10 June 2012

publication alert

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing Jiazhi Hu,Lei Sun,Fenfen Shen,Yufei Chen,Yu Hua,Yang Liu,Mian Zhang,Yiren Hu,Qingsong Wang,Wei Xu,Fei Sun,Jianguo Ji,Johanne M. Murray,Antony M. Carr,Daochun Kong cell, Volume 149, Issue 6, 1221-1232, 8 June 2012

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Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells Chen-Hua Chuang, Dian Yang, Gongshi Bai, Amy Freeland, Steven C. Pruitt, and John C. Schimenti Nucl. Acids Res. 2012 40: 4914-4924

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Structural basis for homeodomain recognition by the cell-cycle regulator Geminin Bo Zhou, Changdong Liu, Zhiwen Xu, and Guang Zhu PNAS June 5, 2012 vol. 109 no. 23 8931-8936

30 May 2012

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Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability Jordi Querol-Audía, Chunli Yan, Xiaojun Xu, Susan E. Tsutakawa, Miaw-Sheue Tsai, John A. Tainer, Priscilla K. Cooper, Eva Nogalesa, and Ivaylo Ivanov PNAS May 29, 2012 vol. 109 no. 22 8528-8533

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Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules Shinichiro Niimi, Shiho Arakawa-Takeuchi, Baasanjav Uranbileg, Jun-ha Park, Shigeki Jinno, and Hiroto Okayama J. Biol. Chem. 2012 287: 18573-18583.

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Two Different Replication Factor C Proteins, Ctf18 and RFC1, Separately Control PCNA-CRL4Cdt2-Mediated Cdt1 Proteolysis during S Phase and following UV Irradiation Yasushi Shiomi, Akiyo Hayashi, Takashi Ishii, Kaori Shinmyozu, Jun-ichi Nakayama, Kaoru Sugasawa, and Hideo Nishitani Mol. Cell. Biol. June 2012 32:2279-2288;

22 May 2012

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Ribonucleotide Reductase Activity Is Coupled to DNA Synthesis via Proliferating Cell Nuclear Antigen Israel Salguero, Estrella Guarino, Marianne E.A. Shepherd, Tom D. Deegan, Courtney G. Havens, Stuart A. MacNeill, Johannes C. Walter, Stephen E. Kearsey Current Biology, Volume 22, Issue 8, 720-726

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Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends Nikesh Patel, John M. Atack, L. David Finger, Jack C. Exell, Peter Thompson, Susan Tsutakawa, John A. Tainer, David M. Williams, and Jane A.Grasby Nucl. Acids Res. 2012 40: 4507-4519

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Flexible tethering of primase and DNA Pol {alpha} in the eukaryotic primosome Rafael Nunez-Ramirez, Sebastian Klinge, Ludovic Sauguet, Roberto Melero, Maria A. Recuero-Checa, Mairi Kilkenny, Rajika L. Perera, Begona Garcia-Alvarez, Richard J. Hall, Eva Nogales, Luca Pellegrini, and Oscar Llorca Nucl. Acids Res. 2012 40: 4726

15 May 2012

publication alert

Characterization of DNA Primase Complex Isolated from the Archaeon, Thermococcus kodakaraensis Wiebke Chemnitz Galal, Miao Pan, Zvi Kelman, and Jerard Hurwitz J. Biol. Chem. 2012 287: 16209-16219.

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Effects of Friedreich's ataxia GAA repeats on DNA replication in mammaliancells Gurangad S. Chandok, Mayank P. Patel, Sergei M. Mirkin, and Maria M. Krasilnikova Nucl. Acids Res. 2012 40: 3964-3974 Open Access

8 May 2012

publication alert

Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation Frederick van Deursen, Sugopa Sengupta, Giacomo De Piccoli, Alberto Sanchez-Diaz and Karim Labib The EMBO Journal (2012), 31,2195 – 2206

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Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components Mai Kanke, Yukako Kodama, Tatsuro S Takahashi, Takuro Nakagawa and Hisao Masukata The EMBO Journal (2012), 31,2182 – 2194

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Depletion of Cellular Pre-Replication Complex Factors Results in Increased Human Cytomegalovirus DNA Replication Tamara Evans Braun, Emma Poole, John Sinclair PLoS ONE 7(5): e36057

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Genome-wide identification and characterization of replication origins by deep sequencing Jia Xu, Yoshimi Yanagisawa, Alexander M Tsankov, Christopher Hart, Keita Aoki, Naveen Kommajosyula, Kathleen E Steinmann, James Bochicchio, Carsten Russ, Aviv Regev, Oliver J Rando, Chad Nusbaum, Hironori Niki, Patrice Milos, Zhiping Weng and Nicholas Rhind Genome Biology 2012, 13:R27