ∙ Zhiguo Zhang
Mol Cell Volume 85, Issue 2P238-261January 16, 2025
publication alert
publication alert
Cell cycle progression of under-replicated cells
Min Huang, Chang Yang, Litong Nie, Huimin Zhang, Dandan Zhu, Chao Wang, Jeong-Min Park, Mrinal Srivastava, Elina Mosa, Siting Li, Mengfan Tang, Xu Feng, Sarah J Keast, Fabio Stossi, Junjie Chen
Nucleic Acids Research, Volume 53, Issue 1, 13 January 2025, gkae1311,
publication alert
H3K56 acetylation regulates chromatin maturation following DNA replication
Shoufu Duan, Ilana M. Nodelman, Hui Zhou, Toshio Tsukiyama, Gregory D. Bowman & Zhiguo Zhang
Nature Communications volume 16, Article number: 134 (2025)
publication alert
Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming
Bertrand Theulot, Alan Tourancheau, Emma Simonin Chavignier, Etienne Jean, Jean-Michel Arbona, Benjamin Audit, Olivier Hyrien, Laurent Lacroix & Benoît Le Tallec
Nature Communications volume 16, Article number: 242 (2025)
publication alert
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li & Christian Speck
Nature Communications volume 16, Article number: 14 (2025)
publication alert
Repair of replication-dependent double-strand breaks differs between the leading and lagging strands
Michael T. Kimble ∙ Aakanksha Sane ∙ Robert J.D. Reid ∙ Matthew J. Johnson ∙ Rodney Rothstein ∙ Lorraine S. Symington
Mol Cell Volume 85, Issue 1P61-77.E6January 02, 2025
publication alert
Communication between DNA polymerases and Replication Protein A within the archaeal replisome
Markel Martínez-Carranza, Léa Vialle, Clément Madru, Florence Cordier, Ayten Dizkirici Tekpinar, Ahmed Haouz, Pierre Legrand, Rémy A. Le Meur, Patrick England, Rémi Dulermo, J. Iñaki Guijarro, Ghislaine Henneke & Ludovic Sauguet
Nature Communications volume 15, Article number: 10926 (2024)
publication alert
DNA replication initiation drives focal mutagenesis and rearrangements in human cancers
Pierre Murat, Guillaume Guilbaud & Julian E. Sale
Nature Communications volume 15, Article number: 10850 (2024)
Subscribe to:
Posts (Atom)