10 July 2025

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Dynamics of replication timing during mammalian development Tsunetoshi Nakatani. Trends in Genetics, Volume 41, Issue 7, 568 - 576

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Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase Min June Yang, Haeun Lee, Donguk Kang, Chin-Ju Park Febs J Volume292, Issue12 June 2025 Pages 3151-3164

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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells Agostina P. Bertolin ∙ Berta Canal ∙ Mona Yekezare ∙ Anne Early ∙ Jingkun Zeng ∙ Rachael Instrell ∙ Michael Howell ∙ John F.X. Diffley Molecular Cell, Volume 85, Issue 13, 2474 - 2486.e6

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The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks Berta Canal ∙ Agostina P. Bertolin ∙ Giselle C. Lee ∙ Lucy S. Drury ∙ Masashi Minamino ∙ John F.X. Diffley Molecular Cell, Volume 85, Issue 13, 2462 - 2473.e6

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DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication Sara Rodríguez-Acebes, Rodrigo Martín-Rufo, Alicia Gómez-Moya, Scott B. Churcher, Alejandro Fernández-Llorente, Guillermo de la Vega-Barranco, Alejandra Perona, Pilar Oroz, Elena Martín-Doncel, Luis Ignacio Toledo, Juan Méndez & Emilio Lecona  Nature Communications volume 16, Article number: 5706 (2025)

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BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication Dongxu Li, Zhi-Min Zhang, Liu Mei, Yao Yu, Yiran Guo, Samuel G. Mackintosh, Jianbin Chen, David F. Allison, Arum Kim, Aaron J. Storey, Ricky D. Edmondson, Stephanie D. Byrum, Alan J. Tackett, Ling Cai, Jeanette G. Cook, Jikui Song & Gang Greg Wang  Nature Communications volume16, Article number: 5502 (2025)

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Specific origin selection and excess functional MCM2–7 loading in ORC-deficient cells Yoshiyuki Shibata , Mihaela Peycheva , Etsuko Shibata , Daniel Malzl , Rushad Pavri , Anindya Dutta Author Notes Nucleic Acids Research, Volume 53, Issue 11, 24 June 2025, gkaf518,

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Regulation of epigenetics and chromosome structure by human ORC2 Zhangli Su ∙ Mengxue Tian ∙ Etsuko Shibata ∙ Yoshiyuki Shibata ∙ Tianyi Yang ∙ Zhenjia Wang ∙ Fulai Jin∙ Chongzhi Zang∙ Anindya Dutta Cell Reports, Volume 44, Issue 6, 115816

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USP37 protects mammalian cells during DNA replication stress by counteracting CUL2LRR1 and TRAIP Fabrizio Villa ∙ Johanna Ainsworth ∙ Karim P.M. Labib Cell Reports, Volume 44, Issue 6, 115739

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Loss of G1-phase CDK-inhibition biases instability between genomic regions by unevenly reducing activity among replication origins Fábia Gomes ∙ Fernando Devesa ∙ Pilar Ayuda-Durán ∙ Pablo Aza ∙ Arantxa Agote-Arán ∙ Debora Cavero ∙ Azman Embarc-Buh ∙ Ana González ∙ Rodrigo Bermejo ∙ Arturo Calzada iScience, Volume 28, Issue 6, 112757

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USP37 prevents premature disassembly of stressed replisomes by TRAIP Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter & Stephen P. Jackson  Nature Communications volume 16, Article number: 5333 (2025)

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An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins Rajkumar Dhanaraju, Rachel Y. Samson, Xu Feng, Alessandro Costa, Giovanni Gonzalez-Gutierrez & Stephen D. Bell  Nature Communications volume 16, Article number: 5230 (2025)

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BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function Kyrie Pappas, Matteo Ferrari, Perianne Smith, Subhiksha Nandakumar, Zahra Khan, Serina B. Young, Justin LaClair, Marco Vincenzo Russo, Emmet Huang-Hobbs, Nikolaus Schultz, Wassim Abida, Wouter Karthaus, Maria Jasin and Charles L. Sawyers PNAS June 3, 2025122 (23) e2426743122